Details for: JCHAIN

Gene ID: 3512

Symbol: JCHAIN

Ensembl ID: ENSG00000132465

Description: joining chain of multimeric IgA and IgM

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 49.3016
    Cell Significance Index: -25.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 42.3301
    Cell Significance Index: -19.9900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 31.1316
    Cell Significance Index: -20.8900
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 25.8248
    Cell Significance Index: 195.8300
  • Cell Name: centroblast (CL0009112)
    Fold Change: 17.0205
    Cell Significance Index: 39.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.8400
    Cell Significance Index: -26.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.0086
    Cell Significance Index: 236.8800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.7191
    Cell Significance Index: -5.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4502
    Cell Significance Index: 65.7400
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.0962
    Cell Significance Index: 8.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8081
    Cell Significance Index: 79.9400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.7332
    Cell Significance Index: 7.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6664
    Cell Significance Index: 601.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4435
    Cell Significance Index: 72.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3655
    Cell Significance Index: 7.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3250
    Cell Significance Index: 35.3500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.3197
    Cell Significance Index: 4.4200
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.2448
    Cell Significance Index: 1.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1944
    Cell Significance Index: 36.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1815
    Cell Significance Index: 125.5500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1338
    Cell Significance Index: 2.0700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1083
    Cell Significance Index: 1.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0966
    Cell Significance Index: 5.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0041
    Cell Significance Index: 0.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0038
    Cell Significance Index: 0.4900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0020
    Cell Significance Index: 0.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0020
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0067
    Cell Significance Index: -12.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0081
    Cell Significance Index: -0.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0113
    Cell Significance Index: -8.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0116
    Cell Significance Index: -21.3300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0141
    Cell Significance Index: -0.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0142
    Cell Significance Index: -21.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0160
    Cell Significance Index: -0.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0170
    Cell Significance Index: -23.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0257
    Cell Significance Index: -14.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0289
    Cell Significance Index: -21.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0320
    Cell Significance Index: -23.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0352
    Cell Significance Index: -4.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0363
    Cell Significance Index: -23.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0364
    Cell Significance Index: -22.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0385
    Cell Significance Index: -21.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0433
    Cell Significance Index: -2.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0505
    Cell Significance Index: -22.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0541
    Cell Significance Index: -19.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0634
    Cell Significance Index: -8.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0727
    Cell Significance Index: -20.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0729
    Cell Significance Index: -14.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0926
    Cell Significance Index: -18.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0945
    Cell Significance Index: -2.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1004
    Cell Significance Index: -21.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1091
    Cell Significance Index: -19.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1127
    Cell Significance Index: -15.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1220
    Cell Significance Index: -20.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1222
    Cell Significance Index: -9.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1236
    Cell Significance Index: -3.0900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1374
    Cell Significance Index: -2.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1374
    Cell Significance Index: -3.8400
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: -0.1379
    Cell Significance Index: -0.4100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1400
    Cell Significance Index: -2.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1452
    Cell Significance Index: -4.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1453
    Cell Significance Index: -15.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1495
    Cell Significance Index: -21.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1746
    Cell Significance Index: -21.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1864
    Cell Significance Index: -21.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1980
    Cell Significance Index: -4.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2032
    Cell Significance Index: -20.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2119
    Cell Significance Index: -16.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2146
    Cell Significance Index: -5.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2207
    Cell Significance Index: -4.6200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2609
    Cell Significance Index: -2.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2698
    Cell Significance Index: -16.5400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2762
    Cell Significance Index: -12.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2968
    Cell Significance Index: -23.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3040
    Cell Significance Index: -20.4400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.3380
    Cell Significance Index: -1.7700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.3551
    Cell Significance Index: -6.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3556
    Cell Significance Index: -15.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3623
    Cell Significance Index: -20.3300
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.3683
    Cell Significance Index: -3.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3685
    Cell Significance Index: -19.1400
  • Cell Name: collagen secreting cell (CL0000667)
    Fold Change: -0.3737
    Cell Significance Index: -2.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3743
    Cell Significance Index: -24.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3834
    Cell Significance Index: -20.1300
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.3942
    Cell Significance Index: -4.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4041
    Cell Significance Index: -24.8400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4043
    Cell Significance Index: -4.4000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4132
    Cell Significance Index: -10.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4165
    Cell Significance Index: -8.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4167
    Cell Significance Index: -15.7800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4288
    Cell Significance Index: -15.7400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.4377
    Cell Significance Index: -5.5300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4432
    Cell Significance Index: -10.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4478
    Cell Significance Index: -12.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4627
    Cell Significance Index: -16.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4922
    Cell Significance Index: -23.1400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.4952
    Cell Significance Index: -7.1900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.5204
    Cell Significance Index: -4.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5235
    Cell Significance Index: -17.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5269
    Cell Significance Index: -16.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Role:** The J chain is a polypeptide that serves as a bridging element, connecting the heavy and light chains of IgA and IgM antibodies, forming a pentameric or hexameric structure. 2. **Expression:** The JCHAIN gene is highly expressed in cells involved in the humoral immune response, including plasma cells, B cells, and thymocytes. 3. **Cellular Distribution:** J chain expression is detected in various immune cells, including IgA and IgM plasma cells, germinal center B cells, and early lymphoid progenitors. 4. **Function:** The J chain is involved in the assembly and secretion of IgA and IgM antibodies, facilitating their interaction with antigens and recognition by immune cells. **Pathways and Functions:** 1. **Adaptive Immune Response:** The J chain is essential for the assembly and secretion of IgA and IgM antibodies, which are critical components of the adaptive immune response. 2. **Antibacterial Humoral Response:** IgA and IgM antibodies are key players in the humoral immune response against bacterial infections, and the J chain is essential for their function. 3. **Antigen Binding:** The J chain facilitates the interaction between IgA and IgM antibodies and antigens, enabling the recognition of pathogens by immune cells. 4. **Cell Surface Interactions:** The J chain is involved in cell surface interactions, including binding to scavenger receptors and facilitating the uptake of ligands by immune cells. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Defects in the JCHAIN gene have been associated with immunodeficiency disorders, such as IgA deficiency, which increases the risk of infections and autoimmune diseases. 2. **Autoimmune Diseases:** Abnormal IgA and IgM production, resulting from J chain dysfunction, may contribute to the development of autoimmune diseases, such as autoimmune hemolytic anemia. 3. **Infectious Diseases:** The J chain is essential for the assembly and secretion of IgA and IgM antibodies, which provide protection against bacterial infections, such as respiratory tract infections and gastrointestinal diseases. 4. **Cancer:** Alterations in IgA and IgM production, resulting from J chain dysfunction, may contribute to the development of certain types of cancer, such as colorectal cancer. In conclusion, the JCHAIN gene plays a critical role in the assembly and function of multimeric IgA and IgM antibodies, which are essential components of the humoral immune response. Understanding the mechanisms of J chain function and its clinical significance is essential for the development of novel therapeutic strategies for immunodeficiency disorders, autoimmune diseases, and infectious diseases.

Genular Protein ID: 1722010817

Symbol: IGJ_HUMAN

Name: Immunoglobulin J chain

UniProtKB Accession Codes:

P01591

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 3 EMDB 26 Ensembl 2 ExpressionAtlas 1 GO 22 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 25 PIR 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 407930

Title: Primary structure of human J chain: alignment of peptides from chemical and enzymatic hydrolyses.

PubMed ID: 407930

DOI: 10.1021/bi00635a002

PubMed ID: 2984306

Title: Human J chain gene. Structure and expression in B lymphoid cells.

PubMed ID: 2984306

DOI: 10.1084/jem.161.4.832

PubMed ID: 25946035

Title: Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.

PubMed ID: 25946035

DOI: 10.1021/acs.jproteome.5b00179

PubMed ID: 1472500

Title: Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M.

PubMed ID: 1472500

DOI: 10.1021/bi00165a014

PubMed ID: 15084671

Title: A proteomic analysis of human bile.

PubMed ID: 15084671

DOI: 10.1074/mcp.m400015-mcp200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 32029686

Title: Structure of the secretory immunoglobulin A core.

PubMed ID: 32029686

DOI: 10.1126/science.aaz5807

PubMed ID: 32029689

Title: Structural insights into immunoglobulin M.

PubMed ID: 32029689

DOI: 10.1126/science.aaz5425

PubMed ID: 37095205

Title: Structural basis for Fc receptor recognition of immunoglobulin M.

PubMed ID: 37095205

DOI: 10.1038/s41594-023-00985-x

Sequence Information:

  • Length: 159
  • Mass: 18099
  • Checksum: B7835C02CCC0CB05
  • Sequence:
    • MKNHLLFWGV LAVFIKAVHV KAQEDERIVL VDNKCKCARI TSRIIRSSED PNEDIVERNI 
RIIVPLNNRE NISDPTSPLR TRFVYHLSDL CKKCDPTEVE LDNQIVTATQ SNICDEDSAT 
ETCYTYDRNK CYTAVVPLVY GGETKMVETA LTPDACYPD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.