Details for: SLC2A3

Gene ID: 6515

Symbol: SLC2A3

Ensembl ID: ENSG00000059804

Description: solute carrier family 2 member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 354.2378
    Cell Significance Index: -55.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 207.9297
    Cell Significance Index: -52.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 136.3176
    Cell Significance Index: -55.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 116.5858
    Cell Significance Index: -59.9700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 88.4174
    Cell Significance Index: -59.3300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 59.1468
    Cell Significance Index: -56.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.8678
    Cell Significance Index: -55.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.9307
    Cell Significance Index: -45.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.1483
    Cell Significance Index: -55.8300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.8859
    Cell Significance Index: -42.6500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.1593
    Cell Significance Index: 144.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.3177
    Cell Significance Index: 61.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.1254
    Cell Significance Index: 91.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.5821
    Cell Significance Index: 134.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.4099
    Cell Significance Index: 308.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.8182
    Cell Significance Index: 52.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.5626
    Cell Significance Index: 449.6200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.4059
    Cell Significance Index: 20.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.3756
    Cell Significance Index: 2536.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.1987
    Cell Significance Index: 1845.3400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.0043
    Cell Significance Index: 6.2400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.9691
    Cell Significance Index: 6.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8103
    Cell Significance Index: 162.5500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6955
    Cell Significance Index: 10.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4691
    Cell Significance Index: 24.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3519
    Cell Significance Index: 22.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3320
    Cell Significance Index: 119.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2993
    Cell Significance Index: 3.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2874
    Cell Significance Index: 39.4700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2781
    Cell Significance Index: 1.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2164
    Cell Significance Index: 25.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1949
    Cell Significance Index: 38.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1240
    Cell Significance Index: 56.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1045
    Cell Significance Index: 2.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0610
    Cell Significance Index: 38.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0490
    Cell Significance Index: 92.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0481
    Cell Significance Index: 43.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0190
    Cell Significance Index: 25.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0129
    Cell Significance Index: 5.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0076
    Cell Significance Index: 4.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0049
    Cell Significance Index: 0.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0295
    Cell Significance Index: -22.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0393
    Cell Significance Index: -29.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0791
    Cell Significance Index: -44.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0805
    Cell Significance Index: -59.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0987
    Cell Significance Index: -53.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0992
    Cell Significance Index: -6.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1542
    Cell Significance Index: -22.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1666
    Cell Significance Index: -17.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1678
    Cell Significance Index: -31.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1722
    Cell Significance Index: -31.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1930
    Cell Significance Index: -40.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2017
    Cell Significance Index: -34.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2764
    Cell Significance Index: -44.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2847
    Cell Significance Index: -4.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3070
    Cell Significance Index: -35.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3333
    Cell Significance Index: -40.9900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3341
    Cell Significance Index: -6.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3727
    Cell Significance Index: -48.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.4552
    Cell Significance Index: -45.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4581
    Cell Significance Index: -28.1600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4596
    Cell Significance Index: -14.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4650
    Cell Significance Index: -48.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4831
    Cell Significance Index: -55.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4919
    Cell Significance Index: -56.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5351
    Cell Significance Index: -11.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5743
    Cell Significance Index: -15.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5905
    Cell Significance Index: -41.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6020
    Cell Significance Index: -46.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6255
    Cell Significance Index: -46.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6277
    Cell Significance Index: -39.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6494
    Cell Significance Index: -30.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.7007
    Cell Significance Index: -24.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7273
    Cell Significance Index: -32.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7524
    Cell Significance Index: -46.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8335
    Cell Significance Index: -46.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.8539
    Cell Significance Index: -59.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9451
    Cell Significance Index: -35.7900
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.9870
    Cell Significance Index: -6.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0033
    Cell Significance Index: -28.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.0288
    Cell Significance Index: -46.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0844
    Cell Significance Index: -56.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.0946
    Cell Significance Index: -51.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.1077
    Cell Significance Index: -31.6100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.1388
    Cell Significance Index: -13.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.2032
    Cell Significance Index: -42.1500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -1.2193
    Cell Significance Index: -5.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.2427
    Cell Significance Index: -39.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2474
    Cell Significance Index: -40.8400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.3232
    Cell Significance Index: -66.8700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.3824
    Cell Significance Index: -19.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.3958
    Cell Significance Index: -37.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.3960
    Cell Significance Index: -57.2000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3972
    Cell Significance Index: -51.2900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.4329
    Cell Significance Index: -21.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.4374
    Cell Significance Index: -49.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.4792
    Cell Significance Index: -25.3500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.4954
    Cell Significance Index: -18.5500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.5153
    Cell Significance Index: -32.1600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.5540
    Cell Significance Index: -31.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Glucose and Ascorbic Acid Transport**: The SLC2A3 protein is a high-affinity glucose transporter, primarily responsible for glucose import across the plasma membrane. It also exhibits low-affinity ascorbic acid transport, making it a crucial component of vitamin C metabolism. 2. **Cellular Expression**: SLC2A3 is highly expressed in immune cells, including T-helper 22 cells, decidual natural killer cells, and endothelial cells. Its expression is also found in lens epithelial cells and anterior lens cells. 3. **Transmembrane Transport**: The SLC2A3 protein is a transmembrane transporter, allowing glucose and ascorbic acid to cross the plasma membrane. 4. **Regulation by Mecp2**: The SLC2A3 gene is regulated by the transcription factor Mecp2, which plays a critical role in neurological development and function. **Pathways and Functions** 1. **Glucose Metabolism**: The SLC2A3 protein plays a key role in glucose metabolism by facilitating glucose import across the plasma membrane. This process is essential for energy production in cells. 2. **Ascorbic Acid Metabolism**: The SLC2A3 protein is involved in ascorbic acid metabolism by transporting ascorbic acid across the plasma membrane. 3. **Immune System**: SLC2A3 is highly expressed in immune cells, suggesting its involvement in immune system function and regulation. 4. **Neurological Development**: The regulation of SLC2A3 by Mecp2 suggests a potential role in neurological development and function. **Clinical Significance** 1. **Diabetes and Metabolic Disorders**: Dysregulation of glucose transporters, including SLC2A3, has been implicated in the development of diabetes and metabolic disorders. 2. **Immune System Disorders**: Impairments in immune cell function, including those involving SLC2A3, may contribute to the pathogenesis of autoimmune and inflammatory diseases. 3. **Neurological Disorders**: Alterations in Mecp2-regulated genes, including SLC2A3, have been associated with neurological disorders, such as autism and schizophrenia. 4. **Vitamin C Deficiency**: Impaired ascorbic acid transport, mediated by SLC2A3, may contribute to vitamin C deficiency and related disorders. In conclusion, the SLC2A3 gene plays a critical role in glucose and ascorbic acid transport, and its dysregulation has been implicated in various diseases, including diabetes, immune system disorders, and neurological disorders. Further research is needed to fully understand the mechanisms by which SLC2A3 contributes to human health and disease.

Genular Protein ID: 1577037221

Symbol: GTR3_HUMAN

Name: N/A

UniProtKB Accession Codes:

P11169 B2R606 D3DUU6 Q6I9U2 Q9UG15

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 11 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 2 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3170580

Title: Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues.

PubMed ID: 3170580

DOI: 10.1016/s0021-9258(19)37577-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8457197

Title: Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors.

PubMed ID: 8457197

DOI: 10.1042/bj2900701

PubMed ID: 9477959

Title: QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 (position) of D-glucose and is involved in substrate selection at the exofacial binding site.

PubMed ID: 9477959

DOI: 10.1021/bi972322u

PubMed ID: 32860739

Title: Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum.

PubMed ID: 32860739

DOI: 10.1016/j.cell.2020.08.015

PubMed ID: 35810171

Title: A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells.

PubMed ID: 35810171

DOI: 10.1038/s41467-022-31762-x

PubMed ID: 26176916

Title: Molecular basis of ligand recognition and transport by glucose transporters.

PubMed ID: 26176916

DOI: 10.1038/nature14655

Sequence Information:

  • Length: 496
  • Mass: 53924
  • Checksum: F601CD6892F16516
  • Sequence:
    • MGTQKVTPAL IFAITVATIG SFQFGYNTGV INAPEKIIKE FINKTLTDKG NAPPSEVLLT 
SLWSLSVAIF SVGGMIGSFS VGLFVNRFGR RNSMLIVNLL AVTGGCFMGL CKVAKSVEML 
ILGRLVIGLF CGLCTGFVPM YIGEISPTAL RGAFGTLNQL GIVVGILVAQ IFGLEFILGS 
EELWPLLLGF TILPAILQSA ALPFCPESPR FLLINRKEEE NAKQILQRLW GTQDVSQDIQ 
EMKDESARMS QEKQVTVLEL FRVSSYRQPI IISIVLQLSQ QLSGINAVFY YSTGIFKDAG 
VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAFCSTLMT VSLLLKDNYN 
GMSFVCIGAI LVFVAFFEIG PGPIPWFIVA ELFSQGPRPA AMAVAGCSNW TSNFLVGLLF 
PSAAHYLGAY VFIIFTGFLI TFLAFTFFKV PETRGRTFED ITRAFEGQAH GADRSGKDGV 
MEMNSIEPAK ETTTNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.