Gene CASP8 - ENSG00000064012 | NCBI Gene ID: 841

Details for: CASP8

Gene ID: 841

Symbol: CASP8

Ensembl ID: ENSG00000064012

Description: caspase 8

Associated with

Activation, myristolyation of bid and translocation to mitochondria
(R-HSA-75108)
Apoptosis
(R-HSA-109581)
Apoptotic cleavage of cellular proteins
(R-HSA-111465)
Apoptotic execution phase
(R-HSA-75153)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Casp8 activity is inhibited
(R-HSA-5218900)
Caspase-mediated cleavage of cytoskeletal proteins
(R-HSA-264870)
Caspase activation via death receptors in the presence of ligand
(R-HSA-140534)
Caspase activation via extrinsic apoptotic signalling pathway
(R-HSA-5357769)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Clec7a/inflammasome pathway
(R-HSA-5660668)
Cytokine signaling in immune system
(R-HSA-1280215)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Death receptor signaling
(R-HSA-73887)
Defective ripk1-mediated regulated necrosis
(R-HSA-9693928)
Dimerization of procaspase-8
(R-HSA-69416)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Fasl/ cd95l signaling
(R-HSA-75157)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Microbial modulation of ripk1-mediated regulated necrosis
(R-HSA-9686347)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Nf-kb activation through fadd/rip-1 pathway mediated by caspase-8 and -10
(R-HSA-933543)
Nod1/2 signaling pathway
(R-HSA-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Programmed cell death
(R-HSA-5357801)
Regulated necrosis
(R-HSA-5218859)
Regulation by c-flip
(R-HSA-3371378)
Regulation of necroptotic cell death
(R-HSA-5675482)
Regulation of nf-kappa b signaling
(R-HSA-9758274)
Regulation of tnfr1 signaling
(R-HSA-5357905)
Ripk1-mediated regulated necrosis
(R-HSA-5213460)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Tak1-dependent ikk and nf-kappa-b activation
(R-HSA-445989)
Tlr3-mediated ticam1-dependent programmed cell death
(R-HSA-9013957)
Tnfr1-induced proapoptotic signaling
(R-HSA-5357786)
Tnf signaling
(R-HSA-75893)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Trail signaling
(R-HSA-75158)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Trif-mediated programmed cell death
(R-HSA-2562578)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Angiogenesis
(GO:0001525)
Apoptotic process
(GO:0006915)
B cell activation
(GO:0042113)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type endopeptidase activity involved in apoptotic process
(GO:0097153)
Cysteine-type endopeptidase activity involved in apoptotic signaling pathway
(GO:0097199)
Cysteine-type peptidase activity
(GO:0008234)
Death effector domain binding
(GO:0035877)
Death receptor binding
(GO:0005123)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Heart development
(GO:0007507)
Identical protein binding
(GO:0042802)
Macrophage differentiation
(GO:0030225)
Natural killer cell activation
(GO:0030101)
Peptidase activity
(GO:0008233)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)
Regulation of cytokine production
(GO:0001817)
Regulation of tumor necrosis factor-mediated signaling pathway
(GO:0010803)
Response to cobalt ion
(GO:0032025)
Response to estradiol
(GO:0032355)
Response to lipopolysaccharide
(GO:0032496)
Response to tumor necrosis factor
(GO:0034612)
Scaffold protein binding
(GO:0097110)
T cell activation
(GO:0042110)
Trail-activated apoptotic signaling pathway
(GO:0036462)
Tumor necrosis factor receptor binding
(GO:0005164)
Ubiquitin protein ligase binding
(GO:0031625)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.33
Marker Score: 1005
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 1.61
Marker Score: 5096
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.54
Marker Score: 4332
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 1.48
Marker Score: 1388
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.45
Marker Score: 449
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.44
Marker Score: 1986
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 1.39
Marker Score: 485
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.38
Marker Score: 72961
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 1.35
Marker Score: 443
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 1.34
Marker Score: 3901
Cell Name: mature T cell (CL0002419)
Fold Change: 1.32
Marker Score: 13109
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.3
Marker Score: 977
Cell Name: blood cell (CL0000081)
Fold Change: 1.27
Marker Score: 14726
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.24
Marker Score: 1047
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 1.23
Marker Score: 1083
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 1.22
Marker Score: 1802
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 1.22
Marker Score: 1317
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.19
Marker Score: 717
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 1.14
Marker Score: 1098
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 1.13
Marker Score: 2765
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.12
Marker Score: 658
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 1.12
Marker Score: 617
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.11
Marker Score: 394
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 1.11
Marker Score: 684
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.11
Marker Score: 2167
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.06
Marker Score: 637
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 1.05
Marker Score: 767
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.03
Marker Score: 1960
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.01
Marker Score: 503
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.01
Marker Score: 790
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71675.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47900
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.98
Marker Score: 806
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30391
Cell Name: Unknown (CL0000548)
Fold Change: 0.96
Marker Score: 703
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.96
Marker Score: 486
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 0.96
Marker Score: 292
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.96
Marker Score: 1240
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2395
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.94
Marker Score: 52609.5
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.93
Marker Score: 707
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 481
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.93
Marker Score: 5942
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.93
Marker Score: 299
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 438
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 0.92
Marker Score: 669
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 0.91
Marker Score: 207
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.91
Marker Score: 811
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.91
Marker Score: 3898
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2705
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.9
Marker Score: 519
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.9
Marker Score: 794.5
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5294
Cell Name: plasmablast (CL0000980)
Fold Change: 0.87
Marker Score: 1161
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.87
Marker Score: 313
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.86
Marker Score: 852
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 311
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 0.86
Marker Score: 443
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.84
Marker Score: 242
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.84
Marker Score: 4774
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.83
Marker Score: 1678
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.82
Marker Score: 1213
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.82
Marker Score: 771
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.81
Marker Score: 590
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.81
Marker Score: 325
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.81
Marker Score: 1900
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.8
Marker Score: 813
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.8
Marker Score: 1421
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.8
Marker Score: 675
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.79
Marker Score: 518
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.79
Marker Score: 602
Cell Name: memory B cell (CL0000787)
Fold Change: 0.79
Marker Score: 594
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1263
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.76
Marker Score: 1872
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.76
Marker Score: 166.5
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.76
Marker Score: 826
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.75
Marker Score: 831
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.75
Marker Score: 505
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.75
Marker Score: 542
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.74
Marker Score: 1275
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.74
Marker Score: 3026
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.74
Marker Score: 389
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.73
Marker Score: 255
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.73
Marker Score: 376.5
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.73
Marker Score: 233
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.72
Marker Score: 141
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.72
Marker Score: 168
Cell Name: naive T cell (CL0000898)
Fold Change: 0.71
Marker Score: 460
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 0.71
Marker Score: 175
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.71
Marker Score: 154
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.71
Marker Score: 244
Cell Name: memory T cell (CL0000813)
Fold Change: 0.7
Marker Score: 303
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 0.7
Marker Score: 187
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7
Marker Score: 2937
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.7
Marker Score: 754
Cell Name: tendon cell (CL0000388)
Fold Change: 0.7
Marker Score: 171
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.69
Marker Score: 173
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.69
Marker Score: 1917
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.69
Marker Score: 155
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.69
Marker Score: 17758

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**Key characteristics** - CASP8 is a member of the caspase family of cysteine proteases, which are responsible for the activation of other caspases. - It is expressed in a wide range of cell types, including immune cells, cancer cells, and neurons. - CASP8 is a key regulator of apoptosis, where it is activated by various stimuli, including intrinsic and extrinsic pathways. - It is involved in the regulation of immune responses, inflammation, and cell death. **Pathways and functions** - **Apoptotic pathway:** CASP8 is a key activator of the apoptotic pathway, which is a tightly regulated process that leads to the death of a cell. - **Immune responses:** CASP8 is also involved in the regulation of immune responses, where it can activate immune cells to kill infected cells or tumor cells. - **Cell death:** CASP8 can also be activated by other apoptotic pathways, such as the FasL/CD95l pathway, and it can induce cell death in a caspase-dependent manner. **Clinical significance** - CASP8 mutations are linked to several human diseases, including cancer and autoimmune disorders. - Targeting CASP8 has emerged as a potential therapeutic strategy for cancer and autoimmune diseases. **Additional information** - CASP8 is a highly conserved protein with a conserved catalytic domain. - It is a key regulator of inflammation, where it can promote the production of inflammatory cytokines. - CASP8 is also involved in cell migration, proliferation, and differentiation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Apoptotic cysteine protease

Genular Protein ID: 3580247173

Symbol: CASP8_HUMAN

Name: Apoptotic cysteine protease

UniProtKB Accession Codes:

Q14790 O14676 Q14791 Q14792 Q14793 Q14794 Q14795 Q14796 Q15780 Q15806 Q53TT5 Q8TDI1 Q8TDI2 Q8TDI3 Q8TDI4 Q8TDI5 Q96T22 Q9C0K4 Q9UQ81

Database IDs:

Citations:

PubMed ID: 8681376

Title: Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.

PubMed ID: 8681376

DOI: 10.1016/s0092-8674(00)81265-9

PubMed ID: 8681377

Title: FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex.

PubMed ID: 8681377

DOI: 10.1016/s0092-8674(00)81266-0

PubMed ID: 8755496

Title: In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

PubMed ID: 8755496

DOI: 10.1073/pnas.93.15.7464

PubMed ID: 9228018

Title: FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis.

PubMed ID: 9228018

DOI: 10.1074/jbc.272.30.18542

PubMed ID: 9931493

Title: Structure and chromosome localization of the human CASP8 gene.

PubMed ID: 9931493

DOI: 10.1016/s0378-1119(98)00565-4

PubMed ID: 11161814

Title: Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2.

PubMed ID: 11161814

DOI: 10.1006/geno.2000.6392

PubMed ID: 12010809

Title: Characterization of caspase-8L: a novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade.

PubMed ID: 12010809

DOI: 10.1182/blood.v99.11.4070

PubMed ID: 11917123

Title: The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum.

PubMed ID: 11917123

DOI: 10.1073/pnas.072088099

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8962078

Title: Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases.

PubMed ID: 8962078

DOI: 10.1073/pnas.93.25.14486

PubMed ID: 9006941

Title: FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens.

PubMed ID: 9006941

DOI: 10.1074/jbc.272.5.2952

PubMed ID: 9184224

Title: FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

PubMed ID: 9184224

DOI: 10.1093/emboj/16.10.2794

PubMed ID: 10860845

Title: Dominant expression of a novel splice variant of caspase-8 in human peripheral blood lymphocytes.

PubMed ID: 10860845

DOI: 10.1006/bbrc.2000.2841

PubMed ID: 9334338

Title: p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum.

PubMed ID: 9334338

DOI: 10.1083/jcb.139.2.327

PubMed ID: 10442631

Title: PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis.

PubMed ID: 10442631

DOI: 10.1038/sj.onc.1202831

PubMed ID: 11427719

Title: A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation.

PubMed ID: 11427719

DOI: 10.1073/pnas.141108798

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15509781

Title: Calcium binding of ARC mediates regulation of caspase 8 and cell death.

PubMed ID: 15509781

DOI: 10.1128/mcb.24.22.9763-9770.2004

PubMed ID: 15069192

Title: Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth.

PubMed ID: 15069192

DOI: 10.1073/pnas.0307459101

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15592525

Title: Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway.

PubMed ID: 15592525

DOI: 10.1038/sj.onc.1208186

PubMed ID: 16378960

Title: The MC160 protein expressed by the dermatotropic poxvirus molluscum contagiosum virus prevents tumor necrosis factor alpha-induced NF-kappaB activation via inhibition of I kappa kinase complex formation.

PubMed ID: 16378960

DOI: 10.1128/jvi.80.2.578-586.2006

PubMed ID: 16916640

Title: Engineered hybrid dimers: tracking the activation pathway of caspase-7.

PubMed ID: 16916640

DOI: 10.1016/j.molcel.2006.06.020

PubMed ID: 17245429

Title: FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies.

PubMed ID: 17245429

DOI: 10.1038/sj.emboj.7601504

PubMed ID: 18846110

Title: Identification of an antiapoptotic protein complex at death receptors.

PubMed ID: 18846110

DOI: 10.1038/cdd.2008.124

PubMed ID: 20937773

Title: Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity.

PubMed ID: 20937773

DOI: 10.1128/mcb.00731-10

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22858542

Title: Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6.

PubMed ID: 22858542

DOI: 10.1038/cdd.2012.98

PubMed ID: 23516580

Title: The E. coli effector protein NleF is a caspase inhibitor.

PubMed ID: 23516580

DOI: 10.1371/journal.pone.0058937

PubMed ID: 25674983

Title: Herpes simplex virus suppresses necroptosis in human cells.

PubMed ID: 25674983

DOI: 10.1016/j.chom.2015.01.003

PubMed ID: 28602583

Title: Coupled Caspase and N-End Rule Ligase Activities Allow Recognition and Degradation of Pluripotency Factor LIN-28 during Non-Apoptotic Development.

PubMed ID: 28602583

DOI: 10.1016/j.devcel.2017.05.013

PubMed ID: 31827281

Title: Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease.

PubMed ID: 31827281

DOI: 10.1038/s41586-019-1828-5

PubMed ID: 31827280

Title: A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1.

PubMed ID: 31827280

DOI: 10.1038/s41586-019-1830-y

PubMed ID: 32929201

Title: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.

PubMed ID: 32929201

DOI: 10.1038/s41556-020-0575-z

PubMed ID: 34012073

Title: The metabolite alpha-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.

PubMed ID: 34012073

DOI: 10.1038/s41422-021-00506-9

PubMed ID: 35446120

Title: Calmodulin binding activates chromobacterium CopC effector to ADP-riboxanate host apoptotic caspases.

PubMed ID: 35446120

DOI: 10.1128/mbio.00690-22

PubMed ID: 35338844

Title: Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases.

PubMed ID: 35338844

DOI: 10.1016/j.molcel.2022.03.010

PubMed ID: 10508784

Title: The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis.

PubMed ID: 10508784

DOI: 10.1016/s0969-2126(99)80179-8

PubMed ID: 10508785

Title: The atomic-resolution structure of human caspase-8, a key activator of apoptosis.

PubMed ID: 10508785

DOI: 10.1016/s0969-2126(99)80180-4

PubMed ID: 12353035

Title: Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.

PubMed ID: 12353035

DOI: 10.1038/nature01063

PubMed ID: 15601643

Title: Association of a common variant of the CASP8 gene with reduced risk of breast cancer.

PubMed ID: 15601643

DOI: 10.1093/jnci/dji001

PubMed ID: 17293864

Title: A common coding variant in CASP8 is associated with breast cancer risk.

PubMed ID: 17293864

DOI: 10.1038/ng1981

PubMed ID: 17450141

Title: A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers.

PubMed ID: 17450141

DOI: 10.1038/ng2030

PubMed ID: 18563783

Title: Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma.

PubMed ID: 18563783

DOI: 10.1002/humu.20803

Sequence Information:

Length: 479
Mass: 55391
Checksum: 7A5FEAA6B39B582F
Sequence:

MDFSRNLYDI GEQLDSEDLA SLKFLSLDYI PQRKQEPIKD ALMLFQRLQE KRMLEESNLS 
FLKELLFRIN RLDLLITYLN TRKEEMEREL QTPGRAQISA YRVMLYQISE EVSRSELRSF 
KFLLQEEISK CKLDDDMNLL DIFIEMEKRV ILGEGKLDIL KRVCAQINKS LLKIINDYEE 
FSKERSSSLE GSPDEFSNGE ELCGVMTISD SPREQDSESQ TLDKVYQMKS KPRGYCLIIN 
NHNFAKAREK VPKLHSIRDR NGTHLDAGAL TTTFEELHFE IKPHDDCTVE QIYEILKIYQ 
LMDHSNMDCF ICCILSHGDK GIIYGTDGQE APIYELTSQF TGLKCPSLAG KPKVFFIQAC 
QGDNYQKGIP VETDSEEQPY LEMDLSSPQT RYIPDEADFL LGMATVNNCV SYRNPAEGTW 
YIQSLCQSLR ERCPRGDDIL TILTEVNYEV SNKDDKKNMG KQMPQPTFTL RKKLVFPSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CASP8

Associated with

Cells (max top 100)

Other Information

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. PubMed ID: 8681376

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. PubMed ID: 8681377

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. PubMed ID: 8755496

FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. PubMed ID: 9228018

Structure and chromosome localization of the human CASP8 gene. PubMed ID: 9931493

Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2. PubMed ID: 11161814

Characterization of caspase-8L: a novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade. PubMed ID: 12010809

The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum. PubMed ID: 11917123

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. PubMed ID: 8962078

FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens. PubMed ID: 9006941

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). PubMed ID: 9184224

Dominant expression of a novel splice variant of caspase-8 in human peripheral blood lymphocytes. PubMed ID: 10860845

p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum. PubMed ID: 9334338

PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis. PubMed ID: 10442631

A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation. PubMed ID: 11427719

An unappreciated role for RNA surveillance. PubMed ID: 14759258

Calcium binding of ARC mediates regulation of caspase 8 and cell death. PubMed ID: 15509781

Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. PubMed ID: 15069192

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway. PubMed ID: 15592525

The MC160 protein expressed by the dermatotropic poxvirus molluscum contagiosum virus prevents tumor necrosis factor alpha-induced NF-kappaB activation via inhibition of I kappa kinase complex formation. PubMed ID: 16378960

Engineered hybrid dimers: tracking the activation pathway of caspase-7. PubMed ID: 16916640

FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies. PubMed ID: 17245429

Identification of an antiapoptotic protein complex at death receptors. PubMed ID: 18846110

Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity. PubMed ID: 20937773

Initial characterization of the human central proteome. PubMed ID: 21269460

Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6. PubMed ID: 22858542

The E. coli effector protein NleF is a caspase inhibitor. PubMed ID: 23516580

Herpes simplex virus suppresses necroptosis in human cells. PubMed ID: 25674983

Coupled Caspase and N-End Rule Ligase Activities Allow Recognition and Degradation of Pluripotency Factor LIN-28 during Non-Apoptotic Development. PubMed ID: 28602583

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease. PubMed ID: 31827281

A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1. PubMed ID: 31827280

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis. PubMed ID: 32929201

The metabolite alpha-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8. PubMed ID: 34012073

Calmodulin binding activates chromobacterium CopC effector to ADP-riboxanate host apoptotic caspases. PubMed ID: 35446120

Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases. PubMed ID: 35338844

The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis. PubMed ID: 10508784

The atomic-resolution structure of human caspase-8, a key activator of apoptosis. PubMed ID: 10508785

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. PubMed ID: 12353035

Association of a common variant of the CASP8 gene with reduced risk of breast cancer. PubMed ID: 15601643

A common coding variant in CASP8 is associated with breast cancer risk. PubMed ID: 17293864

A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers. PubMed ID: 17450141

Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma. PubMed ID: 18563783