Details for: ICAM3

Gene ID: 3385

Symbol: ICAM3

Ensembl ID: ENSG00000076662

Description: intercellular adhesion molecule 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.89
    Marker Score: 28574.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.77
    Marker Score: 8749
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.66
    Marker Score: 11385
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.61
    Marker Score: 6493
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.56
    Marker Score: 4465
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.52
    Marker Score: 1257
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.51
    Marker Score: 29156
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.5
    Marker Score: 10212
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.47
    Marker Score: 6023
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.42
    Marker Score: 6692
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.42
    Marker Score: 2034
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.38
    Marker Score: 2301
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.36
    Marker Score: 1018
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.35
    Marker Score: 1701.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.35
    Marker Score: 2198
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.33
    Marker Score: 14882
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.32
    Marker Score: 6761
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.32
    Marker Score: 762
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.3
    Marker Score: 1351
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.3
    Marker Score: 6451
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.3
    Marker Score: 2043
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.28
    Marker Score: 120473
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.28
    Marker Score: 2141
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.23
    Marker Score: 3824
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.22
    Marker Score: 3267
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.17
    Marker Score: 1846
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.16
    Marker Score: 4234
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.14
    Marker Score: 2108
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.11
    Marker Score: 1274
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.1
    Marker Score: 743
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.07
    Marker Score: 3704
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.06
    Marker Score: 115199
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.03
    Marker Score: 628
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.01
    Marker Score: 2167
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2
    Marker Score: 1757
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.97
    Marker Score: 2718
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.95
    Marker Score: 1074
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.92
    Marker Score: 1409
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.85
    Marker Score: 647
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.84
    Marker Score: 645
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.83
    Marker Score: 1055
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.81
    Marker Score: 549
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.79
    Marker Score: 1352
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.77
    Marker Score: 2503
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.76
    Marker Score: 572
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.75
    Marker Score: 1564
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.71
    Marker Score: 434
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.71
    Marker Score: 454
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.71
    Marker Score: 1101
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.69
    Marker Score: 869
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.65
    Marker Score: 1196
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.65
    Marker Score: 1189
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.64
    Marker Score: 525
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.64
    Marker Score: 1006
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.6
    Marker Score: 369.5
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.6
    Marker Score: 1311
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.54
    Marker Score: 810
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.52
    Marker Score: 1146
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.47
    Marker Score: 1630
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.47
    Marker Score: 1637
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.47
    Marker Score: 1073.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.45
    Marker Score: 2824
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.45
    Marker Score: 504
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.43
    Marker Score: 1124
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.42
    Marker Score: 832
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.42
    Marker Score: 695
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.4
    Marker Score: 2939
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.4
    Marker Score: 1161
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.34
    Marker Score: 1141
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.34
    Marker Score: 304
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.33
    Marker Score: 812
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.29
    Marker Score: 2908
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.28
    Marker Score: 1700.5
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.26
    Marker Score: 545
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.25
    Marker Score: 1274
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.24
    Marker Score: 540
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.23
    Marker Score: 2965
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.22
    Marker Score: 3613
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.16
    Marker Score: 1257
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.14
    Marker Score: 1472
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.09
    Marker Score: 664
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.09
    Marker Score: 1178
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.08
    Marker Score: 257
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.06
    Marker Score: 457
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.05
    Marker Score: 323
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.04
    Marker Score: 702
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.04
    Marker Score: 690
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.04
    Marker Score: 1963
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.02
    Marker Score: 569
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.02
    Marker Score: 502
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1
    Marker Score: 688
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71650
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47879.5
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.99
    Marker Score: 237
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30387
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.98
    Marker Score: 739.5
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.97
    Marker Score: 386
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.95
    Marker Score: 1539
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2392

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Other Information

**Key characteristics:** - ICAM3 is a single-pass transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in high abundance on the cell surface of activated T cells and other immune cells. - ICAM3 is a member of the immunoglobulin superfamily of cell adhesion molecules, which are involved in cell-cell adhesion and signaling. - It is a key molecule in the regulation of immune cell adhesion, migration, and signaling. **Pathways and functions:** - ICAM3 is involved in the regulation of T cell activation and function. - It facilitates the adhesion of T cells to extracellular matrix molecules and to other immune cells. - ICAM3 signaling is essential for the migration and adhesion of T cells to sites of inflammation and infection. - It also plays a role in the regulation of immune cell communication and cooperation. **Clinical significance:** - Mutations in the ICAM3 gene have been linked to several autoimmune diseases, including rheumatoid arthritis, lupus, and psoriasis. - ICAM3 inhibitors are being investigated as potential therapeutics for these diseases, as they could block the adhesion of immune cells to extracellular matrix molecules and inhibit their signaling. - Targeting ICAM3 could provide a novel approach to treat autoimmune diseases characterized by excessive immune cell adhesion and inflammation.

Genular Protein ID: 1493854587

Symbol: ICAM3_HUMAN

Name: Intercellular adhesion molecule 3

UniProtKB Accession Codes:

P32942 Q6PD68

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1448173

Title: Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes.

PubMed ID: 1448173

DOI: 10.1038/360481a0

PubMed ID: 1448174

Title: Cloning and characterization of a new intercellular adhesion molecule ICAM-R.

PubMed ID: 1448174

DOI: 10.1038/360485a0

PubMed ID: 8459213

Title: Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1.

PubMed ID: 8459213

DOI: 10.1084/jem.177.4.1187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8325327

Title: CDw50 and ICAM-3: two names for the same molecule.

PubMed ID: 8325327

DOI: 10.1002/eji.1830230717

PubMed ID: 9298994

Title: Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization.

PubMed ID: 9298994

DOI: 10.1083/jcb.138.6.1409

PubMed ID: 11179968

Title: Structural study of N-linked oligosaccharides of human intercellular adhesion molecule-3 (CD50).

PubMed ID: 11179968

DOI: 10.1046/j.1432-1327.2001.01960.x

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23775590

Title: Novel role of ICAM3 and LFA-1 in the clearance of apoptotic neutrophils by human macrophages.

PubMed ID: 23775590

DOI: 10.1007/s10495-013-0873-z

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15728350

Title: An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2.

PubMed ID: 15728350

DOI: 10.1073/pnas.0500200102

Sequence Information:

  • Length: 547
  • Mass: 59541
  • Checksum: 4B7BDC02F24F3031
  • Sequence:
    • MATMVPSVLW PRACWTLLVC CLLTPGVQGQ EFLLRVEPQN PVLSAGGSLF VNCSTDCPSS 
EKIALETSLS KELVASGMGW AAFNLSNVTG NSRILCSVYC NGSQITGSSN ITVYRLPERV 
ELAPLPPWQP VGQNFTLRCQ VEDGSPRTSL TVVLLRWEEE LSRQPAVEEP AEVTATVLAS 
RDDHGAPFSC RTELDMQPQG LGLFVNTSAP RQLRTFVLPV TPPRLVAPRF LEVETSWPVD 
CTLDGLFPAS EAQVYLALGD QMLNATVMNH GDTLTATATA TARADQEGAR EIVCNVTLGG 
ERREARENLT VFSFLGPIVN LSEPTAHEGS TVTVSCMAGA RVQVTLDGVP AAAPGQPAQL 
QLNATESDDG RSFFCSATLE VDGEFLHRNS SVQLRVLYGP KIDRATCPQH LKWKDKTRHV 
LQCQARGNPY PELRCLKEGS SREVPVGIPF FVNVTHNGTY QCQASSSRGK YTLVVVMDIE 
AGSSHFVPVF VAVLLTLGVV TIVLALMYVF REHQRSGSYH VREESTYLPL TSMQPTEAMG 
EEPSRAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.