Details for: JCHAIN

Gene ID: 3512

Symbol: JCHAIN

Ensembl ID: ENSG00000132465

Description: joining chain of multimeric IgA and IgM

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 20.6
    Marker Score: 21573
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 6.02
    Marker Score: 5130
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 3.74
    Marker Score: 1031
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 3.31
    Marker Score: 870
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.54
    Marker Score: 1253
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.47
    Marker Score: 1500
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 2.26
    Marker Score: 985
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.1
    Marker Score: 724
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.09
    Marker Score: 727
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.91
    Marker Score: 935
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.9
    Marker Score: 7777
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.83
    Marker Score: 689
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.79
    Marker Score: 3117
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.75
    Marker Score: 11186
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.71
    Marker Score: 5078
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.58
    Marker Score: 18373
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.56
    Marker Score: 937
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.53
    Marker Score: 868
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.51
    Marker Score: 3428
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.49
    Marker Score: 1405
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.44
    Marker Score: 349
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.42
    Marker Score: 610
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.4
    Marker Score: 1687
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 1.27
    Marker Score: 979
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.26
    Marker Score: 290
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.24
    Marker Score: 1345
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.24
    Marker Score: 438
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.21
    Marker Score: 318
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.2
    Marker Score: 620
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.13
    Marker Score: 1116
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4740
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.12
    Marker Score: 2351
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.1
    Marker Score: 2996
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.06
    Marker Score: 497
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.06
    Marker Score: 1404
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.04
    Marker Score: 237
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.04
    Marker Score: 1008
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.02
    Marker Score: 324
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.02
    Marker Score: 595
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.01
    Marker Score: 1133
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.01
    Marker Score: 732
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.98
    Marker Score: 331
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.97
    Marker Score: 658
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 446
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.94
    Marker Score: 506
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.94
    Marker Score: 2423
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5264
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.91
    Marker Score: 635
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2719
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 363.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.88
    Marker Score: 788
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5274
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.87
    Marker Score: 872
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.86
    Marker Score: 359
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.86
    Marker Score: 552
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.85
    Marker Score: 810
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.84
    Marker Score: 4051
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.83
    Marker Score: 381
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.81
    Marker Score: 220
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.8
    Marker Score: 1566
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.78
    Marker Score: 665
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1252
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.77
    Marker Score: 320
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.76
    Marker Score: 512
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.75
    Marker Score: 395
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.74
    Marker Score: 562
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 552
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.72
    Marker Score: 211
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.72
    Marker Score: 694
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.72
    Marker Score: 198
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.71
    Marker Score: 521
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 646
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.69
    Marker Score: 164
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.69
    Marker Score: 394
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.68
    Marker Score: 396
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.68
    Marker Score: 432
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.68
    Marker Score: 244
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.68
    Marker Score: 280
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.67
    Marker Score: 1592
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.67
    Marker Score: 336
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.65
    Marker Score: 4319
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.64
    Marker Score: 1043
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.64
    Marker Score: 265
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.62
    Marker Score: 304
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.62
    Marker Score: 734
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.62
    Marker Score: 1548
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.62
    Marker Score: 448
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.59
    Marker Score: 394
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.59
    Marker Score: 142
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.59
    Marker Score: 2463
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 377
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.58
    Marker Score: 149
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.58
    Marker Score: 201
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.58
    Marker Score: 168

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - The JCHAIN gene is located on chromosome 15q26.1. - It is a multi-exon gene with a complex structure. - It encodes a secreted protein that is processed into two mature forms, IgJ and JIC. **Pathways and functions:** - The JCHAIN gene is involved in the adaptive immune response and the humoral immune response. - It is expressed in lymphoid tissues, such as thymocytes, IgA and IgM plasma cells, and macrophages. - IgJ is responsible for the recognition of specific antigens and triggering the activation of the immune response. - JIC is involved in the binding of IgM antibodies to pathogens and the subsequent activation of the immune response. - The JCHAIN protein is also involved in the regulation of inflammation and immune responses. **Clinical significance:** - Mutations in the JCHAIN gene have been linked to several human diseases, including autoimmune disorders, inflammatory diseases, and cancer. - The JCHAIN gene is a potential target for the development of new therapies for these diseases. **Additional information:** - The JCHAIN gene is also known as IGJ_HUMAN. - It is a highly conserved gene, with a similar gene found in mice and rats. - The JCHAIN protein is a multi-functional protein that is involved in both innate and adaptive immune responses.

Genular Protein ID: 1722010817

Symbol: IGJ_HUMAN

Name: Immunoglobulin J chain

UniProtKB Accession Codes:

P01591

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 3 EMDB 23 Ensembl 2 ExpressionAtlas 1 GO 22 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 28 PDBsum 22 PIR 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 SMR 1 STRING 1 SWISS-2DPAGE 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 407930

Title: Primary structure of human J chain: alignment of peptides from chemical and enzymatic hydrolyses.

PubMed ID: 407930

DOI: 10.1021/bi00635a002

PubMed ID: 2984306

Title: Human J chain gene. Structure and expression in B lymphoid cells.

PubMed ID: 2984306

DOI: 10.1084/jem.161.4.832

PubMed ID: 25946035

Title: Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.

PubMed ID: 25946035

DOI: 10.1021/acs.jproteome.5b00179

PubMed ID: 1472500

Title: Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M.

PubMed ID: 1472500

DOI: 10.1021/bi00165a014

PubMed ID: 15084671

Title: A proteomic analysis of human bile.

PubMed ID: 15084671

DOI: 10.1074/mcp.m400015-mcp200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 32029686

Title: Structure of the secretory immunoglobulin A core.

PubMed ID: 32029686

DOI: 10.1126/science.aaz5807

PubMed ID: 32029689

Title: Structural insights into immunoglobulin M.

PubMed ID: 32029689

DOI: 10.1126/science.aaz5425

PubMed ID: 37095205

Title: Structural basis for Fc receptor recognition of immunoglobulin M.

PubMed ID: 37095205

DOI: 10.1038/s41594-023-00985-x

Sequence Information:

  • Length: 159
  • Mass: 18099
  • Checksum: B7835C02CCC0CB05
  • Sequence:
    • MKNHLLFWGV LAVFIKAVHV KAQEDERIVL VDNKCKCARI TSRIIRSSED PNEDIVERNI 
RIIVPLNNRE NISDPTSPLR TRFVYHLSDL CKKCDPTEVE LDNQIVTATQ SNICDEDSAT 
ETCYTYDRNK CYTAVVPLVY GGETKMVETA LTPDACYPD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.