Details for: CL0002102

Cell ID: CL0002102

Cell Name: CD38-negative naive B cell

Marker Score Threshold: 2096
(Derived using integrated single-cell and genomic data)

Description: A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery.

Synonyms: CD38- naive B cell, CD38- naive B lymphocyte, CD38- naive B-cell, CD38- naive B-lymphocyte, CD38-negative naive B lymphocyte, CD38-negative naive B-cell, CD38-negative naive B-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 6
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 5.9
    Ensembl ID: ENSG00000104894
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 5.81
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 5.59
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 5.36
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CD79A (ENSG00000105369)
    Fold Change: 5.32
    Ensembl ID: ENSG00000105369
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 4.96
    Ensembl ID: ENSG00000131143
  • Gene Symbol: MS4A1 (ENSG00000156738)
    Fold Change: 4.69
    Ensembl ID: ENSG00000156738
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 4.65
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 4.59
    Ensembl ID: ENSG00000169442
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 4.22
    Ensembl ID: ENSG00000099622
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 4.16
    Ensembl ID: ENSG00000185650
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 4.15
    Ensembl ID: ENSG00000169100
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.87
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.64
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 3.59
    Ensembl ID: ENSG00000110848
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.56
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 3.52
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.43
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.3
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 3.19
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.17
    Ensembl ID: ENSG00000124172
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 3.16
    Ensembl ID: ENSG00000067082
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.92
    Ensembl ID: ENSG00000122545
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 2.92
    Ensembl ID: ENSG00000168421
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 2.65
    Ensembl ID: ENSG00000117091
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.59
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CD79B (ENSG00000007312)
    Fold Change: 2.51
    Ensembl ID: ENSG00000007312
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.5
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.46
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 2.35
    Ensembl ID: ENSG00000185883
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.32
    Ensembl ID: ENSG00000179218
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.24
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 2.17
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.11
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.08
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CNN2 (ENSG00000064666)
    Fold Change: 2.05
    Ensembl ID: ENSG00000064666
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 2.03
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.96
    Ensembl ID: ENSG00000156110
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.87
    Ensembl ID: ENSG00000026508
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.87
    Ensembl ID: ENSG00000135940
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.86
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CDKN1B (ENSG00000111276)
    Fold Change: 1.84
    Ensembl ID: ENSG00000111276
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.82
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CD22 (ENSG00000012124)
    Fold Change: 1.8
    Ensembl ID: ENSG00000012124
  • Gene Symbol: BLK (ENSG00000136573)
    Fold Change: 1.79
    Ensembl ID: ENSG00000136573
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.77
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.77
    Ensembl ID: ENSG00000196776
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.75
    Ensembl ID: ENSG00000140299
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.71
    Ensembl ID: ENSG00000143119
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.69
    Ensembl ID: ENSG00000213719
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.67
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CD19 (ENSG00000177455)
    Fold Change: 1.67
    Ensembl ID: ENSG00000177455
  • Gene Symbol: CD40 (ENSG00000101017)
    Fold Change: 1.67
    Ensembl ID: ENSG00000101017
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.66
    Ensembl ID: ENSG00000173575
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.64
    Ensembl ID: ENSG00000177105
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.63
    Ensembl ID: ENSG00000145349
  • Gene Symbol: CCR7 (ENSG00000126353)
    Fold Change: 1.62
    Ensembl ID: ENSG00000126353
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.6
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.54
    Ensembl ID: ENSG00000153922
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.51
    Ensembl ID: ENSG00000156273
  • Gene Symbol: MAP3K8 (ENSG00000107968)
    Fold Change: 1.49
    Ensembl ID: ENSG00000107968
  • Gene Symbol: CENPC (ENSG00000145241)
    Fold Change: 1.49
    Ensembl ID: ENSG00000145241
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.48
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.45
    Ensembl ID: ENSG00000197043
  • Gene Symbol: COL19A1 (ENSG00000082293)
    Fold Change: 1.44
    Ensembl ID: ENSG00000082293
  • Gene Symbol: LYST (ENSG00000143669)
    Fold Change: 1.42
    Ensembl ID: ENSG00000143669
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.42
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CXCR5 (ENSG00000160683)
    Fold Change: 1.41
    Ensembl ID: ENSG00000160683
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.39
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.39
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.38
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.38
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.38
    Ensembl ID: ENSG00000122359
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.36
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.35
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.33
    Ensembl ID: ENSG00000160710
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.33
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.32
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.31
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.31
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.27
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.26
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.25
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.23
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.22
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.19
    Ensembl ID: ENSG00000089820
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.13
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 1.12
    Ensembl ID: ENSG00000012779
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.11
    Ensembl ID: ENSG00000104765
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.11
    Ensembl ID: ENSG00000109321
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.08
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.08
    Ensembl ID: ENSG00000171791
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.08
    Ensembl ID: ENSG00000010671
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.07
    Ensembl ID: ENSG00000108561
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.06
    Ensembl ID: ENSG00000149823
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.05
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CD72 (ENSG00000137101)
    Fold Change: 1.04
    Ensembl ID: ENSG00000137101
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.04
    Ensembl ID: ENSG00000143878
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.02
    Ensembl ID: ENSG00000134480
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** * Mature B cell phenotype: CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative * Found in the periphery and has not yet been activated by antigen * Involved in the production of antibodies and the activation of T cells * Plays a crucial role in the adaptive immune system * Regulates various cellular processes, including: + Apoptosis + Cell migration + Cytokine production * Expression of various genes, including: + CD74 + CD37 + B2M + ACTB **Clinical Significance** The CD38-negative naive B cell plays a crucial role in the adaptive immune system, and its dysregulation has been implicated in various diseases, including: * Autoimmune disorders, such as rheumatoid arthritis and lupus * Cancer, including multiple myeloma and lymphoma * Infections, such as HIV and tuberculosis * Neurological disorders, such as Alzheimer's disease and Parkinson's disease The CD38-negative naive B cell is also involved in the regulation of various cellular processes, and its dysregulation can lead to: * Abnormal apoptosis and cell survival * Altered cytokine production and immune responses * Impaired T cell activation and differentiation * Increased susceptibility to infections and diseases Understanding the role of the CD38-negative naive B cell in the adaptive immune system and its dysregulation in various diseases is essential for the development of new therapeutic strategies and treatments. **Pathways and Ontologies** The CD38-negative naive B cell is involved in various cellular processes and pathways, including: * Adaptive immune system * Antigen processing and presentation * Amyloid-beta binding * Cell surface interactions * Cytokine binding * Immune system * Immunoglobulin-mediated immune response * Intracellular protein transport * Lysosomal lumen * Membrane * MHC class II antigen presentation * MHC class II protein binding * Multivesicular body * Negative regulation of apoptotic process * Negative regulation of cell migration * Negative regulation of DNA damage response * Positive regulation of B cell proliferation * Positive regulation of canonical NF-κB signal transduction * Positive regulation of chemokine (C-X-C motif) ligand 2 production * Positive regulation of cytokine-mediated signaling pathway The CD38-negative naive B cell is also involved in various ontologies, including: * Amyloid fiber formation * Amyloid fibril formation * Antigen presentation: folding, assembly, and peptide loading of Class I MHC * Antigen processing-cross presentation * Bacterial infection pathways * Cellular response to iron(III) ion * Cellular response to iron ion * Cellular response to nicotine * Class I MHC-mediated antigen processing & presentation * Cytokine signaling in immune system * Dap12 interactions * Dap12 signaling * Disease * Early endosome lumen * Early endosome membrane * Endoplasmic reticulum * Endoplasmic reticulum lumen * Endosomal/vacuolar pathway * Er-phagosome pathway * Er to Golgi transport vesicle membrane * External side of plasma membrane * Extracellular exosome * Extracellular region * Extracellular space * Focal adhesion * Golgi apparatus * Golgi membrane * Hfe-transferrin receptor complex * Hiv infection * Host interactions of hiv factors * Identical protein binding * Immune system * Immunoregulatory interactions between a lymphoid and a non-lymphoid cell * Infection with mycobacterium tuberculosis * Infectious disease * Innate immune system * Interferon gamma signaling * Interferon signaling * Intracellular iron ion homeostasis * Iron ion transport * Late endosome membrane * Learning or memory * Lysosomal membrane * Membrane * Metabolism of proteins * MHC class II protein complex * MHC class II protein complex binding * MHC class I peptide loading complex * MHC class I protein complex * Modulation by mtb of host immune system * Multicellular organismal-level iron ion homeostasis * Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters * Nef mediated downregulation of MHC class I complex cell surface expression * Negative regulation of epithelial cell proliferation * Negative regulation of forebrain neuron differentiation * Negative regulation of neurogenesis * Negative regulation of neuron projection development * Negative regulation of receptor binding * Neutrophil degranulation * Peptide antigen assembly with MHC class II protein complex * Peptide antigen assembly with MHC class I protein complex * Peptide antigen binding * Phagocytic vesicle membrane * Plasma membrane * Positive regulation of cellular senescence * Positive regulation of ferrous iron binding * Positive regulation of immune response * Positive regulation of protein binding * Positive regulation of receptor-mediated endocytosis * Positive regulation of receptor binding * Positive regulation of T cell activation * Positive regulation of T cell cytokine production * Positive regulation of T cell-mediated cytotoxicity * Positive regulation of transferrin receptor binding * Protein binding * Protein homodimerization activity * Protein homotetramerization * Protein refolding * Recycling endosome membrane * Regulation of erythrocyte differentiation * Regulation of iron ion transport * Response to molecule of bacterial origin * Sars-cov-2 activates/modulates innate and adaptive immune responses * Sars-cov-2 infection * Sars-cov-2-host interactions * Sars-cov infections * Sensory perception of smell * Specific granule lumen * Structural molecule activity * T cell differentiation in thymus * T cell-mediated cytotoxicity * Tertiary granule lumen * The role of nef in hiv-1 replication and disease pathogenesis * Viral infection pathways