Details for: ARHGAP4

Gene ID: 393

Symbol: ARHGAP4

Ensembl ID: ENSG00000089820

Description: Rho GTPase activating protein 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.82
    Marker Score: 1992
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.53
    Marker Score: 1537
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.98
    Marker Score: 20109
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.97
    Marker Score: 8175
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.89
    Marker Score: 105825
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.81
    Marker Score: 3534
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.65
    Marker Score: 2879
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.65
    Marker Score: 1662
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.61
    Marker Score: 85336.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.57
    Marker Score: 865
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.55
    Marker Score: 4902
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.55
    Marker Score: 3781
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.55
    Marker Score: 18016
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.5
    Marker Score: 1273
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.49
    Marker Score: 6384
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.49
    Marker Score: 989
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.47
    Marker Score: 1382
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.4
    Marker Score: 3494.5
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.4
    Marker Score: 323
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.39
    Marker Score: 679
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.36
    Marker Score: 3807
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.35
    Marker Score: 1622.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.35
    Marker Score: 13373
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.34
    Marker Score: 2399
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.31
    Marker Score: 1293
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.29
    Marker Score: 1206
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.28
    Marker Score: 774
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.28
    Marker Score: 3547
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.27
    Marker Score: 8118
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.27
    Marker Score: 1112
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.26
    Marker Score: 1285
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.25
    Marker Score: 915
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.25
    Marker Score: 1426
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.24
    Marker Score: 439
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.22
    Marker Score: 1794
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.2
    Marker Score: 1200
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.2
    Marker Score: 816
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.2
    Marker Score: 363
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.19
    Marker Score: 2042
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.19
    Marker Score: 4870
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.19
    Marker Score: 2494
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.18
    Marker Score: 406
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.17
    Marker Score: 1620
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.17
    Marker Score: 570
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.16
    Marker Score: 2202
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.15
    Marker Score: 469
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.12
    Marker Score: 1327
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.11
    Marker Score: 3295
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.11
    Marker Score: 477
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.09
    Marker Score: 1145
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.07
    Marker Score: 1155
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.06
    Marker Score: 804
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.06
    Marker Score: 772
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.06
    Marker Score: 9265
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.05
    Marker Score: 368
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.05
    Marker Score: 2057
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.05
    Marker Score: 757
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.04
    Marker Score: 1471
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.03
    Marker Score: 653
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.03
    Marker Score: 322
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.02
    Marker Score: 908
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.01
    Marker Score: 727
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1
    Marker Score: 585
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71723
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1
    Marker Score: 2708.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47947
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.99
    Marker Score: 837
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.99
    Marker Score: 610
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.98
    Marker Score: 650
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.98
    Marker Score: 322
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.97
    Marker Score: 483
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.97
    Marker Score: 334
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.96
    Marker Score: 788.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.96
    Marker Score: 553
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.96
    Marker Score: 926
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2399
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.94
    Marker Score: 466
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.93
    Marker Score: 1162
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.92
    Marker Score: 725
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.92
    Marker Score: 484
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2709
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.9
    Marker Score: 751
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.9
    Marker Score: 290
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.89
    Marker Score: 677
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.89
    Marker Score: 612
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.88
    Marker Score: 232
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.88
    Marker Score: 223
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.87
    Marker Score: 2096
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5248
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.85
    Marker Score: 13277
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4831
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.85
    Marker Score: 295
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.84
    Marker Score: 269
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.83
    Marker Score: 741
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.82
    Marker Score: 355
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.82
    Marker Score: 492

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - It is a GTPase that is involved in the Cdc42 gtpase cycle and the Rho GTPase cycle. - It is a key regulator of cell migration by promoting the disassembly of the cell adhesion complex and facilitating the migration of immune cells. - It also plays a role in cell proliferation and survival by regulating the activation of the MAPK pathway. **Pathways and functions:** - **Cdc42 gtpase cycle:** ARHGAP4 is a key regulator of the Cdc42 gtpase cycle, which is involved in cell cycle progression, cell cycle checkpoints, and cell migration. - **Rho GTPase cycle:** It is involved in the Rho GTPase cycle, which is essential for the activation of Rho proteins. - **Regulation of small gtpase mediated signal transduction:** ARHGAP4 negatively regulates the small GTPase-mediated signal transduction pathway, which is involved in cell migration and survival. - **Negative regulation of axon extension:** It also plays a role in the negative regulation of axon extension by inhibiting the activation of the Rho GTPase cycle. **Clinical significance:** - Mutations in ARHGAP4 have been linked to several human diseases, including leukemia, lymphoma, and autoimmune disorders. - Targeting ARHGAP4 has emerged as a promising therapeutic strategy for these diseases, as it can inhibit tumor growth and metastasis. - However, the development of effective ARHGAP4 inhibitors is challenging due to the protein's crucial role in immune cell function.

Genular Protein ID: 429244918

Symbol: RHG04_HUMAN

Name: Rho-GAP hematopoietic protein C1

UniProtKB Accession Codes:

P98171 Q14144 Q86UY3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8570618

Title: An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells.

PubMed ID: 8570618

DOI: 10.1073/pnas.93.2.695

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8590280

Title: Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 8590280

DOI: 10.1093/dnares/2.4.167

PubMed ID: 7981673

Title: Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae.

PubMed ID: 7981673

DOI: 10.1093/hmg/3.7.1061

PubMed ID: 16417406

Title: Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.

PubMed ID: 16417406

DOI: 10.1371/journal.pbio.0040038

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 946
  • Mass: 105026
  • Checksum: ED3D48C5DAA24969
  • Sequence:
    • MAAHGKLRRE RGLQAEYETQ VKEMRWQLSE QLRCLELQGE LRRELLQELA EFMRRRAEVE 
LEYSRGLEKL AERFSSRGGR LGSSREHQSF RKEPSLLSPL HCWAVLLQHT RQQSRESAAL 
SEVLAGPLAQ RLSHIAEDVG RLVKKSRDLE QQLQDELLEV VSELQTAKKT YQAYHMESVN 
AEAKLREAER QEEKRAGRSV PTTTAGATEA GPLRKSSLKK GGRLVEKRQA KFMEHKLKCT 
KARNEYLLSL ASVNAAVSNY YLHDVLDLMD CCDTGFHLAL GQVLRSYTAA ESRTQASQVQ 
GLGSLEEAVE ALDPPGDKAK VLEVHATVFC PPLRFDYHPH DGDEVAEICV EMELRDEILP 
RAQNIQSRLD RQTIETEEVN KTLKATLQAL LEVVASDDGD VLDSFQTSPS TESLKSTSSD 
PGSRQAGRRR GQQQETETFY LTKLQEYLSG RSILAKLQAK HEKLQEALQR GDKEEQEVSW 
TQYTQRKFQK SRQPRPSSQY NQRLFGGDME KFIQSSGQPV PLVVESCIRF INLNGLQHEG 
IFRVSGAQLR VSEIRDAFER GEDPLVEGCT AHDLDSVAGV LKLYFRSLEP PLFPPDLFGE 
LLASSELEAT AERVEHVSRL LWRLPAPVLV VLRYLFTFLN HLAQYSDENM MDPYNLAVCF 
GPTLLPVPAG QDPVALQGRV NQLVQTLIVQ PDRVFPPLTS LPGPVYEKCM APPSASCLGD 
AQLESLGADN EPELEAEMPA QEDDLEGVVE AVACFAYTGR TAQELSFRRG DVLRLHERAS 
SDWWRGEHNG MRGLIPHKYI TLPAGTEKQV VGAGLQTAGE SGSSPEGLLA SELVHRPEPC 
TSPEAMGPSG HRRRCLVPAS PEQHVEVDKA VAQNMDSVFK ELLGKTSVRQ GLGPASTTSP 
SPGPRSPKAP PSSRLGRNKG FSRGPGAPAS PSASHPQGLD TTPKPH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.