Details for: CL0011024

Cell ID: CL0011024

Cell Name: double negative T regulatory cell

Marker Score Threshold: 967
(Derived using integrated single-cell and genomic data)

Description: A double negative thymocyte that is CD3-positive, CD4-negative, CD8-negative, that that are present in the periphery in very low numbers and predominantly produce INF-gamma, TNF-alpha, and a low amount of TGF-beta, but not IL-2, IL-4, IL-10 or IL-13 upon activation.

Synonyms: CD4-negative, CD8-negative, alpha-beta regulatory T cells, DN Treg, double-negative alpha-beta regulatory T cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 4.35
    Ensembl ID: ENSG00000198851
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.29
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.28
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 4.17
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.05
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 4.03
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.93
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 3.9
    Ensembl ID: ENSG00000167286
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.84
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 3.75
    Ensembl ID: ENSG00000104894
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 3.75
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.71
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.67
    Ensembl ID: ENSG00000067560
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.48
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 3.44
    Ensembl ID: ENSG00000117091
  • Gene Symbol: CD3G (ENSG00000160654)
    Fold Change: 3.4
    Ensembl ID: ENSG00000160654
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 3.23
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 3.12
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.12
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 3.1
    Ensembl ID: ENSG00000143119
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 2.93
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.84
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.82
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 2.81
    Ensembl ID: ENSG00000197043
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.8
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 2.63
    Ensembl ID: ENSG00000173762
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.62
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 2.59
    Ensembl ID: ENSG00000110848
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.56
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.51
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.49
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.48
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.48
    Ensembl ID: ENSG00000077549
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.44
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 2.38
    Ensembl ID: ENSG00000116824
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.38
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 2.32
    Ensembl ID: ENSG00000185883
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.32
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.26
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.26
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 2.26
    Ensembl ID: ENSG00000141522
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 2.2
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.16
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ADGRE5 (ENSG00000123146)
    Fold Change: 2.1
    Ensembl ID: ENSG00000123146
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.08
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.08
    Ensembl ID: ENSG00000165629
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 2.02
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.01
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.98
    Ensembl ID: ENSG00000026508
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.97
    Ensembl ID: ENSG00000133639
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.95
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.88
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.88
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.84
    Ensembl ID: ENSG00000182718
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.84
    Ensembl ID: ENSG00000168421
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.83
    Ensembl ID: ENSG00000136717
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.79
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.78
    Ensembl ID: ENSG00000141480
  • Gene Symbol: CD27 (ENSG00000139193)
    Fold Change: 1.78
    Ensembl ID: ENSG00000139193
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.62
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.59
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.59
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 1.58
    Ensembl ID: ENSG00000198821
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.57
    Ensembl ID: ENSG00000196954
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.57
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.57
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.57
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CDC25B (ENSG00000101224)
    Fold Change: 1.56
    Ensembl ID: ENSG00000101224
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.56
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.56
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.55
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.52
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.52
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.51
    Ensembl ID: ENSG00000146731
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.51
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CDKN1B (ENSG00000111276)
    Fold Change: 1.49
    Ensembl ID: ENSG00000111276
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.46
    Ensembl ID: ENSG00000197894
  • Gene Symbol: CASP1 (ENSG00000137752)
    Fold Change: 1.42
    Ensembl ID: ENSG00000137752
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.37
    Ensembl ID: ENSG00000138279
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.36
    Ensembl ID: ENSG00000143799
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.36
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.34
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.29
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.29
    Ensembl ID: ENSG00000099624
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.27
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CD5 (ENSG00000110448)
    Fold Change: 1.26
    Ensembl ID: ENSG00000110448
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.19
    Ensembl ID: ENSG00000085662
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.18
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.17
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.15
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CASP8 (ENSG00000064012)
    Fold Change: 1.14
    Ensembl ID: ENSG00000064012
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.13
    Ensembl ID: ENSG00000114423
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.11
    Ensembl ID: ENSG00000113328
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.11
    Ensembl ID: ENSG00000134480
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.07
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.06
    Ensembl ID: ENSG00000071553
  • Gene Symbol: CD8B (ENSG00000172116)
    Fold Change: 1.06
    Ensembl ID: ENSG00000172116
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.05
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.03
    Ensembl ID: ENSG00000140299
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 1.03
    Ensembl ID: ENSG00000152495
Hovered Details

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Hovered Details

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**Key Characteristics** * CD3-positive, CD4-negative, and CD8-negative * Lacks co-receptors CD4 and CD8 * Expresses CD3E, a subunit of the T-cell receptor complex * Predominantly found in the periphery * Produces a distinct cytokine profile: + IFN-γ + TNF-α + Low levels of TGF-β + No IL-2, IL-4, IL-10, or IL-13 * Plays a crucial role in maintaining immune homeostasis and preventing excessive immune responses **Clinical Significance** DN Tregs have been implicated in various immune-related disorders, including: * Autoimmune diseases: DN Tregs have been shown to play a role in regulating immune responses and preventing autoimmunity. * Cancer: DN Tregs have been found to suppress anti-tumor immune responses, contributing to cancer progression. * Inflammation: DN Tregs can modulate inflammatory responses by producing anti-inflammatory cytokines. * Transplantation: DN Tregs have been explored as a potential tool for modulating immune responses in transplant patients. The dysregulation of DN Tregs has been implicated in various diseases, including: * Multiple sclerosis * Rheumatoid arthritis * Type 1 diabetes * Cancer * Inflammatory bowel disease Understanding the function and regulation of DN Tregs is crucial for developing novel therapeutic strategies for immune-related disorders. **Genetic and Molecular Characteristics** * Gene Symbol: CD3E * Ensembl ID: ENSG00000198851 * Pathways/Ontology: Adaptive immune response, Adaptive immune system, Alpha-beta T cell activation, Alpha-beta T cell receptor complex, Apoptotic signaling pathway, Calcium-mediated signaling, Cd4-positive, alpha-beta T cell proliferation, Cell-cell junction, Cell body, Cell surface receptor signaling pathway, Cerebellum development, Costimulation by the CD28 family, Dendrite development, Dendritic spine, Downstream TCR signaling, Endoplasmic reticulum, External side of plasma membrane, Gamma-delta T cell activation, Gamma-delta T cell receptor complex, Generation of second messenger molecules, Golgi apparatus, Golgi membrane, G protein-coupled receptor signaling pathway, Identical protein binding, Immune system, Immunoregulatory interactions between a lymphoid and a non-lymphoid cell, Negative regulation of gene expression, Negative regulation of Smoothened signaling pathway, Negative thymic T cell selection, Pd-1 signaling, Phosphorylation of CD3 and TCR zeta chains, Plasma membrane, Positive regulation of calcium-mediated signaling, Positive regulation of CD4-positive, alpha-beta T cell proliferation, Positive regulation of cell-cell adhesion mediated by integrin, Positive regulation of cell-matrix adhesion, Positive regulation of gene expression, Positive regulation of interleukin-2 production, Positive regulation of interleukin-4 production, Positive regulation of peptidyl-tyrosine phosphorylation, Positive regulation of T cell anergy, Positive regulation of T cell proliferation, Positive regulation of type II interferon production, Positive thymic T cell selection, Protein-containing complex assembly, Protein binding, Protein kinase binding, Regulation of apoptotic process, Sh3 domain binding, Signal complex assembly, Signaling receptor complex adaptor activity, Smoothened signaling pathway, T cell activation, T cell anergy, T cell costimulation, T cell receptor binding, T cell receptor complex, T cell receptor signaling pathway, TCR signaling, Translocation of Zap-70 to immunological synapse, Transmembrane receptor protein tyrosine kinase signaling pathway, Transmembrane signaling receptor activity **Cellular and Molecular Processes** * Cell-cell interactions and communication * Signaling pathways, including calcium-mediated signaling and TCR signaling * Gene expression and regulation * Apoptosis and cell death * Immune response modulation and regulation **Biological and Pathological Processes** * Autoimmune diseases * Cancer * Inflammation and immune regulation * Transplantation and immune modulation **Therapeutic Targets** * DN Tregs have been explored as a potential tool for modulating immune responses in transplant patients. * Novel therapeutic strategies targeting DN Tregs may be developed to treat immune-related disorders. **Future Research Directions** * Elucidating the mechanisms of DN Treg function and regulation * Investigating the role of DN Tregs in various immune-related disorders * Developing novel therapeutic strategies targeting DN Tregs.