Details for: HMGA1

Gene ID: 3159

Symbol: HMGA1

Ensembl ID: ENSG00000137309

Description: high mobility group AT-hook 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 131.5373
    Cell Significance Index: -20.4600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 114.8933
    Cell Significance Index: -47.3300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 101.8813
    Cell Significance Index: -41.3900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 93.9957
    Cell Significance Index: -48.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 76.7810
    Cell Significance Index: -19.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 70.7726
    Cell Significance Index: -47.4900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.3889
    Cell Significance Index: -42.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.7668
    Cell Significance Index: -40.4000
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 18.7525
    Cell Significance Index: 8.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.0018
    Cell Significance Index: -34.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.6648
    Cell Significance Index: -46.0300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 10.8664
    Cell Significance Index: 82.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.8390
    Cell Significance Index: -30.2200
  • Cell Name: centroblast (CL0009112)
    Fold Change: 7.4109
    Cell Significance Index: 17.2900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.9366
    Cell Significance Index: 75.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 6.2147
    Cell Significance Index: 166.2400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.0507
    Cell Significance Index: 48.3100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 5.4340
    Cell Significance Index: 41.0300
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 5.2937
    Cell Significance Index: 30.0900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 5.1351
    Cell Significance Index: 36.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.8061
    Cell Significance Index: 566.7900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.5836
    Cell Significance Index: 29.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 4.2101
    Cell Significance Index: 543.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.4680
    Cell Significance Index: -7.5900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.4215
    Cell Significance Index: 21.1800
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.0329
    Cell Significance Index: 9.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.9431
    Cell Significance Index: 40.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.3609
    Cell Significance Index: 1289.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.2830
    Cell Significance Index: 147.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.2602
    Cell Significance Index: 64.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.1496
    Cell Significance Index: 45.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.1295
    Cell Significance Index: 346.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.1134
    Cell Significance Index: 157.5100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.0581
    Cell Significance Index: 4.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.9938
    Cell Significance Index: 69.2900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.8864
    Cell Significance Index: 16.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.8763
    Cell Significance Index: 132.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7425
    Cell Significance Index: 90.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6910
    Cell Significance Index: 747.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6473
    Cell Significance Index: 1487.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.6262
    Cell Significance Index: 47.7600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.5888
    Cell Significance Index: 10.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4306
    Cell Significance Index: 38.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.4132
    Cell Significance Index: 66.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2306
    Cell Significance Index: 26.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1322
    Cell Significance Index: 51.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1182
    Cell Significance Index: 137.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0535
    Cell Significance Index: 28.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0022
    Cell Significance Index: 28.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9821
    Cell Significance Index: 177.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8270
    Cell Significance Index: 43.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6938
    Cell Significance Index: 68.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6166
    Cell Significance Index: 122.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5663
    Cell Significance Index: 61.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5077
    Cell Significance Index: 23.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4596
    Cell Significance Index: 14.7200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4501
    Cell Significance Index: 4.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4491
    Cell Significance Index: 12.5500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.3424
    Cell Significance Index: 5.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3400
    Cell Significance Index: 64.7000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3308
    Cell Significance Index: 5.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3236
    Cell Significance Index: 11.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3176
    Cell Significance Index: 20.0200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2837
    Cell Significance Index: 6.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2659
    Cell Significance Index: 76.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1178
    Cell Significance Index: 23.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0904
    Cell Significance Index: 1.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0381
    Cell Significance Index: 28.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0329
    Cell Significance Index: 11.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0174
    Cell Significance Index: -1.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0204
    Cell Significance Index: -0.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0204
    Cell Significance Index: -38.4400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0254
    Cell Significance Index: -0.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0320
    Cell Significance Index: -59.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0321
    Cell Significance Index: -4.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0377
    Cell Significance Index: -58.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0437
    Cell Significance Index: -59.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0509
    Cell Significance Index: -5.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0519
    Cell Significance Index: -38.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0522
    Cell Significance Index: -38.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0670
    Cell Significance Index: -42.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0725
    Cell Significance Index: -40.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0895
    Cell Significance Index: -15.2800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0969
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1007
    Cell Significance Index: -62.8900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1026
    Cell Significance Index: -0.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1047
    Cell Significance Index: -47.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1420
    Cell Significance Index: -19.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1620
    Cell Significance Index: -4.0500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1674
    Cell Significance Index: -1.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1699
    Cell Significance Index: -8.8500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1734
    Cell Significance Index: -1.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1837
    Cell Significance Index: -2.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1844
    Cell Significance Index: -10.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2131
    Cell Significance Index: -24.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2402
    Cell Significance Index: -27.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2478
    Cell Significance Index: -52.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2999
    Cell Significance Index: -43.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3821
    Cell Significance Index: -5.7300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3942
    Cell Significance Index: -6.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HMGA1 is a 420-kDa protein that belongs to the HMG family of proteins. It is characterized by its ability to bind to DNA and regulate gene expression, particularly in the context of cell proliferation and differentiation. HMGA1 is highly mobile and can bind to DNA in a non-specific manner, allowing it to regulate gene expression at multiple genomic loci. This protein is also capable of interacting with other proteins and RNA polymerase II, modulating its activity and influencing transcriptional regulation. HMGA1 has been shown to be involved in various cellular processes, including DNA repair, telomere maintenance, and chromatin remodeling. **Pathways and Functions** HMGA1 is involved in several key pathways, including: 1. **DNA replication and repair**: HMGA1 plays a crucial role in regulating DNA replication and repair, particularly in the context of telomere maintenance and DNA damage response. 2. **Transcription regulation**: HMGA1 regulates gene expression by interacting with RNA polymerase II and other transcription factors, modulating the activity of transcriptional regulatory complexes. 3. **Chromatin remodeling**: HMGA1 is involved in chromatin remodeling, particularly in the context of gene expression and DNA repair. 4. **Cell proliferation and differentiation**: HMGA1 regulates cell proliferation and differentiation, particularly in the context of hematopoietic stem cells and epithelial cells. 5. **Stress response**: HMGA1 is involved in the stress response, particularly in the context of DNA damage and telomere stress. **Clinical Significance** HMGA1 has been implicated in the pathogenesis of various diseases, including: 1. **Cancer**: HMGA1 is overexpressed in many types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **HIV-1 infection**: HMGA1 is involved in the regulation of HIV-1 gene expression and is associated with viral replication and disease progression. 3. **Autoimmune disorders**: HMGA1 is involved in the regulation of immune responses and is associated with autoimmune disorders, such as rheumatoid arthritis and lupus. 4. **Neurological disorders**: HMGA1 is involved in the regulation of neuronal development and function and is associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, HMGA1 is a multifunctional protein that plays a critical role in various cellular processes, including gene regulation, cell proliferation, and stress response. Its involvement in the pathogenesis of various diseases highlights the importance of HMGA1 as a potential therapeutic target for the treatment of cancer, HIV-1 infection, and autoimmune disorders.

Genular Protein ID: 385002873

Symbol: HMGA1_HUMAN

Name: High mobility group protein HMG-I/HMG-Y

UniProtKB Accession Codes:

P17096 P10910 Q5T6U9 Q9UKB0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 16 Ensembl 5 ExpressionAtlas 1 GO 36 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 7 RefSeq 12 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 3 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2505228

Title: Cloning of cDNAs coding for human HMG I and HMG Y proteins: both are capable of binding to the octamer sequence motif.

PubMed ID: 2505228

DOI: 10.1093/nar/17.15.5947

PubMed ID: 2701943

Title: Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y.

PubMed ID: 2701943

DOI: 10.1128/mcb.9.5.2114-2123.1989

PubMed ID: 8414980

Title: Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene.

PubMed ID: 8414980

DOI: 10.1093/nar/21.18.4259

PubMed ID: 10428834

Title: Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor.

PubMed ID: 10428834

DOI: 10.1074/jbc.274.32.22563

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3619901

Title: The human chromosomal protein HMG I contains two identical palindrome amino acid sequences.

PubMed ID: 3619901

DOI: 10.1016/0006-291x(87)90589-4

PubMed ID: 2920035

Title: The amino acid sequence of the chromosomal protein HMG-Y, its relation to HMG-I and possible domains for the preferential binding of the proteins to stretches of A-T base pairs.

PubMed ID: 2920035

DOI: 10.1016/0006-291x(89)92770-8

PubMed ID: 1692833

Title: The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure.

PubMed ID: 1692833

DOI: 10.1016/s0021-9258(19)38926-4

PubMed ID: 11978964

Title: Intragenic breakpoint within RAD51L1 in a t(6;14)(p21.3;q24) of a pulmonary chondroid hamartoma.

PubMed ID: 11978964

DOI: 10.1159/000057011

PubMed ID: 12653562

Title: During apoptosis of tumor cells HMGA1a protein undergoes methylation: identification of the modification site by mass spectrometry.

PubMed ID: 12653562

DOI: 10.1021/bi027338l

PubMed ID: 16157300

Title: Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a.

PubMed ID: 16157300

DOI: 10.1016/j.bbrc.2005.08.179

PubMed ID: 15835918

Title: Tandem mass spectrometry for the examination of the posttranslational modifications of high-mobility group A1 proteins: symmetric and asymmetric dimethylation of Arg25 in HMGA1a protein.

PubMed ID: 15835918

DOI: 10.1021/bi0475525

PubMed ID: 16159886

Title: Dynamics of human protein arginine methyltransferase 1(PRMT1) in vivo.

PubMed ID: 16159886

DOI: 10.1074/jbc.m502458200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17960875

Title: Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity.

PubMed ID: 17960875

DOI: 10.1021/pr700571d

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28190768

Title: Serine ADP-ribosylation depends on HPF1.

PubMed ID: 28190768

DOI: 10.1016/j.molcel.2017.01.003

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 9253416

Title: The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif.

PubMed ID: 9253416

DOI: 10.1038/nsb0897-657

Sequence Information:

  • Length: 107
  • Mass: 11676
  • Checksum: E9C4E3F2200914B8
  • Sequence:
    • MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE VPTPKRPRGR 
PKGSKNKGAA KTRKTTTTPG RKPRGRPKKL EKEEEEGISQ ESSEEEQ

Genular Protein ID: 1389318697

Symbol: Q5T6U8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5T6U8

Database IDs:

ARBA 18 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 6 HOGENOM 1 IntAct 1 InterPro 3 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 1 PharmGKB 1 RefSeq 5 SAM 1 SMART 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 96
  • Mass: 10679
  • Checksum: B82DCAA29E6D18FD
  • Sequence:
    • MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPKEPSEV PTPKRPRGRP KGSKNKGAAK 
TRKTTTTPGR KPRGRPKKLE KEEEEGISQE SSEEEQ

Genular Protein ID: 194026575

Symbol: A0A994J434_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A994J434

Database IDs:

ARBA 18 CTD 1 EMBL 1 Ensembl 2 GO 5 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 106
  • Mass: 11548
  • Checksum: E750213969E9B65F
  • Sequence:
    • MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQEPSEV PTPKRPRGRP 
KGSKNKGAAK TRKTTTTPGR KPRGRPKKLE KEEEEGISQE SSEEEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.