Details for: CYTIP

Gene ID: 9595

Symbol: CYTIP

Ensembl ID: ENSG00000115165

Description: cytohesin 1 interacting protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.6
    Marker Score: 35,666
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.16
    Marker Score: 1,580
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.13
    Marker Score: 9,149
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.03
    Marker Score: 3,366
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.02
    Marker Score: 2,370
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.99
    Marker Score: 8,396
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.97
    Marker Score: 7,167
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.83
    Marker Score: 149,861
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.72
    Marker Score: 2,289
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.69
    Marker Score: 1,577
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.67
    Marker Score: 828
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.58
    Marker Score: 1,111
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.53
    Marker Score: 2,497
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.5
    Marker Score: 2,338
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.48
    Marker Score: 3,416
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.46
    Marker Score: 7,777
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.45
    Marker Score: 28,529
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.44
    Marker Score: 2,356
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.43
    Marker Score: 1,763
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.43
    Marker Score: 1,196
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.43
    Marker Score: 1,247
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.41
    Marker Score: 5,047
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 2.37
    Marker Score: 5,332
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.33
    Marker Score: 10,004
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.31
    Marker Score: 1,965
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.29
    Marker Score: 4,094
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.28
    Marker Score: 5,556
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.27
    Marker Score: 14,506
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.27
    Marker Score: 4,440
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.26
    Marker Score: 3,936
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.21
    Marker Score: 670
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 2.18
    Marker Score: 479
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.18
    Marker Score: 1,572
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.1
    Marker Score: 1,355
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.1
    Marker Score: 6,229
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.09
    Marker Score: 3,589
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.05
    Marker Score: 2,214
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.05
    Marker Score: 1,550
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.04
    Marker Score: 1,492
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 2.02
    Marker Score: 2,238
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.02
    Marker Score: 1,218
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2
    Marker Score: 1,101
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.99
    Marker Score: 1,770
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.99
    Marker Score: 855
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.95
    Marker Score: 5,390
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.95
    Marker Score: 1,709
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.9
    Marker Score: 1,093
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.88
    Marker Score: 665
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.87
    Marker Score: 1,674
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.81
    Marker Score: 2,659
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.77
    Marker Score: 545
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.76
    Marker Score: 614
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.76
    Marker Score: 1,082
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.71
    Marker Score: 1,296
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.71
    Marker Score: 3,327
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.7
    Marker Score: 391
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.65
    Marker Score: 437
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.63
    Marker Score: 531
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.62
    Marker Score: 1,343
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.57
    Marker Score: 955
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.55
    Marker Score: 556
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.54
    Marker Score: 3,999
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.54
    Marker Score: 537
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.54
    Marker Score: 1,669
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.51
    Marker Score: 2,005
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.49
    Marker Score: 1,311
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.48
    Marker Score: 1,082
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.48
    Marker Score: 1,393
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.46
    Marker Score: 1,241
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.46
    Marker Score: 1,457
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,611
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.44
    Marker Score: 955
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.44
    Marker Score: 36,884
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.44
    Marker Score: 474
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.43
    Marker Score: 858
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.38
    Marker Score: 2,244
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.34
    Marker Score: 584
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.34
    Marker Score: 302
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.31
    Marker Score: 1,699
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.31
    Marker Score: 73,234
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.3
    Marker Score: 1,063
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.29
    Marker Score: 1,403
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.27
    Marker Score: 323
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.23
    Marker Score: 292
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.21
    Marker Score: 1,206
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2
    Marker Score: 12,173
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.19
    Marker Score: 2,960
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.18
    Marker Score: 811
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.18
    Marker Score: 1,203
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.17
    Marker Score: 266
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.16
    Marker Score: 4,828
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.16
    Marker Score: 1,104
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.14
    Marker Score: 786
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.14
    Marker Score: 367
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.14
    Marker Score: 1,271
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.14
    Marker Score: 634
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.14
    Marker Score: 764
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4,726
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.1
    Marker Score: 6,696
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.1
    Marker Score: 1,253

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** CYTIP is predominantly expressed in immune cells, including mature T cells, NKp46-positive innate lymphoid cells, and non-classical monocytes. 2. **Protein-protein interactions:** CYTIP interacts with cytohesin 1, a GAP that regulates Rho GTPases, and other proteins involved in cell adhesion and migration. 3. **Gene expression:** CYTIP is significantly expressed in various types of immune cells, including CD4-positive, alpha-beta memory T cells, CD8-positive, alpha-beta memory T cells, and NKp46-positive innate lymphoid cells. 4. **Enzyme activity:** CYTIP is involved in the regulation of cell adhesion and migration through its interaction with cytohesin 1 and other proteins. **Pathways and Functions:** 1. **Regulation of cell adhesion:** CYTIP plays a crucial role in regulating cell adhesion through its interaction with cytohesin 1 and other proteins involved in cell adhesion and migration. 2. **Immune cell migration:** CYTIP is involved in the regulation of immune cell migration, including the migration of T cells and NK cells to sites of infection or inflammation. 3. **Regulation of the immune response:** CYTIP is involved in the regulation of the immune response, including the activation and regulation of immune cells, such as T cells and NK cells. 4. **Cytoskeletal organization:** CYTIP is involved in the regulation of cytoskeletal organization, which is essential for cell migration and adhesion. **Clinical Significance:** 1. **Immune-related disorders:** Alterations in CYTIP expression have been observed in various immune-related disorders, including autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** CYTIP has been implicated in the progression of certain types of cancer, including leukemia and lymphoma. 3. **Infectious diseases:** CYTIP plays a crucial role in the regulation of the immune response to infectious diseases, including bacterial and viral infections. 4. **Vaccine development:** CYTIP may be a useful target for vaccine development, as alterations in CYTIP expression have been observed in individuals with impaired immune responses. **Conclusion:** In conclusion, the CYTIP gene plays a critical role in regulating immune cell function and regulation, including cell adhesion, migration, and regulation of the immune response. Alterations in CYTIP expression have been observed in various immune-related disorders, including autoimmune diseases, cancer, and infectious diseases. Further research is needed to fully understand the role of CYTIP in immune-related disorders and to explore its potential as a therapeutic target. **Future Directions:** 1. **Elucidation of CYTIP's role in immune-related disorders:** Further research is needed to elucidate the role of CYTIP in immune-related disorders, including autoimmune diseases and cancer. 2. **Development of CYTIP-based therapies:** CYTIP-based therapies may be developed to treat immune-related disorders, including autoimmune diseases and cancer. 3. **Investigation of CYTIP's interaction with other proteins:** The interaction between CYTIP and other proteins involved in cell adhesion and migration needs to be further investigated. 4. **Elucidation of CYTIP's role in cancer:** The role of CYTIP in cancer needs to be further investigated, including its involvement in cancer cell migration and adhesion.

Genular Protein ID: 4183011290

Symbol: CYTIP_HUMAN

Name: Cytohesin-interacting protein

UniProtKB Accession Codes:

O60759 B4DWH9 Q15630 Q8NE32

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11867758

Title: Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity.

PubMed ID: 11867758

DOI: 10.1073/pnas.052712999

PubMed ID: 12606567

Title: Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration.

PubMed ID: 12606567

DOI: 10.1093/emboj/cdg101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8241278

Title: Cloning a cDNA from human NK/T cells which codes for an unusual leucine zipper containing protein.

PubMed ID: 8241278

DOI: 10.1016/0167-4781(93)90165-a

PubMed ID: 17577583

Title: Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes.

PubMed ID: 17577583

DOI: 10.1016/j.bbrc.2007.05.162

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 359
  • Mass: 40010
  • Checksum: 76F0E0ED02EDD8C2
  • Sequence:
    • MSLQRLLQHS SNGNLADFCA GPAYSSYSTL TGSLTMDDNR RIQMLADTVA TLPRGRKQLA 
LTRSSSLSDF SWSQRKLVTV EKQDNETFGF EIQSYRPQNQ NACSSEMFTL ICKIQEDSPA 
HCAGLQAGDV LANINGVSTE GFTYKQVVDL IRSSGNLLTI ETLNGTMILK RTELEAKLQV 
LKQTLKQKWV EYRSLQLQEH RLLHGDAANC PSLENMDLDE LSLFGPLPGP GPALVDRNRL 
SSESSCKSWL SSMTMDSEDG YQTCVSEDSS RGAFSRQTST DDECFIPKEG DDFLRRSSSR 
RNRSISNTSS GSMSPLWEGN LSSMFGTLPR KSRKGSVRKQ LLKFIPGLHR AVEEEESRF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.