DUSP2 | ENSG00000158050 | NCBI 1844

Details for: DUSP2

Gene ID: 1844

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: DUSP2

Ensembl ID: ENSG00000158050

Description: dual specificity phosphatase 2

Cell Significance Landscape

Display Count:

Associated with

Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of mapk pathway
(R-HSA-5675221)
Raf-independent mapk1/3 activation
(R-HSA-112409)
Raf/map kinase cascade
(R-HSA-5673001)
Cytoplasm
(GO:0005737)
Endoderm formation
(GO:0001706)
Map kinase tyrosine/serine/threonine phosphatase activity
(GO:0017017)
Map kinase tyrosine phosphatase activity
(GO:0033550)
Mitogen-activated protein kinase binding
(GO:0051019)
Myosin phosphatase activity
(GO:0017018)
Negative regulation of mapk cascade
(GO:0043409)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein tyrosine/threonine phosphatase activity
(GO:0008330)
Protein tyrosine phosphatase activity
(GO:0004725)
Signal transduction
(GO:0007165)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 90.71

rCSI 68.02%

PRS 94.7
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 74.78

rCSI 50.38%

PRS 91.04
CD4-positive helper T cell CL0000492

CSI 64.44

rCSI 48.74%

PRS 90.53
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 58.93

rCSI 39.28%

PRS 90.83
mucosal invariant T cell CL0000940

CSI 55.38

rCSI 44.75%

PRS 87.87
mature T cell CL0002419

CSI 46.32

rCSI 36.03%

PRS 92.22
activated type II NK T cell CL0000931

CSI 43.68

rCSI 49.16%

PRS 91.38
CD8-positive, alpha-beta memory T cell CL0000909

CSI 38.48

rCSI 40.19%

PRS 91.76
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 36.54

rCSI 33.28%

PRS 90.6
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 36.47

rCSI 62.39%

PRS 91.41
gamma-delta T cell CL0000798

CSI 34.96

rCSI 41.06%

PRS 92.24
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 33.76

rCSI 40.91%

PRS 60.38
group 3 innate lymphoid cell CL0001071

CSI 33.69

rCSI 25.31%

PRS 84.78
T-helper 1 cell CL0000545

CSI 29.68

rCSI 53.57%

PRS 93.53
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 29.45

rCSI 58.7%

PRS 90.45
T-helper 17 cell CL0000899

CSI 25.54

rCSI 20.28%

PRS 94.49
pro-B cell CL0000826

CSI 24.82

rCSI 20.55%

PRS 81.6
blood vessel endothelial cell CL0000071

CSI 24.32

rCSI 50.46%

PRS 75.87
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 23.51

rCSI 28.07%

PRS 92.99
naive T cell CL0000898

CSI 20.51

rCSI 14.27%

PRS 92.17
mature B cell CL0000785

CSI 20.44

rCSI 17.77%

PRS 88.38
secretory cell CL0000151

CSI 19.81

rCSI 20.67%

PRS 78.37
mature NK T cell CL0000814

CSI 19.78

rCSI 25.3%

PRS 89.12
myofibroblast cell CL0000186

CSI 19.58

rCSI 27.12%

PRS 76.47
early lymphoid progenitor CL0000936

CSI 18.92

rCSI 16.62%

PRS 83.95
activated CD4-positive, alpha-beta T cell CL0000896

CSI 18.46

rCSI 17.07%

PRS 92.77
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 18.25

rCSI 47.23%

PRS 94.16
endothelial cell of lymphatic vessel CL0002138

CSI 17.91

rCSI 35.5%

PRS 84.65
CD4-positive, alpha-beta memory T cell CL0000897

CSI 17.9

rCSI 12.85%

PRS 91.04
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 16.19

rCSI 11.37%

PRS 92.46
conventional dendritic cell CL0000990

CSI 15.51

rCSI 12.95%

PRS 79.76
memory B cell CL0000787

CSI 15

rCSI 14.81%

PRS 91.54
double-positive, alpha-beta thymocyte CL0000809

CSI 14.89

rCSI 15.18%

PRS 88.68
T follicular helper cell CL0002038

CSI 14.18

rCSI 10.61%

PRS 91.14
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 13.86

rCSI 13.61%

PRS 91.58
activated CD8-positive, alpha-beta T cell CL0000906

CSI 13.4

rCSI 13.17%

PRS 91.91
interstitial cell of Cajal CL0002088

CSI 12.88

rCSI 16.39%

PRS 84.02
CD14-positive monocyte CL0001054

CSI 12.86

rCSI 16.02%

PRS 87.91
alternatively activated macrophage CL0000890

CSI 12.65

rCSI 15.91%

PRS 88.04
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 12.31

rCSI 16.76%

PRS 94.8
platelet CL0000233

CSI 12.28

rCSI 50.96%

PRS 76.85
effector CD8-positive, alpha-beta T cell CL0001050

CSI 11.37

rCSI 8.65%

PRS 90.85
ionocyte CL0005006

CSI 10.59

rCSI 11.35%

PRS 80.34
myeloid dendritic cell CL0000782

CSI 10.56

rCSI 15.3%

PRS 91.07
respiratory basal cell CL0002633

CSI 10.45

rCSI 10.82%

PRS 83.31
IgA plasma cell CL0000987

CSI 10.45

rCSI 10.7%

PRS 86.9
microglial cell CL0000129

CSI 10.39

rCSI 41.82%

PRS 80.78
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 10.21

rCSI 51.21%

PRS 90.14
erythrocyte CL0000232

CSI 10.17

rCSI 23.09%

PRS 79.85
basal cell CL0000646

CSI 10.14

rCSI 13.56%

PRS 77.88
group 2 innate lymphoid cell CL0001069

CSI 10.09

rCSI 54.6%

PRS 95.08
CD1c-positive myeloid dendritic cell CL0002399

CSI 10.07

rCSI 12.16%

PRS 86.56
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 10.05

rCSI 5.93%

PRS 93.36
dendritic cell CL0000451

CSI 9.98

rCSI 12.3%

PRS 83.39
immature B cell CL0000816

CSI 9.96

rCSI 7.4%

PRS 89.4
mast cell CL0000097

CSI 9.91

rCSI 21.4%

PRS 84.64
alpha-beta T cell CL0000789

CSI 9.79

rCSI 11.47%

PRS 91.8
intermediate monocyte CL0002393

CSI 9.47

rCSI 14.29%

PRS 84.23
T cell CL0000084

CSI 9.41

rCSI 18.39%

PRS 94.48
CD4-positive, alpha-beta thymocyte CL0000810

CSI 9.41

rCSI 7.53%

PRS 91.99
vascular associated smooth muscle cell CL0000359

CSI 9.39

rCSI 30.44%

PRS 77.2
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 9.31

rCSI 11.7%

PRS 93.69
mononuclear phagocyte CL0000113

CSI 9.03

rCSI 19.89%

PRS 82.78
natural T-regulatory cell CL0000903

CSI 8.9

rCSI 16.85%

PRS 96.09
plasmablast CL0000980

CSI 8.37

rCSI 6.59%

PRS 84.12
epithelial cell of lower respiratory tract CL0002632

CSI 8.29

rCSI 6.43%

PRS 82.7
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 8.17

rCSI 37.14%

PRS 94.49
megakaryocyte-erythroid progenitor cell CL0000050

CSI 8.1

rCSI 7.32%

PRS 77.24
memory T cell CL0000813

CSI 7.81

rCSI 15.04%

PRS 94.86
regulatory T cell CL0000815

CSI 7.49

rCSI 8.68%

PRS 80.23
intraepithelial lymphocyte CL0002496

CSI 7.21

rCSI 19.62%

PRS 94.76
class switched memory B cell CL0000972

CSI 7.08

rCSI 5.29%

PRS 90.91
common myeloid progenitor CL0000049

CSI 6.63

rCSI 5.36%

PRS 81.35
dendritic cell, human CL0001056

CSI 6.59

rCSI 10.13%

PRS 87.44
conjunctival epithelial cell CL1000432

CSI 6.58

rCSI 10.05%

PRS 79.39
CD14-low, CD16-positive monocyte CL0002396

CSI 6.53

rCSI 5.03%

PRS 81.85
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 6.4

rCSI 8.8%

PRS 93.55
innate lymphoid cell CL0001065

CSI 6.37

rCSI 13.15%

PRS 76.46
monocyte CL0000576

CSI 6.19

rCSI 11.19%

PRS 84.55
myeloid leukocyte CL0000766

CSI 6.07

rCSI 5.6%

PRS 80.54
alveolar macrophage CL0000583

CSI 5.93

rCSI 9.76%

PRS 82.97
respiratory suprabasal cell CL4033048

CSI 5.86

rCSI 7.52%

PRS 82.43
granulocyte CL0000094

CSI 5.58

rCSI 8.52%

PRS 86.29
granulocyte monocyte progenitor cell CL0000557

CSI 5.55

rCSI 4.81%

PRS 83.05
fallopian tube secretory epithelial cell CL4030006

CSI 5.45

rCSI 5.24%

PRS 78.39
lung macrophage CL1001603

CSI 5.26

rCSI 11.75%

PRS 86.01
ciliated epithelial cell CL0000067

CSI 5.15

rCSI 4.53%

PRS 68.19
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 5.12

rCSI 59.45%

PRS 93.73
unswitched memory B cell CL0000970

CSI 5.02

rCSI 4.22%

PRS 91.21
nasal mucosa goblet cell CL0002480

CSI 4.99

rCSI 5.79%

PRS 82.92
promyelocyte CL0000836

CSI 4.95

rCSI 7.14%

PRS 84.85
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 4.94

rCSI 29.88%

PRS 90.07
double negative thymocyte CL0002489

CSI 4.88

rCSI 3.39%

PRS 89.87
Langerhans cell CL0000453

CSI 4.87

rCSI 7.44%

PRS 89.78
enteric smooth muscle cell CL0002504

CSI 4.69

rCSI 6.69%

PRS 79.96
CD14-positive, CD16-positive monocyte CL0002397

CSI 4.47

rCSI 5.86%

PRS 89.37
inflammatory macrophage CL0000863

CSI 4.36

rCSI 7.45%

PRS 93.27
pulmonary ionocyte CL0017000

CSI 4.33

rCSI 5.27%

PRS 85.67
mature alpha-beta T cell CL0000791

CSI 4.06

rCSI 14.68%

PRS 93.35
colon epithelial cell CL0011108

CSI 3.9

rCSI 4.08%

PRS 76.48

Merkel cell CL0000242

CSI 0.4

rCSI 9.8%

PRS 96.0%
pro-T cell CL0000827

CSI 0.4

rCSI 10.1%

PRS 97.5%
type EC enteroendocrine cell CL0000577

CSI 0.4

rCSI 1.6%

PRS 83.1%
basal cell of epithelium of trachea CL1000348

CSI 0.6

rCSI 3.9%

PRS 85.1%
cytotoxic T cell CL0000910

CSI 0.7

rCSI 4.0%

PRS 83.0%
group 3 innate lymphoid cell, human CL0001078

CSI 0.7

rCSI 14.7%

PRS 93.4%
IgM plasma cell CL0000986

CSI 0.7

rCSI 3.2%

PRS 94.4%
blood vessel smooth muscle cell CL0019018

CSI 0.7

rCSI 5.9%

PRS 73.2%
bronchiolar smooth muscle cell CL4033017

CSI 0.8

rCSI 11.5%

PRS 87.6%
NKp44-negative group 3 innate lymphoid cell, human CL0001080

CSI 0.8

rCSI 24.8%

PRS 95.3%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.8

rCSI 3.3%

PRS 93.4%
helper T cell CL0000912

CSI 0.8

rCSI 1.2%

PRS 78.7%
mammary gland epithelial cell CL0002327

CSI 0.9

rCSI 3.1%

PRS 87.1%
hair follicular keratinocyte CL2000092

CSI 0.9

rCSI 15.9%

PRS 89.4%
hepatic pit cell CL2000054

CSI 1.1

rCSI 14.5%

PRS 92.1%
transitional stage B cell CL0000818

CSI 1.1

rCSI 3.7%

PRS 93.8%
Hofbauer cell CL3000001

CSI 1.2

rCSI 2.2%

PRS 87.0%
megakaryocyte CL0000556

CSI 1.2

rCSI 5.1%

PRS 84.7%
respiratory goblet cell CL0002370

CSI 1.2

rCSI 13.0%

PRS 87.3%
activated CD4-positive, alpha-beta T cell, human CL0001043

CSI 1.4

rCSI 3.3%

PRS 96.0%
vein endothelial cell of respiratory system CL4033008

CSI 1.4

rCSI 9.6%

PRS 86.0%
B-2 B cell CL0000822

CSI 1.5

rCSI 32.2%

PRS 93.6%
follicular B cell CL0000843

CSI 1.5

rCSI 5.6%

PRS 92.8%
transit amplifying cell CL0009010

CSI 1.7

rCSI 2.6%

PRS 87.5%
glandular epithelial cell CL0000150

CSI 1.7

rCSI 4.5%

PRS 90.6%
tracheobronchial serous cell CL0019001

CSI 1.8

rCSI 7.9%

PRS 86.2%
myoepithelial cell CL0000185

CSI 1.9

rCSI 4.7%

PRS 84.3%
large pre-B-II cell CL0000957

CSI 1.9

rCSI 5.4%

PRS 84.8%
intestine goblet cell CL0019031

CSI 1.9

rCSI 1.7%

PRS 76.7%
acinar cell CL0000622

CSI 1.9

rCSI 2.9%

PRS 88.1%
B-1 B cell CL0000819

CSI 2.0

rCSI 52.0%

PRS 94.0%
luminal cell of prostate epithelium CL0002340

CSI 2.0

rCSI 10.9%

PRS 86.9%
colon macrophage CL0009038

CSI 2.1

rCSI 9.7%

PRS 90.8%
duct epithelial cell CL0000068

CSI 2.2

rCSI 3.2%

PRS 83.8%
basophil CL0000767

CSI 2.2

rCSI 4.7%

PRS 90.2%
common lymphoid progenitor CL0000051

CSI 2.3

rCSI 3.1%

PRS 93.0%
intestinal crypt stem cell of colon CL0009043

CSI 2.4

rCSI 17.7%

PRS 88.9%
mesodermal cell CL0000222

CSI 2.4

rCSI 2.8%

PRS 76.7%
transit amplifying cell of colon CL0009011

CSI 2.4

rCSI 2.8%

PRS 80.8%
bronchial goblet cell CL1000312

CSI 2.4

rCSI 9.6%

PRS 87.0%
lung resident memory CD4-positive, alpha-beta T cell CL4033038

CSI 2.4

rCSI 23.6%

PRS 93.9%
tissue-resident macrophage CL0000864

CSI 2.4

rCSI 11.4%

PRS 90.1%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 2.6

rCSI 7.3%

PRS 94.3%
germinal center B cell CL0000844

CSI 2.6

rCSI 7.6%

PRS 88.9%
common dendritic progenitor CL0001029

CSI 2.7

rCSI 3.3%

PRS 87.7%
basal cell of prostate epithelium CL0002341

CSI 2.7

rCSI 7.7%

PRS 85.8%
Kupffer cell CL0000091

CSI 2.7

rCSI 6.2%

PRS 79.9%
lung interstitial macrophage CL4033043

CSI 3.0

rCSI 6.8%

PRS 90.7%
CD8-positive, alpha-beta thymocyte CL0000811

CSI 3.0

rCSI 4.7%

PRS 94.1%
tracheal goblet cell CL1000329

CSI 3.1

rCSI 6.9%

PRS 86.1%
decidual natural killer cell, human CL0002343

CSI 3.2

rCSI 32.1%

PRS 91.7%
basal-myoepithelial cell of mammary gland CL0002324

CSI 3.2

rCSI 6.1%

PRS 89.9%
elicited macrophage CL0000861

CSI 3.3

rCSI 3.0%

PRS 86.7%
fraction A pre-pro B cell CL0002045

CSI 3.3

rCSI 3.8%

PRS 89.5%
mucous neck cell CL0000651

CSI 3.5

rCSI 5.0%

PRS 85.9%
myeloid dendritic cell, human CL0001057

CSI 3.5

rCSI 19.4%

PRS 92.2%
IgG plasma cell CL0000985

CSI 3.5

rCSI 4.2%

PRS 89.0%
colon epithelial cell CL0011108

CSI 3.9

rCSI 4.1%

PRS 76.5%
mature alpha-beta T cell CL0000791

CSI 4.1

rCSI 14.7%

PRS 93.4%
pulmonary ionocyte CL0017000

CSI 4.3

rCSI 5.3%

PRS 85.7%
inflammatory macrophage CL0000863

CSI 4.4

rCSI 7.5%

PRS 93.3%
CD14-positive, CD16-positive monocyte CL0002397

CSI 4.5

rCSI 5.9%

PRS 89.4%
enteric smooth muscle cell CL0002504

CSI 4.7

rCSI 6.7%

PRS 80.0%
Langerhans cell CL0000453

CSI 4.9

rCSI 7.4%

PRS 89.8%
double negative thymocyte CL0002489

CSI 4.9

rCSI 3.4%

PRS 89.9%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 4.9

rCSI 29.9%

PRS 90.1%
promyelocyte CL0000836

CSI 5.0

rCSI 7.1%

PRS 84.9%
nasal mucosa goblet cell CL0002480

CSI 5.0

rCSI 5.8%

PRS 82.9%
unswitched memory B cell CL0000970

CSI 5.0

rCSI 4.2%

PRS 91.2%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 5.1

rCSI 59.5%

PRS 93.7%
ciliated epithelial cell CL0000067

CSI 5.2

rCSI 4.5%

PRS 68.2%
lung macrophage CL1001603

CSI 5.3

rCSI 11.8%

PRS 86.0%
fallopian tube secretory epithelial cell CL4030006

CSI 5.5

rCSI 5.2%

PRS 78.4%
granulocyte monocyte progenitor cell CL0000557

CSI 5.6

rCSI 4.8%

PRS 83.1%
granulocyte CL0000094

CSI 5.6

rCSI 8.5%

PRS 86.3%
respiratory suprabasal cell CL4033048

CSI 5.9

rCSI 7.5%

PRS 82.4%
alveolar macrophage CL0000583

CSI 5.9

rCSI 9.8%

PRS 83.0%
myeloid leukocyte CL0000766

CSI 6.1

rCSI 5.6%

PRS 80.5%
monocyte CL0000576

CSI 6.2

rCSI 11.2%

PRS 84.6%
innate lymphoid cell CL0001065

CSI 6.4

rCSI 13.2%

PRS 76.5%
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 6.4

rCSI 8.8%

PRS 93.6%
CD14-low, CD16-positive monocyte CL0002396

CSI 6.5

rCSI 5.0%

PRS 81.9%
conjunctival epithelial cell CL1000432

CSI 6.6

rCSI 10.1%

PRS 79.4%
dendritic cell, human CL0001056

CSI 6.6

rCSI 10.1%

PRS 87.4%
common myeloid progenitor CL0000049

CSI 6.6

rCSI 5.4%

PRS 81.4%
class switched memory B cell CL0000972

CSI 7.1

rCSI 5.3%

PRS 90.9%
intraepithelial lymphocyte CL0002496

CSI 7.2

rCSI 19.6%

PRS 94.8%
regulatory T cell CL0000815

CSI 7.5

rCSI 8.7%

PRS 80.2%
memory T cell CL0000813

CSI 7.8

rCSI 15.0%

PRS 94.9%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 8.1

rCSI 7.3%

PRS 77.2%
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 8.2

rCSI 37.1%

PRS 94.5%
epithelial cell of lower respiratory tract CL0002632

CSI 8.3

rCSI 6.4%

PRS 82.7%
plasmablast CL0000980

CSI 8.4

rCSI 6.6%

PRS 84.1%
natural T-regulatory cell CL0000903

CSI 8.9

rCSI 16.9%

PRS 96.1%
mononuclear phagocyte CL0000113

CSI 9.0

rCSI 19.9%

PRS 82.8%
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 9.3

rCSI 11.7%

PRS 93.7%
vascular associated smooth muscle cell CL0000359

CSI 9.4

rCSI 30.4%

PRS 77.2%
CD4-positive, alpha-beta thymocyte CL0000810

CSI 9.4

rCSI 7.5%

PRS 92.0%
T cell CL0000084

CSI 9.4

rCSI 18.4%

PRS 94.5%
intermediate monocyte CL0002393

CSI 9.5

rCSI 14.3%

PRS 84.2%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

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Target Cell Context(s): Comma-separated if multiple.

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Query Gene
Node Color (Target Cell CSI, relative to current network):
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- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary **[DUSP2](/details-gene/1844)** (Dual Specificity Phosphatase 2), also known as PAC-1, is a protein-coding gene located on chromosome 2q11.2. It encodes a nuclear and cytoplasmic phosphatase that plays a critical role in cellular signal transduction. As a member of the dual-specificity phosphatase family, [DUSP2](/details-gene/1844) dephosphorylates and inactivates key components of the mitogen-activated protein kinase (MAPK) pathway, such as ERK, JNK, and p38 ([Link](https://doi.org/10.1038/367651a0)). Its expression is particularly prominent in lymphoid cells, including various subsets of Natural Killer (NK) cells and T cells. This specific expression pattern suggests that [DUSP2](/details-gene/1844) functions as a crucial negative regulator of immune cell activation, controlling the magnitude and duration of responses downstream of antigen or cytokine stimulation. ## Cellular Roles and Expression Landscape The expression profile of **[DUSP2](/details-gene/1844)** strongly indicates a specialized function within the hematopoietic system, particularly in the lymphoid lineage. **Overall**, the gene shows its most significant expression in cytotoxic and helper lymphocytes. It is a top marker for [CD16-negative, CD56-bright natural killer cell, human](/details-cell/CL0000938) (CSI: 90.71) and is also highly significant in [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907) (CSI: 74.78), [CD4-positive helper T cell](/details-cell/CL0000492) (CSI: 64.44), and [CD16-positive, CD56-dim natural killer cell, human](/details-cell/CL0000939) (CSI: 58.93). Its high significance extends across a broad range of T cell subsets, including mucosal invariant T cells, gamma-delta T cells, and various memory and effector phenotypes. This consistent high expression across diverse lymphocyte populations underscores its fundamental role as a regulator of adaptive and innate immune cell signaling. The data suggests that [DUSP2](/details-gene/1844) is not merely a lineage marker but a key functional component responsible for maintaining immune homeostasis and preventing excessive or prolonged immune activation in these cell types. ## Pathways and Molecular Function Functionally, **[DUSP2](/details-gene/1844)** is annotated as a protein phosphatase with activity towards both tyrosine and serine/threonine residues ([GO:0017017](https://www.ebi.ac.uk/QuickGO/term/GO:0017017)). Its primary molecular function is to inactivate MAP kinases through direct dephosphorylation, a process categorized as [map kinase tyrosine phosphatase activity](/details-go/GO:0033550) and [negative regulation of mapk cascade](/details-go/GO:0043409). This activity is central to several key Reactome pathways, including [Mapk family signaling cascades](/details-reactome/R-HSA-5683057) and, more specifically, the [Negative regulation of mapk pathway](/details-reactome/R-HSA-5675221). The MAPK cascade is a critical downstream pathway for T cell receptor (TCR) and NK cell activating receptor signaling, controlling cellular processes such as proliferation, differentiation, and effector function. The high expression of [DUSP2](/details-gene/1844) in T cells and NK cells is consistent with its role as an essential feedback inhibitor. By terminating MAPK signals, [DUSP2](/details-gene/1844) likely establishes an activation threshold, ensuring that lymphocytes respond appropriately to stimuli without triggering uncontrolled or chronic inflammation ([Link](https://doi.org/10.1038/367651a0)). ## Research Directions The specific expression pattern and established function of **[DUSP2](/details-gene/1844)** as a negative immune regulator present several avenues for future investigation. Its role as a brake on lymphocyte activation is of particular interest in contexts of both autoimmunity and cancer immunotherapy. **Proposed Hypotheses:** 1. Given its top significance in [CD16-negative, CD56-bright natural killer cell, human](/details-cell/CL0000938), a subset known for potent cytokine production, it is hypothesized that [DUSP2](/details-gene/1844) is a key determinant of the functional polarization of NK cells. High [DUSP2](/details-gene/1844) levels may temper MAPK signaling to favor a cytokine-secreting phenotype over a cytotoxic one, and its dynamic regulation could control the switch between these effector programs. 2. The high expression of [DUSP2](/details-gene/1844) in memory T cell populations, such as [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907), suggests it is critical for maintaining T cell quiescence. We hypothesize that loss of [DUSP2](/details-gene/1844) function would lower the activation threshold of memory T cells, leading to their premature exhaustion or heightened susceptibility to autoimmune activation. **Experimental Approach:** To test the hypothesis regarding the role of [DUSP2](/details-gene/1844) in NK cell functional polarization, one could utilize a CRISPR-Cas9-based approach to knock out the gene in primary human NK cells. These [DUSP2](/details-gene/1844)-deficient NK cells, alongside wild-type controls, would be stimulated with either cytokines (e.g., IL-12 and IL-15) or target tumor cells (e.g., K562). The functional output could be assessed by quantifying cytotoxicity via a degranulation assay (CD107a surface expression) and measuring cytokine secretion (e.g., IFN-gamma and TNF-alpha) using ELISA or intracellular flow cytometry. Parallel phosphoproteomic analysis would be employed to confirm hyperactivation of MAPK pathway components (e.g., p-ERK, p-JNK) in the knockout cells, directly linking the molecular mechanism to the functional phenotype. **Therapeutic Potential:** As an intracellular phosphatase that negatively regulates immune activation, [DUSP2](/details-gene/1844) represents a potential therapeutic target, primarily for **inhibition**. Developing a small molecule inhibitor of [DUSP2](/details-gene/1844) could enhance the anti-tumor activity of T cells and NK cells. Such an agent might be used in combination with immune checkpoint inhibitors (e.g., anti-PD-1) to lower the activation threshold of tumor-infiltrating lymphocytes and overcome resistance. However, because [DUSP2](/details-gene/1844) is broadly expressed across many lymphocyte subsets, systemic inhibition carries a significant risk of inducing off-target immune-related adverse events, necessitating careful consideration of delivery strategies or the development of highly specific inhibitors.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Dual specificity protein phosphatase PAC-1

Genular Protein ID: 2782122287

Symbol: DUSP2_HUMAN

Name: Dual specificity protein phosphatase PAC-1

UniProtKB Accession Codes:

Q05923 Q53T45

Database IDs:

Citations:

PubMed ID: 7681221

Title: PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase.

PubMed ID: 7681221

DOI: 10.1126/science.7681221

PubMed ID: 7590752

Title: Genomic organization and chromosomal localization of the DUSP2 gene, encoding a MAP kinase phosphatase, to human 2p11.2-q11.

PubMed ID: 7590752

DOI: 10.1006/geno.1995.1110

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8107850

Title: Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1.

PubMed ID: 8107850

DOI: 10.1038/367651a0

PubMed ID: 12575935

Title: Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP.

PubMed ID: 12575935

DOI: 10.1016/s0969-2126(02)00943-7

Sequence Information:

Length: 314
Mass: 34400
Checksum: FDD3543C6DE10CA5
Sequence:

MGLEAARELE CAALGTLLRD PREAERTLLL DCRPFLAFCR RHVRAARPVP WNALLRRRAR 
GPPAAVLACL LPDRALRTRL VRGELARAVV LDEGSASVAE LRPDSPAHVL LAALLHETRA 
GPTAVYFLRG GFDGFQGCCP DLCSEAPAPA LPPTGDKTSR SDSRAPVYDQ GGPVEILPYL 
FLGSCSHSSD LQGLQACGIT AVLNVSASCP NHFEGLFRYK SIPVEDNQMV EISAWFQEAI 
GFIDWVKNSG GRVLVHCQAG ISRSATICLA YLMQSRRVRL DEAFDFVKQR RGVISPNFSF 
MGQLLQFETQ VLCH

Details for: DUSP2

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. PubMed ID: 7681221

Genomic organization and chromosomal localization of the DUSP2 gene, encoding a MAP kinase phosphatase, to human 2p11.2-q11. PubMed ID: 7590752

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334