Details for: IRF4

Gene ID: 3662

Symbol: IRF4

Ensembl ID: ENSG00000137265

Description: interferon regulatory factor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 44.6815
    Cell Significance Index: -6.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.7949
    Cell Significance Index: -7.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 18.6335
    Cell Significance Index: -7.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 9.9260
    Cell Significance Index: 348.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.6693
    Cell Significance Index: -6.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.5947
    Cell Significance Index: 114.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 4.5812
    Cell Significance Index: 146.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.0914
    Cell Significance Index: 117.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.9658
    Cell Significance Index: -7.9500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.8711
    Cell Significance Index: 44.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0033
    Cell Significance Index: 43.4000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.7891
    Cell Significance Index: -7.0600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.5349
    Cell Significance Index: 26.3700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.1949
    Cell Significance Index: -3.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1249
    Cell Significance Index: 214.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9352
    Cell Significance Index: 92.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7673
    Cell Significance Index: 692.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6994
    Cell Significance Index: 20.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3773
    Cell Significance Index: 41.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3364
    Cell Significance Index: 5.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3360
    Cell Significance Index: 54.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3219
    Cell Significance Index: 20.7700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1929
    Cell Significance Index: 3.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1896
    Cell Significance Index: 13.1100
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.1294
    Cell Significance Index: 1.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1188
    Cell Significance Index: 14.0200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0519
    Cell Significance Index: 0.5200
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.0106
    Cell Significance Index: 0.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0022
    Cell Significance Index: 0.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0009
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0042
    Cell Significance Index: -0.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0043
    Cell Significance Index: -0.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0046
    Cell Significance Index: -3.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0053
    Cell Significance Index: -8.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0059
    Cell Significance Index: -8.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0109
    Cell Significance Index: -8.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0115
    Cell Significance Index: -7.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0132
    Cell Significance Index: -7.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0143
    Cell Significance Index: -8.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0165
    Cell Significance Index: -7.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0175
    Cell Significance Index: -1.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0193
    Cell Significance Index: -6.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0197
    Cell Significance Index: -2.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0235
    Cell Significance Index: -4.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0236
    Cell Significance Index: -6.7800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0237
    Cell Significance Index: -1.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0278
    Cell Significance Index: -5.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0296
    Cell Significance Index: -5.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0366
    Cell Significance Index: -7.7000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0371
    Cell Significance Index: -1.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0396
    Cell Significance Index: -1.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0431
    Cell Significance Index: -5.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0437
    Cell Significance Index: -7.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0469
    Cell Significance Index: -6.8200
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0470
    Cell Significance Index: -0.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0470
    Cell Significance Index: -1.0000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0482
    Cell Significance Index: -1.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0494
    Cell Significance Index: -1.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0511
    Cell Significance Index: -6.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0597
    Cell Significance Index: -6.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0605
    Cell Significance Index: -6.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0605
    Cell Significance Index: -6.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0634
    Cell Significance Index: -8.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0679
    Cell Significance Index: -7.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0805
    Cell Significance Index: -2.2500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0814
    Cell Significance Index: -1.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0836
    Cell Significance Index: -3.9300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0902
    Cell Significance Index: -1.7600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0972
    Cell Significance Index: -0.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1019
    Cell Significance Index: -6.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1069
    Cell Significance Index: -8.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1117
    Cell Significance Index: -8.3300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1130
    Cell Significance Index: -1.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1298
    Cell Significance Index: -6.7600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1313
    Cell Significance Index: -1.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1362
    Cell Significance Index: -8.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1362
    Cell Significance Index: -6.3500
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.1394
    Cell Significance Index: -0.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1442
    Cell Significance Index: -8.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1462
    Cell Significance Index: -3.0600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1468
    Cell Significance Index: -2.3600
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1515
    Cell Significance Index: -1.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1605
    Cell Significance Index: -8.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1720
    Cell Significance Index: -4.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1780
    Cell Significance Index: -6.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1847
    Cell Significance Index: -8.1700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1877
    Cell Significance Index: -1.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1976
    Cell Significance Index: -6.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1980
    Cell Significance Index: -6.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2012
    Cell Significance Index: -7.3900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2115
    Cell Significance Index: -3.9100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2161
    Cell Significance Index: -2.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2205
    Cell Significance Index: -8.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2322
    Cell Significance Index: -8.0700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2345
    Cell Significance Index: -2.5700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2375
    Cell Significance Index: -3.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2403
    Cell Significance Index: -6.4400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2419
    Cell Significance Index: -3.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IRF4 is a member of the interferon regulatory factor family of transcription factors, which are characterized by their ability to regulate gene expression in response to interferons and other cytokines. IRF4 is a dimeric transcription factor that binds to specific DNA sequences, thereby regulating the transcription of target genes involved in immune responses. IRF4 is highly conserved across species, with high sequence identity to its mouse and rat counterparts. IRF4 has been shown to interact with other transcription factors, including NF-κB and STAT1, to regulate the expression of target genes. **Pathways and Functions** IRF4 is involved in several key pathways and functions, including: 1. **Interferon signaling**: IRF4 is a key regulator of IFN-alpha/beta and IFN-gamma signaling pathways, which are essential for the induction of antiviral and anti-tumor responses. 2. **B cell development and function**: IRF4 is essential for B cell development and function, particularly in the differentiation of B-1 B cells and the production of IgG and IgA antibodies. 3. **Th17 cell differentiation**: IRF4 is required for the differentiation of Th17 cells, which are involved in the regulation of immune responses to pathogens and in the development of autoimmune diseases. 4. **Cytokine production**: IRF4 regulates the production of cytokines, including IL-4, IL-13, and IL-10, which are important for immune homeostasis and the prevention of autoimmune diseases. 5. **Epithelial cell function**: IRF4 is expressed in epithelial cells and is involved in the regulation of epithelial cell function, including the production of antimicrobial peptides and the regulation of immune responses. **Clinical Significance** IRF4 has significant clinical implications, particularly in the context of autoimmune diseases and cancer. Mutations in the IRF4 gene have been associated with autoimmune diseases, such as rheumatoid arthritis and lupus, while dysregulation of IRF4 has been implicated in the development of cancer, including lymphoma and melanoma. IRF4 has also been shown to have potential as a therapeutic target in the treatment of autoimmune diseases and cancer. In summary, IRF4 is a critical transcription factor that plays a central role in the regulation of immune responses, particularly in the development and function of B cells and Th17 cells. Its dysregulation has significant clinical implications, particularly in the context of autoimmune diseases and cancer. Further research is needed to fully elucidate the role of IRF4 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3805261851

Symbol: IRF4_HUMAN

Name: Interferon regulatory factor 4

UniProtKB Accession Codes:

Q15306 Q5VUI7 Q99660

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 4 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8921401

Title: Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25.

PubMed ID: 8921401

DOI: 10.1006/geno.1996.0547

PubMed ID: 9326949

Title: Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma.

PubMed ID: 9326949

DOI: 10.1038/ng1097-226

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10196196

Title: SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1.

PubMed ID: 10196196

DOI: 10.1074/jbc.274.16.11115

PubMed ID: 12651066

Title: Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system.

PubMed ID: 12651066

DOI: 10.1016/s0198-8859(03)00024-7

PubMed ID: 18483556

Title: A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.

PubMed ID: 18483556

DOI: 10.1371/journal.pgen.1000074

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24267888

Title: A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway.

PubMed ID: 24267888

DOI: 10.1016/j.cell.2013.10.022

PubMed ID: 33951726

Title: Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients.

PubMed ID: 33951726

DOI: 10.1084/jem.20201750

Sequence Information:

  • Length: 451
  • Mass: 51772
  • Checksum: 17CD1327C6F5BFFA
  • Sequence:
    • MNLEGGGRGG EFGMSAVSCG NGKLRQWLID QIDSGKYPGL VWENEEKSIF RIPWKHAGKQ 
DYNREEDAAL FKAWALFKGK FREGIDKPDP PTWKTRLRCA LNKSNDFEEL VERSQLDISD 
PYKVYRIVPE GAKKGAKQLT LEDPQMSMSH PYTMTTPYPS LPAQQVHNYM MPPLDRSWRD 
YVPDQPHPEI PYQCPMTFGP RGHHWQGPAC ENGCQVTGTF YACAPPESQA PGVPTEPSIR 
SAEALAFSDC RLHICLYYRE ILVKELTTSS PEGCRISHGH TYDASNLDQV LFPYPEDNGQ 
RKNIEKLLSH LERGVVLWMA PDGLYAKRLC QSRIYWDGPL ALCNDRPNKL ERDQTCKLFD 
TQQFLSELQA FAHHGRSLPR FQVTLCFGEE FPDPQRQRKL ITAHVEPLLA RQLYYFAQQN 
SGHFLRGYDL PEHISNPEDY HRSIRHSSIQ E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.