Details for: ARHGAP4

Gene ID: 393

Symbol: ARHGAP4

Ensembl ID: ENSG00000089820

Description: Rho GTPase activating protein 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 77.9837
    Cell Significance Index: -12.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 37.6609
    Cell Significance Index: -15.3000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 32.8742
    Cell Significance Index: -16.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.2179
    Cell Significance Index: -6.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.9496
    Cell Significance Index: -16.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.8949
    Cell Significance Index: -12.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.0925
    Cell Significance Index: -12.5700
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 3.3969
    Cell Significance Index: 9.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.3122
    Cell Significance Index: -13.0700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.2588
    Cell Significance Index: -8.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.6838
    Cell Significance Index: 71.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.6047
    Cell Significance Index: 168.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.7700
    Cell Significance Index: 32.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7544
    Cell Significance Index: 173.5500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.5373
    Cell Significance Index: 45.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4332
    Cell Significance Index: 1294.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2497
    Cell Significance Index: 65.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9298
    Cell Significance Index: 151.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8990
    Cell Significance Index: 106.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8107
    Cell Significance Index: 88.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4114
    Cell Significance Index: 24.7000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3749
    Cell Significance Index: 2.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3174
    Cell Significance Index: 21.9500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.3162
    Cell Significance Index: 3.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2898
    Cell Significance Index: 8.3500
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.1789
    Cell Significance Index: 0.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1565
    Cell Significance Index: 7.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1360
    Cell Significance Index: 7.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0603
    Cell Significance Index: 11.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0445
    Cell Significance Index: 30.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0439
    Cell Significance Index: 0.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0424
    Cell Significance Index: 8.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0417
    Cell Significance Index: 8.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0280
    Cell Significance Index: 0.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0225
    Cell Significance Index: 0.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0127
    Cell Significance Index: 1.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0105
    Cell Significance Index: 1.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0025
    Cell Significance Index: 4.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0013
    Cell Significance Index: -0.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0045
    Cell Significance Index: -6.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0078
    Cell Significance Index: -2.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0085
    Cell Significance Index: -11.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0116
    Cell Significance Index: -5.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0154
    Cell Significance Index: -11.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0165
    Cell Significance Index: -12.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0171
    Cell Significance Index: -12.6500
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0213
    Cell Significance Index: -0.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0223
    Cell Significance Index: -12.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0230
    Cell Significance Index: -0.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0239
    Cell Significance Index: -15.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0324
    Cell Significance Index: -14.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0342
    Cell Significance Index: -6.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0462
    Cell Significance Index: -13.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0472
    Cell Significance Index: -6.4900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0625
    Cell Significance Index: -0.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0667
    Cell Significance Index: -8.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0667
    Cell Significance Index: -14.0500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0713
    Cell Significance Index: -1.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0738
    Cell Significance Index: -12.6000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0740
    Cell Significance Index: -1.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0862
    Cell Significance Index: -11.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0889
    Cell Significance Index: -6.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0890
    Cell Significance Index: -12.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0896
    Cell Significance Index: -2.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0923
    Cell Significance Index: -10.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1012
    Cell Significance Index: -13.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1012
    Cell Significance Index: -2.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1103
    Cell Significance Index: -11.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1207
    Cell Significance Index: -5.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1454
    Cell Significance Index: -10.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1470
    Cell Significance Index: -7.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1476
    Cell Significance Index: -8.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1517
    Cell Significance Index: -7.8800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1546
    Cell Significance Index: -2.6700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1559
    Cell Significance Index: -2.2800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1622
    Cell Significance Index: -0.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1634
    Cell Significance Index: -10.3000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1657
    Cell Significance Index: -7.2100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1725
    Cell Significance Index: -2.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1726
    Cell Significance Index: -12.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1807
    Cell Significance Index: -5.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1843
    Cell Significance Index: -12.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1973
    Cell Significance Index: -12.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2028
    Cell Significance Index: -12.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2040
    Cell Significance Index: -9.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2077
    Cell Significance Index: -16.4500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.2095
    Cell Significance Index: -1.3900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2127
    Cell Significance Index: -1.1600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.2309
    Cell Significance Index: -1.8700
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: -0.2343
    Cell Significance Index: -1.7200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2395
    Cell Significance Index: -3.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2433
    Cell Significance Index: -7.7500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.2478
    Cell Significance Index: -2.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2532
    Cell Significance Index: -11.2000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2652
    Cell Significance Index: -3.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2804
    Cell Significance Index: -9.1800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2811
    Cell Significance Index: -4.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2812
    Cell Significance Index: -10.6500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.2856
    Cell Significance Index: -2.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ARHGAP4 is a member of the Rho GTPase Activating Protein (RhoGAP) family, which plays a pivotal role in regulating Rho GTPase activity. The protein is characterized by its ability to activate and inactivate Rho GTPases, including RhoA, Rac1, and Cdc42, thereby modulating various cellular processes. ARHGAP4 is highly expressed in immune cells, where it regulates cell migration, adhesion, and cytoskeletal organization. **Pathways and Functions:** ARHGAP4 is involved in several key signaling pathways, including: 1. **Rho GTPase cycle**: ARHGAP4 regulates the activity of Rho GTPases, which in turn modulate the cytoskeleton, cell migration, and cell cycle progression. 2. **Cytoskeleton organization**: ARHGAP4 is essential for maintaining the cytoskeletal structure and organization, particularly in immune cells, where it regulates cell migration and adhesion. 3. **Cell migration**: ARHGAP4 regulates cell migration by modulating the activity of Rho GTPases, which in turn control the cytoskeleton and cell adhesion molecules. 4. **Negative regulation of axon extension**: ARHGAP4 is involved in regulating axon extension in neurons, where it modulates the activity of Rho GTPases. 5. **Negative regulation of cell migration**: ARHGAP4 regulates cell migration by modulating the activity of Rho GTPases, which in turn control the cytoskeleton and cell adhesion molecules. **Clinical Significance:** Dysregulation of ARHGAP4 has been implicated in various diseases, including: 1. **Cancer**: ARHGAP4 is often downregulated in cancer cells, leading to increased cell migration and invasion. 2. **Neurological disorders**: ARHGAP4 is involved in regulating axon extension and cytoskeletal organization, which are critical processes in neurological disorders, such as multiple sclerosis. 3. **Inflammatory diseases**: ARHGAP4 regulates immune cell migration and activation, which are critical processes in inflammatory diseases, such as rheumatoid arthritis. In conclusion, ARHGAP4 plays a crucial role in regulating cell migration, cytoskeletal organization, and signaling pathways involving Rho GTPases. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining immune homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which ARHGAP4 regulates cellular processes and to explore its potential as a therapeutic target.

Genular Protein ID: 429244918

Symbol: RHG04_HUMAN

Name: Rho-GAP hematopoietic protein C1

UniProtKB Accession Codes:

P98171 Q14144 Q86UY3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8570618

Title: An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells.

PubMed ID: 8570618

DOI: 10.1073/pnas.93.2.695

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8590280

Title: Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 8590280

DOI: 10.1093/dnares/2.4.167

PubMed ID: 7981673

Title: Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae.

PubMed ID: 7981673

DOI: 10.1093/hmg/3.7.1061

PubMed ID: 16417406

Title: Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.

PubMed ID: 16417406

DOI: 10.1371/journal.pbio.0040038

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 946
  • Mass: 105026
  • Checksum: ED3D48C5DAA24969
  • Sequence:
    • MAAHGKLRRE RGLQAEYETQ VKEMRWQLSE QLRCLELQGE LRRELLQELA EFMRRRAEVE 
LEYSRGLEKL AERFSSRGGR LGSSREHQSF RKEPSLLSPL HCWAVLLQHT RQQSRESAAL 
SEVLAGPLAQ RLSHIAEDVG RLVKKSRDLE QQLQDELLEV VSELQTAKKT YQAYHMESVN 
AEAKLREAER QEEKRAGRSV PTTTAGATEA GPLRKSSLKK GGRLVEKRQA KFMEHKLKCT 
KARNEYLLSL ASVNAAVSNY YLHDVLDLMD CCDTGFHLAL GQVLRSYTAA ESRTQASQVQ 
GLGSLEEAVE ALDPPGDKAK VLEVHATVFC PPLRFDYHPH DGDEVAEICV EMELRDEILP 
RAQNIQSRLD RQTIETEEVN KTLKATLQAL LEVVASDDGD VLDSFQTSPS TESLKSTSSD 
PGSRQAGRRR GQQQETETFY LTKLQEYLSG RSILAKLQAK HEKLQEALQR GDKEEQEVSW 
TQYTQRKFQK SRQPRPSSQY NQRLFGGDME KFIQSSGQPV PLVVESCIRF INLNGLQHEG 
IFRVSGAQLR VSEIRDAFER GEDPLVEGCT AHDLDSVAGV LKLYFRSLEP PLFPPDLFGE 
LLASSELEAT AERVEHVSRL LWRLPAPVLV VLRYLFTFLN HLAQYSDENM MDPYNLAVCF 
GPTLLPVPAG QDPVALQGRV NQLVQTLIVQ PDRVFPPLTS LPGPVYEKCM APPSASCLGD 
AQLESLGADN EPELEAEMPA QEDDLEGVVE AVACFAYTGR TAQELSFRRG DVLRLHERAS 
SDWWRGEHNG MRGLIPHKYI TLPAGTEKQV VGAGLQTAGE SGSSPEGLLA SELVHRPEPC 
TSPEAMGPSG HRRRCLVPAS PEQHVEVDKA VAQNMDSVFK ELLGKTSVRQ GLGPASTTSP 
SPGPRSPKAP PSSRLGRNKG FSRGPGAPAS PSASHPQGLD TTPKPH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.