Details for: HLA DMB

Gene ID: 3109

Symbol: HLA DMB

Ensembl ID: ENSG00000242574

Description: major histocompatibility complex, class II, DM beta

Associated with

  • Adaptive immune system
    (R-HSA-1280218)
  • Immune system
    (R-HSA-168256)
  • Mhc class ii antigen presentation
    (R-HSA-2132295)
  • Adaptive immune response
    (GO:0002250)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class ii
    (GO:0019886)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Late endosome membrane
    (GO:0031902)
  • Lysosomal membrane
    (GO:0005765)
  • Mhc class ii protein complex
    (GO:0042613)
  • Mhc class ii protein complex assembly
    (GO:0002399)
  • Mhc class ii protein complex binding
    (GO:0023026)
  • Peptide antigen assembly with mhc class ii protein complex
    (GO:0002503)
  • Peptide antigen binding
    (GO:0042605)
  • Positive regulation of immune response
    (GO:0050778)
  • Positive regulation of t cell activation
    (GO:0050870)
  • Positive regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell
    (GO:2001190)
  • Positive regulation of t cell proliferation
    (GO:0042102)
  • Protein binding
    (GO:0005515)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 5.04
    Marker Score: 5277
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.56
    Marker Score: 2769
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.46
    Marker Score: 3407
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.39
    Marker Score: 2391
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.84
    Marker Score: 1728
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.74
    Marker Score: 3134
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.67
    Marker Score: 1609
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.46
    Marker Score: 872
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.45
    Marker Score: 84841
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.4
    Marker Score: 4180
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.38
    Marker Score: 60951
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.37
    Marker Score: 7037
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.37
    Marker Score: 2228
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.36
    Marker Score: 4948
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.32
    Marker Score: 6017.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.14
    Marker Score: 1055
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.12
    Marker Score: 1893
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.9
    Marker Score: 106113
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.89
    Marker Score: 450
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.83
    Marker Score: 422
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.78
    Marker Score: 1926
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.77
    Marker Score: 1773
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.75
    Marker Score: 1327
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.75
    Marker Score: 3413
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.66
    Marker Score: 1146
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.64
    Marker Score: 6792
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.62
    Marker Score: 2496
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.62
    Marker Score: 1952
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.6
    Marker Score: 9699
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.46
    Marker Score: 967
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.41
    Marker Score: 14286
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.36
    Marker Score: 3376
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.31
    Marker Score: 308
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.27
    Marker Score: 1498
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.25
    Marker Score: 14482
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.21
    Marker Score: 505
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.18
    Marker Score: 1714
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.18
    Marker Score: 409
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.17
    Marker Score: 2879
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.17
    Marker Score: 604
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.14
    Marker Score: 266
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.14
    Marker Score: 1146
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.13
    Marker Score: 1149
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.12
    Marker Score: 557
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.06
    Marker Score: 2877
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.04
    Marker Score: 1753
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1
    Marker Score: 588
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.98
    Marker Score: 934
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 492
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.95
    Marker Score: 636
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.95
    Marker Score: 2295
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 446
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.91
    Marker Score: 1015
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2719
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5168
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.91
    Marker Score: 271
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 362
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.9
    Marker Score: 226
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.9
    Marker Score: 215
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.88
    Marker Score: 432
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5258
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.86
    Marker Score: 260
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.85
    Marker Score: 459
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.84
    Marker Score: 560
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.83
    Marker Score: 217
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.81
    Marker Score: 591
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 604.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.79
    Marker Score: 4153
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.79
    Marker Score: 435
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.79
    Marker Score: 1264
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.78
    Marker Score: 1986
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1255
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.76
    Marker Score: 221
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.76
    Marker Score: 201
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.75
    Marker Score: 4909.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.75
    Marker Score: 1225
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.74
    Marker Score: 256
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.74
    Marker Score: 302
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.73
    Marker Score: 6405
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 656
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.71
    Marker Score: 1141
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2949
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.7
    Marker Score: 192
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.7
    Marker Score: 591
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.69
    Marker Score: 470
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.69
    Marker Score: 190
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.69
    Marker Score: 336
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.69
    Marker Score: 174.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.68
    Marker Score: 319
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.67
    Marker Score: 426
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.67
    Marker Score: 460
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.67
    Marker Score: 523
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.67
    Marker Score: 643
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.66
    Marker Score: 3169
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.65
    Marker Score: 371

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * The DMB gene is located on chromosome 15q21.1. * It is a large gene with a calculated molecular weight of 120,000 bp. * The DMB protein is a glycoprotein with a molecular weight of approximately 500 kDa. * It is expressed in a variety of cell types, including thymocytes, myeloid dendritic cells, B cells, and macrophages. **Pathways and functions:** * The DMB protein is expressed on the surface of antigen-presenting cells, such as dendritic cells and macrophages. * It complexifies with peptide antigens derived from extracellular proteins, such as those presented by MHC class I molecules. * This complex is then transported to the cell surface, where it binds to MHC class II molecules. * This binding triggers the activation of T cells, which are a type of white blood cell that recognizes and responds to foreign pathogens. **Clinical significance:** * Mutations in the DMB gene have been linked to several autoimmune diseases, including rheumatoid arthritis, Crohn's disease, and lupus. * The DMB protein is a potential target for immunotherapy in these diseases, as it is expressed on the surface of immune cells that are responsible for attacking the body's own tissues. * Researchers are currently exploring the use of DMB-based vaccines to treat autoimmune diseases. **Other important points:** * The DMB gene is also expressed in low-level in healthy individuals. * It is a highly conserved gene, with a similar gene found in other mammals. * The DMB protein is a multi-functional protein that can also bind to other molecules, such as CD80 and CD86.

Genular Protein ID: 3194037244

Symbol: DMB_HUMAN

Name: HLA class II histocompatibility antigen, DM beta chain

UniProtKB Accession Codes:

P28068 O77936 Q13012 Q29751 Q58ZE2 Q5SNZ8 Q5STC4 Q9XRX2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 21 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 5 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1922365

Title: A new human HLA class II-related locus, DM.

PubMed ID: 1922365

DOI: 10.1038/353571a0

PubMed ID: 8034636

Title: Genomic organization of HLA-DMA and HLA-DMB. Comparison of the gene organization of all six class II families in the human major histocompatibility complex.

PubMed ID: 8034636

DOI: 10.1016/s0021-9258(17)32242-1

PubMed ID: 8568858

Title: Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.

PubMed ID: 8568858

DOI: 10.1006/jmbi.1996.0001

PubMed ID: 15787724

Title: Identification of a novel HLA-DMB allele (DMB*0107) in the Korean population.

PubMed ID: 15787724

DOI: 10.1111/j.1399-0039.2005.00385.x

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8225438

Title: Limited polymorphism in HLA-DM does not involve the peptide binding groove.

PubMed ID: 8225438

DOI: 10.1007/bf00171797

PubMed ID: 8406617

Title: Characterization of HLA-DMB polymorphism.

PubMed ID: 8406617

DOI: 10.1007/bf00184526

PubMed ID: 9157091

Title: Three HLA-DMB variants in Korean patients with autoimmune diseases.

PubMed ID: 9157091

DOI: 10.1016/0198-8859(95)00171-9

PubMed ID: 10885572

Title: The nucleotide sequence of a new DMB allele, DMB*0106.

PubMed ID: 10885572

DOI: 10.1034/j.1399-0039.2000.550514.x

PubMed ID: 8849454

Title: Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM.

PubMed ID: 8849454

DOI: 10.1126/science.274.5287.618

PubMed ID: 8757605

Title: Targeting signal and subcellular compartments involved in the intracellular trafficking of HLA-DMB.

PubMed ID: 8757605

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 9768757

Title: The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation.

PubMed ID: 9768757

DOI: 10.1016/s1074-7613(00)80620-2

PubMed ID: 16547258

Title: Small molecules that enhance the catalytic efficiency of HLA-DM.

PubMed ID: 16547258

DOI: 10.4049/jimmunol.176.7.4208

PubMed ID: 23260142

Title: Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection.

PubMed ID: 23260142

DOI: 10.1016/j.cell.2012.11.025

Sequence Information:

  • Length: 263
  • Mass: 28931
  • Checksum: 9B50E72DD2A2454A
  • Sequence:
    • MITFLPLLLG LSLGCTGAGG FVAHVESTCL LDDAGTPKDF TYCISFNKDL LTCWDPEENK 
MAPCEFGVLN SLANVLSQHL NQKDTLMQRL RNGLQNCATH TQPFWGSLTN RTRPPSVQVA 
KTTPFNTREP VMLACYVWGF YPAEVTITWR KNGKLVMPHS SAHKTAQPNG DWTYQTLSHL 
ALTPSYGDTY TCVVEHTGAP EPILRDWTPG LSPMQTLKVS VSAVTLGLGL IIFSLGVISW 
RRAGHSSYTP LPGSNYSEGW HIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.