Details for: HLA DMB

Gene ID: 3109

Symbol: HLA DMB

Ensembl ID: ENSG00000242574

Description: major histocompatibility complex, class II, DM beta

Associated with

  • Adaptive immune system
    (R-HSA-1280218)
  • Immune system
    (R-HSA-168256)
  • Mhc class ii antigen presentation
    (R-HSA-2132295)
  • Adaptive immune response
    (GO:0002250)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class ii
    (GO:0019886)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Late endosome membrane
    (GO:0031902)
  • Lysosomal membrane
    (GO:0005765)
  • Mhc class ii protein complex
    (GO:0042613)
  • Mhc class ii protein complex assembly
    (GO:0002399)
  • Mhc class ii protein complex binding
    (GO:0023026)
  • Peptide antigen assembly with mhc class ii protein complex
    (GO:0002503)
  • Peptide antigen binding
    (GO:0042605)
  • Positive regulation of immune response
    (GO:0050778)
  • Positive regulation of t cell activation
    (GO:0050870)
  • Positive regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell
    (GO:2001190)
  • Positive regulation of t cell proliferation
    (GO:0042102)
  • Protein binding
    (GO:0005515)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 95.7278
    Cell Significance Index: -14.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.0207
    Cell Significance Index: -18.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 39.0312
    Cell Significance Index: -9.9000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 35.9847
    Cell Significance Index: -18.5100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 35.4569
    Cell Significance Index: -16.7400
  • Cell Name: centroblast (CL0009112)
    Fold Change: 12.8543
    Cell Significance Index: 29.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.1010
    Cell Significance Index: -14.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.6293
    Cell Significance Index: -15.0800
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4.9374
    Cell Significance Index: 22.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8697
    Cell Significance Index: -15.2700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 3.7150
    Cell Significance Index: 46.9400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.4216
    Cell Significance Index: 63.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.9675
    Cell Significance Index: 349.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.9288
    Cell Significance Index: -6.4100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.8891
    Cell Significance Index: 43.2900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.7210
    Cell Significance Index: 23.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.5537
    Cell Significance Index: 1394.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.2967
    Cell Significance Index: 61.4400
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 2.1494
    Cell Significance Index: 5.6700
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.0628
    Cell Significance Index: 6.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.7553
    Cell Significance Index: 334.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6897
    Cell Significance Index: 109.0100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.4546
    Cell Significance Index: 9.6500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.3752
    Cell Significance Index: 10.9800
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.3383
    Cell Significance Index: 5.5700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8810
    Cell Significance Index: 52.8900
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.8676
    Cell Significance Index: 5.2400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7724
    Cell Significance Index: 13.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6890
    Cell Significance Index: 35.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6471
    Cell Significance Index: 584.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6140
    Cell Significance Index: 60.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5925
    Cell Significance Index: 64.4500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.4543
    Cell Significance Index: 3.6800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3754
    Cell Significance Index: 4.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3674
    Cell Significance Index: 59.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3437
    Cell Significance Index: 23.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3372
    Cell Significance Index: 7.7900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2715
    Cell Significance Index: 4.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0510
    Cell Significance Index: 31.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0465
    Cell Significance Index: 4.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0208
    Cell Significance Index: 15.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0165
    Cell Significance Index: 2.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0064
    Cell Significance Index: 0.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0060
    Cell Significance Index: 2.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0042
    Cell Significance Index: 0.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0014
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0066
    Cell Significance Index: -12.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0080
    Cell Significance Index: -14.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0082
    Cell Significance Index: -6.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0091
    Cell Significance Index: -13.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0103
    Cell Significance Index: -5.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0109
    Cell Significance Index: -14.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0112
    Cell Significance Index: -1.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0169
    Cell Significance Index: -3.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0200
    Cell Significance Index: -14.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0270
    Cell Significance Index: -17.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0282
    Cell Significance Index: -0.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0317
    Cell Significance Index: -6.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0333
    Cell Significance Index: -3.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0338
    Cell Significance Index: -12.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0347
    Cell Significance Index: -1.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0360
    Cell Significance Index: -16.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0362
    Cell Significance Index: -1.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0363
    Cell Significance Index: -4.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0412
    Cell Significance Index: -7.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0434
    Cell Significance Index: -8.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0583
    Cell Significance Index: -7.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0618
    Cell Significance Index: -8.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0623
    Cell Significance Index: -1.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0760
    Cell Significance Index: -3.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0770
    Cell Significance Index: -1.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0920
    Cell Significance Index: -10.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0956
    Cell Significance Index: -12.3500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1153
    Cell Significance Index: -1.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1158
    Cell Significance Index: -16.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1223
    Cell Significance Index: -5.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1271
    Cell Significance Index: -7.7900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1390
    Cell Significance Index: -2.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1422
    Cell Significance Index: -14.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1544
    Cell Significance Index: -7.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1606
    Cell Significance Index: -11.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1717
    Cell Significance Index: -13.1800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1898
    Cell Significance Index: -2.8600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2065
    Cell Significance Index: -3.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2069
    Cell Significance Index: -13.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2087
    Cell Significance Index: -9.7300
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.2199
    Cell Significance Index: -1.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2235
    Cell Significance Index: -16.6600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2243
    Cell Significance Index: -2.9800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2298
    Cell Significance Index: -18.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2655
    Cell Significance Index: -10.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2764
    Cell Significance Index: -15.5100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2772
    Cell Significance Index: -2.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2794
    Cell Significance Index: -14.6700
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.2819
    Cell Significance Index: -1.4100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2986
    Cell Significance Index: -4.3400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3056
    Cell Significance Index: -3.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3229
    Cell Significance Index: -9.5100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.3360
    Cell Significance Index: -3.4800
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.3399
    Cell Significance Index: -2.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HLA DMB is a beta chain of the MHC class II molecule, which is composed of two alpha chains (DMB and DRA) and two beta chains (DMB and DRB). The beta chains are responsible for presenting peptide antigens to T-cells through their groove. HLA DMB is a critical component of the MHC class II molecule, as it interacts with the alpha chains and the peptide antigen to facilitate T-cell activation. The expression of HLA DMB is restricted to cells of the immune system, including antigen-presenting cells (APCs) such as dendritic cells and macrophages, and B cells. **Pathways and Functions** HLA DMB is involved in several key pathways and functions, including: 1. **Antigen Processing and Presentation**: HLA DMB is responsible for presenting peptide antigens to T-cells through its groove. This process involves the processing of antigens by proteasomes and the loading of peptides onto the MHC class II molecule. 2. **Adaptive Immune Response**: HLA DMB plays a critical role in initiating the adaptive immune response by presenting peptide antigens to T-cells. This leads to the activation of T-cells, which then proliferate and differentiate into effector cells. 3. **Positive Regulation of Immune Response**: HLA DMB is involved in the positive regulation of immune responses, including T-cell activation and proliferation. 4. **Antigen Presenting Cell Function**: HLA DMB is expressed on the surface of antigen-presenting cells (APCs) such as dendritic cells and macrophages, where it plays a critical role in presenting peptide antigens to T-cells. **Clinical Significance** HLA DMB has significant clinical implications, particularly in the context of autoimmune diseases and transplantation. For example: 1. **Autoimmune Diseases**: HLA DMB has been implicated in the pathogenesis of several autoimmune diseases, including rheumatoid arthritis and lupus. Variations in the HLA DMB gene have been associated with an increased risk of developing these diseases. 2. **Transplantation**: HLA DMB is a critical component of the MHC class II molecule, which is used to match donors and recipients in organ transplantation. Variations in the HLA DMB gene can affect the compatibility of organ transplants and the risk of rejection. 3. **Cancer Immunotherapy**: HLA DMB has been targeted in cancer immunotherapy, where it is used to present tumor antigens to T-cells and stimulate an immune response against cancer cells. In conclusion, HLA DMB is a critical component of the MHC class II molecule, which plays a central role in the adaptive immune response. Its expression and function have significant clinical implications, particularly in the context of autoimmune diseases and transplantation.

Genular Protein ID: 3194037244

Symbol: DMB_HUMAN

Name: HLA class II histocompatibility antigen, DM beta chain

UniProtKB Accession Codes:

P28068 O77936 Q13012 Q29751 Q58ZE2 Q5SNZ8 Q5STC4 Q9XRX2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 21 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1922365

Title: A new human HLA class II-related locus, DM.

PubMed ID: 1922365

DOI: 10.1038/353571a0

PubMed ID: 8034636

Title: Genomic organization of HLA-DMA and HLA-DMB. Comparison of the gene organization of all six class II families in the human major histocompatibility complex.

PubMed ID: 8034636

DOI: 10.1016/s0021-9258(17)32242-1

PubMed ID: 8568858

Title: Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.

PubMed ID: 8568858

DOI: 10.1006/jmbi.1996.0001

PubMed ID: 15787724

Title: Identification of a novel HLA-DMB allele (DMB*0107) in the Korean population.

PubMed ID: 15787724

DOI: 10.1111/j.1399-0039.2005.00385.x

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8225438

Title: Limited polymorphism in HLA-DM does not involve the peptide binding groove.

PubMed ID: 8225438

DOI: 10.1007/bf00171797

PubMed ID: 8406617

Title: Characterization of HLA-DMB polymorphism.

PubMed ID: 8406617

DOI: 10.1007/bf00184526

PubMed ID: 9157091

Title: Three HLA-DMB variants in Korean patients with autoimmune diseases.

PubMed ID: 9157091

DOI: 10.1016/0198-8859(95)00171-9

PubMed ID: 10885572

Title: The nucleotide sequence of a new DMB allele, DMB*0106.

PubMed ID: 10885572

DOI: 10.1034/j.1399-0039.2000.550514.x

PubMed ID: 8849454

Title: Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM.

PubMed ID: 8849454

DOI: 10.1126/science.274.5287.618

PubMed ID: 8757605

Title: Targeting signal and subcellular compartments involved in the intracellular trafficking of HLA-DMB.

PubMed ID: 8757605

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 9768757

Title: The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation.

PubMed ID: 9768757

DOI: 10.1016/s1074-7613(00)80620-2

PubMed ID: 16547258

Title: Small molecules that enhance the catalytic efficiency of HLA-DM.

PubMed ID: 16547258

DOI: 10.4049/jimmunol.176.7.4208

PubMed ID: 23260142

Title: Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection.

PubMed ID: 23260142

DOI: 10.1016/j.cell.2012.11.025

Sequence Information:

  • Length: 263
  • Mass: 28931
  • Checksum: 9B50E72DD2A2454A
  • Sequence:
    • MITFLPLLLG LSLGCTGAGG FVAHVESTCL LDDAGTPKDF TYCISFNKDL LTCWDPEENK 
MAPCEFGVLN SLANVLSQHL NQKDTLMQRL RNGLQNCATH TQPFWGSLTN RTRPPSVQVA 
KTTPFNTREP VMLACYVWGF YPAEVTITWR KNGKLVMPHS SAHKTAQPNG DWTYQTLSHL 
ALTPSYGDTY TCVVEHTGAP EPILRDWTPG LSPMQTLKVS VSAVTLGLGL IIFSLGVISW 
RRAGHSSYTP LPGSNYSEGW HIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.