Details for: IRF4

Gene ID: 3662

Symbol: IRF4

Ensembl ID: ENSG00000137265

Description: interferon regulatory factor 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.74
    Marker Score: 481
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.74
    Marker Score: 456
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.72
    Marker Score: 2066
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.62
    Marker Score: 2826
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1152
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.26
    Marker Score: 3421
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 839
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4788
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.07
    Marker Score: 490
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71797
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48022
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.97
    Marker Score: 337
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5274
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.91
    Marker Score: 778
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 363
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.87
    Marker Score: 1161.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5274
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.83
    Marker Score: 501.5
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.82
    Marker Score: 210
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.82
    Marker Score: 1556
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1250
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 582
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.76
    Marker Score: 200
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 685
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.71
    Marker Score: 556
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 449
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.65
    Marker Score: 10247
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.64
    Marker Score: 1298
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.63
    Marker Score: 4015
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.6
    Marker Score: 673
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.59
    Marker Score: 259
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.59
    Marker Score: 1242
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.59
    Marker Score: 340
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.53
    Marker Score: 352
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.52
    Marker Score: 390
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.51
    Marker Score: 457
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.51
    Marker Score: 155
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.49
    Marker Score: 205
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.49
    Marker Score: 1273
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 469
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.47
    Marker Score: 255
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.47
    Marker Score: 147
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.47
    Marker Score: 342
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.46
    Marker Score: 198
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.45
    Marker Score: 108
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.45
    Marker Score: 102
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 269
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.44
    Marker Score: 101
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.44
    Marker Score: 101
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.43
    Marker Score: 462
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.43
    Marker Score: 102
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.42
    Marker Score: 310
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 110
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.41
    Marker Score: 395
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.41
    Marker Score: 282
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.4
    Marker Score: 291
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.39
    Marker Score: 139
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.39
    Marker Score: 124
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.39
    Marker Score: 226
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.38
    Marker Score: 231
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.38
    Marker Score: 154
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.37
    Marker Score: 186
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.37
    Marker Score: 3637
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.35
    Marker Score: 243
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.35
    Marker Score: 4111
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.34
    Marker Score: 289
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.34
    Marker Score: 141
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.33
    Marker Score: 327
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.33
    Marker Score: 164
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.33
    Marker Score: 363
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.31
    Marker Score: 99
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.31
    Marker Score: 3101
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.3
    Marker Score: 220
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.3
    Marker Score: 836
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.29
    Marker Score: 194
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.29
    Marker Score: 296
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.29
    Marker Score: 270
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.28
    Marker Score: 334
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.28
    Marker Score: 145
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.28
    Marker Score: 133
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.27
    Marker Score: 155
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 0.27
    Marker Score: 74
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.27
    Marker Score: 349
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.26
    Marker Score: 1714
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.26
    Marker Score: 294
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.26
    Marker Score: 13525
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.25
    Marker Score: 408
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.25
    Marker Score: 276
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.25
    Marker Score: 209
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.24
    Marker Score: 137

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Other Information

## Summary IRF4 is a transcription factor that plays a critical role in regulating the immune response. It is expressed in a variety of cell types, including plasmablasts, B cells, and epithelial cells. IRF4 has been shown to be essential for the development and maintenance of immune tolerance and for the regulation of inflammation. ## Key characteristics * IRF4 is a transcription factor that belongs to the IRF family of transcription factors. * It is a key regulator of the immune response and is involved in the regulation of inflammation, cell growth, and differentiation. * IRF4 is a nuclear protein that is found in a complex with other transcription factors, such as NF-κB and STAT3. * It is activated by a variety of stimuli, including cytokines, growth factors, and cellular stress factors. * IRF4 can bind to DNA and regulate the expression of a number of target genes. * It is a key regulator of the development and maintenance of immune tolerance. ## Pathways and functions * IRF4 is involved in the regulation of inflammation. It is expressed in inflammatory cells, such as macrophages and dendritic cells, and it is essential for the production of inflammatory cytokines. * IRF4 is also involved in the regulation of cell growth and differentiation. It is expressed in cells that are dividing or differentiating, and it is essential for these processes. * IRF4 is a key regulator of the immune response. It is expressed in a variety of cell types, and it plays a critical role in the development and maintenance of immune tolerance. * IRF4 is also involved in the regulation of cell cycle progression and apoptosis. ## Clinical significance IRF4 is a promising target for the treatment of cancer. It is expressed in a number of cancer cells, and it is known to promote cancer growth and survival. Inhibition of IRF4 has been shown to inhibit cancer growth in preclinical models, and it is currently being investigated as a potential treatment for cancer.

Genular Protein ID: 3805261851

Symbol: IRF4_HUMAN

Name: Interferon regulatory factor 4

UniProtKB Accession Codes:

Q15306 Q5VUI7 Q99660

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 4 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 7 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8921401

Title: Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25.

PubMed ID: 8921401

DOI: 10.1006/geno.1996.0547

PubMed ID: 9326949

Title: Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma.

PubMed ID: 9326949

DOI: 10.1038/ng1097-226

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10196196

Title: SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1.

PubMed ID: 10196196

DOI: 10.1074/jbc.274.16.11115

PubMed ID: 12651066

Title: Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system.

PubMed ID: 12651066

DOI: 10.1016/s0198-8859(03)00024-7

PubMed ID: 18483556

Title: A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.

PubMed ID: 18483556

DOI: 10.1371/journal.pgen.1000074

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24267888

Title: A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway.

PubMed ID: 24267888

DOI: 10.1016/j.cell.2013.10.022

PubMed ID: 33951726

Title: Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients.

PubMed ID: 33951726

DOI: 10.1084/jem.20201750

Sequence Information:

  • Length: 451
  • Mass: 51772
  • Checksum: 17CD1327C6F5BFFA
  • Sequence:
    • MNLEGGGRGG EFGMSAVSCG NGKLRQWLID QIDSGKYPGL VWENEEKSIF RIPWKHAGKQ 
DYNREEDAAL FKAWALFKGK FREGIDKPDP PTWKTRLRCA LNKSNDFEEL VERSQLDISD 
PYKVYRIVPE GAKKGAKQLT LEDPQMSMSH PYTMTTPYPS LPAQQVHNYM MPPLDRSWRD 
YVPDQPHPEI PYQCPMTFGP RGHHWQGPAC ENGCQVTGTF YACAPPESQA PGVPTEPSIR 
SAEALAFSDC RLHICLYYRE ILVKELTTSS PEGCRISHGH TYDASNLDQV LFPYPEDNGQ 
RKNIEKLLSH LERGVVLWMA PDGLYAKRLC QSRIYWDGPL ALCNDRPNKL ERDQTCKLFD 
TQQFLSELQA FAHHGRSLPR FQVTLCFGEE FPDPQRQRKL ITAHVEPLLA RQLYYFAQQN 
SGHFLRGYDL PEHISNPEDY HRSIRHSSIQ E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.