Details for: CASP8

Gene ID: 841

Symbol: CASP8

Ensembl ID: ENSG00000064012

Description: caspase 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 97.2065
    Cell Significance Index: -15.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 44.7479
    Cell Significance Index: -11.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.7008
    Cell Significance Index: -18.1600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 37.6760
    Cell Significance Index: -19.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.0743
    Cell Significance Index: -16.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.7206
    Cell Significance Index: -12.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.8584
    Cell Significance Index: -13.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.6428
    Cell Significance Index: -14.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.2245
    Cell Significance Index: -16.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.4320
    Cell Significance Index: 168.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6503
    Cell Significance Index: 327.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3140
    Cell Significance Index: 250.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1760
    Cell Significance Index: 1061.8600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1597
    Cell Significance Index: 31.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1363
    Cell Significance Index: 123.6000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.0975
    Cell Significance Index: 2.9400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8503
    Cell Significance Index: 15.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7993
    Cell Significance Index: 23.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7989
    Cell Significance Index: 129.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6509
    Cell Significance Index: 8.8800
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.6006
    Cell Significance Index: 6.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4011
    Cell Significance Index: 11.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3952
    Cell Significance Index: 20.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3882
    Cell Significance Index: 25.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3398
    Cell Significance Index: 9.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3384
    Cell Significance Index: 8.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3382
    Cell Significance Index: 41.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3185
    Cell Significance Index: 57.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2605
    Cell Significance Index: 7.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2575
    Cell Significance Index: 12.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2431
    Cell Significance Index: 132.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2138
    Cell Significance Index: 21.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2026
    Cell Significance Index: 4.6800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1917
    Cell Significance Index: 9.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1637
    Cell Significance Index: 4.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1561
    Cell Significance Index: 18.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0897
    Cell Significance Index: 18.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0837
    Cell Significance Index: 37.0000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0835
    Cell Significance Index: 1.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0677
    Cell Significance Index: 8.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0572
    Cell Significance Index: 7.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0207
    Cell Significance Index: 14.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0139
    Cell Significance Index: 26.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0005
    Cell Significance Index: 1.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0016
    Cell Significance Index: -2.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0019
    Cell Significance Index: -0.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0019
    Cell Significance Index: -0.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0026
    Cell Significance Index: -0.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0029
    Cell Significance Index: -2.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0040
    Cell Significance Index: -0.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0098
    Cell Significance Index: -13.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0099
    Cell Significance Index: -7.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0110
    Cell Significance Index: -4.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0134
    Cell Significance Index: -4.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0143
    Cell Significance Index: -9.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0184
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0252
    Cell Significance Index: -18.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0307
    Cell Significance Index: -19.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0326
    Cell Significance Index: -18.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0329
    Cell Significance Index: -4.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0485
    Cell Significance Index: -3.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0540
    Cell Significance Index: -15.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0552
    Cell Significance Index: -9.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0576
    Cell Significance Index: -2.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0609
    Cell Significance Index: -7.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0624
    Cell Significance Index: -7.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0702
    Cell Significance Index: -5.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0787
    Cell Significance Index: -9.0200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0869
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0918
    Cell Significance Index: -19.3300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0932
    Cell Significance Index: -2.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0967
    Cell Significance Index: -2.0600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1082
    Cell Significance Index: -0.5900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1294
    Cell Significance Index: -2.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1540
    Cell Significance Index: -16.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1589
    Cell Significance Index: -7.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1743
    Cell Significance Index: -11.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1806
    Cell Significance Index: -6.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1978
    Cell Significance Index: -4.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1991
    Cell Significance Index: -10.3700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2131
    Cell Significance Index: -2.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2210
    Cell Significance Index: -5.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2225
    Cell Significance Index: -17.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2382
    Cell Significance Index: -14.6400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2503
    Cell Significance Index: -2.5100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2514
    Cell Significance Index: -2.0500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2612
    Cell Significance Index: -2.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2615
    Cell Significance Index: -16.0300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2855
    Cell Significance Index: -4.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2874
    Cell Significance Index: -16.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2875
    Cell Significance Index: -18.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2996
    Cell Significance Index: -13.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3457
    Cell Significance Index: -18.1500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3476
    Cell Significance Index: -4.4100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3610
    Cell Significance Index: -5.5900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3627
    Cell Significance Index: -6.1100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3891
    Cell Significance Index: -13.6300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3909
    Cell Significance Index: -3.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4031
    Cell Significance Index: -10.6000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4227
    Cell Significance Index: -7.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** Caspase 8 is a cysteine protease with a characteristic caspase fold, consisting of four domains: the prodomain, the large subunit, the small subunit, and the activation loop. 2. **Function:** Caspase 8 is a key regulator of apoptosis, specifically activated by death receptors in response to extrinsic apoptotic signals. 3. **Expression:** Caspase 8 is expressed in various cell types, including T cells, natural killer cells, and macrophages, where it plays a crucial role in immune response and regulation of cytokine production. 4. **Regulation:** Caspase 8 is regulated by its prodomain, which inhibits its activity until it is cleaved and activated by death receptors. **Pathways and Functions:** 1. **Apoptosis:** Caspase 8 is activated by death receptors, leading to the cleavage and activation of downstream caspases, which execute cell death. 2. **Immune Response:** Caspase 8 participates in the regulation of cytokine production, particularly IL-1β, and modulates the activity of other immune cells, such as macrophages and T cells. 3. **Angiogenesis:** Caspase 8 is involved in the regulation of angiogenic processes, particularly in the context of tumor growth and metastasis. 4. **Regulation of Cytokine Production:** Caspase 8 modulates the production of cytokines, including IL-1β, TNF-α, and IL-12, which are essential for immune response and inflammation. **Clinical Significance:** 1. **Cancer:** Dysregulation of caspase 8 has been implicated in various cancers, including breast, lung, and colon cancer, where it contributes to tumor growth and metastasis. 2. **Autoimmune Diseases:** Caspase 8 is involved in the regulation of cytokine production and immune response, which can contribute to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Infectious Diseases:** Caspase 8 participates in the regulation of cytokine production and immune response, which can contribute to the severity of infectious diseases, such as sepsis and tuberculosis. 4. **Immunotherapy:** Caspase 8 has been identified as a potential target for immunotherapy, particularly in cancer treatment, where it can be targeted to induce apoptosis in tumor cells. In conclusion, caspase 8 is a critical regulator of apoptosis and immune response, with significant implications for cancer, autoimmune diseases, and infectious diseases. Further research is needed to fully understand its role in these processes and to develop therapeutic strategies that target caspase 8 for the treatment of these diseases.

Genular Protein ID: 3580247173

Symbol: CASP8_HUMAN

Name: Apoptotic cysteine protease

UniProtKB Accession Codes:

Q14790 O14676 Q14791 Q14792 Q14793 Q14794 Q14795 Q14796 Q15780 Q15806 Q53TT5 Q8TDI1 Q8TDI2 Q8TDI3 Q8TDI4 Q8TDI5 Q96T22 Q9C0K4 Q9UQ81

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 2 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 1 ELM 1 EMBL 28 EMDB 2 Ensembl 14 EvolutionaryTrace 1 ExpressionAtlas 1 GO 62 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MEROPS 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 27 PDBsum 27 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 Pumba 1 RNAct 1 Reactome 22 RefSeq 16 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8681376

Title: Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.

PubMed ID: 8681376

DOI: 10.1016/s0092-8674(00)81265-9

PubMed ID: 8681377

Title: FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex.

PubMed ID: 8681377

DOI: 10.1016/s0092-8674(00)81266-0

PubMed ID: 8755496

Title: In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

PubMed ID: 8755496

DOI: 10.1073/pnas.93.15.7464

PubMed ID: 9228018

Title: FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis.

PubMed ID: 9228018

DOI: 10.1074/jbc.272.30.18542

PubMed ID: 9931493

Title: Structure and chromosome localization of the human CASP8 gene.

PubMed ID: 9931493

DOI: 10.1016/s0378-1119(98)00565-4

PubMed ID: 11161814

Title: Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2.

PubMed ID: 11161814

DOI: 10.1006/geno.2000.6392

PubMed ID: 12010809

Title: Characterization of caspase-8L: a novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade.

PubMed ID: 12010809

DOI: 10.1182/blood.v99.11.4070

PubMed ID: 11917123

Title: The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum.

PubMed ID: 11917123

DOI: 10.1073/pnas.072088099

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8962078

Title: Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases.

PubMed ID: 8962078

DOI: 10.1073/pnas.93.25.14486

PubMed ID: 9006941

Title: FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens.

PubMed ID: 9006941

DOI: 10.1074/jbc.272.5.2952

PubMed ID: 9184224

Title: FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

PubMed ID: 9184224

DOI: 10.1093/emboj/16.10.2794

PubMed ID: 10860845

Title: Dominant expression of a novel splice variant of caspase-8 in human peripheral blood lymphocytes.

PubMed ID: 10860845

DOI: 10.1006/bbrc.2000.2841

PubMed ID: 9334338

Title: p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum.

PubMed ID: 9334338

DOI: 10.1083/jcb.139.2.327

PubMed ID: 10442631

Title: PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis.

PubMed ID: 10442631

DOI: 10.1038/sj.onc.1202831

PubMed ID: 11427719

Title: A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation.

PubMed ID: 11427719

DOI: 10.1073/pnas.141108798

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15509781

Title: Calcium binding of ARC mediates regulation of caspase 8 and cell death.

PubMed ID: 15509781

DOI: 10.1128/mcb.24.22.9763-9770.2004

PubMed ID: 15069192

Title: Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth.

PubMed ID: 15069192

DOI: 10.1073/pnas.0307459101

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15592525

Title: Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway.

PubMed ID: 15592525

DOI: 10.1038/sj.onc.1208186

PubMed ID: 16619028

Title: Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression.

PubMed ID: 16619028

DOI: 10.1038/sj.emboj.7601085

PubMed ID: 16378960

Title: The MC160 protein expressed by the dermatotropic poxvirus molluscum contagiosum virus prevents tumor necrosis factor alpha-induced NF-kappaB activation via inhibition of I kappa kinase complex formation.

PubMed ID: 16378960

DOI: 10.1128/jvi.80.2.578-586.2006

PubMed ID: 16916640

Title: Engineered hybrid dimers: tracking the activation pathway of caspase-7.

PubMed ID: 16916640

DOI: 10.1016/j.molcel.2006.06.020

PubMed ID: 17245429

Title: FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies.

PubMed ID: 17245429

DOI: 10.1038/sj.emboj.7601504

PubMed ID: 18846110

Title: Identification of an antiapoptotic protein complex at death receptors.

PubMed ID: 18846110

DOI: 10.1038/cdd.2008.124

PubMed ID: 18216014

Title: Identification of a critical tyrosine residue in caspase 8 that promotes cell migration.

PubMed ID: 18216014

DOI: 10.1074/jbc.m800549200

PubMed ID: 20937773

Title: Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity.

PubMed ID: 20937773

DOI: 10.1128/mcb.00731-10

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22858542

Title: Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6.

PubMed ID: 22858542

DOI: 10.1038/cdd.2012.98

PubMed ID: 23516580

Title: The E. coli effector protein NleF is a caspase inhibitor.

PubMed ID: 23516580

DOI: 10.1371/journal.pone.0058937

PubMed ID: 25674983

Title: Herpes simplex virus suppresses necroptosis in human cells.

PubMed ID: 25674983

DOI: 10.1016/j.chom.2015.01.003

PubMed ID: 27109099

Title: Caspase-8 tyrosine-380 phosphorylation inhibits CD95 DISC function by preventing procaspase-8 maturation and cycling within the complex.

PubMed ID: 27109099

DOI: 10.1038/onc.2016.99

PubMed ID: 28602583

Title: Coupled Caspase and N-End Rule Ligase Activities Allow Recognition and Degradation of Pluripotency Factor LIN-28 during Non-Apoptotic Development.

PubMed ID: 28602583

DOI: 10.1016/j.devcel.2017.05.013

PubMed ID: 31827281

Title: Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease.

PubMed ID: 31827281

DOI: 10.1038/s41586-019-1828-5

PubMed ID: 31827280

Title: A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1.

PubMed ID: 31827280

DOI: 10.1038/s41586-019-1830-y

PubMed ID: 32929201

Title: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.

PubMed ID: 32929201

DOI: 10.1038/s41556-020-0575-z

PubMed ID: 34012073

Title: The metabolite alpha-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.

PubMed ID: 34012073

DOI: 10.1038/s41422-021-00506-9

PubMed ID: 35446120

Title: Calmodulin binding activates chromobacterium CopC effector to ADP-riboxanate host apoptotic caspases.

PubMed ID: 35446120

DOI: 10.1128/mbio.00690-22

PubMed ID: 35338844

Title: Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases.

PubMed ID: 35338844

DOI: 10.1016/j.molcel.2022.03.010

PubMed ID: 10508784

Title: The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis.

PubMed ID: 10508784

DOI: 10.1016/s0969-2126(99)80179-8

PubMed ID: 10508785

Title: The atomic-resolution structure of human caspase-8, a key activator of apoptosis.

PubMed ID: 10508785

DOI: 10.1016/s0969-2126(99)80180-4

PubMed ID: 12353035

Title: Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.

PubMed ID: 12353035

DOI: 10.1038/nature01063

PubMed ID: 15601643

Title: Association of a common variant of the CASP8 gene with reduced risk of breast cancer.

PubMed ID: 15601643

DOI: 10.1093/jnci/dji001

PubMed ID: 17293864

Title: A common coding variant in CASP8 is associated with breast cancer risk.

PubMed ID: 17293864

DOI: 10.1038/ng1981

PubMed ID: 17450141

Title: A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers.

PubMed ID: 17450141

DOI: 10.1038/ng2030

PubMed ID: 18563783

Title: Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma.

PubMed ID: 18563783

DOI: 10.1002/humu.20803

Sequence Information:

  • Length: 479
  • Mass: 55391
  • Checksum: 7A5FEAA6B39B582F
  • Sequence:
    • MDFSRNLYDI GEQLDSEDLA SLKFLSLDYI PQRKQEPIKD ALMLFQRLQE KRMLEESNLS 
FLKELLFRIN RLDLLITYLN TRKEEMEREL QTPGRAQISA YRVMLYQISE EVSRSELRSF 
KFLLQEEISK CKLDDDMNLL DIFIEMEKRV ILGEGKLDIL KRVCAQINKS LLKIINDYEE 
FSKERSSSLE GSPDEFSNGE ELCGVMTISD SPREQDSESQ TLDKVYQMKS KPRGYCLIIN 
NHNFAKAREK VPKLHSIRDR NGTHLDAGAL TTTFEELHFE IKPHDDCTVE QIYEILKIYQ 
LMDHSNMDCF ICCILSHGDK GIIYGTDGQE APIYELTSQF TGLKCPSLAG KPKVFFIQAC 
QGDNYQKGIP VETDSEEQPY LEMDLSSPQT RYIPDEADFL LGMATVNNCV SYRNPAEGTW 
YIQSLCQSLR ERCPRGDDIL TILTEVNYEV SNKDDKKNMG KQMPQPTFTL RKKLVFPSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.