Details for: VPREB3

Gene ID: 29802

Symbol: VPREB3

Ensembl ID: ENSG00000128218

Description: V-set pre-B cell surrogate light chain 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: centroblast (CL0009112)
    Fold Change: 28.1047
    Cell Significance Index: 65.5700
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 25.3303
    Cell Significance Index: -3.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.1250
    Cell Significance Index: -4.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.0630
    Cell Significance Index: 597.0800
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 4.6380
    Cell Significance Index: 14.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.5178
    Cell Significance Index: 87.9400
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.2133
    Cell Significance Index: 14.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.0901
    Cell Significance Index: -3.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.2930
    Cell Significance Index: 49.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.2224
    Cell Significance Index: 143.3800
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.9051
    Cell Significance Index: 9.5300
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.3220
    Cell Significance Index: 6.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.1024
    Cell Significance Index: -4.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0888
    Cell Significance Index: 29.1800
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.9081
    Cell Significance Index: 4.5600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.5982
    Cell Significance Index: 7.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5454
    Cell Significance Index: 53.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4991
    Cell Significance Index: 10.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4591
    Cell Significance Index: 414.5300
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.3403
    Cell Significance Index: 2.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3168
    Cell Significance Index: 34.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2944
    Cell Significance Index: 47.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2662
    Cell Significance Index: 15.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1807
    Cell Significance Index: 34.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1632
    Cell Significance Index: 11.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0381
    Cell Significance Index: 2.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0273
    Cell Significance Index: 1.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0180
    Cell Significance Index: 7.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0108
    Cell Significance Index: 0.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0092
    Cell Significance Index: 0.2700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.0047
    Cell Significance Index: 0.0500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0019
    Cell Significance Index: 0.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0012
    Cell Significance Index: 0.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0003
    Cell Significance Index: -0.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0020
    Cell Significance Index: -3.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0034
    Cell Significance Index: -5.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.8300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0038
    Cell Significance Index: -0.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0050
    Cell Significance Index: -1.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0055
    Cell Significance Index: -4.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0060
    Cell Significance Index: -4.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0060
    Cell Significance Index: -0.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0068
    Cell Significance Index: -0.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0078
    Cell Significance Index: -5.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0079
    Cell Significance Index: -0.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0084
    Cell Significance Index: -4.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0088
    Cell Significance Index: -1.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0094
    Cell Significance Index: -6.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0105
    Cell Significance Index: -3.7500
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0111
    Cell Significance Index: -0.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0112
    Cell Significance Index: -0.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0115
    Cell Significance Index: -2.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0124
    Cell Significance Index: -1.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0126
    Cell Significance Index: -5.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0191
    Cell Significance Index: -3.7900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0193
    Cell Significance Index: -0.2500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0212
    Cell Significance Index: -0.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0215
    Cell Significance Index: -2.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0223
    Cell Significance Index: -2.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0223
    Cell Significance Index: -4.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0243
    Cell Significance Index: -4.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0249
    Cell Significance Index: -3.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0253
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0255
    Cell Significance Index: -5.3700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0265
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0360
    Cell Significance Index: -4.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0364
    Cell Significance Index: -5.2900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0376
    Cell Significance Index: -0.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0401
    Cell Significance Index: -4.1000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0401
    Cell Significance Index: -0.5700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0402
    Cell Significance Index: -1.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0408
    Cell Significance Index: -4.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0409
    Cell Significance Index: -2.5100
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.0452
    Cell Significance Index: -0.2400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0494
    Cell Significance Index: -0.5200
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.0518
    Cell Significance Index: -0.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0594
    Cell Significance Index: -2.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0624
    Cell Significance Index: -4.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0633
    Cell Significance Index: -4.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0671
    Cell Significance Index: -4.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0702
    Cell Significance Index: -1.4700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0728
    Cell Significance Index: -0.9200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0732
    Cell Significance Index: -1.8700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0736
    Cell Significance Index: -0.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0803
    Cell Significance Index: -6.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0826
    Cell Significance Index: -4.2900
  • Cell Name: lymphocyte of B lineage (CL0000945)
    Fold Change: -0.0835
    Cell Significance Index: -0.6200
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0837
    Cell Significance Index: -0.8800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0871
    Cell Significance Index: -0.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0905
    Cell Significance Index: -4.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0920
    Cell Significance Index: -5.1700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0969
    Cell Significance Index: -1.4600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1034
    Cell Significance Index: -0.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1062
    Cell Significance Index: -6.5300
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1121
    Cell Significance Index: -0.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1153
    Cell Significance Index: -5.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1160
    Cell Significance Index: -4.2600
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1183
    Cell Significance Index: -0.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The VPREB3 gene exhibits several key characteristics that underscore its importance in B cell biology: 1. **Expression Pattern:** The VPREB3 gene is expressed in a range of B cell subsets, including germinal center B cells, late pro-B cells, and mature B cells, suggesting a dynamic role in B cell development and maturation. 2. **Cell Surface Interactions:** The VPRE3_HUMAN protein is involved in cell surface interactions, which is critical for B cell development and function. 3. **Endoplasmic Reticulum Function:** The VPREB3 gene is implicated in the regulation of endoplasmic reticulum function, which is essential for protein folding and secretion. 4. **Immunoglobulin Production:** The VPREB3 gene plays a crucial role in the regulation of immunoglobulin production, highlighting its significance in the immune response. **Pathways and Functions:** The VPREB3 gene is involved in several key pathways and functions, including: 1. **Cell Surface Interactions:** The VPRE3_HUMAN protein is involved in cell surface interactions, which is critical for B cell development and function. 2. **Endoplasmic Reticulum Function:** The VPREB3 gene is implicated in the regulation of endoplasmic reticulum function, which is essential for protein folding and secretion. 3. **Immunoglobulin Production:** The VPREB3 gene plays a crucial role in the regulation of immunoglobulin production, highlighting its significance in the immune response. 4. **Immune Response:** The VPREB3 gene is involved in the regulation of the immune response, including the activation of B cells and the production of immunoglobulins. **Clinical Significance:** The VPREB3 gene has significant clinical implications, including: 1. **Immunodeficiency:** Mutations in the VPREB3 gene have been associated with immunodeficiency disorders, highlighting its importance in maintaining the integrity of the immune response. 2. **Autoimmune Diseases:** The VPREB3 gene is also implicated in the regulation of autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. 3. **Cancer:** The VPREB3 gene has been shown to be involved in the development and progression of certain types of cancer, including lymphoma and leukemia. In conclusion, the VPREB3 gene is a critical component of the immune system, playing a pivotal role in the development and maturation of B cells. Its involvement in cell surface interactions, endoplasmic reticulum function, and immunoglobulin production highlights its significance in maintaining the integrity of the immune response. The clinical implications of the VPREB3 gene are significant, with implications for immunodeficiency disorders, autoimmune diseases, and cancer.

Genular Protein ID: 4087849919

Symbol: VPRE3_HUMAN

Name: Pre-B lymphocyte protein 3

UniProtKB Accession Codes:

Q9UKI3 B2R587

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10702669

Title: VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse.

PubMed ID: 10702669

DOI: 10.1159/000015468

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 123
  • Mass: 13710
  • Checksum: BF09AC5196059E85
  • Sequence:
    • MACRCLSFLL MGTFLSVSQT VLAQLDALLV FPGQVAQLSC TLSPQHVTIR DYGVSWYQQR 
AGSAPRYLLY YRSEEDHHRP ADIPDRFSAA KDEAHNACVL TISPVQPEDD ADYYCSVGYG 
FSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.