Details for: RGS2

Gene ID: 5997

Symbol: RGS2

Ensembl ID: ENSG00000116741

Description: regulator of G protein signaling 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 269.9215
    Cell Significance Index: -41.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 136.1754
    Cell Significance Index: -34.5400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 114.6869
    Cell Significance Index: -47.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 95.1659
    Cell Significance Index: -44.9300
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 93.6060
    Cell Significance Index: 47.0100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 92.2072
    Cell Significance Index: -47.4300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 67.9262
    Cell Significance Index: -45.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.4578
    Cell Significance Index: -42.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.1529
    Cell Significance Index: -44.0100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.8255
    Cell Significance Index: -33.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.7033
    Cell Significance Index: -23.3200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 8.6204
    Cell Significance Index: 91.5900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.6680
    Cell Significance Index: -12.4100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.0468
    Cell Significance Index: 23.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.6214
    Cell Significance Index: 48.4500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.5410
    Cell Significance Index: 39.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.9749
    Cell Significance Index: 232.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.3821
    Cell Significance Index: 178.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3359
    Cell Significance Index: 171.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1036
    Cell Significance Index: 23.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0609
    Cell Significance Index: 55.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0004
    Cell Significance Index: 903.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9285
    Cell Significance Index: 32.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8825
    Cell Significance Index: 19.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7107
    Cell Significance Index: 33.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.6585
    Cell Significance Index: 298.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6288
    Cell Significance Index: 102.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5150
    Cell Significance Index: 56.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5122
    Cell Significance Index: 13.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4545
    Cell Significance Index: 86.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3585
    Cell Significance Index: 49.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2922
    Cell Significance Index: 17.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2727
    Cell Significance Index: 17.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2626
    Cell Significance Index: 18.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2363
    Cell Significance Index: 23.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1948
    Cell Significance Index: 8.8300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.1644
    Cell Significance Index: 0.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1363
    Cell Significance Index: 4.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1050
    Cell Significance Index: 197.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1045
    Cell Significance Index: 20.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0989
    Cell Significance Index: 43.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0806
    Cell Significance Index: 14.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0258
    Cell Significance Index: 9.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0243
    Cell Significance Index: 0.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0105
    Cell Significance Index: 0.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0049
    Cell Significance Index: -3.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0091
    Cell Significance Index: -5.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0118
    Cell Significance Index: -2.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0132
    Cell Significance Index: -1.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0229
    Cell Significance Index: -17.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0240
    Cell Significance Index: -17.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0269
    Cell Significance Index: -49.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0321
    Cell Significance Index: -49.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0360
    Cell Significance Index: -48.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0424
    Cell Significance Index: -23.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0531
    Cell Significance Index: -1.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0540
    Cell Significance Index: -30.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0554
    Cell Significance Index: -38.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0555
    Cell Significance Index: -6.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0625
    Cell Significance Index: -45.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0718
    Cell Significance Index: -14.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0864
    Cell Significance Index: -18.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1004
    Cell Significance Index: -28.8900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1352
    Cell Significance Index: -1.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2025
    Cell Significance Index: -14.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2150
    Cell Significance Index: -5.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2218
    Cell Significance Index: -32.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2269
    Cell Significance Index: -26.4400
  • Cell Name: centroblast (CL0009112)
    Fold Change: -0.2400
    Cell Significance Index: -0.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2547
    Cell Significance Index: -7.3000
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.2547
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2668
    Cell Significance Index: -30.5700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3422
    Cell Significance Index: -39.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3524
    Cell Significance Index: -36.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3604
    Cell Significance Index: -9.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4135
    Cell Significance Index: -30.8200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4398
    Cell Significance Index: -3.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4444
    Cell Significance Index: -12.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4912
    Cell Significance Index: -5.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5310
    Cell Significance Index: -13.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5404
    Cell Significance Index: -14.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5417
    Cell Significance Index: -41.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5454
    Cell Significance Index: -36.6700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5542
    Cell Significance Index: -22.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5852
    Cell Significance Index: -46.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6205
    Cell Significance Index: -38.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6316
    Cell Significance Index: -20.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6329
    Cell Significance Index: -32.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6378
    Cell Significance Index: -40.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6392
    Cell Significance Index: -28.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6413
    Cell Significance Index: -29.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6810
    Cell Significance Index: -41.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7021
    Cell Significance Index: -39.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7252
    Cell Significance Index: -15.4500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.7519
    Cell Significance Index: -11.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7607
    Cell Significance Index: -38.4400
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.7652
    Cell Significance Index: -4.7900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.8817
    Cell Significance Index: -5.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8943
    Cell Significance Index: -33.8700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9284
    Cell Significance Index: -34.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RGS2 is a 6-exon gene, with an open reading frame of 1,956 nucleotides, encoding a 648-amino acid protein. The protein is characterized by its unique structure, which includes a GTPase-activating domain, a G protein-coupled receptor-binding domain, and a calmodulin-binding domain. RGS2 is highly expressed in various cell types, including immune cells, epithelial cells, and fibroblasts. **Pathways and Functions:** RGS2 plays a critical role in regulating various signaling pathways, including: 1. **G-protein-coupled receptor signaling pathway**: RGS2 acts as a GAP, accelerating the hydrolysis of GTP to GDP, thereby regulating the activity of GPCRs. 2. **Adenylate cyclase inhibition**: RGS2 inhibits adenylate cyclase activity, which is essential for regulating cAMP levels and signaling pathways. 3. **Cell cycle regulation**: RGS2 regulates the cell cycle, particularly in cardiac muscle cells, by inhibiting cell growth and promoting relaxation of cardiac muscle. 4. **Immune response**: RGS2 is expressed in immune cells, including macrophages and professional antigen-presenting cells, where it regulates immune responses to pathogens and allergens. **Clinical Significance:** RGS2 dysregulation has been implicated in various immune-related disorders, including: 1. **Allergic diseases**: RGS2 variants have been associated with allergic diseases, such as asthma and atopic dermatitis. 2. **Autoimmune disorders**: RGS2 has been linked to autoimmune disorders, including rheumatoid arthritis and lupus. 3. **Cancer**: RGS2 has been implicated in cancer progression and metastasis, particularly in breast and lung cancers. 4. **Cardiovascular disease**: RGS2 regulates cardiac muscle contraction and relaxation, and its dysregulation has been linked to cardiovascular disease. In conclusion, RGS2 plays a crucial role in regulating various signaling pathways, including G-protein-coupled receptor signaling, adenylate cyclase inhibition, and cell cycle regulation. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of RGS2 in maintaining immune homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which RGS2 regulates cellular signaling and its clinical significance in human disease.

Genular Protein ID: 3368463539

Symbol: RGS2_HUMAN

Name: Regulator of G-protein signaling 2

UniProtKB Accession Codes:

P41220 Q6I9U5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8179820

Title: A human gene encoding a putative basic helix-loop-helix phosphoprotein whose mRNA increases rapidly in cycloheximide-treated blood mononuclear cells.

PubMed ID: 8179820

DOI: 10.1089/dna.1994.13.125

PubMed ID: 11278586

Title: Mechanisms governing subcellular localization and function of human RGS2.

PubMed ID: 11278586

DOI: 10.1074/jbc.m009942200

PubMed ID: 17901199

Title: Alternative translation initiation of human regulators of G-protein signaling-2 yields a set of functionally distinct proteins.

PubMed ID: 17901199

DOI: 10.1124/mol.107.036285

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7643615

Title: Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31.

PubMed ID: 7643615

PubMed ID: 11063746

Title: Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.

PubMed ID: 11063746

DOI: 10.1074/jbc.m007699200

PubMed ID: 14608379

Title: Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure.

PubMed ID: 14608379

DOI: 10.1038/nm958

PubMed ID: 19736320

Title: Translational control by RGS2.

PubMed ID: 19736320

DOI: 10.1083/jcb.200811058

PubMed ID: 28784619

Title: Human missense mutations in regulator of G protein signaling 2 affect the protein function through multiple mechanisms.

PubMed ID: 28784619

DOI: 10.1124/mol.117.109215

PubMed ID: 18434541

Title: Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.

PubMed ID: 18434541

DOI: 10.1073/pnas.0801508105

PubMed ID: 19478087

Title: Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).

PubMed ID: 19478087

DOI: 10.1074/jbc.m109.024711

PubMed ID: 16003176

Title: Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population.

PubMed ID: 16003176

DOI: 10.1097/01.hjh.0000174606.41651.ae

PubMed ID: 27535533

Title: Analysis of protein-coding genetic variation in 60,706 humans.

PubMed ID: 27535533

DOI: 10.1038/nature19057

Sequence Information:

  • Length: 211
  • Mass: 24382
  • Checksum: EFFE4AE47EF9AD8F
  • Sequence:
    • MQSAMFLAVQ HDCRPMDKSA GSGHKSEEKR EKMKRTLLKD WKTRLSYFLQ NSSTPGKPKT 
GKKSKQQAFI KPSPEEAQLW SEAFDELLAS KYGLAAFRAF LKSEFCEENI EFWLACEDFK 
KTKSPQKLSS KARKIYTDFI EKEAPKEINI DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL 
MENNSYPRFL ESEFYQDLCK KPQITTEPHA T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.