Details for: HLA DQA2

Gene ID: 3118

Symbol: HLA DQA2

Ensembl ID: ENSG00000237541

Description: major histocompatibility complex, class II, DQ alpha 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 90.9060
    Cell Significance Index: -14.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.4074
    Cell Significance Index: -11.0100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 37.0539
    Cell Significance Index: -19.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.5170
    Cell Significance Index: -14.2000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.4113
    Cell Significance Index: -17.1800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.6112
    Cell Significance Index: -14.2500
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 2.9000
    Cell Significance Index: 7.6500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.6642
    Cell Significance Index: 41.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.6341
    Cell Significance Index: -5.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6077
    Cell Significance Index: 34.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.4729
    Cell Significance Index: 39.4000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.3009
    Cell Significance Index: 26.9900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.2410
    Cell Significance Index: 21.3200
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.0130
    Cell Significance Index: 4.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0124
    Cell Significance Index: 192.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6903
    Cell Significance Index: 68.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6180
    Cell Significance Index: 558.0100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4984
    Cell Significance Index: 7.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3714
    Cell Significance Index: 43.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3458
    Cell Significance Index: 56.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3214
    Cell Significance Index: 9.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2367
    Cell Significance Index: 25.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2058
    Cell Significance Index: 13.2800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1896
    Cell Significance Index: 3.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1212
    Cell Significance Index: 2.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0993
    Cell Significance Index: 6.8700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0490
    Cell Significance Index: 2.1300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0035
    Cell Significance Index: 0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0002
    Cell Significance Index: -0.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0037
    Cell Significance Index: -0.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0051
    Cell Significance Index: -0.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0064
    Cell Significance Index: -0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0074
    Cell Significance Index: -13.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0101
    Cell Significance Index: -0.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0107
    Cell Significance Index: -4.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0137
    Cell Significance Index: -8.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0177
    Cell Significance Index: -13.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0207
    Cell Significance Index: -11.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0236
    Cell Significance Index: -13.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0241
    Cell Significance Index: -17.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0273
    Cell Significance Index: -17.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0350
    Cell Significance Index: -3.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0379
    Cell Significance Index: -1.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0388
    Cell Significance Index: -17.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0408
    Cell Significance Index: -8.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0415
    Cell Significance Index: -5.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0430
    Cell Significance Index: -15.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0459
    Cell Significance Index: -7.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0465
    Cell Significance Index: -2.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0694
    Cell Significance Index: -13.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0721
    Cell Significance Index: -14.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0750
    Cell Significance Index: -10.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0889
    Cell Significance Index: -16.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0904
    Cell Significance Index: -1.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1042
    Cell Significance Index: -11.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1093
    Cell Significance Index: -7.7300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1179
    Cell Significance Index: -0.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1203
    Cell Significance Index: -17.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1223
    Cell Significance Index: -15.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1328
    Cell Significance Index: -16.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1356
    Cell Significance Index: -14.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1758
    Cell Significance Index: -5.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1956
    Cell Significance Index: -9.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2238
    Cell Significance Index: -16.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2334
    Cell Significance Index: -17.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2490
    Cell Significance Index: -6.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2976
    Cell Significance Index: -7.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2984
    Cell Significance Index: -15.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3048
    Cell Significance Index: -19.2100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3086
    Cell Significance Index: -4.4800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3335
    Cell Significance Index: -5.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3462
    Cell Significance Index: -16.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3499
    Cell Significance Index: -8.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3621
    Cell Significance Index: -10.6700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.3691
    Cell Significance Index: -4.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3726
    Cell Significance Index: -12.2000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3778
    Cell Significance Index: -9.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3839
    Cell Significance Index: -13.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4318
    Cell Significance Index: -15.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4597
    Cell Significance Index: -14.6400
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.4649
    Cell Significance Index: -4.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4835
    Cell Significance Index: -16.8000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4875
    Cell Significance Index: -8.2800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4905
    Cell Significance Index: -12.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4983
    Cell Significance Index: -10.4300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5082
    Cell Significance Index: -11.7400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.5144
    Cell Significance Index: -7.2200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.5201
    Cell Significance Index: -7.3900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5212
    Cell Significance Index: -10.1900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.5244
    Cell Significance Index: -7.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5490
    Cell Significance Index: -14.6600
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -0.5497
    Cell Significance Index: -3.3200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.5549
    Cell Significance Index: -5.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5609
    Cell Significance Index: -14.7500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5618
    Cell Significance Index: -14.0200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.5865
    Cell Significance Index: -7.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6095
    Cell Significance Index: -16.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6096
    Cell Significance Index: -17.4800
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.6180
    Cell Significance Index: -8.7900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.6248
    Cell Significance Index: -12.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The HLA DQA2 gene is characterized by its involvement in the adaptive immune response, specifically in the presentation of peptide antigens to T-cells. It is part of the HLA complex, which is a group of genes that encode proteins responsible for the presentation of antigens to the immune system. The HLA DQA2 gene is specifically expressed in cells of the immune system, including T-helper 17 cells, B cells, and dendritic cells, which are key players in the adaptive immune response. The HLA DQA2 gene is also characterized by its interaction with other molecules and pathways involved in the immune response. For example, it interacts with CD28, a costimulatory molecule that enhances T-cell activation, and with the T-cell receptor (TCR) signaling pathway. Additionally, HLA DQA2 is involved in the processing and presentation of peptide antigens, which is a critical step in the activation of T-cells. **Pathways and Functions** The HLA DQA2 gene is involved in several key pathways and functions of the immune response, including: 1. **Antigen processing and presentation**: HLA DQA2 is involved in the processing and presentation of peptide antigens to T-cells. This process involves the degradation of antigens into peptides, which are then loaded onto the HLA-DR molecule and presented to T-cells. 2. **T-cell activation**: HLA DQA2 plays a critical role in the activation of T-cells. The presentation of peptide antigens to T-cells by HLA DQA2 is necessary for the activation of T-cells and the initiation of an immune response. 3. **Cytokine signaling**: HLA DQA2 is involved in the signaling of cytokines, which are signaling molecules that play a key role in the regulation of the immune response. 4. **Immune response regulation**: HLA DQA2 is involved in the regulation of the immune response, including the activation of T-cells and the production of cytokines. **Clinical Significance** The HLA DQA2 gene has significant clinical implications, particularly in the context of autoimmune diseases and transplantation. For example: 1. **Autoimmune diseases**: HLA DQA2 is involved in the presentation of peptide antigens to T-cells, which can contribute to the development of autoimmune diseases such as rheumatoid arthritis and lupus. 2. **Transplantation**: HLA DQA2 is involved in the rejection of transplanted organs, as the presentation of peptide antigens to T-cells can lead to the activation of immune responses against the graft. 3. **Cancer**: HLA DQA2 is involved in the presentation of peptide antigens to T-cells, which can contribute to the development of cancer. 4. **Infectious diseases**: HLA DQA2 is involved in the presentation of peptide antigens to T-cells, which can contribute to the development of infectious diseases such as HIV and tuberculosis. In conclusion, the HLA DQA2 gene plays a critical role in the adaptive immune response by presenting peptide antigens to T-cells. Its expression is widespread in various cells of the immune system, and its interaction with other molecules and pathways involved in the immune response highlights its importance in immune function. The clinical significance of HLA DQA2 is significant, particularly in the context of autoimmune diseases, transplantation, cancer, and infectious diseases.

Genular Protein ID: 1137033647

Symbol: DQA2_HUMAN

Name: HLA class II histocompatibility antigen, DQ alpha 2 chain

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3036828

Title: Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes.

PubMed ID: 3036828

DOI: 10.1016/s0021-9258(18)47482-0

PubMed ID: 6584734

Title: Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes.

PubMed ID: 6584734

DOI: 10.1038/308327a0

PubMed ID: 3610256

Title: Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene and functional splicing of the HLA-DQ alpha gene using a retroviral vector.

PubMed ID: 3610256

DOI: 10.1007/bf00345456

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 8026991

Title: Limited polymorphism of the HLA-DQA2 promoter and identification of a variant octamer.

PubMed ID: 8026991

DOI: 10.1016/0198-8859(94)90264-x

PubMed ID: 2513578

Title: Ancient roots for polymorphism at the HLA-DQ alpha locus in primates.

PubMed ID: 2513578

DOI: 10.1073/pnas.86.24.9986

PubMed ID: 9036956

Title: The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells.

PubMed ID: 9036956

PubMed ID: 8598037

Title: Invariant chain structure and MHC class II function.

PubMed ID: 8598037

DOI: 10.1016/s0092-8674(00)81025-9

PubMed ID: 11684289

Title: Presentation of antigens by MHC class II molecules: getting the most out of them.

PubMed ID: 11684289

DOI: 10.1016/s0161-5890(01)00069-4

PubMed ID: 18046453

Title: MHC class II molecules on the move for successful antigen presentation.

PubMed ID: 18046453

DOI: 10.1038/sj.emboj.7601945

PubMed ID: 17241953

Title: Autophagy in MHC class II presentation: sampling from within.

PubMed ID: 17241953

DOI: 10.1016/j.immuni.2007.01.005

PubMed ID: 19092054

Title: MHC class II transport at a glance.

PubMed ID: 19092054

DOI: 10.1242/jcs.035089

PubMed ID: 19533806

Title: CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.

PubMed ID: 19533806

DOI: 10.3748/wjg.15.2855

PubMed ID: 22407913

Title: HLA-DQA2 and HLA-DQB2 genes are specifically expressed in human Langerhans cells and encode a new HLA class II molecule.

PubMed ID: 22407913

DOI: 10.4049/jimmunol.1103048

Sequence Information:

  • Length: 255
  • Mass: 28033
  • Checksum: 85B13D9FDF2905FE
  • Sequence:
  • MILNKALLLG ALALTAVMSP CGGEDIVADH VASYGVNFYQ SHGPSGQYTH EFDGDEEFYV 
    DLETKETVWQ LPMFSKFISF DPQSALRNMA VGKHTLEFMM RQSNSTAATN EVPEVTVFSK 
    FPVTLGQPNT LICLVDNIFP PVVNITWLSN GHSVTEGVSE TSFLSKSDHS FFKISYLTFL 
    PSADEIYDCK VEHWGLDEPL LKHWEPEIPA PMSELTETLV CALGLSVGLM GIVVGTVFII 
    QGLRSVGASR HQGLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.