Details for: HLA DQB1

Gene ID: 3119

Symbol: HLA DQB1

Ensembl ID: ENSG00000179344

Description: major histocompatibility complex, class II, DQ beta 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.91
    Marker Score: 2979
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 4.68
    Marker Score: 3300
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4.6
    Marker Score: 9640.5
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 4.58
    Marker Score: 4795
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4.08
    Marker Score: 4020
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.47
    Marker Score: 3974
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.47
    Marker Score: 2109
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 3.16
    Marker Score: 1903
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 3.09
    Marker Score: 8015.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3
    Marker Score: 2680
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.99
    Marker Score: 1059
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.93
    Marker Score: 75055
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.89
    Marker Score: 5623
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.84
    Marker Score: 2674
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.84
    Marker Score: 8419
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.7
    Marker Score: 4703
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.64
    Marker Score: 1999
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.52
    Marker Score: 16434
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.39
    Marker Score: 3459.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.36
    Marker Score: 3994
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.36
    Marker Score: 8736
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.31
    Marker Score: 550
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.31
    Marker Score: 3790
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 2.23
    Marker Score: 513
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 2.2
    Marker Score: 2386
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.19
    Marker Score: 11489
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.17
    Marker Score: 5521
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.16
    Marker Score: 3477
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.16
    Marker Score: 25116
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.13
    Marker Score: 1051
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.12
    Marker Score: 118759
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.1
    Marker Score: 489
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.05
    Marker Score: 12450
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.02
    Marker Score: 3120
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.94
    Marker Score: 1283
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.93
    Marker Score: 1923
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.9
    Marker Score: 1311
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.88
    Marker Score: 1502
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.87
    Marker Score: 4524
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.86
    Marker Score: 18379
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.84
    Marker Score: 7627
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.82
    Marker Score: 2199
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.79
    Marker Score: 18124
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.76
    Marker Score: 734
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.68
    Marker Score: 586
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.54
    Marker Score: 1821.5
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.53
    Marker Score: 894
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.53
    Marker Score: 4278
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.52
    Marker Score: 1548
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.49
    Marker Score: 577
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.49
    Marker Score: 1491
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.48
    Marker Score: 450
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.47
    Marker Score: 1068
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.46
    Marker Score: 503
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166855
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.44
    Marker Score: 9215
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.43
    Marker Score: 1046
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 1.39
    Marker Score: 417
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.36
    Marker Score: 1170
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.34
    Marker Score: 321
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.29
    Marker Score: 1089
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.29
    Marker Score: 3512
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.28
    Marker Score: 3197
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.28
    Marker Score: 1222
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.27
    Marker Score: 655
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.25
    Marker Score: 329
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.19
    Marker Score: 1195
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.19
    Marker Score: 304
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 1.15
    Marker Score: 616
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.14
    Marker Score: 600
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.14
    Marker Score: 655
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.12
    Marker Score: 4699
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.09
    Marker Score: 1214
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.08
    Marker Score: 739
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.08
    Marker Score: 483
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.06
    Marker Score: 902
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.06
    Marker Score: 2402
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.06
    Marker Score: 5077
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.05
    Marker Score: 14122
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.04
    Marker Score: 265
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.04
    Marker Score: 519
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.04
    Marker Score: 516
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.04
    Marker Score: 690
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.02
    Marker Score: 915
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1
    Marker Score: 467
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.99
    Marker Score: 998
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30391
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.97
    Marker Score: 1946
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.97
    Marker Score: 2034
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.97
    Marker Score: 231
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.96
    Marker Score: 471
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.95
    Marker Score: 358
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2401
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.94
    Marker Score: 539
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.94
    Marker Score: 1244
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.93
    Marker Score: 568
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.92
    Marker Score: 1075
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735

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Other Information

**Key characteristics** * The DQB1 gene is a member of the HLA class II family of MHC genes. * It is expressed on myeloid dendritic cells, CD14-low monocyte, CD38-negative naive B cell, and thymocyte. * It is not expressed on CD16-positive monocyte, CD1c-positive myeloid dendritic cell, and IgG-negative class switched memory B cell. * The DQB1 protein is a type I MHC class II protein, which means that it is expressed on the surface of professional antigen-presenting cells. * The DQB1 protein is a heterodimeric protein, meaning that it consists of two subunits that are non-covalently associated. **Pathways and functions** The DQB1 gene is involved in the adaptive immune response, antigen processing and presentation of exogenous peptide antigen via mhc class ii, cytokine signaling in immune system, Golgi membrane, humoral immune response, immune response, immune system, interferon gamma signaling, interferon signaling, lysosomal membrane, Mhc class ii protein complex binding, Mhc class ii receptor activity, peptide antigen assembly with mhc class ii protein complex, peptide antigen binding, positive regulation of immune response, positive regulation of t cell activation, protein binding, and T cell receptor signaling pathway. **Clinical significance** The DQB1 gene is a tumor antigen for several types of cancer, including melanoma, lung cancer, and breast cancer. Immunotherapy targeting the DQB1 gene has been shown to be effective in treating these cancers.

Genular Protein ID: 2267932439

Symbol: DQB1_HUMAN

Name: HLA class II histocompatibility antigen, DQ beta 1 chain

UniProtKB Accession Codes:

P01920 A1KR27 A2RPH3 A4Q9R4 A4USG2 A4USG5 A6N8I7 A9YQA0 B0S7Y7 B1A0K6 B1GXI3 B3VLT3 B5BLN7 B7VU69 C0MQ34 C0MQ35 C8ZL52 C8ZLJ8 C8ZLJ9 C9DRQ3 O19708 O19713 O19724 O62861 O78046 O78221 O78223 O98034 O98201 P01917 P01918 P01919 P03992 P05537 P79482 P79526 P79544 P79551 Q08GC8 Q09035 Q0E4V9 Q1M312 Q29731 Q29877 Q29884 Q29915 Q29966 Q2P9N3 Q2QK85 Q30061 Q30075 Q30076 Q30080 Q30081 Q30082 Q30083 Q30084 Q30089 Q30095 Q31633 Q38I47 Q45UE3 Q4QZB5 Q53I44 Q564J6 Q5G841 Q5ISH1 Q5ISH3 Q5W1E1 Q5Y7G8 Q643R4 Q6B9X1 Q70VH8 Q7YP69 Q8HWH0 Q8MH58 Q8SNB4 Q8SND1 Q8SP70 Q8WMA3 Q9BD17 Q9MYH2 Q9TPA9 Q9XRY6 Q9XRY7 Q9XRZ2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CPTC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 100 Ensembl 6 EvolutionaryTrace 1 GO 23 Gene3D 1 GeneCards 1 GeneReviews 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 Orphanet 8 PANTHER 2 PDB 11 PDBsum 9 PIR 11 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 7 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 UCSC 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6415003

Title: Molecular analysis of human class II transplantation antigens and their genes.

PubMed ID: 6415003

DOI: 10.1016/0198-8859(83)90087-3

PubMed ID: 6954511

Title: Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: similarities with immunoglobulins and HLA-A, -B, and -C antigens.

PubMed ID: 6954511

DOI: 10.1073/pnas.79.12.3687

PubMed ID: 6316358

Title: Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC beta gene.

PubMed ID: 6316358

DOI: 10.1073/pnas.80.23.7313

PubMed ID: 6206493

Title: Cloning and sequence analysis of the human major histocompatibility complex gene DC-3 beta.

PubMed ID: 6206493

DOI: 10.1073/pnas.81.16.5199

PubMed ID: 2998758

Title: DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression.

PubMed ID: 2998758

DOI: 10.1002/j.1460-2075.1985.tb04012.x

PubMed ID: 2888727

Title: Allelic forms of the alpha- and beta-chain genes encoding DQw1-positive heterodimers.

PubMed ID: 2888727

DOI: 10.1007/bf00346523

PubMed ID: 3036828

Title: Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes.

PubMed ID: 3036828

DOI: 10.1016/s0021-9258(18)47482-0

PubMed ID: 3584986

Title: Complete sequence of the HLA DQ alpha and DQ beta cDNA from a DR5/DQw3 cell line.

PubMed ID: 3584986

PubMed ID: 3259543

Title: MHC class II sequences of an HLA-DR2 narcoleptic.

PubMed ID: 3259543

DOI: 10.1007/bf00364432

PubMed ID: 2050393

Title: Full length beta chain cDNAs of DQw9 and DQw8 molecules encode proteins that differ only at amino acid 57.

PubMed ID: 2050393

DOI: 10.1007/bf00216702

PubMed ID: 8988543

Title: Complete coding region of the new HLA-DQB1*0612 allele, obtained by RT-PCR.

PubMed ID: 8988543

DOI: 10.1111/j.1399-0039.1996.tb02674.x

PubMed ID: 9271631

Title: HLA class II haplotype and sequence analysis support a role for DQ in narcolepsy.

PubMed ID: 9271631

DOI: 10.1007/s002510050295

PubMed ID: 16140993

Title: Ancient haplotypes of the HLA Class II region.

PubMed ID: 16140993

DOI: 10.1101/gr.3554305

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2925231

Title: Sequence analysis of HLA class II domains: characterization of the DQw3 family of DQB genes.

PubMed ID: 2925231

DOI: 10.1007/bf00373644

PubMed ID: 2494138

Title: No difference in the nucleotide sequence of the DQ beta beta 1 domain between narcoleptic and healthy individuals with DR2,Dw2.

PubMed ID: 2494138

DOI: 10.1016/0198-8859(89)90058-x

PubMed ID: 2777341

Title: Complete sequences of DQA1 and DQB1 cDNA clones corresponding to the DQw4 specificity.

PubMed ID: 2777341

DOI: 10.1007/bf02421214

PubMed ID: 8929711

Title: Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM).

PubMed ID: 8929711

DOI: 10.1111/j.1399-0039.1996.tb02512.x

PubMed ID: 11098940

Title: Identification by sequencing based typing and complete coding region analysis of three new HLA class II alleles: DRB3*0210, DRB3*0211 and DQB1*0310.

PubMed ID: 11098940

DOI: 10.1034/j.1399-0039.2000.560412.x

PubMed ID: 7928445

Title: HLA-DQB1*0305 and -DQB1*0304 alleles among Sardinians. Evolutionary and practical implications for oligotyping.

PubMed ID: 7928445

DOI: 10.1016/0198-8859(94)90060-4

PubMed ID: 6576979

Title: Primary structure of human class II histocompatibility antigens 3rd communication. Amino acid sequence comparison between DR and DC subclass antigens derived from a lymphoblastoid B cell line homozygous at the HLA loci (HLA-A3,3; B7,7; Dw2,2; DR2,2: MT1,1; Dc1,1: MB1,1).

PubMed ID: 6576979

DOI: 10.1515/bchm2.1983.364.1.749

PubMed ID: 2212675

Title: Two divergent routes of evolution gave rise to the DRw13 haplotypes.

PubMed ID: 2212675

PubMed ID: 3020127

Title: Analysis of DR-beta and DQ-beta chain cDNA clones from a DR7 haplotype.

PubMed ID: 3020127

PubMed ID: 17868257

Title: Identification of a novel allele HLA-DQB1*0622.

PubMed ID: 17868257

DOI: 10.1111/j.1399-0039.2007.00927.x

PubMed ID: 2886427

Title: Structural and functional variability among DQ beta alleles of DR2 subtypes.

PubMed ID: 2886427

DOI: 10.1007/bf00345459

PubMed ID: 9174147

Title: A novel allele, DQB1*0307, in a West African family.

PubMed ID: 9174147

DOI: 10.1111/j.1399-0039.1997.tb02789.x

PubMed ID: 11782280

Title: Identification of a novel HLA-DQB1*06 allele, DQB1*0618.

PubMed ID: 11782280

DOI: 10.1034/j.1399-0039.2001.580409.x

PubMed ID: 9458130

Title: Identification of a new DQB1*0613 allele in a family.

PubMed ID: 9458130

DOI: 10.1111/j.1399-0039.1997.tb02935.x

PubMed ID: 17559588

Title: HLA-DQB1*0319, a novel HLA-DQB1 allele, shows strong haplotype association to HLA-DRB1*1102.

PubMed ID: 17559588

DOI: 10.1111/j.1399-0039.2007.00848.x

PubMed ID: 18331527

Title: HLA-DQB1*0634, a novel DQB1 allele found by high-resolution HLA typing of a sibling pair for potential bone marrow transplantation.

PubMed ID: 18331527

DOI: 10.1111/j.1399-0039.2008.01021.x

PubMed ID: 18588576

Title: Novel alleles at the HLA-DRB1 and -DQB1 loci.

PubMed ID: 18588576

DOI: 10.1111/j.1399-0039.2008.01070.x

PubMed ID: 19254265

Title: Sequence-based HLA high-resolution retyping of a bone marrow donor/recipient pair reveals the novel HLA allele DQB1*0322.

PubMed ID: 19254265

DOI: 10.1111/j.1399-0039.2008.01201.x

PubMed ID: 19493242

Title: DQB1*0323 is the result of a gene conversion event between a DQB1*06 and a DQB1*030303 allele.

PubMed ID: 19493242

DOI: 10.1111/j.1399-0039.2009.01231.x

PubMed ID: 8896183

Title: Characterization of a new DQB1 allele (DQB1*0610) which differs from DQB1*0602 at the highly polymorphic 57-codon.

PubMed ID: 8896183

DOI: 10.1111/j.1399-0039.1996.tb02633.x

PubMed ID: 8988541

Title: A new HLA-DQB1*0306 allele sharing motifs from DQB1*03032 and DQB1*04 sequences.

PubMed ID: 8988541

DOI: 10.1111/j.1399-0039.1996.tb02672.x

PubMed ID: 15361133

Title: Identification of two novel HLA class II alleles, DQB1*0311 and DQB1*0620.

PubMed ID: 15361133

DOI: 10.1111/j.1399-0039.2004.00307.x

PubMed ID: 15853909

Title: Identification of a novel HLA-DQB1 allele, DQB1*0314, by sequence-based typing in the Korean population.

PubMed ID: 15853909

DOI: 10.1111/j.1399-0039.2005.00397.x

PubMed ID: 17212715

Title: A novel HLA-DQB1*06 allele, DQB1*0628, found through routine sequence-based HLA typing and confirmation of DQB1*060302.

PubMed ID: 17212715

DOI: 10.1111/j.1399-0039.2006.00733.x

PubMed ID: 17999653

Title: Identification of a novel HLA-DQB1 allele, HLA-DQB1*0632.

PubMed ID: 17999653

DOI: 10.1111/j.1399-0039.2007.00967.x

PubMed ID: 19392794

Title: Two new HLA-DQB alleles routinely identified by sequence-based typing: DQB1*030103 and DQB1*0505.

PubMed ID: 19392794

DOI: 10.1111/j.1399-0039.2009.01248.x

PubMed ID: 10323344

Title: Identification of a novel DQB1 allele DBQ1*0616.

PubMed ID: 10323344

DOI: 10.1034/j.1399-0039.1999.530410.x

PubMed ID: 9802612

Title: A novel DRB3 allele (DRB3*0208), a new allelic variant of DRB1*1502 (DRB1*15023) and two new DQB1 (DQB1*03012 and DQB1*0614) alleles.

PubMed ID: 9802612

DOI: 10.1111/j.1399-0039.1998.tb03047.x

PubMed ID: 8896171

Title: Strategy for distinguishing a new DQB1 allele (DQB1*0611) from the closely related DQB1*0602 allele via sequence specific PCR or direct DNA sequencing.

PubMed ID: 8896171

DOI: 10.1111/j.1399-0039.1996.tb02621.x

PubMed ID: 16441489

Title: HLA-DRB1*0826 and HLA-DQB1*0627, two novel class II alleles identified in blood stem cell donors of Caucasian origin.

PubMed ID: 16441489

DOI: 10.1111/j.1399-0039.2006.00515.x

PubMed ID: 1440562

Title: Two novel HLA-DQB1*06 alleles reveal additional heterogeneity of HLA-DQw1.

PubMed ID: 1440562

DOI: 10.1111/j.1399-0039.1992.tb01958.x

PubMed ID: 2308943

Title: Allelic diversification at the class II DQB locus of the mammalian major histocompatibility complex.

PubMed ID: 2308943

DOI: 10.1073/pnas.87.5.1835

PubMed ID: 2010218

Title: Rapid typing of HLA-DQB1 DNA polymorphism using nonradioactive oligonucleotide probes and amplified DNA.

PubMed ID: 2010218

DOI: 10.1007/bf01719235

PubMed ID: 6952552

Title: Evolutionary relationship between HLA-DR antigen beta-chains, HLA-A, B, C antigen subunits and immunoglobulin chains.

PubMed ID: 6952552

DOI: 10.1111/j.1365-3083.1981.tb00603.x

PubMed ID: 18565458

Title: CSF hypocretin-1 assessment in sleep and neurological disorders.

PubMed ID: 18565458

DOI: 10.1016/s1474-4422(08)70140-6

PubMed ID: 8598037

Title: Invariant chain structure and MHC class II function.

PubMed ID: 8598037

DOI: 10.1016/s0092-8674(00)81025-9

PubMed ID: 11684289

Title: Presentation of antigens by MHC class II molecules: getting the most out of them.

PubMed ID: 11684289

DOI: 10.1016/s0161-5890(01)00069-4

PubMed ID: 18046453

Title: MHC class II molecules on the move for successful antigen presentation.

PubMed ID: 18046453

DOI: 10.1038/sj.emboj.7601945

PubMed ID: 17241953

Title: Autophagy in MHC class II presentation: sampling from within.

PubMed ID: 17241953

DOI: 10.1016/j.immuni.2007.01.005

PubMed ID: 19092054

Title: MHC class II transport at a glance.

PubMed ID: 19092054

DOI: 10.1242/jcs.035089

PubMed ID: 19533806

Title: CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.

PubMed ID: 19533806

DOI: 10.3748/wjg.15.2855

PubMed ID: 11376336

Title: Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes.

PubMed ID: 11376336

DOI: 10.1038/88694

PubMed ID: 14769912

Title: Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy.

PubMed ID: 14769912

DOI: 10.1073/pnas.0308458100

PubMed ID: 15020763

Title: Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease.

PubMed ID: 15020763

DOI: 10.1073/pnas.0306885101

PubMed ID: 17629515

Title: A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease.

PubMed ID: 17629515

DOI: 10.1016/j.immuni.2007.05.015

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 261
  • Mass: 29991
  • Checksum: 79B1E571A628CF96
  • Sequence:
    • MSWKKALRIP GGLRAATVTL MLAMLSTPVA EGRDSPEDFV YQFKAMCYFT NGTERVRYVT 
RYIYNREEYA RFDSDVEVYR AVTPLGPPDA EYWNSQKEVL ERTRAELDTV CRHNYQLELR 
TTLQRRVEPT VTISPSRTEA LNHHNLLVCS VTDFYPAQIK VRWFRNDQEE TTGVVSTPLI 
RNGDWTFQIL VMLEMTPQHG DVYTCHVEHP SLQNPITVEW RAQSESAQSK MLSGIGGFVL 
GLIFLGLGLI IHHRSQKGLL H

Genular Protein ID: 1462464936

Symbol: Q5Y7A9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5Y7A9

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 32 GO 5 Gene3D 1 GenomeRNAi 1 InterPro 8 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 16140993

Title: Ancient haplotypes of the HLA Class II region.

PubMed ID: 16140993

DOI: 10.1101/gr.3554305

PubMed ID: 23714642

Title: Phase-defined complete sequencing of the HLA genes by next-generation sequencing.

PubMed ID: 23714642

DOI: 10.1186/1471-2164-14-355

PubMed ID: 28547825

Title: Dual redundant sequencing strategy: Full-length gene characterisation of 1056 novel and confirmatory HLA alleles.

PubMed ID: 28547825

DOI: 10.1111/tan.13057

PubMed ID: 30337930

Title: Reference Grade Characterization of Polymorphisms in Full-Length HLA Class I and II Genes With Short-Read Sequencing on the ION PGM System and Long-Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio Platform.

PubMed ID: 30337930

DOI: .3389/fimmu.2018.02294

Sequence Information:

  • Length: 261
  • Mass: 29781
  • Checksum: 321527DC13AD1046
  • Sequence:
    • MSWKKALRIP GDLRVATVTL MLAMLSSLLA EGRDSPEDFV YQFKGMCYFT NGTERVRLVT 
RHIYNREEYA RFDSDVGVYR AVTPQGRPDA EYWNSQKEVL EGTRAELDTV CRHNYEVAFR 
GILQRRVEPT VTISPSRTEA LNHHNLLVCS VTDFYPGQIK VRWFRNDQEE TAGVVSTPLI 
RNGDWTFQIL VMLEMTPQRG DVYTCHVEHP SLQSPITVEW RAQSESAQSK MLSGVGGFVL 
GLIFLGLGLI IRQRSQKGLL H

Genular Protein ID: 3345764557

Symbol: Q5Y7D6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5Y7D6

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 45 Ensembl 3 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 8 MANE-Select 1 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OpenTargets 1 PANTHER 2 PROSITE 3 PeptideAtlas 2 Pfam 2 PharmGKB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 16140993

Title: Ancient haplotypes of the HLA Class II region.

PubMed ID: 16140993

DOI: 10.1101/gr.3554305

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23714642

Title: Phase-defined complete sequencing of the HLA genes by next-generation sequencing.

PubMed ID: 23714642

DOI: 10.1186/1471-2164-14-355

PubMed ID: 28547825

Title: Dual redundant sequencing strategy: Full-length gene characterisation of 1056 novel and confirmatory HLA alleles.

PubMed ID: 28547825

DOI: 10.1111/tan.13057

PubMed ID: 30337930

Title: Reference Grade Characterization of Polymorphisms in Full-Length HLA Class I and II Genes With Short-Read Sequencing on the ION PGM System and Long-Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio Platform.

PubMed ID: 30337930

DOI: .3389/fimmu.2018.02294

PubMed ID: 29327506

Title: Next generation sequencing characterizes the extent of HLA diversity in an Argentinian registry population.

PubMed ID: 29327506

DOI: .1111/tan.13210

PubMed ID: 31981322

Title: Characterization of two novel HLA-DQB1*06:02:01 variants, identified in Brazilian individuals.

PubMed ID: 31981322

Sequence Information:

  • Length: 261
  • Mass: 29791
  • Checksum: 955BF0E22AA4BD79
  • Sequence:
    • MSWKKALRIP GDLRVATVTL MLAMLSSLLA EGRDSPEDFV FQFKGMCYFT NGTERVRLVT 
RYIYNREEYA RFDSDVGVYR AVTPQGRPDA EYWNSQKEVL EGTRAELDTV CRHNYEVAFR 
GILQRRVEPT VTISPSRTEA LNHHNLLVCS VTDFYPGQIK VRWFRNDQEE TAGVVSTPLI 
RNGDWTFQIL VMLEMTPQRG DVYTCHVEHP SLQSPITVEW RAQSESAQSK MLSGVGGFVL 
GLIFLGLGLI IRQRSQKGLL H

Genular Protein ID: 773728169

Symbol: Q5Y7D3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5Y7D3 U3Q031

Database IDs:

ARBA 11 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DNASU 1 EMBL 15 Ensembl 3 GO 6 Gene3D 1 GenomeRNAi 1 HGNC 1 InterPro 8 KEGG 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PDB 19 PDBsum 7 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 2 SUPFAM 2 UCSC 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 16140993

Title: Ancient haplotypes of the HLA Class II region.

PubMed ID: 16140993

DOI: 10.1101/gr.3554305

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22362761

Title: Structural and functional studies of trans-encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) protein molecule.

PubMed ID: 22362761

DOI: 10.1074/jbc.m111.320374

PubMed ID: 24777060

Title: T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease.

PubMed ID: 24777060

DOI: 10.1038/nsmb.2817

PubMed ID: 28364043

Title: Unraveling the structural basis for the unusually rich association of human leukocyte antigen DQ2.5 with class-II-associated invariant chain peptides.

PubMed ID: 28364043

DOI: 10.1074/jbc.m117.785139

PubMed ID: 30337930

Title: Reference Grade Characterization of Polymorphisms in Full-Length HLA Class I and II Genes With Short-Read Sequencing on the ION PGM System and Long-Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio Platform.

PubMed ID: 30337930

DOI: .3389/fimmu.2018.02294

PubMed ID: 34417258

Title: A high-affinity human TCR-like antibody detects celiac disease gluten peptide-MHC complexes and inhibits T cell activation. .

PubMed ID: 34417258

DOI: 10.1126/sciimmunol.abg4925

PubMed ID: 35065967

Title: Structural basis of T cell receptor specificity and cross-reactivity of two HLA-DQ2.5-restricted gluten epitopes in celiac disease.

PubMed ID: 35065967

DOI: 10.1016/j.jbc.2022.101619

Sequence Information:

  • Length: 261
  • Mass: 29733
  • Checksum: 8957ACD3E93DD105
  • Sequence:
    • MSWKKALRIP GGLRAATVTL MLSMLSTPVA EGRDSPEDFV YQFKGMCYFT NGTERVRLVS 
RSIYNREEIV RFDSDVGEFR AVTLLGLPAA EYWNSQKDIL ERKRAAVDRV CRHNYQLELR 
TTLQRRVEPT VTISPSRTEA LNHHNLLVCS VTDFYPAQIK VRWFRNDQEE TAGVVSTPLI 
RNGDWTFQIL VMLEMTPQRG DVYTCHVEHP SLQSPITVEW RAQSESAQSK MLSGIGGFVL 
GLIFLGLGLI IHHRSQKGLL H

Genular Protein ID: 2669682166

Symbol: Q5SU54_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5SU54

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 13 Ensembl 2 GO 5 Gene3D 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 InterPro 8 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 1 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 31748512

Title: In vivo clonal expansion and phenotypes of hypocretin-specific CD4<sup>+</sup> T cells in narcolepsy patients and controls.

PubMed ID: 31748512

DOI: 10.1038/s41467-019-13234-x

Sequence Information:

  • Length: 269
  • Mass: 30493
  • Checksum: 8406DCC525CF48CA
  • Sequence:
    • MSWKKALRIP GDLRVATVTL MLAMLSSLLA EGRDSPEDFV FQFKGMCYFT NGTERVRLVT 
RYIYNREEYA RFDSDVGVYR AVTPQGRPDA EYWNSQKEVL EGTRAELDTV CRHNYEVAFR 
GILQRRVEPT VTISPSRTEA LNHHNLLVCS VTDFYPGQIK VRWFRNDQEE TAGVVSTPLI 
RNGDWTFQIL VMLEMTPQRG DVYTCHVEHP SLQSPITVEW RAQSESAQSK MLSGVGGFVL 
GLIFLGLGLI IRQRSQKGPQ GPPPAGLLH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.