Details for: CD72

Gene ID: 971

Symbol: CD72

Ensembl ID: ENSG00000137101

Description: CD72 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 38.5740
    Cell Significance Index: -6.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.5513
    Cell Significance Index: -5.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.8745
    Cell Significance Index: -6.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.5500
    Cell Significance Index: 293.5500
  • Cell Name: centroblast (CL0009112)
    Fold Change: 4.3977
    Cell Significance Index: 10.2600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.1888
    Cell Significance Index: 49.3400
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.6368
    Cell Significance Index: 8.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.5160
    Cell Significance Index: -6.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.7786
    Cell Significance Index: 209.7600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4256
    Cell Significance Index: -3.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1885
    Cell Significance Index: 31.8500
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.9347
    Cell Significance Index: 4.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4458
    Cell Significance Index: 84.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2785
    Cell Significance Index: 27.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2465
    Cell Significance Index: 222.5400
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.2059
    Cell Significance Index: 1.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1443
    Cell Significance Index: 28.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1439
    Cell Significance Index: 20.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1402
    Cell Significance Index: 22.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1170
    Cell Significance Index: 12.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0707
    Cell Significance Index: 1.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0619
    Cell Significance Index: 3.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0530
    Cell Significance Index: 3.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0373
    Cell Significance Index: 7.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0333
    Cell Significance Index: 2.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0303
    Cell Significance Index: 3.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0247
    Cell Significance Index: 17.0500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0241
    Cell Significance Index: 0.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0223
    Cell Significance Index: 4.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0212
    Cell Significance Index: 0.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0208
    Cell Significance Index: 38.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0194
    Cell Significance Index: 36.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0189
    Cell Significance Index: 11.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0172
    Cell Significance Index: 0.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0158
    Cell Significance Index: 0.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0130
    Cell Significance Index: 20.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0125
    Cell Significance Index: 6.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0101
    Cell Significance Index: 3.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0062
    Cell Significance Index: 0.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0042
    Cell Significance Index: 1.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0017
    Cell Significance Index: 0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0008
    Cell Significance Index: -1.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0032
    Cell Significance Index: -0.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0045
    Cell Significance Index: -0.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0055
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0075
    Cell Significance Index: -5.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0079
    Cell Significance Index: -0.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0082
    Cell Significance Index: -6.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0088
    Cell Significance Index: -1.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0095
    Cell Significance Index: -5.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0096
    Cell Significance Index: -7.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0099
    Cell Significance Index: -4.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0113
    Cell Significance Index: -7.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0175
    Cell Significance Index: -5.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0191
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0227
    Cell Significance Index: -3.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0237
    Cell Significance Index: -2.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0254
    Cell Significance Index: -3.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0266
    Cell Significance Index: -1.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0272
    Cell Significance Index: -1.0300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0291
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0322
    Cell Significance Index: -6.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0414
    Cell Significance Index: -3.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0438
    Cell Significance Index: -3.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0461
    Cell Significance Index: -5.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0479
    Cell Significance Index: -5.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0534
    Cell Significance Index: -0.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0542
    Cell Significance Index: -5.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0615
    Cell Significance Index: -2.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0771
    Cell Significance Index: -1.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0872
    Cell Significance Index: -6.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0875
    Cell Significance Index: -5.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0885
    Cell Significance Index: -5.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0912
    Cell Significance Index: -6.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0945
    Cell Significance Index: -1.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0958
    Cell Significance Index: -5.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0974
    Cell Significance Index: -5.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0996
    Cell Significance Index: -2.5600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1051
    Cell Significance Index: -4.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1085
    Cell Significance Index: -5.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1152
    Cell Significance Index: -3.6900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1263
    Cell Significance Index: -3.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1291
    Cell Significance Index: -6.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1311
    Cell Significance Index: -3.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1430
    Cell Significance Index: -5.0100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1504
    Cell Significance Index: -2.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1560
    Cell Significance Index: -4.9700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1596
    Cell Significance Index: -1.6800
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.1656
    Cell Significance Index: -1.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1689
    Cell Significance Index: -5.5300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1690
    Cell Significance Index: -2.0900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1700
    Cell Significance Index: -2.8600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1719
    Cell Significance Index: -2.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1759
    Cell Significance Index: -2.4000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1778
    Cell Significance Index: -1.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1779
    Cell Significance Index: -6.5300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1793
    Cell Significance Index: -2.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1822
    Cell Significance Index: -6.3300
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1859
    Cell Significance Index: -1.2100
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.1914
    Cell Significance Index: -0.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** CD72 is a transmembrane receptor composed of two extracellular domains and one intracellular domain. 2. **Function:** CD72 interacts with semaphorins, other semaphorin receptors, and other molecules, influencing cell adhesion, migration, and signaling pathways. 3. **Expression:** CD72 is highly expressed in B cells, retinal bipolar neurons, and other immune cells, including germinal center B cells, naive B cells, and B-1 B cells. 4. **Cellular localization:** CD72 is primarily expressed on the surface of immune cells, including B cells, and is also found in the nervous system, where it may play a role in axon guidance and neuronal development. **Pathways and Functions:** 1. **Axon guidance:** CD72 interacts with semaphorins, which are involved in axon guidance and neuronal development. This interaction regulates the migration and positioning of neurons during development. 2. **Cell adhesion:** CD72 binds to semaphorins and other molecules, influencing cell adhesion and migration in various tissues, including the nervous system and immune system. 3. **Signaling receptor binding:** CD72 interacts with various ligands, including semaphorins, other semaphorin receptors, and other molecules, influencing signaling pathways that regulate cell growth, differentiation, and survival. 4. **Transmembrane signaling:** CD72 is involved in transmembrane signaling, where it regulates the activation and function of immune cells, including B cells. **Clinical Significance:** CD72 plays a crucial role in the development and function of immune cells, particularly B cells. Alterations in CD72 expression or function may contribute to various immune-related disorders, including: 1. **Immunodeficiency:** CD72 deficiency has been linked to immunodeficiency syndromes, where impaired B cell development and function lead to recurrent infections. 2. **Autoimmune diseases:** CD72 may also play a role in autoimmune diseases, such as multiple sclerosis, where dysregulation of immune cell function contributes to disease pathology. 3. **Cancer:** CD72 expression has been observed in various types of cancer, including lymphoma and leukemia, where it may contribute to tumor progression and immune evasion. In conclusion, CD72 is a semaphorin receptor that plays a critical role in the development and function of immune cells, particularly B cells. Its dysregulation may contribute to various immune-related disorders, highlighting the importance of further research into the molecular mechanisms underlying CD72 function and its role in human disease.

Genular Protein ID: 3039198905

Symbol: CD72_HUMAN

Name: B-cell differentiation antigen CD72

UniProtKB Accession Codes:

P21854

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2141045

Title: Identification of a human protein homologous to the mouse Lyb-2 B cell differentiation antigen and sequence of the corresponding cDNA.

PubMed ID: 2141045

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 359
  • Mass: 40220
  • Checksum: 87A52C028AC17E44
  • Sequence:
    • MAEAITYADL RFVKAPLKKS ISSRLGQDPG ADDDGEITYE NVQVPAVLGV PSSLASSVLG 
DKAAVKSEQP TASWRAVTSP AVGRILPCRT TCLRYLLLGL LLTCLLLGVT AICLGVRYLQ 
VSQQLQQTNR VLEVTNSSLR QQLRLKITQL GQSAEDLQGS RRELAQSQEA LQVEQRAHQA 
AEGQLQACQA DRQKTKETLQ SEEQQRRALE QKLSNMENRL KPFFTCGSAD TCCPSGWIMH 
QKSCFYISLT SKNWQESQKQ CETLSSKLAT FSEIYPQSHS YYFLNSLLPN GGSGNSYWTG 
LSSNKDWKLT DDTQRTRTYA QSSKCNKVHK TWSWWTLESE SCRSSLPYIC EMTAFRFPD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.