Cell ID: CL0011024

Cell Name: double negative T regulatory cell

CSI Thresholds:

Select	Context	Threshold
	Overall	6.9296
	Blood	22.5740
	Blood + COVID-19	12.0502
	Influenza	8.4806
	Blood + Healthy	8.1780
	COVID-19	6.5105
	Blood + Influenza	4.6931
	Healthy	3.6025

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(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: A double negative thymocyte that is CD3-positive, CD4-negative, CD8-negative, that that are present in the periphery in very low numbers and predominantly produce INF-gamma, TNF-alpha, and a low amount of TGF-beta, but not IL-2, IL-4, IL-10 or IL-13 upon activation.

Synonyms: CD4-negative, CD8-negative, alpha-beta regulatory T cells, DN Treg, double-negative alpha-beta regulatory T cell