Details for: DUSP2

Gene ID: 1844

Symbol: DUSP2

Ensembl ID: ENSG00000158050

Description: dual specificity phosphatase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 162.7822
    Cell Significance Index: -25.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 99.8646
    Cell Significance Index: -25.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 71.6389
    Cell Significance Index: -36.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 64.1518
    Cell Significance Index: -30.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 45.2742
    Cell Significance Index: -30.3800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 28.9038
    Cell Significance Index: 77.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.5198
    Cell Significance Index: -25.3000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.4776
    Cell Significance Index: -29.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9842
    Cell Significance Index: -27.5600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.7372
    Cell Significance Index: -14.7500
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 4.6949
    Cell Significance Index: 19.5400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.4379
    Cell Significance Index: 53.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.9894
    Cell Significance Index: 81.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.9677
    Cell Significance Index: -7.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5857
    Cell Significance Index: 82.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.4652
    Cell Significance Index: 647.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2929
    Cell Significance Index: 152.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1798
    Cell Significance Index: 145.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0247
    Cell Significance Index: 72.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8234
    Cell Significance Index: 148.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6863
    Cell Significance Index: 67.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5813
    Cell Significance Index: 27.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5773
    Cell Significance Index: 10.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4474
    Cell Significance Index: 404.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3869
    Cell Significance Index: 49.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3750
    Cell Significance Index: 60.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2885
    Cell Significance Index: 54.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2459
    Cell Significance Index: 26.7500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2085
    Cell Significance Index: 1.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1541
    Cell Significance Index: 3.5600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.1225
    Cell Significance Index: 1.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0899
    Cell Significance Index: 49.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0651
    Cell Significance Index: 13.0700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0643
    Cell Significance Index: 3.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0594
    Cell Significance Index: 111.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0381
    Cell Significance Index: 1.0200
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.0366
    Cell Significance Index: 0.3800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0278
    Cell Significance Index: 0.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0034
    Cell Significance Index: 0.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0070
    Cell Significance Index: -5.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0099
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0161
    Cell Significance Index: -11.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0164
    Cell Significance Index: -0.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0172
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0189
    Cell Significance Index: -11.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0206
    Cell Significance Index: -14.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0216
    Cell Significance Index: -2.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0230
    Cell Significance Index: -35.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0265
    Cell Significance Index: -36.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0299
    Cell Significance Index: -16.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0338
    Cell Significance Index: -21.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0461
    Cell Significance Index: -4.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0475
    Cell Significance Index: -34.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0664
    Cell Significance Index: -23.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0707
    Cell Significance Index: -32.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0723
    Cell Significance Index: -12.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0798
    Cell Significance Index: -11.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0888
    Cell Significance Index: -4.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0909
    Cell Significance Index: -19.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0939
    Cell Significance Index: -27.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0943
    Cell Significance Index: -2.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1132
    Cell Significance Index: -5.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1246
    Cell Significance Index: -2.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1250
    Cell Significance Index: -8.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1345
    Cell Significance Index: -26.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1505
    Cell Significance Index: -19.2900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2034
    Cell Significance Index: -4.2200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2054
    Cell Significance Index: -2.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2295
    Cell Significance Index: -26.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2366
    Cell Significance Index: -9.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2443
    Cell Significance Index: -27.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2580
    Cell Significance Index: -19.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2640
    Cell Significance Index: -27.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2769
    Cell Significance Index: -18.6200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2780
    Cell Significance Index: -12.0900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2913
    Cell Significance Index: -4.3900
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.3047
    Cell Significance Index: -0.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3104
    Cell Significance Index: -6.6100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3112
    Cell Significance Index: -3.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3404
    Cell Significance Index: -17.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3576
    Cell Significance Index: -8.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3582
    Cell Significance Index: -21.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3668
    Cell Significance Index: -28.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3840
    Cell Significance Index: -9.8100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.4342
    Cell Significance Index: -6.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4628
    Cell Significance Index: -36.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4689
    Cell Significance Index: -21.8600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.4933
    Cell Significance Index: -4.0800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.4970
    Cell Significance Index: -2.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4971
    Cell Significance Index: -14.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4984
    Cell Significance Index: -31.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5089
    Cell Significance Index: -16.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5227
    Cell Significance Index: -32.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5314
    Cell Significance Index: -14.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5448
    Cell Significance Index: -30.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5815
    Cell Significance Index: -25.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6108
    Cell Significance Index: -15.7000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.6488
    Cell Significance Index: -11.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6529
    Cell Significance Index: -11.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Dual specificity phosphatase activity**: DUSP2 has the unique ability to dephosphorylate both tyrosine and threonine residues on target proteins, making it a critical regulator of cell signaling pathways. 2. **High expression in immune cells**: DUSP2 is highly expressed in immune cells, including T cells, natural killer cells, and innate lymphoid cells, where it plays a crucial role in regulating the MAPK signaling pathway. 3. **Regulation of MAPK signaling**: DUSP2 is a key regulator of the MAPK signaling pathway, which is involved in various cellular processes, including cell growth, differentiation, and apoptosis. 4. **Negative regulation of MAPK pathway**: DUSP2 negatively regulates the MAPK pathway by dephosphorylating and thereby inactivating MAPK kinases, thereby preventing the activation of downstream targets. **Pathways and Functions:** 1. **MAPK signaling pathway**: DUSP2 regulates the MAPK signaling pathway by dephosphorylating and thereby inactivating MAPK kinases, thereby preventing the activation of downstream targets. 2. **Raf-independent MAPK1/3 activation**: DUSP2 regulates the activation of MAPK1 and MAPK3, which are involved in various cellular processes, including cell growth, differentiation, and apoptosis. 3. **Negative regulation of MAPK cascade**: DUSP2 negatively regulates the MAPK cascade by dephosphorylating and thereby inactivating MAPK kinases, thereby preventing the activation of downstream targets. 4. **Protein dephosphorylation**: DUSP2 dephosphorylates and thereby inactivates various proteins, including MAPK kinases, protein kinases, and phosphatases. **Clinical Significance:** 1. **Immune regulation**: DUSP2 plays a critical role in regulating immune responses, including T cell activation, natural killer cell function, and innate lymphoid cell function. 2. **Cancer**: DUSP2 has been implicated in various cancers, including lung, breast, and colon cancer, where it is involved in regulating cell proliferation, differentiation, and apoptosis. 3. **Inflammatory disorders**: DUSP2 has been implicated in various inflammatory disorders, including rheumatoid arthritis, lupus, and multiple sclerosis, where it is involved in regulating inflammatory responses. 4. **Therapeutic applications**: DUSP2 has been identified as a potential therapeutic target for various diseases, including cancer and inflammatory disorders, where its inhibition or modulation can lead to improved therapeutic outcomes. In conclusion, DUSP2 is a critical regulator of cell signaling pathways, particularly in the context of immune responses. Its high expression in immune cells and its role in regulating the MAPK signaling pathway make it a key player in regulating immune responses and various diseases. Further research is needed to fully understand the role of DUSP2 in human disease and to explore its therapeutic potential.

Genular Protein ID: 2782122287

Symbol: DUSP2_HUMAN

Name: Dual specificity protein phosphatase PAC-1

UniProtKB Accession Codes:

Q05923 Q53T45

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 5 Ensembl 1 EvolutionaryTrace 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 8 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7681221

Title: PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase.

PubMed ID: 7681221

DOI: 10.1126/science.7681221

PubMed ID: 7590752

Title: Genomic organization and chromosomal localization of the DUSP2 gene, encoding a MAP kinase phosphatase, to human 2p11.2-q11.

PubMed ID: 7590752

DOI: 10.1006/geno.1995.1110

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8107850

Title: Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1.

PubMed ID: 8107850

DOI: 10.1038/367651a0

PubMed ID: 12575935

Title: Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP.

PubMed ID: 12575935

DOI: 10.1016/s0969-2126(02)00943-7

Sequence Information:

  • Length: 314
  • Mass: 34400
  • Checksum: FDD3543C6DE10CA5
  • Sequence:
    • MGLEAARELE CAALGTLLRD PREAERTLLL DCRPFLAFCR RHVRAARPVP WNALLRRRAR 
GPPAAVLACL LPDRALRTRL VRGELARAVV LDEGSASVAE LRPDSPAHVL LAALLHETRA 
GPTAVYFLRG GFDGFQGCCP DLCSEAPAPA LPPTGDKTSR SDSRAPVYDQ GGPVEILPYL 
FLGSCSHSSD LQGLQACGIT AVLNVSASCP NHFEGLFRYK SIPVEDNQMV EISAWFQEAI 
GFIDWVKNSG GRVLVHCQAG ISRSATICLA YLMQSRRVRL DEAFDFVKQR RGVISPNFSF 
MGQLLQFETQ VLCH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.