Details for: HLA DQA1

Gene ID: 3117

Symbol: HLA DQA1

Ensembl ID: ENSG00000196735

Description: major histocompatibility complex, class II, DQ alpha 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 190.7805
    Cell Significance Index: -29.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 85.7109
    Cell Significance Index: -21.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 74.4578
    Cell Significance Index: -38.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 67.0377
    Cell Significance Index: -31.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.0986
    Cell Significance Index: -29.7100
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 18.4312
    Cell Significance Index: 76.7100
  • Cell Name: centroblast (CL0009112)
    Fold Change: 13.3515
    Cell Significance Index: 31.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.1101
    Cell Significance Index: -35.1200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.0678
    Cell Significance Index: -24.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.7064
    Cell Significance Index: -30.4100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 6.3807
    Cell Significance Index: 109.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.6634
    Cell Significance Index: 667.8900
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 5.3061
    Cell Significance Index: 16.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4641
    Cell Significance Index: -9.7700
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 4.2950
    Cell Significance Index: 11.3300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.5930
    Cell Significance Index: 55.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.4270
    Cell Significance Index: 85.6700
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.0411
    Cell Significance Index: 13.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8922
    Cell Significance Index: 41.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2811
    Cell Significance Index: 37.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.2713
    Cell Significance Index: 22.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.1210
    Cell Significance Index: 29.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.0211
    Cell Significance Index: 11.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9274
    Cell Significance Index: 59.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9099
    Cell Significance Index: 41.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8577
    Cell Significance Index: 163.2200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.6762
    Cell Significance Index: 10.1900
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.4702
    Cell Significance Index: 2.8400
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.4642
    Cell Significance Index: 1.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4328
    Cell Significance Index: 390.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4065
    Cell Significance Index: 40.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3863
    Cell Significance Index: 7.1400
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.2623
    Cell Significance Index: 2.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2221
    Cell Significance Index: 36.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0961
    Cell Significance Index: 9.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0779
    Cell Significance Index: 8.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0315
    Cell Significance Index: 23.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0262
    Cell Significance Index: 16.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0125
    Cell Significance Index: 5.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0077
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0094
    Cell Significance Index: -7.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0152
    Cell Significance Index: -28.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0207
    Cell Significance Index: -38.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0215
    Cell Significance Index: -0.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0240
    Cell Significance Index: -36.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0270
    Cell Significance Index: -15.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0283
    Cell Significance Index: -38.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0501
    Cell Significance Index: -27.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0503
    Cell Significance Index: -36.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0519
    Cell Significance Index: -10.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0567
    Cell Significance Index: -35.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0674
    Cell Significance Index: -3.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0793
    Cell Significance Index: -35.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0819
    Cell Significance Index: -5.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0868
    Cell Significance Index: -31.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1020
    Cell Significance Index: -20.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1076
    Cell Significance Index: -19.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1279
    Cell Significance Index: -21.8400
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.1419
    Cell Significance Index: -0.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1423
    Cell Significance Index: -28.5500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1445
    Cell Significance Index: -5.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1466
    Cell Significance Index: -8.9900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1512
    Cell Significance Index: -1.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1523
    Cell Significance Index: -19.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1583
    Cell Significance Index: -18.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1760
    Cell Significance Index: -8.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1799
    Cell Significance Index: -10.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1935
    Cell Significance Index: -23.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2000
    Cell Significance Index: -25.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2011
    Cell Significance Index: -27.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2157
    Cell Significance Index: -6.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2279
    Cell Significance Index: -26.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2389
    Cell Significance Index: -34.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2582
    Cell Significance Index: -4.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2911
    Cell Significance Index: -30.3100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3390
    Cell Significance Index: -8.6600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3598
    Cell Significance Index: -15.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4249
    Cell Significance Index: -32.6100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.4424
    Cell Significance Index: -6.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4465
    Cell Significance Index: -33.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4701
    Cell Significance Index: -37.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5250
    Cell Significance Index: -11.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5613
    Cell Significance Index: -31.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5743
    Cell Significance Index: -16.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5787
    Cell Significance Index: -30.0600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.5794
    Cell Significance Index: -9.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5914
    Cell Significance Index: -31.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6348
    Cell Significance Index: -40.0100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.6388
    Cell Significance Index: -15.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6595
    Cell Significance Index: -24.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6618
    Cell Significance Index: -30.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6692
    Cell Significance Index: -15.4600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.7232
    Cell Significance Index: -9.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7246
    Cell Significance Index: -32.0500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.7383
    Cell Significance Index: -6.2400
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.7956
    Cell Significance Index: -8.6900
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.7974
    Cell Significance Index: -8.2600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.8169
    Cell Significance Index: -8.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8445
    Cell Significance Index: -31.9800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.8577
    Cell Significance Index: -16.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The HLA DQA1 gene is part of the major histocompatibility complex (MHC) class II, which is responsible for presenting peptide antigens to CD4+ T-cells. The DQ alpha 1 chain is one of the two chains that make up the HLA class II molecule, the other being the DQ beta 1 chain. The HLA DQA1 gene is located on chromosome 6p21.3 and has a length of approximately 10 kb. The gene contains 10 exons that code for the DQ alpha 1 chain, which is composed of 75 amino acids. **Pathways and Functions** The HLA DQA1 gene is involved in several key pathways and functions, including: 1. **Antigen Presentation**: The HLA DQA1 gene plays a critical role in the presentation of peptide antigens to CD4+ T-cells. The DQ alpha 1 chain is responsible for binding to the peptide antigen and presenting it to the T-cell receptor (TCR) on the surface of the T-cell. 2. **Activation of T-cells**: The presentation of peptide antigens by the HLA DQA1 gene leads to the activation of CD4+ T-cells, which is essential for the initiation of an immune response. 3. **Costimulation**: The HLA DQA1 gene is also involved in costimulation, which is the second signal required for T-cell activation. The DQ alpha 1 chain interacts with CD80 and CD86 molecules on the surface of antigen-presenting cells, leading to the activation of CD4+ T-cells. 4. **Cytokine Signaling**: The HLA DQA1 gene is involved in cytokine signaling, which is the communication between immune cells that leads to the activation of immune responses. **Clinical Significance** Dysregulation of the HLA DQA1 gene has been implicated in various autoimmune and inflammatory diseases, including: 1. **Autoimmune Diseases**: The HLA DQA1 gene has been associated with several autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and multiple sclerosis. 2. **Infectious Diseases**: The HLA DQA1 gene has been implicated in the susceptibility to certain infectious diseases, including tuberculosis and HIV. 3. **Transplantation Rejection**: The HLA DQA1 gene plays a critical role in the rejection of transplanted organs, as the immune system recognizes the HLA molecules on the surface of the transplanted organ as foreign. In conclusion, the HLA DQA1 gene plays a crucial role in the adaptive immune response, and dysregulation of this gene has been implicated in various autoimmune and inflammatory diseases. Further research is needed to fully understand the mechanisms by which the HLA DQA1 gene regulates the immune response and to develop effective therapeutic strategies for the treatment of diseases associated with HLA DQA1 dysfunction.

Genular Protein ID: 4198346093

Symbol: DQA1_HUMAN

Name: HLA class II histocompatibility antigen, DQ alpha 1 chain

UniProtKB Accession Codes:

P01909 O19630 O19706 P01907 P01908 P04225 P04226 P05536 P79553 Q06751 Q29876 Q29994 Q2Q6Y6 Q2Q6Y7 Q2Q6Y8 Q2WCM3 Q30064 Q30067 Q30068 Q30070 Q30071 Q30072 Q30073 Q30086 Q30101 Q5Y7D5 Q5Y7F5 Q6ICU6 Q6PR46 Q6QDB1 Q860W2 Q860W4 Q9BD37 Q9TPM3 Q9UM31

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 2 BioGRID-ORCS 1 BioMuta 1 CDD 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 75 EMDB 1 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneReviews 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 26 PDBsum 26 PIR 7 PRO 1 PROSITE 2 PathwayCommons 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6415485

Title: The heavy chain of human B-cell alloantigen HLA-DS has a variable N-terminal region and a constant immunoglobulin-like region.

PubMed ID: 6415485

DOI: 10.1038/305813a0

PubMed ID: 6585297

Title: Both alpha and beta chains of HLA-DC class II histocompatibility antigens display extensive polymorphism in their amino-terminal domains.

PubMed ID: 6585297

DOI: 10.1002/j.1460-2075.1984.tb01826.x

PubMed ID: 6584734

Title: Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes.

PubMed ID: 6584734

DOI: 10.1038/308327a0

PubMed ID: 3584986

Title: Complete sequence of the HLA DQ alpha and DQ beta cDNA from a DR5/DQw3 cell line.

PubMed ID: 3584986

PubMed ID: 9271631

Title: HLA class II haplotype and sequence analysis support a role for DQ in narcolepsy.

PubMed ID: 9271631

DOI: 10.1007/s002510050295

PubMed ID: 16140993

Title: Ancient haplotypes of the HLA Class II region.

PubMed ID: 16140993

DOI: 10.1101/gr.3554305

PubMed ID: 16866887

Title: Four novel human leukocyte antigen-DQA1 alleles identified in the Korean population.

PubMed ID: 16866887

DOI: 10.1111/j.1399-0039.2006.00645.x

PubMed ID: 3036828

Title: Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes.

PubMed ID: 3036828

DOI: 10.1016/s0021-9258(18)47482-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3879967

Title: Nucleotide sequence of an HLA-DQ alpha chain derived from a DRw9 cell line: genetic and evolutionary implications.

PubMed ID: 3879967

DOI: 10.1073/pnas.82.10.3420

PubMed ID: 3259543

Title: MHC class II sequences of an HLA-DR2 narcoleptic.

PubMed ID: 3259543

DOI: 10.1007/bf00364432

PubMed ID: 8929711

Title: Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM).

PubMed ID: 8929711

DOI: 10.1111/j.1399-0039.1996.tb02512.x

PubMed ID: 6576979

Title: Primary structure of human class II histocompatibility antigens 3rd communication. Amino acid sequence comparison between DR and DC subclass antigens derived from a lymphoblastoid B cell line homozygous at the HLA loci (HLA-A3,3; B7,7; Dw2,2; DR2,2: MT1,1; Dc1,1: MB1,1).

PubMed ID: 6576979

DOI: 10.1515/bchm2.1983.364.1.749

PubMed ID: 2493052

Title: Molecular analysis of the HLA class II genes in two DRw6-related haplotypes, DRw13 DQw1 and DRw14 DQw3.

PubMed ID: 2493052

PubMed ID: 15853899

Title: High-resolution genotyping of HLA-DQA1 in the GoKinD study and identification of novel alleles HLA-DQA1*040102, HLA-DQA1*0402 and HLA-DQA1*0404.

PubMed ID: 15853899

DOI: 10.1111/j.1399-0039.2005.00389.x

PubMed ID: 3372263

Title: Sequence analysis of HLA class II genes from insulin-dependent diabetic individuals.

PubMed ID: 3372263

DOI: 10.1016/0198-8859(88)90034-1

PubMed ID: 10395113

Title: Identification of a novel HLA-DQA1 allele (DQA1*0106) by sequence-based DQA1 typing.

PubMed ID: 10395113

DOI: 10.1034/j.1399-0039.1999.530613.x

PubMed ID: 1362295

Title: HLA class II nucleotide sequences, 1992.

PubMed ID: 1362295

DOI: 10.1111/j.1399-0039.1992.tb02050.x

PubMed ID: 3129499

Title: Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes.

PubMed ID: 3129499

PubMed ID: 6815651

Title: cDNA clone for the heavy chain of the human B cell alloantigen DC1: strong sequence homology to the HLA-DR heavy chain.

PubMed ID: 6815651

DOI: 10.1073/pnas.79.20.6337

PubMed ID: 2513578

Title: Ancient roots for polymorphism at the HLA-DQ alpha locus in primates.

PubMed ID: 2513578

DOI: 10.1073/pnas.86.24.9986

PubMed ID: 2888727

Title: Allelic forms of the alpha- and beta-chain genes encoding DQw1-positive heterodimers.

PubMed ID: 2888727

DOI: 10.1007/bf00346523

PubMed ID: 8598037

Title: Invariant chain structure and MHC class II function.

PubMed ID: 8598037

DOI: 10.1016/s0092-8674(00)81025-9

PubMed ID: 11684289

Title: Presentation of antigens by MHC class II molecules: getting the most out of them.

PubMed ID: 11684289

DOI: 10.1016/s0161-5890(01)00069-4

PubMed ID: 17241953

Title: Autophagy in MHC class II presentation: sampling from within.

PubMed ID: 17241953

DOI: 10.1016/j.immuni.2007.01.005

PubMed ID: 18046453

Title: MHC class II molecules on the move for successful antigen presentation.

PubMed ID: 18046453

DOI: 10.1038/sj.emboj.7601945

PubMed ID: 19092054

Title: MHC class II transport at a glance.

PubMed ID: 19092054

DOI: 10.1242/jcs.035089

PubMed ID: 19533806

Title: CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.

PubMed ID: 19533806

DOI: 10.3748/wjg.15.2855

PubMed ID: 11376336

Title: Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes.

PubMed ID: 11376336

DOI: 10.1038/88694

PubMed ID: 14769912

Title: Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy.

PubMed ID: 14769912

DOI: 10.1073/pnas.0308458100

PubMed ID: 15020763

Title: Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease.

PubMed ID: 15020763

DOI: 10.1073/pnas.0306885101

PubMed ID: 17629515

Title: A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease.

PubMed ID: 17629515

DOI: 10.1016/j.immuni.2007.05.015

Sequence Information:

  • Length: 254
  • Mass: 27805
  • Checksum: 84E12B5A80E2A028
  • Sequence:
    • MILNKALMLG ALALTTVMSP CGGEDIVADH VASYGVNLYQ SYGPSGQYTH EFDGDEQFYV 
DLGRKETVWC LPVLRQFRFD PQFALTNIAV LKHNLNSLIK RSNSTAATNE VPEVTVFSKS 
PVTLGQPNIL ICLVDNIFPP VVNITWLSNG HSVTEGVSET SFLSKSDHSF FKISYLTLLP 
SAEESYDCKV EHWGLDKPLL KHWEPEIPAP MSELTETVVC ALGLSVGLVG IVVGTVFIIR 
GLRSVGASRH QGPL

Genular Protein ID: 3783762636

Symbol: A0A173ADG5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A173ADG5

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 45 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 1 InterPro 9 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SAM 2 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 21199956

Title: A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC.

PubMed ID: 21199956

DOI: 10.1084/jem.20100725

PubMed ID: 30337930

Title: Reference Grade Characterization of Polymorphisms in Full-Length HLA Class I and II Genes With Short-Read Sequencing on the ION PGM System and Long-Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio Platform.

PubMed ID: 30337930

DOI: .3389/fimmu.2018.02294

PubMed ID: 31576659

Title: Recognition of the novel HLA-A*11:01:01:25 allele in the tribal population of Nagaland, North-East India.

PubMed ID: 31576659

Sequence Information:

  • Length: 255
  • Mass: 28000
  • Checksum: BE0CF3CED76CBAA3
  • Sequence:
    • MILNKALLLG ALALTTVMSP CGGEDIVADH VASCGVNLYQ FYGPSGQYTH EFDGDEQFYV 
DLERKETAWR WPEFSKFGGF DPQGALRNMA VAKHNLNIMI KRYNSTAATN EVPEVTVFSK 
SPVTLGQPNT LICLVDNIFP PVVNITWLSN GQSVTEGVSE TSFLSKSDHS FFKISYLTFL 
PSADEIYDCK VEHWGLDQPL LKHWEPEIPA PMSELTETVV CALGLSVGLM GIVVGTVFII 
QGLRSVGASR HQGPL

Genular Protein ID: 4033336679

Symbol: Q8MH44_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8MH44

Database IDs:

BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 RefSeq 1

Citations:

PubMed ID: 15900489

Title: A new splicing acceptor site and poly(A)+ sequence signal within DQA1*0401 and DQA1*0501 mRNA 3'UTR contribute to increase the extraordinary diversity of mRNA isoforms.

PubMed ID: 15900489

DOI: 10.1007/s00251-005-0769-3

Sequence Information:

  • Length: 14
  • Mass: 1435
  • Checksum: C5EEA0FE15DF8EBD
  • Sequence:
    • GLRSVGASRH QGPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.