Details for: HLA DQA2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 90.9060
Cell Significance Index: -14.1400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 43.4074
Cell Significance Index: -11.0100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 37.0539
Cell Significance Index: -19.0600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 11.5170
Cell Significance Index: -14.2000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.4113
Cell Significance Index: -17.1800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.6112
Cell Significance Index: -14.2500 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 2.9000
Cell Significance Index: 7.6500 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 2.6642
Cell Significance Index: 41.2200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.6341
Cell Significance Index: -5.7700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.6077
Cell Significance Index: 34.8300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.4729
Cell Significance Index: 39.4000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.3009
Cell Significance Index: 26.9900 - Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: 1.2410
Cell Significance Index: 21.3200 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 1.0130
Cell Significance Index: 4.5300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0124
Cell Significance Index: 192.6700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6903
Cell Significance Index: 68.2900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6180
Cell Significance Index: 558.0100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.4984
Cell Significance Index: 7.5100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3714
Cell Significance Index: 43.8000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3458
Cell Significance Index: 56.2400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.3214
Cell Significance Index: 9.4400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2367
Cell Significance Index: 25.7500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2058
Cell Significance Index: 13.2800 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.1896
Cell Significance Index: 3.3500 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.1212
Cell Significance Index: 2.2400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0993
Cell Significance Index: 6.8700 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.0490
Cell Significance Index: 2.1300 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0035
Cell Significance Index: 0.0400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0002
Cell Significance Index: -0.1400 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0037
Cell Significance Index: -0.1500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0051
Cell Significance Index: -0.1800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0064
Cell Significance Index: -0.3900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0074
Cell Significance Index: -13.9800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0101
Cell Significance Index: -0.2900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0107
Cell Significance Index: -4.7300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0137
Cell Significance Index: -8.5400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0177
Cell Significance Index: -13.1100 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0207
Cell Significance Index: -11.3200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0236
Cell Significance Index: -13.3100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0241
Cell Significance Index: -17.6400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0273
Cell Significance Index: -17.3400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0350
Cell Significance Index: -3.5800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0379
Cell Significance Index: -1.7200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0388
Cell Significance Index: -17.6300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0408
Cell Significance Index: -8.5900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0415
Cell Significance Index: -5.3200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0430
Cell Significance Index: -15.4400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0459
Cell Significance Index: -7.8300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.0465
Cell Significance Index: -2.7900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0694
Cell Significance Index: -13.7800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0721
Cell Significance Index: -14.4600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0750
Cell Significance Index: -10.3000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0889
Cell Significance Index: -16.0300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0904
Cell Significance Index: -1.9300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1042
Cell Significance Index: -11.9400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1093
Cell Significance Index: -7.7300 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.1179
Cell Significance Index: -0.9600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1203
Cell Significance Index: -17.4800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1223
Cell Significance Index: -15.8100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1328
Cell Significance Index: -16.3300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1356
Cell Significance Index: -14.1200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1758
Cell Significance Index: -5.6300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1956
Cell Significance Index: -9.2000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2238
Cell Significance Index: -16.6800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2334
Cell Significance Index: -17.9100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2490
Cell Significance Index: -6.9600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2976
Cell Significance Index: -7.4400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2984
Cell Significance Index: -15.5000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3048
Cell Significance Index: -19.2100 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.3086
Cell Significance Index: -4.4800 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.3335
Cell Significance Index: -5.6100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3462
Cell Significance Index: -16.1400 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3499
Cell Significance Index: -8.9400 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3621
Cell Significance Index: -10.6700 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.3691
Cell Significance Index: -4.9200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3726
Cell Significance Index: -12.2000 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.3778
Cell Significance Index: -9.4200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3839
Cell Significance Index: -13.4500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4318
Cell Significance Index: -15.8500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4597
Cell Significance Index: -14.6400 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: -0.4649
Cell Significance Index: -4.8200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4835
Cell Significance Index: -16.8000 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.4875
Cell Significance Index: -8.2800 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.4905
Cell Significance Index: -12.2500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4983
Cell Significance Index: -10.4300 - Cell Name: peg cell (CL4033014)
Fold Change: -0.5082
Cell Significance Index: -11.7400 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.5144
Cell Significance Index: -7.2200 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.5201
Cell Significance Index: -7.3900 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.5212
Cell Significance Index: -10.1900 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.5244
Cell Significance Index: -7.6700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.5490
Cell Significance Index: -14.6600 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: -0.5497
Cell Significance Index: -3.3200 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.5549
Cell Significance Index: -5.2800 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.5609
Cell Significance Index: -14.7500 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.5618
Cell Significance Index: -14.0200 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.5865
Cell Significance Index: -7.2600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.6095
Cell Significance Index: -16.5900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.6096
Cell Significance Index: -17.4800 - Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.6180
Cell Significance Index: -8.7900 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.6248
Cell Significance Index: -12.4600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1137033647
Symbol: DQA2_HUMAN
Name: HLA class II histocompatibility antigen, DQ alpha 2 chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3036828
Title: Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes.
PubMed ID: 3036828
PubMed ID: 6584734
Title: Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes.
PubMed ID: 6584734
DOI: 10.1038/308327a0
PubMed ID: 3610256
Title: Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene and functional splicing of the HLA-DQ alpha gene using a retroviral vector.
PubMed ID: 3610256
DOI: 10.1007/bf00345456
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 8026991
Title: Limited polymorphism of the HLA-DQA2 promoter and identification of a variant octamer.
PubMed ID: 8026991
PubMed ID: 2513578
Title: Ancient roots for polymorphism at the HLA-DQ alpha locus in primates.
PubMed ID: 2513578
PubMed ID: 9036956
Title: The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells.
PubMed ID: 9036956
PubMed ID: 8598037
Title: Invariant chain structure and MHC class II function.
PubMed ID: 8598037
PubMed ID: 11684289
Title: Presentation of antigens by MHC class II molecules: getting the most out of them.
PubMed ID: 11684289
PubMed ID: 18046453
Title: MHC class II molecules on the move for successful antigen presentation.
PubMed ID: 18046453
PubMed ID: 17241953
Title: Autophagy in MHC class II presentation: sampling from within.
PubMed ID: 17241953
PubMed ID: 19092054
PubMed ID: 19533806
Title: CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.
PubMed ID: 19533806
DOI: 10.3748/wjg.15.2855
PubMed ID: 22407913
Title: HLA-DQA2 and HLA-DQB2 genes are specifically expressed in human Langerhans cells and encode a new HLA class II molecule.
PubMed ID: 22407913
Sequence Information:
- Length: 255
- Mass: 28033
- Checksum: 85B13D9FDF2905FE
- Sequence:
MILNKALLLG ALALTAVMSP CGGEDIVADH VASYGVNFYQ SHGPSGQYTH EFDGDEEFYV DLETKETVWQ LPMFSKFISF DPQSALRNMA VGKHTLEFMM RQSNSTAATN EVPEVTVFSK FPVTLGQPNT LICLVDNIFP PVVNITWLSN GHSVTEGVSE TSFLSKSDHS FFKISYLTFL PSADEIYDCK VEHWGLDEPL LKHWEPEIPA PMSELTETLV CALGLSVGLM GIVVGTVFII QGLRSVGASR HQGLL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.