Gene IGHD - ENSG00000211898 | NCBI Gene ID: 3495

Details for: IGHD

Gene ID: 3495

Symbol: IGHD

Ensembl ID: ENSG00000211898

Description: immunoglobulin heavy constant delta

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Potential therapeutics for sars
(R-HSA-9679191)
Sars-cov infections
(R-HSA-9679506)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Igd immunoglobulin complex
(GO:0071738)
Immune response
(GO:0006955)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)
Positive regulation of interleukin-1 production
(GO:0032732)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 4.11
Marker Score: 4050
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.39
Marker Score: 847
Cell Name: naive B cell (CL0000788)
Fold Change: 2.39
Marker Score: 2136
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.22
Marker Score: 3867
Cell Name: follicular B cell (CL0000843)
Fold Change: 2.2
Marker Score: 2382
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 2.11
Marker Score: 4417
Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.8
Marker Score: 415
Cell Name: germinal center B cell (CL0000844)
Fold Change: 1.34
Marker Score: 816
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.3
Marker Score: 13134
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.2
Marker Score: 720
Cell Name: goblet cell (CL0000160)
Fold Change: 1.15
Marker Score: 7666
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251805
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.03
Marker Score: 2794
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71823
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48048
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.97
Marker Score: 2884
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5318
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2743
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5290
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.83
Marker Score: 637
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.8
Marker Score: 191
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1269
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 708
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.75
Marker Score: 510.5
Cell Name: centroblast (CL0009112)
Fold Change: 0.72
Marker Score: 353
Cell Name: immature B cell (CL0000816)
Fold Change: 0.72
Marker Score: 474
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.69
Marker Score: 404
Cell Name: memory B cell (CL0000787)
Fold Change: 0.69
Marker Score: 521
Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.63
Marker Score: 743
Cell Name: centrocyte (CL0009111)
Fold Change: 0.57
Marker Score: 136
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 446
Cell Name: B cell (CL0000236)
Fold Change: 0.55
Marker Score: 527
Cell Name: mature B cell (CL0000785)
Fold Change: 0.55
Marker Score: 402
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.5
Marker Score: 173
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 277
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.44
Marker Score: 250
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.44
Marker Score: 471
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.4
Marker Score: 144
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.38
Marker Score: 378
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.37
Marker Score: 129
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.37
Marker Score: 351
Cell Name: blood cell (CL0000081)
Fold Change: 0.32
Marker Score: 3767
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.29
Marker Score: 743
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.28
Marker Score: 74
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.27
Marker Score: 133
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.25
Marker Score: 121
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.24
Marker Score: 229
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.23
Marker Score: 337
Cell Name: plasma cell (CL0000786)
Fold Change: 0.23
Marker Score: 260
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.23
Marker Score: 59
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.23
Marker Score: 80
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.23
Marker Score: 150
Cell Name: thymocyte (CL0000893)
Fold Change: 0.22
Marker Score: 227
Cell Name: leukocyte (CL0000738)
Fold Change: 0.21
Marker Score: 118
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.2
Marker Score: 70
Cell Name: mast cell (CL0000097)
Fold Change: 0.2
Marker Score: 116
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.2
Marker Score: 805
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.19
Marker Score: 96
Cell Name: plasmablast (CL0000980)
Fold Change: 0.19
Marker Score: 252
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.19
Marker Score: 99
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.19
Marker Score: 122
Cell Name: T cell (CL0000084)
Fold Change: 0.17
Marker Score: 298
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.17
Marker Score: 242.5
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.17
Marker Score: 90
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.17
Marker Score: 216
Cell Name: pericyte (CL0000669)
Fold Change: 0.16
Marker Score: 95
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.16
Marker Score: 669
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.16
Marker Score: 351
Cell Name: early promyelocyte (CL0002154)
Fold Change: 0.15
Marker Score: 124
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.15
Marker Score: 183
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.15
Marker Score: 109
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.15
Marker Score: 770
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.15
Marker Score: 124
Cell Name: keratocyte (CL0002363)
Fold Change: 0.14
Marker Score: 33
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.14
Marker Score: 233
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.14
Marker Score: 90
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 0.14
Marker Score: 102
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.13
Marker Score: 90
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.13
Marker Score: 849
Cell Name: myelocyte (CL0002193)
Fold Change: 0.13
Marker Score: 56
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.13
Marker Score: 28
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.13
Marker Score: 55
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.12
Marker Score: 30
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 0.12
Marker Score: 27
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.12
Marker Score: 28
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.12
Marker Score: 73
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.11
Marker Score: 182
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.11
Marker Score: 68
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.11
Marker Score: 61
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.11
Marker Score: 92
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.11
Marker Score: 27
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.1
Marker Score: 93
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.1
Marker Score: 23
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 0.1
Marker Score: 140
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.1
Marker Score: 28
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.1
Marker Score: 42

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Other Information

Description

**Key characteristics:** - The IGHD gene is located on chromosome 21. - It is a member of the immunoglobulin heavy chain family. - It is expressed in plasma cells, B cells, and memory B cells. - It is involved in the adaptive immune response and the regulation of inflammation. **Pathways and functions:** - The IGHD gene is involved in the adaptive immune response. - It is a key regulator of B cell activation and differentiation. - It is expressed in plasma cells, which are responsible for the production and secretion of antibodies. - It is also expressed in B cells, which are responsible for the humoral immune response. - It is involved in the regulation of inflammation and immune responses to pathogens. **Clinical significance:** - Mutations in the IGHD gene have been linked to several autoimmune diseases, including systemic sclerosis, rheumatoid arthritis, and lupus. - The IGHD gene is also involved in the pathogenesis of some viral infections, such as HIV. - Targeting the IGHD gene has been investigated as a potential therapeutic strategy for autoimmune diseases. **Additional notes:** - The IGHD gene is also involved in the regulation of the immune response to allergens and parasites. - It is a key regulator of the activation of B cells and the generation of second messengers. - The expression of IGHD is regulated by a variety of factors, including cytokines, hormones, and genetic variations.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.