Details for: HLA DQA1

Gene ID: 3117

Symbol: HLA DQA1

Ensembl ID: ENSG00000196735

Description: major histocompatibility complex, class II, DQ alpha 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.99
    Marker Score: 3026.5
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 4.45
    Marker Score: 3142
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.81
    Marker Score: 3582
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 3.76
    Marker Score: 7875
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.74
    Marker Score: 3686
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.54
    Marker Score: 2156
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.15
    Marker Score: 2814
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 3.09
    Marker Score: 1863
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.05
    Marker Score: 9043
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.98
    Marker Score: 7714
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.92
    Marker Score: 1033
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.92
    Marker Score: 5085
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.8
    Marker Score: 2115
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.78
    Marker Score: 71201
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.69
    Marker Score: 3080
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.62
    Marker Score: 3799
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.56
    Marker Score: 1260
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.51
    Marker Score: 3011
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.37
    Marker Score: 563
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.32
    Marker Score: 4528
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.27
    Marker Score: 528
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 2.24
    Marker Score: 516
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 2.24
    Marker Score: 2426
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.08
    Marker Score: 1434
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.95
    Marker Score: 1947
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.9
    Marker Score: 3123
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.82
    Marker Score: 2202
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.81
    Marker Score: 7507
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.76
    Marker Score: 1848
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.71
    Marker Score: 882
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.65
    Marker Score: 3982
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.62
    Marker Score: 565
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.57
    Marker Score: 1138
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.55
    Marker Score: 1029.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.55
    Marker Score: 15354
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.55
    Marker Score: 3938
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.52
    Marker Score: 2580
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.51
    Marker Score: 1513
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.5
    Marker Score: 879
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.48
    Marker Score: 17256
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.46
    Marker Score: 9541
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.45
    Marker Score: 367
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.43
    Marker Score: 1050
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.39
    Marker Score: 8457
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.38
    Marker Score: 796
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.38
    Marker Score: 576
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.36
    Marker Score: 1382
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 1.33
    Marker Score: 398
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.27
    Marker Score: 1210
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.25
    Marker Score: 907
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.15
    Marker Score: 396
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.13
    Marker Score: 11491
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.13
    Marker Score: 298
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4744
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.13
    Marker Score: 562
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.12
    Marker Score: 1800
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.12
    Marker Score: 1127
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.09
    Marker Score: 5732
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.08
    Marker Score: 3024
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.07
    Marker Score: 6836
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.05
    Marker Score: 361
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.02
    Marker Score: 2775
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.02
    Marker Score: 699
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.01
    Marker Score: 534
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1
    Marker Score: 240
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.99
    Marker Score: 411
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.98
    Marker Score: 234
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.96
    Marker Score: 517
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.96
    Marker Score: 448.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.95
    Marker Score: 288
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.95
    Marker Score: 1258
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.94
    Marker Score: 467
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.92
    Marker Score: 425
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.91
    Marker Score: 1015
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.91
    Marker Score: 231
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 363
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5157
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.88
    Marker Score: 233
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.87
    Marker Score: 338
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5255
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.86
    Marker Score: 758
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.86
    Marker Score: 301
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.86
    Marker Score: 1012
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.86
    Marker Score: 721
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.85
    Marker Score: 533
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.85
    Marker Score: 47504
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.85
    Marker Score: 3140
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.84
    Marker Score: 845
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.84
    Marker Score: 2102
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 633.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.81
    Marker Score: 5387
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.8
    Marker Score: 247
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.79
    Marker Score: 258
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.79
    Marker Score: 503

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Other Information

**Key characteristics**: - The DQA1 gene is located on chromosome 15q21.1. - It is a member of the HLA class II histocompatibility complex. - The protein is expressed in high levels in myeloid dendritic cells and some immune cells. - It is involved in the regulation of adaptive immune responses. **Pathways and functions**: - The DQA1 protein is a key component of the adaptive immune response. - It is involved in the recognition of MHC class II molecules by T cells. - It is expressed on the surface of myeloid dendritic cells and some immune cells. - It is involved in the activation of T cells and the induction of an adaptive immune response. - It is also involved in the regulation of autoimmune responses. **Clinical significance**: - Mutations in the DQA1 gene have been linked to the development of several autoimmune diseases, including systemic sclerosis, rheumatoid arthritis, and psoriasis. - The DQA1 protein is a potential target for the treatment of autoimmune diseases. - Antibodies against DQA1 have been shown to be effective in reducing inflammation and disease activity in animal models of autoimmune diseases.

Genular Protein ID: 4198346093

Symbol: DQA1_HUMAN

Name: HLA class II histocompatibility antigen, DQ alpha 1 chain

UniProtKB Accession Codes:

P01909 O19630 O19706 P01907 P01908 P04225 P04226 P05536 P79553 Q06751 Q29876 Q29994 Q2Q6Y6 Q2Q6Y7 Q2Q6Y8 Q2WCM3 Q30064 Q30067 Q30068 Q30070 Q30071 Q30072 Q30073 Q30086 Q30101 Q5Y7D5 Q5Y7F5 Q6ICU6 Q6PR46 Q6QDB1 Q860W2 Q860W4 Q9BD37 Q9TPM3 Q9UM31

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 2 BioGRID-ORCS 1 BioMuta 1 CDD 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 75 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneReviews 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 21 PIR 7 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6415485

Title: The heavy chain of human B-cell alloantigen HLA-DS has a variable N-terminal region and a constant immunoglobulin-like region.

PubMed ID: 6415485

DOI: 10.1038/305813a0

PubMed ID: 6585297

Title: Both alpha and beta chains of HLA-DC class II histocompatibility antigens display extensive polymorphism in their amino-terminal domains.

PubMed ID: 6585297

DOI: 10.1002/j.1460-2075.1984.tb01826.x

PubMed ID: 6584734

Title: Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes.

PubMed ID: 6584734

DOI: 10.1038/308327a0

PubMed ID: 3584986

Title: Complete sequence of the HLA DQ alpha and DQ beta cDNA from a DR5/DQw3 cell line.

PubMed ID: 3584986

PubMed ID: 9271631

Title: HLA class II haplotype and sequence analysis support a role for DQ in narcolepsy.

PubMed ID: 9271631

DOI: 10.1007/s002510050295

PubMed ID: 16140993

Title: Ancient haplotypes of the HLA Class II region.

PubMed ID: 16140993

DOI: 10.1101/gr.3554305

PubMed ID: 16866887

Title: Four novel human leukocyte antigen-DQA1 alleles identified in the Korean population.

PubMed ID: 16866887

DOI: 10.1111/j.1399-0039.2006.00645.x

PubMed ID: 3036828

Title: Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes.

PubMed ID: 3036828

DOI: 10.1016/s0021-9258(18)47482-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3879967

Title: Nucleotide sequence of an HLA-DQ alpha chain derived from a DRw9 cell line: genetic and evolutionary implications.

PubMed ID: 3879967

DOI: 10.1073/pnas.82.10.3420

PubMed ID: 3259543

Title: MHC class II sequences of an HLA-DR2 narcoleptic.

PubMed ID: 3259543

DOI: 10.1007/bf00364432

PubMed ID: 8929711

Title: Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM).

PubMed ID: 8929711

DOI: 10.1111/j.1399-0039.1996.tb02512.x

PubMed ID: 6576979

Title: Primary structure of human class II histocompatibility antigens 3rd communication. Amino acid sequence comparison between DR and DC subclass antigens derived from a lymphoblastoid B cell line homozygous at the HLA loci (HLA-A3,3; B7,7; Dw2,2; DR2,2: MT1,1; Dc1,1: MB1,1).

PubMed ID: 6576979

DOI: 10.1515/bchm2.1983.364.1.749

PubMed ID: 2493052

Title: Molecular analysis of the HLA class II genes in two DRw6-related haplotypes, DRw13 DQw1 and DRw14 DQw3.

PubMed ID: 2493052

PubMed ID: 15853899

Title: High-resolution genotyping of HLA-DQA1 in the GoKinD study and identification of novel alleles HLA-DQA1*040102, HLA-DQA1*0402 and HLA-DQA1*0404.

PubMed ID: 15853899

DOI: 10.1111/j.1399-0039.2005.00389.x

PubMed ID: 3372263

Title: Sequence analysis of HLA class II genes from insulin-dependent diabetic individuals.

PubMed ID: 3372263

DOI: 10.1016/0198-8859(88)90034-1

PubMed ID: 10395113

Title: Identification of a novel HLA-DQA1 allele (DQA1*0106) by sequence-based DQA1 typing.

PubMed ID: 10395113

DOI: 10.1034/j.1399-0039.1999.530613.x

PubMed ID: 1362295

Title: HLA class II nucleotide sequences, 1992.

PubMed ID: 1362295

DOI: 10.1111/j.1399-0039.1992.tb02050.x

PubMed ID: 3129499

Title: Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes.

PubMed ID: 3129499

PubMed ID: 6815651

Title: cDNA clone for the heavy chain of the human B cell alloantigen DC1: strong sequence homology to the HLA-DR heavy chain.

PubMed ID: 6815651

DOI: 10.1073/pnas.79.20.6337

PubMed ID: 2513578

Title: Ancient roots for polymorphism at the HLA-DQ alpha locus in primates.

PubMed ID: 2513578

DOI: 10.1073/pnas.86.24.9986

PubMed ID: 2888727

Title: Allelic forms of the alpha- and beta-chain genes encoding DQw1-positive heterodimers.

PubMed ID: 2888727

DOI: 10.1007/bf00346523

PubMed ID: 8598037

Title: Invariant chain structure and MHC class II function.

PubMed ID: 8598037

DOI: 10.1016/s0092-8674(00)81025-9

PubMed ID: 11684289

Title: Presentation of antigens by MHC class II molecules: getting the most out of them.

PubMed ID: 11684289

DOI: 10.1016/s0161-5890(01)00069-4

PubMed ID: 17241953

Title: Autophagy in MHC class II presentation: sampling from within.

PubMed ID: 17241953

DOI: 10.1016/j.immuni.2007.01.005

PubMed ID: 18046453

Title: MHC class II molecules on the move for successful antigen presentation.

PubMed ID: 18046453

DOI: 10.1038/sj.emboj.7601945

PubMed ID: 19092054

Title: MHC class II transport at a glance.

PubMed ID: 19092054

DOI: 10.1242/jcs.035089

PubMed ID: 19533806

Title: CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.

PubMed ID: 19533806

DOI: 10.3748/wjg.15.2855

PubMed ID: 11376336

Title: Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes.

PubMed ID: 11376336

DOI: 10.1038/88694

PubMed ID: 14769912

Title: Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy.

PubMed ID: 14769912

DOI: 10.1073/pnas.0308458100

PubMed ID: 15020763

Title: Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease.

PubMed ID: 15020763

DOI: 10.1073/pnas.0306885101

PubMed ID: 17629515

Title: A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease.

PubMed ID: 17629515

DOI: 10.1016/j.immuni.2007.05.015

Sequence Information:

  • Length: 254
  • Mass: 27805
  • Checksum: 84E12B5A80E2A028
  • Sequence:
    • MILNKALMLG ALALTTVMSP CGGEDIVADH VASYGVNLYQ SYGPSGQYTH EFDGDEQFYV 
DLGRKETVWC LPVLRQFRFD PQFALTNIAV LKHNLNSLIK RSNSTAATNE VPEVTVFSKS 
PVTLGQPNIL ICLVDNIFPP VVNITWLSNG HSVTEGVSET SFLSKSDHSF FKISYLTLLP 
SAEESYDCKV EHWGLDKPLL KHWEPEIPAP MSELTETVVC ALGLSVGLVG IVVGTVFIIR 
GLRSVGASRH QGPL

Genular Protein ID: 4033336679

Symbol: Q8MH44_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8MH44

Database IDs:

BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Genevisible 1 GenomeRNAi 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 RefSeq 1

Citations:

PubMed ID: 15900489

Title: A new splicing acceptor site and poly(A)+ sequence signal within DQA1*0401 and DQA1*0501 mRNA 3'UTR contribute to increase the extraordinary diversity of mRNA isoforms.

PubMed ID: 15900489

DOI: 10.1007/s00251-005-0769-3

Sequence Information:

  • Length: 14
  • Mass: 1435
  • Checksum: C5EEA0FE15DF8EBD
  • Sequence:
    • GLRSVGASRH QGPL

Genular Protein ID: 3783762636

Symbol: A0A173ADG5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A173ADG5

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 46 ExpressionAtlas 1 GO 5 Gene3D 1 GenomeRNAi 1 GlyCosmos 1 InterPro 8 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SAM 2 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 21199956

Title: A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC.

PubMed ID: 21199956

DOI: 10.1084/jem.20100725

PubMed ID: 30337930

Title: Reference Grade Characterization of Polymorphisms in Full-Length HLA Class I and II Genes With Short-Read Sequencing on the ION PGM System and Long-Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio Platform.

PubMed ID: 30337930

DOI: .3389/fimmu.2018.02294

PubMed ID: 31576659

Title: Recognition of the novel HLA-A*11:01:01:25 allele in the tribal population of Nagaland, North-East India.

PubMed ID: 31576659

Sequence Information:

  • Length: 255
  • Mass: 28000
  • Checksum: BE0CF3CED76CBAA3
  • Sequence:
    • MILNKALLLG ALALTTVMSP CGGEDIVADH VASCGVNLYQ FYGPSGQYTH EFDGDEQFYV 
DLERKETAWR WPEFSKFGGF DPQGALRNMA VAKHNLNIMI KRYNSTAATN EVPEVTVFSK 
SPVTLGQPNT LICLVDNIFP PVVNITWLSN GQSVTEGVSE TSFLSKSDHS FFKISYLTFL 
PSADEIYDCK VEHWGLDQPL LKHWEPEIPA PMSELTETVV CALGLSVGLM GIVVGTVFII 
QGLRSVGASR HQGPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.