Details for: HLA DQB1

Gene ID: 3119

Symbol: HLA DQB1

Ensembl ID: ENSG00000179344

Description: major histocompatibility complex, class II, DQ beta 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 214.6000
    Cell Significance Index: -33.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.9936
    Cell Significance Index: -25.8700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 84.0226
    Cell Significance Index: -43.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 78.5389
    Cell Significance Index: -37.0800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 55.2441
    Cell Significance Index: -37.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.8866
    Cell Significance Index: -33.1500
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 17.0424
    Cell Significance Index: 70.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.3116
    Cell Significance Index: -35.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.0404
    Cell Significance Index: -33.9100
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 8.9088
    Cell Significance Index: 39.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7708
    Cell Significance Index: -34.6100
  • Cell Name: centroblast (CL0009112)
    Fold Change: 5.6492
    Cell Significance Index: 13.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.8793
    Cell Significance Index: 575.4200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 4.8260
    Cell Significance Index: 82.9100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4504
    Cell Significance Index: -9.7400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 3.7548
    Cell Significance Index: 77.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.6694
    Cell Significance Index: 67.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.5276
    Cell Significance Index: 159.9000
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 3.2715
    Cell Significance Index: 8.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.2542
    Cell Significance Index: 57.5100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.7302
    Cell Significance Index: 22.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.6240
    Cell Significance Index: 29.8100
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.5201
    Cell Significance Index: 7.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9998
    Cell Significance Index: 129.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.9839
    Cell Significance Index: 68.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.5363
    Cell Significance Index: 23.0200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.4824
    Cell Significance Index: 12.6000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4566
    Cell Significance Index: 42.7800
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.3354
    Cell Significance Index: 8.0700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.2733
    Cell Significance Index: 19.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.0875
    Cell Significance Index: 29.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9714
    Cell Significance Index: 105.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7109
    Cell Significance Index: 115.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5245
    Cell Significance Index: 51.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5086
    Cell Significance Index: 17.8700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.5020
    Cell Significance Index: 3.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3477
    Cell Significance Index: 66.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2426
    Cell Significance Index: 107.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2237
    Cell Significance Index: 202.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2195
    Cell Significance Index: 26.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2151
    Cell Significance Index: 10.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1519
    Cell Significance Index: 114.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1117
    Cell Significance Index: 60.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1085
    Cell Significance Index: 11.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0582
    Cell Significance Index: 10.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0146
    Cell Significance Index: 1.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0161
    Cell Significance Index: -30.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0211
    Cell Significance Index: -15.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0247
    Cell Significance Index: -38.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0278
    Cell Significance Index: -17.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0290
    Cell Significance Index: -39.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0374
    Cell Significance Index: -0.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0389
    Cell Significance Index: -21.9300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0525
    Cell Significance Index: -2.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0540
    Cell Significance Index: -39.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0630
    Cell Significance Index: -40.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0833
    Cell Significance Index: -29.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0848
    Cell Significance Index: -38.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0883
    Cell Significance Index: -17.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0958
    Cell Significance Index: -20.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1043
    Cell Significance Index: -20.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1086
    Cell Significance Index: -18.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1132
    Cell Significance Index: -14.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1413
    Cell Significance Index: -5.7900
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1432
    Cell Significance Index: -1.1600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1506
    Cell Significance Index: -3.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1883
    Cell Significance Index: -21.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1924
    Cell Significance Index: -22.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2051
    Cell Significance Index: -6.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2173
    Cell Significance Index: -29.8400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2459
    Cell Significance Index: -28.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2633
    Cell Significance Index: -38.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2951
    Cell Significance Index: -6.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3215
    Cell Significance Index: -33.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3665
    Cell Significance Index: -10.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3717
    Cell Significance Index: -26.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4010
    Cell Significance Index: -10.2500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.4083
    Cell Significance Index: -5.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4272
    Cell Significance Index: -31.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4316
    Cell Significance Index: -33.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4609
    Cell Significance Index: -11.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5316
    Cell Significance Index: -42.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5453
    Cell Significance Index: -28.6300
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.5580
    Cell Significance Index: -5.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6081
    Cell Significance Index: -37.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6122
    Cell Significance Index: -17.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6335
    Cell Significance Index: -32.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6355
    Cell Significance Index: -35.6600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6427
    Cell Significance Index: -9.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7143
    Cell Significance Index: -45.0200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7170
    Cell Significance Index: -26.3200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.7377
    Cell Significance Index: -10.7100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7558
    Cell Significance Index: -32.8700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.8138
    Cell Significance Index: -7.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8265
    Cell Significance Index: -36.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8905
    Cell Significance Index: -41.5200
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.9150
    Cell Significance Index: -6.0700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.9239
    Cell Significance Index: -22.3800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9376
    Cell Significance Index: -27.6200
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.9416
    Cell Significance Index: -4.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The HLA-DQB1 gene is a transmembrane glycoprotein that is composed of two subunits, alpha (α) and beta (β). The β chain is further divided into three domains: the α1 domain, the α2 domain, and the α3 domain. The β chain is non-covalently associated with the α chain to form the MHC class II heterodimer. The HLA-DQB1 gene is highly polymorphic, with multiple alleles that are inherited from the parents and can be expressed in different combinations to produce a diverse range of MHC molecules. **Pathways and Functions** The HLA-DQB1 gene is involved in several key pathways and functions, including: 1. **Antigen processing and presentation**: The HLA-DQB1 gene is responsible for processing and presenting antigens to T-cells via MHC class II molecules. This process involves the endocytosis of antigens, their transport to the endoplasmic reticulum, and their presentation to T-cells through the MHC class II heterodimer. 2. **Cytokine signaling**: The HLA-DQB1 gene is involved in the regulation of cytokine signaling, which is essential for the coordination of the immune response. The MHC class II molecules interact with T-cells and other immune cells to regulate the production of cytokines, which are signaling molecules that promote or inhibit immune responses. 3. **T-cell activation**: The HLA-DQB1 gene plays a critical role in T-cell activation, which is the process by which T-cells become responsive to antigens. The MHC class II molecules interact with T-cells to activate the T-cell receptor (TCR) complex, which triggers a signaling cascade that leads to T-cell activation. **Clinical Significance** The HLA-DQB1 gene has significant clinical implications, including: 1. **Autoimmune diseases**: Variations in the HLA-DQB1 gene have been associated with an increased risk of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Transplantation**: The HLA-DQB1 gene plays a critical role in the rejection of transplanted organs. Individuals with compatible HLA-DQB1 alleles are less likely to experience transplant rejection. 3. **Infectious diseases**: The HLA-DQB1 gene is involved in the presentation of antigens to T-cells, which is essential for the elimination of infectious pathogens. Variations in the HLA-DQB1 gene can affect the ability of the immune system to respond to infections. 4. **Cancer**: The HLA-DQB1 gene has been implicated in the development and progression of certain types of cancer, including multiple myeloma and lymphoma. In conclusion, the HLA-DQB1 gene is a critical component of the immune system, and its dysregulation can have significant clinical implications. Further research is needed to fully understand the mechanisms by which the HLA-DQB1 gene regulates the immune response and to identify potential therapeutic targets for the treatment of autoimmune and infectious diseases.

Genular Protein ID: 2267932439

Symbol: DQB1_HUMAN

Name: HLA class II histocompatibility antigen, DQ beta 1 chain

UniProtKB Accession Codes:

P01920 A1KR27 A2RPH3 A4Q9R4 A4USG2 A4USG5 A6N8I7 A9YQA0 B0S7Y7 B1A0K6 B1GXI3 B3VLT3 B5BLN7 B7VU69 C0MQ34 C0MQ35 C8ZL52 C8ZLJ8 C8ZLJ9 C9DRQ3 O19708 O19713 O19724 O62861 O78046 O78221 O78223 O98034 O98201 P01917 P01918 P01919 P03992 P05537 P79482 P79526 P79544 P79551 Q08GC8 Q09035 Q0E4V9 Q1M312 Q29731 Q29877 Q29884 Q29915 Q29966 Q2P9N3 Q2QK85 Q30061 Q30075 Q30076 Q30080 Q30081 Q30082 Q30083 Q30084 Q30089 Q30095 Q31633 Q38I47 Q45UE3 Q4QZB5 Q53I44 Q564J6 Q5G841 Q5ISH1 Q5ISH3 Q5W1E1 Q5Y7G8 Q643R4 Q6B9X1 Q70VH8 Q7YP69 Q8HWH0 Q8MH58 Q8SNB4 Q8SND1 Q8SP70 Q8WMA3 Q9BD17 Q9MYH2 Q9TPA9 Q9XRY6 Q9XRY7 Q9XRZ2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CPTC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 100 EMDB 1 Ensembl 6 EvolutionaryTrace 1 GO 23 Gene3D 1 GeneCards 1 GeneReviews 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 Orphanet 7 PANTHER 2 PDB 10 PDBsum 10 PIR 11 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 7 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 UCSC 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6415003

Title: Molecular analysis of human class II transplantation antigens and their genes.

PubMed ID: 6415003

DOI: 10.1016/0198-8859(83)90087-3

PubMed ID: 6954511

Title: Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: similarities with immunoglobulins and HLA-A, -B, and -C antigens.

PubMed ID: 6954511

DOI: 10.1073/pnas.79.12.3687

PubMed ID: 6316358

Title: Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC beta gene.

PubMed ID: 6316358

DOI: 10.1073/pnas.80.23.7313

PubMed ID: 6206493

Title: Cloning and sequence analysis of the human major histocompatibility complex gene DC-3 beta.

PubMed ID: 6206493

DOI: 10.1073/pnas.81.16.5199

PubMed ID: 2998758

Title: DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression.

PubMed ID: 2998758

DOI: 10.1002/j.1460-2075.1985.tb04012.x

PubMed ID: 2888727

Title: Allelic forms of the alpha- and beta-chain genes encoding DQw1-positive heterodimers.

PubMed ID: 2888727

DOI: 10.1007/bf00346523

PubMed ID: 3036828

Title: Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes.

PubMed ID: 3036828

DOI: 10.1016/s0021-9258(18)47482-0

PubMed ID: 3584986

Title: Complete sequence of the HLA DQ alpha and DQ beta cDNA from a DR5/DQw3 cell line.

PubMed ID: 3584986

PubMed ID: 3259543

Title: MHC class II sequences of an HLA-DR2 narcoleptic.

PubMed ID: 3259543

DOI: 10.1007/bf00364432

PubMed ID: 2050393

Title: Full length beta chain cDNAs of DQw9 and DQw8 molecules encode proteins that differ only at amino acid 57.

PubMed ID: 2050393

DOI: 10.1007/bf00216702

PubMed ID: 8988543

Title: Complete coding region of the new HLA-DQB1*0612 allele, obtained by RT-PCR.

PubMed ID: 8988543

DOI: 10.1111/j.1399-0039.1996.tb02674.x

PubMed ID: 9271631

Title: HLA class II haplotype and sequence analysis support a role for DQ in narcolepsy.

PubMed ID: 9271631

DOI: 10.1007/s002510050295

PubMed ID: 16140993

Title: Ancient haplotypes of the HLA Class II region.

PubMed ID: 16140993

DOI: 10.1101/gr.3554305

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2925231

Title: Sequence analysis of HLA class II domains: characterization of the DQw3 family of DQB genes.

PubMed ID: 2925231

DOI: 10.1007/bf00373644

PubMed ID: 2494138

Title: No difference in the nucleotide sequence of the DQ beta beta 1 domain between narcoleptic and healthy individuals with DR2,Dw2.

PubMed ID: 2494138

DOI: 10.1016/0198-8859(89)90058-x

PubMed ID: 2777341

Title: Complete sequences of DQA1 and DQB1 cDNA clones corresponding to the DQw4 specificity.

PubMed ID: 2777341

DOI: 10.1007/bf02421214

PubMed ID: 8929711

Title: Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM).

PubMed ID: 8929711

DOI: 10.1111/j.1399-0039.1996.tb02512.x

PubMed ID: 11098940

Title: Identification by sequencing based typing and complete coding region analysis of three new HLA class II alleles: DRB3*0210, DRB3*0211 and DQB1*0310.

PubMed ID: 11098940

DOI: 10.1034/j.1399-0039.2000.560412.x

PubMed ID: 7928445

Title: HLA-DQB1*0305 and -DQB1*0304 alleles among Sardinians. Evolutionary and practical implications for oligotyping.

PubMed ID: 7928445

DOI: 10.1016/0198-8859(94)90060-4

PubMed ID: 6576979

Title: Primary structure of human class II histocompatibility antigens 3rd communication. Amino acid sequence comparison between DR and DC subclass antigens derived from a lymphoblastoid B cell line homozygous at the HLA loci (HLA-A3,3; B7,7; Dw2,2; DR2,2: MT1,1; Dc1,1: MB1,1).

PubMed ID: 6576979

DOI: 10.1515/bchm2.1983.364.1.749

PubMed ID: 2212675

Title: Two divergent routes of evolution gave rise to the DRw13 haplotypes.

PubMed ID: 2212675

PubMed ID: 3020127

Title: Analysis of DR-beta and DQ-beta chain cDNA clones from a DR7 haplotype.

PubMed ID: 3020127

PubMed ID: 17868257

Title: Identification of a novel allele HLA-DQB1*0622.

PubMed ID: 17868257

DOI: 10.1111/j.1399-0039.2007.00927.x

PubMed ID: 2886427

Title: Structural and functional variability among DQ beta alleles of DR2 subtypes.

PubMed ID: 2886427

DOI: 10.1007/bf00345459

PubMed ID: 9174147

Title: A novel allele, DQB1*0307, in a West African family.

PubMed ID: 9174147

DOI: 10.1111/j.1399-0039.1997.tb02789.x

PubMed ID: 11782280

Title: Identification of a novel HLA-DQB1*06 allele, DQB1*0618.

PubMed ID: 11782280

DOI: 10.1034/j.1399-0039.2001.580409.x

PubMed ID: 9458130

Title: Identification of a new DQB1*0613 allele in a family.

PubMed ID: 9458130

DOI: 10.1111/j.1399-0039.1997.tb02935.x

PubMed ID: 17559588

Title: HLA-DQB1*0319, a novel HLA-DQB1 allele, shows strong haplotype association to HLA-DRB1*1102.

PubMed ID: 17559588

DOI: 10.1111/j.1399-0039.2007.00848.x

PubMed ID: 18331527

Title: HLA-DQB1*0634, a novel DQB1 allele found by high-resolution HLA typing of a sibling pair for potential bone marrow transplantation.

PubMed ID: 18331527

DOI: 10.1111/j.1399-0039.2008.01021.x

PubMed ID: 18588576

Title: Novel alleles at the HLA-DRB1 and -DQB1 loci.

PubMed ID: 18588576

DOI: 10.1111/j.1399-0039.2008.01070.x

PubMed ID: 19254265

Title: Sequence-based HLA high-resolution retyping of a bone marrow donor/recipient pair reveals the novel HLA allele DQB1*0322.

PubMed ID: 19254265

DOI: 10.1111/j.1399-0039.2008.01201.x

PubMed ID: 19493242

Title: DQB1*0323 is the result of a gene conversion event between a DQB1*06 and a DQB1*030303 allele.

PubMed ID: 19493242

DOI: 10.1111/j.1399-0039.2009.01231.x

PubMed ID: 8896183

Title: Characterization of a new DQB1 allele (DQB1*0610) which differs from DQB1*0602 at the highly polymorphic 57-codon.

PubMed ID: 8896183

DOI: 10.1111/j.1399-0039.1996.tb02633.x

PubMed ID: 8988541

Title: A new HLA-DQB1*0306 allele sharing motifs from DQB1*03032 and DQB1*04 sequences.

PubMed ID: 8988541

DOI: 10.1111/j.1399-0039.1996.tb02672.x

PubMed ID: 15361133

Title: Identification of two novel HLA class II alleles, DQB1*0311 and DQB1*0620.

PubMed ID: 15361133

DOI: 10.1111/j.1399-0039.2004.00307.x

PubMed ID: 15853909

Title: Identification of a novel HLA-DQB1 allele, DQB1*0314, by sequence-based typing in the Korean population.

PubMed ID: 15853909

DOI: 10.1111/j.1399-0039.2005.00397.x

PubMed ID: 17212715

Title: A novel HLA-DQB1*06 allele, DQB1*0628, found through routine sequence-based HLA typing and confirmation of DQB1*060302.

PubMed ID: 17212715

DOI: 10.1111/j.1399-0039.2006.00733.x

PubMed ID: 17999653

Title: Identification of a novel HLA-DQB1 allele, HLA-DQB1*0632.

PubMed ID: 17999653

DOI: 10.1111/j.1399-0039.2007.00967.x

PubMed ID: 19392794

Title: Two new HLA-DQB alleles routinely identified by sequence-based typing: DQB1*030103 and DQB1*0505.

PubMed ID: 19392794

DOI: 10.1111/j.1399-0039.2009.01248.x

PubMed ID: 10323344

Title: Identification of a novel DQB1 allele DBQ1*0616.

PubMed ID: 10323344

DOI: 10.1034/j.1399-0039.1999.530410.x

PubMed ID: 9802612

Title: A novel DRB3 allele (DRB3*0208), a new allelic variant of DRB1*1502 (DRB1*15023) and two new DQB1 (DQB1*03012 and DQB1*0614) alleles.

PubMed ID: 9802612

DOI: 10.1111/j.1399-0039.1998.tb03047.x

PubMed ID: 8896171

Title: Strategy for distinguishing a new DQB1 allele (DQB1*0611) from the closely related DQB1*0602 allele via sequence specific PCR or direct DNA sequencing.

PubMed ID: 8896171

DOI: 10.1111/j.1399-0039.1996.tb02621.x

PubMed ID: 16441489

Title: HLA-DRB1*0826 and HLA-DQB1*0627, two novel class II alleles identified in blood stem cell donors of Caucasian origin.

PubMed ID: 16441489

DOI: 10.1111/j.1399-0039.2006.00515.x

PubMed ID: 1440562

Title: Two novel HLA-DQB1*06 alleles reveal additional heterogeneity of HLA-DQw1.

PubMed ID: 1440562

DOI: 10.1111/j.1399-0039.1992.tb01958.x

PubMed ID: 2308943

Title: Allelic diversification at the class II DQB locus of the mammalian major histocompatibility complex.

PubMed ID: 2308943

DOI: 10.1073/pnas.87.5.1835

PubMed ID: 2010218

Title: Rapid typing of HLA-DQB1 DNA polymorphism using nonradioactive oligonucleotide probes and amplified DNA.

PubMed ID: 2010218

DOI: 10.1007/bf01719235

PubMed ID: 6952552

Title: Evolutionary relationship between HLA-DR antigen beta-chains, HLA-A, B, C antigen subunits and immunoglobulin chains.

PubMed ID: 6952552

DOI: 10.1111/j.1365-3083.1981.tb00603.x

PubMed ID: 18565458

Title: CSF hypocretin-1 assessment in sleep and neurological disorders.

PubMed ID: 18565458

DOI: 10.1016/s1474-4422(08)70140-6

PubMed ID: 8598037

Title: Invariant chain structure and MHC class II function.

PubMed ID: 8598037

DOI: 10.1016/s0092-8674(00)81025-9

PubMed ID: 11684289

Title: Presentation of antigens by MHC class II molecules: getting the most out of them.

PubMed ID: 11684289

DOI: 10.1016/s0161-5890(01)00069-4

PubMed ID: 18046453

Title: MHC class II molecules on the move for successful antigen presentation.

PubMed ID: 18046453

DOI: 10.1038/sj.emboj.7601945

PubMed ID: 17241953

Title: Autophagy in MHC class II presentation: sampling from within.

PubMed ID: 17241953

DOI: 10.1016/j.immuni.2007.01.005

PubMed ID: 19092054

Title: MHC class II transport at a glance.

PubMed ID: 19092054

DOI: 10.1242/jcs.035089

PubMed ID: 19533806

Title: CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.

PubMed ID: 19533806

DOI: 10.3748/wjg.15.2855

PubMed ID: 11376336

Title: Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes.

PubMed ID: 11376336

DOI: 10.1038/88694

PubMed ID: 14769912

Title: Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy.

PubMed ID: 14769912

DOI: 10.1073/pnas.0308458100

PubMed ID: 15020763

Title: Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease.

PubMed ID: 15020763

DOI: 10.1073/pnas.0306885101

PubMed ID: 17629515

Title: A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease.

PubMed ID: 17629515

DOI: 10.1016/j.immuni.2007.05.015

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 261
  • Mass: 29991
  • Checksum: 79B1E571A628CF96
  • Sequence:
    • MSWKKALRIP GGLRAATVTL MLAMLSTPVA EGRDSPEDFV YQFKAMCYFT NGTERVRYVT 
RYIYNREEYA RFDSDVEVYR AVTPLGPPDA EYWNSQKEVL ERTRAELDTV CRHNYQLELR 
TTLQRRVEPT VTISPSRTEA LNHHNLLVCS VTDFYPAQIK VRWFRNDQEE TTGVVSTPLI 
RNGDWTFQIL VMLEMTPQHG DVYTCHVEHP SLQNPITVEW RAQSESAQSK MLSGIGGFVL 
GLIFLGLGLI IHHRSQKGLL H

Genular Protein ID: 3345764557

Symbol: Q5Y7D6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5Y7D6

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 45 Ensembl 3 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 9 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 PANTHER 2 PROSITE 3 PeptideAtlas 2 Pfam 2 PharmGKB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 16140993

Title: Ancient haplotypes of the HLA Class II region.

PubMed ID: 16140993

DOI: 10.1101/gr.3554305

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23714642

Title: Phase-defined complete sequencing of the HLA genes by next-generation sequencing.

PubMed ID: 23714642

DOI: 10.1186/1471-2164-14-355

PubMed ID: 28547825

Title: Dual redundant sequencing strategy: Full-length gene characterisation of 1056 novel and confirmatory HLA alleles.

PubMed ID: 28547825

DOI: 10.1111/tan.13057

PubMed ID: 30337930

Title: Reference Grade Characterization of Polymorphisms in Full-Length HLA Class I and II Genes With Short-Read Sequencing on the ION PGM System and Long-Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio Platform.

PubMed ID: 30337930

DOI: .3389/fimmu.2018.02294

PubMed ID: 29327506

Title: Next generation sequencing characterizes the extent of HLA diversity in an Argentinian registry population.

PubMed ID: 29327506

DOI: .1111/tan.13210

PubMed ID: 31981322

Title: Characterization of two novel HLA-DQB1*06:02:01 variants, identified in Brazilian individuals.

PubMed ID: 31981322

Sequence Information:

  • Length: 261
  • Mass: 29791
  • Checksum: 955BF0E22AA4BD79
  • Sequence:
    • MSWKKALRIP GDLRVATVTL MLAMLSSLLA EGRDSPEDFV FQFKGMCYFT NGTERVRLVT 
RYIYNREEYA RFDSDVGVYR AVTPQGRPDA EYWNSQKEVL EGTRAELDTV CRHNYEVAFR 
GILQRRVEPT VTISPSRTEA LNHHNLLVCS VTDFYPGQIK VRWFRNDQEE TAGVVSTPLI 
RNGDWTFQIL VMLEMTPQRG DVYTCHVEHP SLQSPITVEW RAQSESAQSK MLSGVGGFVL 
GLIFLGLGLI IRQRSQKGLL H

Genular Protein ID: 773728169

Symbol: Q5Y7D3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5Y7D3 U3Q031

Database IDs:

ARBA 11 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 3 GO 6 Gene3D 1 HGNC 1 InterPro 9 KEGG 1 NCBI Taxonomy 1 PANTHER 2 PDB 19 PDBsum 7 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 2 SUPFAM 2 UCSC 1

Citations:

PubMed ID: 16140993

Title: Ancient haplotypes of the HLA Class II region.

PubMed ID: 16140993

DOI: 10.1101/gr.3554305

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22362761

Title: Structural and functional studies of trans-encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) protein molecule.

PubMed ID: 22362761

DOI: 10.1074/jbc.m111.320374

PubMed ID: 24777060

Title: T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease.

PubMed ID: 24777060

DOI: 10.1038/nsmb.2817

PubMed ID: 28364043

Title: Unraveling the structural basis for the unusually rich association of human leukocyte antigen DQ2.5 with class-II-associated invariant chain peptides.

PubMed ID: 28364043

DOI: 10.1074/jbc.m117.785139

PubMed ID: 30337930

Title: Reference Grade Characterization of Polymorphisms in Full-Length HLA Class I and II Genes With Short-Read Sequencing on the ION PGM System and Long-Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio Platform.

PubMed ID: 30337930

DOI: .3389/fimmu.2018.02294

PubMed ID: 34417258

Title: A high-affinity human TCR-like antibody detects celiac disease gluten peptide-MHC complexes and inhibits T cell activation.

PubMed ID: 34417258

DOI: 10.1126/sciimmunol.abg4925

PubMed ID: 35065967

Title: Structural basis of T cell receptor specificity and cross-reactivity of two HLA-DQ2.5-restricted gluten epitopes in celiac disease.

PubMed ID: 35065967

DOI: 10.1016/j.jbc.2022.101619

Sequence Information:

  • Length: 261
  • Mass: 29733
  • Checksum: 8957ACD3E93DD105
  • Sequence:
    • MSWKKALRIP GGLRAATVTL MLSMLSTPVA EGRDSPEDFV YQFKGMCYFT NGTERVRLVS 
RSIYNREEIV RFDSDVGEFR AVTLLGLPAA EYWNSQKDIL ERKRAAVDRV CRHNYQLELR 
TTLQRRVEPT VTISPSRTEA LNHHNLLVCS VTDFYPAQIK VRWFRNDQEE TAGVVSTPLI 
RNGDWTFQIL VMLEMTPQRG DVYTCHVEHP SLQSPITVEW RAQSESAQSK MLSGIGGFVL 
GLIFLGLGLI IHHRSQKGLL H

Genular Protein ID: 2669682166

Symbol: Q5SU54_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5SU54

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 2 GO 5 Gene3D 1 GeneTree 1 HGNC 1 InterPro 9 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 1 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 31748512

Title: In vivo clonal expansion and phenotypes of hypocretin-specific CD4<sup>+</sup> T cells in narcolepsy patients and controls.

PubMed ID: 31748512

DOI: 10.1038/s41467-019-13234-x

Sequence Information:

  • Length: 269
  • Mass: 30493
  • Checksum: 8406DCC525CF48CA
  • Sequence:
    • MSWKKALRIP GDLRVATVTL MLAMLSSLLA EGRDSPEDFV FQFKGMCYFT NGTERVRLVT 
RYIYNREEYA RFDSDVGVYR AVTPQGRPDA EYWNSQKEVL EGTRAELDTV CRHNYEVAFR 
GILQRRVEPT VTISPSRTEA LNHHNLLVCS VTDFYPGQIK VRWFRNDQEE TAGVVSTPLI 
RNGDWTFQIL VMLEMTPQRG DVYTCHVEHP SLQSPITVEW RAQSESAQSK MLSGVGGFVL 
GLIFLGLGLI IRQRSQKGPQ GPPPAGLLH

Genular Protein ID: 1462464936

Symbol: Q5Y7A9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5Y7A9

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 32 GO 5 Gene3D 1 InterPro 9 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 16140993

Title: Ancient haplotypes of the HLA Class II region.

PubMed ID: 16140993

DOI: 10.1101/gr.3554305

PubMed ID: 23714642

Title: Phase-defined complete sequencing of the HLA genes by next-generation sequencing.

PubMed ID: 23714642

DOI: 10.1186/1471-2164-14-355

PubMed ID: 28547825

Title: Dual redundant sequencing strategy: Full-length gene characterisation of 1056 novel and confirmatory HLA alleles.

PubMed ID: 28547825

DOI: 10.1111/tan.13057

PubMed ID: 30337930

Title: Reference Grade Characterization of Polymorphisms in Full-Length HLA Class I and II Genes With Short-Read Sequencing on the ION PGM System and Long-Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio Platform.

PubMed ID: 30337930

DOI: .3389/fimmu.2018.02294

Sequence Information:

  • Length: 261
  • Mass: 29781
  • Checksum: 321527DC13AD1046
  • Sequence:
    • MSWKKALRIP GDLRVATVTL MLAMLSSLLA EGRDSPEDFV YQFKGMCYFT NGTERVRLVT 
RHIYNREEYA RFDSDVGVYR AVTPQGRPDA EYWNSQKEVL EGTRAELDTV CRHNYEVAFR 
GILQRRVEPT VTISPSRTEA LNHHNLLVCS VTDFYPGQIK VRWFRNDQEE TAGVVSTPLI 
RNGDWTFQIL VMLEMTPQRG DVYTCHVEHP SLQSPITVEW RAQSESAQSK MLSGVGGFVL 
GLIFLGLGLI IRQRSQKGLL H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.