Details for: ICAM3

Gene ID: 3385

Symbol: ICAM3

Ensembl ID: ENSG00000076662

Description: intercellular adhesion molecule 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 107.7822
    Cell Significance Index: -16.7700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 48.6697
    Cell Significance Index: -25.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 43.4845
    Cell Significance Index: -20.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.3946
    Cell Significance Index: -16.5200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 10.5921
    Cell Significance Index: 28.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.1148
    Cell Significance Index: -15.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6654
    Cell Significance Index: -18.4100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.3247
    Cell Significance Index: -9.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.1806
    Cell Significance Index: 122.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.2076
    Cell Significance Index: 610.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.8493
    Cell Significance Index: 76.2200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.3280
    Cell Significance Index: 7.1000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.7224
    Cell Significance Index: 17.2700
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.0085
    Cell Significance Index: 4.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9852
    Cell Significance Index: 889.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9793
    Cell Significance Index: 115.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7103
    Cell Significance Index: 115.5200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7001
    Cell Significance Index: 12.9400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.5263
    Cell Significance Index: 3.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4720
    Cell Significance Index: 32.6400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 0.4676
    Cell Significance Index: 6.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3520
    Cell Significance Index: 16.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3504
    Cell Significance Index: 40.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3258
    Cell Significance Index: 32.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2932
    Cell Significance Index: 13.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0968
    Cell Significance Index: 52.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0842
    Cell Significance Index: 10.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0801
    Cell Significance Index: 15.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0660
    Cell Significance Index: 9.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0563
    Cell Significance Index: 1.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0531
    Cell Significance Index: 1.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0423
    Cell Significance Index: 7.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0345
    Cell Significance Index: 4.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0058
    Cell Significance Index: 0.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0004
    Cell Significance Index: 0.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0019
    Cell Significance Index: -1.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0028
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0083
    Cell Significance Index: -15.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0097
    Cell Significance Index: -17.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0100
    Cell Significance Index: -4.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0110
    Cell Significance Index: -8.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0113
    Cell Significance Index: -17.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0133
    Cell Significance Index: -18.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0174
    Cell Significance Index: -0.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0214
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0255
    Cell Significance Index: -4.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0258
    Cell Significance Index: -19.1200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0294
    Cell Significance Index: -0.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0302
    Cell Significance Index: -3.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0335
    Cell Significance Index: -18.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0342
    Cell Significance Index: -1.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0344
    Cell Significance Index: -1.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0375
    Cell Significance Index: -4.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0389
    Cell Significance Index: -24.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0390
    Cell Significance Index: -0.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0491
    Cell Significance Index: -22.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0529
    Cell Significance Index: -18.9900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0566
    Cell Significance Index: -2.3200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0580
    Cell Significance Index: -1.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0673
    Cell Significance Index: -19.3700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0715
    Cell Significance Index: -0.3900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0720
    Cell Significance Index: -0.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0826
    Cell Significance Index: -16.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0887
    Cell Significance Index: -2.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0913
    Cell Significance Index: -5.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0936
    Cell Significance Index: -19.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0965
    Cell Significance Index: -7.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1037
    Cell Significance Index: -11.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1535
    Cell Significance Index: -4.1000
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1620
    Cell Significance Index: -1.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1660
    Cell Significance Index: -24.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1702
    Cell Significance Index: -17.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1852
    Cell Significance Index: -13.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2043
    Cell Significance Index: -15.6800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2410
    Cell Significance Index: -1.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2482
    Cell Significance Index: -19.6600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2670
    Cell Significance Index: -4.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2785
    Cell Significance Index: -8.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2974
    Cell Significance Index: -20.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3034
    Cell Significance Index: -19.1300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3248
    Cell Significance Index: -3.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3386
    Cell Significance Index: -19.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3457
    Cell Significance Index: -21.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3465
    Cell Significance Index: -18.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3711
    Cell Significance Index: -10.3700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3971
    Cell Significance Index: -17.2700
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.4370
    Cell Significance Index: -4.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4372
    Cell Significance Index: -19.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4460
    Cell Significance Index: -12.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4583
    Cell Significance Index: -7.6700
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.4645
    Cell Significance Index: -3.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4825
    Cell Significance Index: -12.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4846
    Cell Significance Index: -17.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5108
    Cell Significance Index: -13.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5118
    Cell Significance Index: -19.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5122
    Cell Significance Index: -10.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5205
    Cell Significance Index: -18.2400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.5294
    Cell Significance Index: -8.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5391
    Cell Significance Index: -15.8800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.5395
    Cell Significance Index: -7.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ICAM3 is a type of adhesion molecule, specifically a member of the immunoglobulin superfamily. It is composed of four immunoglobulin-like domains and is expressed on the surface of immune cells. ICAM3 is known for its ability to bind to integrins, which are transmembrane receptors that facilitate cell-cell adhesion. The interaction between ICAM3 and integrins is crucial for the regulation of immune responses, including the activation of T cells and the migration of immune cells to sites of inflammation. **Pathways and Functions:** ICAM3 is involved in various signaling pathways that regulate immune responses. The most notable pathways include: 1. **Adaptive Immune System:** ICAM3 is expressed on the surface of T cells, which are central to the adaptive immune response. The interaction between ICAM3 and integrins on T cells facilitates the activation of T cells and the coordination of immune responses. 2. **C-type Lectin Receptors (CLRs):** ICAM3 interacts with CLR ligands, which are carbohydrate molecules that are expressed on the surface of immune cells. This interaction regulates the activation of immune cells and the clearance of pathogens. 3. **Innate Immune System:** ICAM3 is also expressed on the surface of innate immune cells, including monocytes and natural killer cells. The interaction between ICAM3 and integrins on these cells regulates the migration of immune cells to sites of inflammation. **Clinical Significance:** ICAM3 plays a crucial role in various immune-related disorders, including: 1. **Autoimmune Diseases:** ICAM3 is involved in the regulation of immune responses in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Infectious Diseases:** ICAM3 is involved in the clearance of pathogens, including viruses and bacteria. 3. **Cancer:** ICAM3 is expressed on the surface of cancer cells and is involved in the regulation of tumor progression and metastasis. In conclusion, ICAM3 is a critical component of the immune system, facilitating cell-cell adhesion and signaling between immune cells. Its dysregulation is implicated in various immune-related disorders, highlighting the importance of ICAM3 in the regulation of immune responses. Further research is needed to fully understand the role of ICAM3 in immune function and disease.

Genular Protein ID: 1493854587

Symbol: ICAM3_HUMAN

Name: Intercellular adhesion molecule 3

UniProtKB Accession Codes:

P32942 Q6PD68

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1448173

Title: Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes.

PubMed ID: 1448173

DOI: 10.1038/360481a0

PubMed ID: 1448174

Title: Cloning and characterization of a new intercellular adhesion molecule ICAM-R.

PubMed ID: 1448174

DOI: 10.1038/360485a0

PubMed ID: 8459213

Title: Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1.

PubMed ID: 8459213

DOI: 10.1084/jem.177.4.1187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8325327

Title: CDw50 and ICAM-3: two names for the same molecule.

PubMed ID: 8325327

DOI: 10.1002/eji.1830230717

PubMed ID: 9298994

Title: Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization.

PubMed ID: 9298994

DOI: 10.1083/jcb.138.6.1409

PubMed ID: 11179968

Title: Structural study of N-linked oligosaccharides of human intercellular adhesion molecule-3 (CD50).

PubMed ID: 11179968

DOI: 10.1046/j.1432-1327.2001.01960.x

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23775590

Title: Novel role of ICAM3 and LFA-1 in the clearance of apoptotic neutrophils by human macrophages.

PubMed ID: 23775590

DOI: 10.1007/s10495-013-0873-z

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15728350

Title: An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2.

PubMed ID: 15728350

DOI: 10.1073/pnas.0500200102

Sequence Information:

  • Length: 547
  • Mass: 59541
  • Checksum: 4B7BDC02F24F3031
  • Sequence:
    • MATMVPSVLW PRACWTLLVC CLLTPGVQGQ EFLLRVEPQN PVLSAGGSLF VNCSTDCPSS 
EKIALETSLS KELVASGMGW AAFNLSNVTG NSRILCSVYC NGSQITGSSN ITVYRLPERV 
ELAPLPPWQP VGQNFTLRCQ VEDGSPRTSL TVVLLRWEEE LSRQPAVEEP AEVTATVLAS 
RDDHGAPFSC RTELDMQPQG LGLFVNTSAP RQLRTFVLPV TPPRLVAPRF LEVETSWPVD 
CTLDGLFPAS EAQVYLALGD QMLNATVMNH GDTLTATATA TARADQEGAR EIVCNVTLGG 
ERREARENLT VFSFLGPIVN LSEPTAHEGS TVTVSCMAGA RVQVTLDGVP AAAPGQPAQL 
QLNATESDDG RSFFCSATLE VDGEFLHRNS SVQLRVLYGP KIDRATCPQH LKWKDKTRHV 
LQCQARGNPY PELRCLKEGS SREVPVGIPF FVNVTHNGTY QCQASSSRGK YTLVVVMDIE 
AGSSHFVPVF VAVLLTLGVV TIVLALMYVF REHQRSGSYH VREESTYLPL TSMQPTEAMG 
EEPSRAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.