Details for: ZNF10

Gene ID: 7556

Symbol: ZNF10

Ensembl ID: ENSG00000256223

Description: zinc finger protein 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 113.4718
    Cell Significance Index: -17.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 68.7580
    Cell Significance Index: -17.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.5666
    Cell Significance Index: -17.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.2433
    Cell Significance Index: -16.7300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.2418
    Cell Significance Index: -16.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5653
    Cell Significance Index: -18.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9933
    Cell Significance Index: 55.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8865
    Cell Significance Index: 177.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8525
    Cell Significance Index: 21.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8083
    Cell Significance Index: 35.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8029
    Cell Significance Index: 21.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7907
    Cell Significance Index: 29.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7353
    Cell Significance Index: 263.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5775
    Cell Significance Index: 44.3200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4833
    Cell Significance Index: 6.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4825
    Cell Significance Index: 56.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3731
    Cell Significance Index: 336.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3444
    Cell Significance Index: 99.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3303
    Cell Significance Index: 16.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3036
    Cell Significance Index: 30.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2998
    Cell Significance Index: 18.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2473
    Cell Significance Index: 40.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2201
    Cell Significance Index: 23.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2137
    Cell Significance Index: 11.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2041
    Cell Significance Index: 5.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2029
    Cell Significance Index: 24.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1963
    Cell Significance Index: 2.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1932
    Cell Significance Index: 11.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1735
    Cell Significance Index: 4.1600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1710
    Cell Significance Index: 10.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1700
    Cell Significance Index: 3.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1689
    Cell Significance Index: 3.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1684
    Cell Significance Index: 30.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1678
    Cell Significance Index: 19.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1297
    Cell Significance Index: 5.8800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1189
    Cell Significance Index: 13.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0850
    Cell Significance Index: 5.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0840
    Cell Significance Index: 37.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0756
    Cell Significance Index: 2.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0669
    Cell Significance Index: 12.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0642
    Cell Significance Index: 8.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0608
    Cell Significance Index: 33.2300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0467
    Cell Significance Index: 0.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0465
    Cell Significance Index: 9.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0303
    Cell Significance Index: 3.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0114
    Cell Significance Index: 21.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0042
    Cell Significance Index: -7.6600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0047
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0055
    Cell Significance Index: -3.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0067
    Cell Significance Index: -9.1700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0077
    Cell Significance Index: -0.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0101
    Cell Significance Index: -6.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0107
    Cell Significance Index: -1.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0114
    Cell Significance Index: -8.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0146
    Cell Significance Index: -8.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0172
    Cell Significance Index: -0.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0198
    Cell Significance Index: -14.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0244
    Cell Significance Index: -11.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0388
    Cell Significance Index: -8.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0401
    Cell Significance Index: -4.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0473
    Cell Significance Index: -6.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0536
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0575
    Cell Significance Index: -6.5900
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0629
    Cell Significance Index: -0.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0638
    Cell Significance Index: -3.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0771
    Cell Significance Index: -5.4500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0832
    Cell Significance Index: -1.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0963
    Cell Significance Index: -2.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0975
    Cell Significance Index: -12.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1038
    Cell Significance Index: -4.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1147
    Cell Significance Index: -2.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1207
    Cell Significance Index: -7.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1218
    Cell Significance Index: -3.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1249
    Cell Significance Index: -2.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1271
    Cell Significance Index: -3.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1357
    Cell Significance Index: -7.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1399
    Cell Significance Index: -2.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1540
    Cell Significance Index: -11.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1672
    Cell Significance Index: -17.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1783
    Cell Significance Index: -10.9300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1833
    Cell Significance Index: -3.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1833
    Cell Significance Index: -6.0000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1866
    Cell Significance Index: -3.6900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1966
    Cell Significance Index: -3.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2000
    Cell Significance Index: -6.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2047
    Cell Significance Index: -6.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2055
    Cell Significance Index: -16.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2243
    Cell Significance Index: -4.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2310
    Cell Significance Index: -15.5300
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2516
    Cell Significance Index: -1.5800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2533
    Cell Significance Index: -4.2600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2541
    Cell Significance Index: -5.4900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2572
    Cell Significance Index: -3.6100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2654
    Cell Significance Index: -3.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2880
    Cell Significance Index: -10.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3138
    Cell Significance Index: -7.2500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.3151
    Cell Significance Index: -2.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3229
    Cell Significance Index: -10.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF10 is a transcription factor that exhibits the following characteristics: 1. **Zinc Finger Motif**: ZNF10 contains a zinc finger motif, which allows it to bind to specific DNA sequences with high affinity. 2. **Transcriptional Regulation**: ZNF10 regulates gene expression by binding to RNA polymerase II-specific DNA sequences, thereby modulating transcriptional activity. 3. **Widespread Expression**: ZNF10 is expressed in various cell types, including renal principal cells, cortical neurons, and GABAergic interneurons, highlighting its role in maintaining tissue homeostasis. 4. **Metal Ion Binding**: ZNF10 exhibits metal ion binding capabilities, which may influence its transcriptional activity. **Pathways and Functions:** ZNF10 is involved in several biological pathways, including: 1. **Generic Transcription Pathway**: ZNF10 regulates gene expression by influencing the generic transcription pathway. 2. **RNA Polymerase II Transcription**: ZNF10 interacts with RNA polymerase II to modulate transcriptional activity. 3. **Regulation of Transcription by RNA Polymerase II**: ZNF10 regulates transcription by interacting with RNA polymerase II-specific DNA sequences. 4. **Metal Ion Binding**: ZNF10 binds to metal ions, which may influence its transcriptional activity. **Clinical Significance:** The dysregulation of ZNF10 has significant implications for various diseases, including: 1. **Neurological Disorders**: Alterations in ZNF10 expression have been linked to neurological disorders, such as epilepsy and schizophrenia. 2. **Renal Diseases**: ZNF10 is involved in maintaining renal function, and its dysregulation may contribute to renal diseases, such as kidney failure. 3. **Cancer**: ZNF10 has been implicated in cancer development and progression, highlighting its potential as a therapeutic target. In conclusion, ZNF10 is a transcription factor that plays a crucial role in regulating gene expression in various tissues, including the CNS and kidneys. Its dysregulation has significant implications for various diseases, emphasizing the need for further research into the molecular mechanisms underlying its function.

Genular Protein ID: 1247928119

Symbol: ZNF10_HUMAN

Name: Zinc finger protein 10

UniProtKB Accession Codes:

P21506 B2RBS1 Q8TC91

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23665872

Title: Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.

PubMed ID: 23665872

DOI: 10.1007/s00018-013-1359-4

Sequence Information:

  • Length: 573
  • Mass: 66455
  • Checksum: 5C850DBC8FF4A064
  • Sequence:
    • MDAKSLTAWS RTLVTFKDVF VDFTREEWKL LDTAQQIVYR NVMLENYKNL VSLGYQLTKP 
DVILRLEKGE EPWLVEREIH QETHPDSETA FEIKSSVSSR SIFKDKQSCD IKMEGMARND 
LWYLSLEEVW KCRDQLDKYQ ENPERHLRQV AFTQKKVLTQ ERVSESGKYG GNCLLPAQLV 
LREYFHKRDS HTKSLKHDLV LNGHQDSCAS NSNECGQTFC QNIHLIQFAR THTGDKSYKC 
PDNDNSLTHG SSLGISKGIH REKPYECKEC GKFFSWRSNL TRHQLIHTGE KPYECKECGK 
SFSRSSHLIG HQKTHTGEEP YECKECGKSF SWFSHLVTHQ RTHTGDKLYT CNQCGKSFVH 
SSRLIRHQRT HTGEKPYECP ECGKSFRQST HLILHQRTHV RVRPYECNEC GKSYSQRSHL 
VVHHRIHTGL KPFECKDCGK CFSRSSHLYS HQRTHTGEKP YECHDCGKSF SQSSALIVHQ 
RIHTGEKPYE CCQCGKAFIR KNDLIKHQRI HVGEETYKCN QCGIIFSQNS PFIVHQIAHT 
GEQFLTCNQC GTALVNTSNL IGYQTNHIRE NAY

Genular Protein ID: 1507327707

Symbol: Q9UG14_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UG14

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 540
  • Mass: 62522
  • Checksum: F5C0705973464C5E
  • Sequence:
    • AQQIVYRNVM LENYKNLVSL GYQLTKPDVI LRLEKGEEPW LVEREIHQET HPDSETAFEI 
KSSVSSRSIF KDKQSCDIKM EGMARNDLWY LSLEEVWKCR DQLDKYQENP ERHLRQVAFT 
QKKVLTQERV SESGKYGGNC LLPAQLVLRE YFHKRDSHTK SLKHDLVLNG HQDSCASNSN 
ECGQTFCQNI HLIQFARTHT GDKSYKCPDN DNSLTHGSSL GISKGIHREK PYECKECGKF 
FSWRSNLTRH QLIHTGEKPY ECKECGKSFS RSSHLIGHQK THTGEEPYEC KECGKSFSWF 
SHLVTHQRTH TGDKLYTCNQ CGKSFVHSSR LIRHQRTHTG EKPYECPECG KSFRQSTHLI 
LHQRTHVRVR PYECNECGKS YSQRSHLVVH HRIHTGLKPF ECKDCGKCFS RSSHLYSHQR 
THTGEKPYEC HDCGKSFSQS SALIVHQRIH TGEKPYECCQ CGKAFIRKND LIKHQRIHVG 
EETYKCNQCG IIFSQNSPFI VHQIAHTGEQ FLTCNQCGTA LVNTSNLIGY QTNHIRENAY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.