Gene HLA DQA2 - ENSG00000237541 | NCBI Gene ID: 3118

Details for: HLA DQA2

Gene ID: 3118

Symbol: HLA DQA2

Ensembl ID: ENSG00000237541

Description: major histocompatibility complex, class II, DQ alpha 2

Associated with

Adaptive immune system
(R-HSA-1280218)
Costimulation by the cd28 family
(R-HSA-388841)
Cytokine signaling in immune system
(R-HSA-1280215)
Downstream tcr signaling
(R-HSA-202424)
Generation of second messenger molecules
(R-HSA-202433)
Immune system
(R-HSA-168256)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Mhc class ii antigen presentation
(R-HSA-2132295)
Pd-1 signaling
(R-HSA-389948)
Phosphorylation of cd3 and tcr zeta chains
(R-HSA-202427)
Tcr signaling
(R-HSA-202403)
Translocation of zap-70 to immunological synapse
(R-HSA-202430)
Adaptive immune response
(GO:0002250)
Antigen processing and presentation of exogenous peptide antigen via mhc class ii
(GO:0019886)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Endocytic vesicle membrane
(GO:0030666)
Er to golgi transport vesicle membrane
(GO:0012507)
Golgi membrane
(GO:0000139)
Immune response
(GO:0006955)
Late endosome membrane
(GO:0031902)
Lumenal side of endoplasmic reticulum membrane
(GO:0098553)
Lysosomal membrane
(GO:0005765)
Mhc class ii protein complex
(GO:0042613)
Mhc class ii protein complex binding
(GO:0023026)
Mhc class ii receptor activity
(GO:0032395)
Peptide antigen assembly with mhc class ii protein complex
(GO:0002503)
Peptide antigen binding
(GO:0042605)
Plasma membrane
(GO:0005886)
Positive regulation of immune response
(GO:0050778)
Positive regulation of t cell activation
(GO:0050870)
Protein binding
(GO:0005515)
Trans-golgi network membrane
(GO:0032588)
Transport vesicle membrane
(GO:0030658)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 2.89
Marker Score: 1896.5
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 1.99
Marker Score: 2396
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.98
Marker Score: 1970
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.91
Marker Score: 2183
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 1.89
Marker Score: 1863
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.76
Marker Score: 2548
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.75
Marker Score: 3057
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.6
Marker Score: 4141
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.59
Marker Score: 1154
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.56
Marker Score: 39832
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.55
Marker Score: 3016
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.49
Marker Score: 895
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 1.35
Marker Score: 2820
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 1.24
Marker Score: 752
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 1.19
Marker Score: 463
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.15
Marker Score: 477
Cell Name: naive B cell (CL0000788)
Fold Change: 1.14
Marker Score: 1020
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4787
Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.13
Marker Score: 260
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.07
Marker Score: 493
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 1.06
Marker Score: 1518
Cell Name: Langerhans cell (CL0000453)
Fold Change: 0.99
Marker Score: 295
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30405
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.98
Marker Score: 346
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 499
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.96
Marker Score: 652
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 453
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.95
Marker Score: 654
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2409
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5257
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 367
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2735
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.9
Marker Score: 2452
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 319
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.88
Marker Score: 1448
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5273
Cell Name: osteoclast (CL0000092)
Fold Change: 0.86
Marker Score: 426
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.84
Marker Score: 486
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 612
Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.79
Marker Score: 933
Cell Name: goblet cell (CL0000160)
Fold Change: 0.79
Marker Score: 5254
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1262
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 698
Cell Name: blood cell (CL0000081)
Fold Change: 0.76
Marker Score: 8863
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.76
Marker Score: 193
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 0.75
Marker Score: 1910
Cell Name: mature B cell (CL0000785)
Fold Change: 0.75
Marker Score: 549.5
Cell Name: B cell (CL0000236)
Fold Change: 0.71
Marker Score: 676
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.71
Marker Score: 453
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.7
Marker Score: 344
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.69
Marker Score: 3643
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.68
Marker Score: 1641
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.67
Marker Score: 1674
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.67
Marker Score: 422
Cell Name: memory B cell (CL0000787)
Fold Change: 0.66
Marker Score: 503
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.63
Marker Score: 613
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.63
Marker Score: 687
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.63
Marker Score: 292
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.62
Marker Score: 3796
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.62
Marker Score: 215
Cell Name: ionocyte (CL0005006)
Fold Change: 0.62
Marker Score: 187
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.6
Marker Score: 318
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 0.59
Marker Score: 191
Cell Name: immature B cell (CL0000816)
Fold Change: 0.58
Marker Score: 385
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.58
Marker Score: 298
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.57
Marker Score: 2362.5
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.57
Marker Score: 960
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.55
Marker Score: 557
Cell Name: leukocyte (CL0000738)
Fold Change: 0.54
Marker Score: 311
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.54
Marker Score: 170
Cell Name: centrocyte (CL0009111)
Fold Change: 0.53
Marker Score: 126
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.52
Marker Score: 282
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.52
Marker Score: 522
Cell Name: colon macrophage (CL0009038)
Fold Change: 0.51
Marker Score: 142
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.5
Marker Score: 1495
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.5
Marker Score: 505
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.5
Marker Score: 27837
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.48
Marker Score: 3090
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.48
Marker Score: 331
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.48
Marker Score: 491
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.48
Marker Score: 408
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.48
Marker Score: 1339
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.47
Marker Score: 123
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.45
Marker Score: 156
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.44
Marker Score: 369
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.43
Marker Score: 181
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.43
Marker Score: 282.5
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.43
Marker Score: 250
Cell Name: macrophage (CL0000235)
Fold Change: 0.42
Marker Score: 470
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.42
Marker Score: 396
Cell Name: plasmablast (CL0000980)
Fold Change: 0.42
Marker Score: 556
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.41
Marker Score: 2645
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.4
Marker Score: 807
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.4
Marker Score: 280
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.39
Marker Score: 224
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.39
Marker Score: 3994
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.39
Marker Score: 624
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.38
Marker Score: 92

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**Key characteristics:** - The DQA2 gene is located on chromosome 15q21.1. - It is a member of the HLA class II histocompatibility complex. - It is expressed in high levels in cells that are presenting antigens to T cells. - It is a key regulator of the adaptive immune response. **Pathways and functions:** - DQA2 is expressed in high levels on the surface of T-helper 17 cells and other immune cells that are presenting antigens to T cells. - It is a key regulator of the immune response to viral infection. - It is also involved in the regulation of inflammation and autoimmune disorders. **Clinical significance:** - Mutations in the DQA2 gene have been linked to an increased risk of autoimmune disorders, such as rheumatoid arthritis, Crohn's disease, and ulcerative colitis. - DQA2 is a potential target for the treatment of autoimmune disorders. - It is currently being investigated as a vaccine for cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

HLA class II histocompatibility antigen, DQ alpha 2 chain

Genular Protein ID: 1137033647

Symbol: DQA2_HUMAN

Name: HLA class II histocompatibility antigen, DQ alpha 2 chain

UniProtKB Accession Codes:

P01906 A2BF37 B0V0E7 O19789 Q5SQ94 Q5SR04

Database IDs:

Citations:

PubMed ID: 3036828

Title: Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes.

PubMed ID: 3036828

DOI: 10.1016/s0021-9258(18)47482-0

PubMed ID: 6584734

Title: Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes.

PubMed ID: 6584734

DOI: 10.1038/308327a0

PubMed ID: 3610256

Title: Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene and functional splicing of the HLA-DQ alpha gene using a retroviral vector.

PubMed ID: 3610256

DOI: 10.1007/bf00345456

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 8026991

Title: Limited polymorphism of the HLA-DQA2 promoter and identification of a variant octamer.

PubMed ID: 8026991

DOI: 10.1016/0198-8859(94)90264-x

PubMed ID: 2513578

Title: Ancient roots for polymorphism at the HLA-DQ alpha locus in primates.

PubMed ID: 2513578

DOI: 10.1073/pnas.86.24.9986

PubMed ID: 9036956

Title: The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells.

PubMed ID: 9036956

PubMed ID: 8598037

Title: Invariant chain structure and MHC class II function.

PubMed ID: 8598037

DOI: 10.1016/s0092-8674(00)81025-9

PubMed ID: 11684289

Title: Presentation of antigens by MHC class II molecules: getting the most out of them.

PubMed ID: 11684289

DOI: 10.1016/s0161-5890(01)00069-4

PubMed ID: 18046453

Title: MHC class II molecules on the move for successful antigen presentation.

PubMed ID: 18046453

DOI: 10.1038/sj.emboj.7601945

PubMed ID: 17241953

Title: Autophagy in MHC class II presentation: sampling from within.

PubMed ID: 17241953

DOI: 10.1016/j.immuni.2007.01.005

PubMed ID: 19092054

Title: MHC class II transport at a glance.

PubMed ID: 19092054

DOI: 10.1242/jcs.035089

PubMed ID: 19533806

Title: CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.

PubMed ID: 19533806

DOI: 10.3748/wjg.15.2855

PubMed ID: 22407913

Title: HLA-DQA2 and HLA-DQB2 genes are specifically expressed in human Langerhans cells and encode a new HLA class II molecule.

PubMed ID: 22407913

DOI: 10.4049/jimmunol.1103048

Sequence Information:

Length: 255
Mass: 28033
Checksum: 85B13D9FDF2905FE
Sequence:

MILNKALLLG ALALTAVMSP CGGEDIVADH VASYGVNFYQ SHGPSGQYTH EFDGDEEFYV 
DLETKETVWQ LPMFSKFISF DPQSALRNMA VGKHTLEFMM RQSNSTAATN EVPEVTVFSK 
FPVTLGQPNT LICLVDNIFP PVVNITWLSN GHSVTEGVSE TSFLSKSDHS FFKISYLTFL 
PSADEIYDCK VEHWGLDEPL LKHWEPEIPA PMSELTETLV CALGLSVGLM GIVVGTVFII 
QGLRSVGASR HQGLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: HLA DQA2

Associated with

Cells (max top 100)

Other Information

Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes. PubMed ID: 3036828

Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes. PubMed ID: 6584734

Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene and functional splicing of the HLA-DQ alpha gene using a retroviral vector. PubMed ID: 3610256

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

Limited polymorphism of the HLA-DQA2 promoter and identification of a variant octamer. PubMed ID: 8026991

Ancient roots for polymorphism at the HLA-DQ alpha locus in primates. PubMed ID: 2513578

The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells. PubMed ID: 9036956

Invariant chain structure and MHC class II function. PubMed ID: 8598037

Presentation of antigens by MHC class II molecules: getting the most out of them. PubMed ID: 11684289

MHC class II molecules on the move for successful antigen presentation. PubMed ID: 18046453

Autophagy in MHC class II presentation: sampling from within. PubMed ID: 17241953

MHC class II transport at a glance. PubMed ID: 19092054

CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract. PubMed ID: 19533806

HLA-DQA2 and HLA-DQB2 genes are specifically expressed in human Langerhans cells and encode a new HLA class II molecule. PubMed ID: 22407913