Details for: HLA DMA

Gene ID: 3108

Symbol: HLA DMA

Ensembl ID: ENSG00000204257

Description: major histocompatibility complex, class II, DM alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 8.97
    Marker Score: 9398
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 5.02
    Marker Score: 3044
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 4.69
    Marker Score: 3312.5
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 3.58
    Marker Score: 7497
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.49
    Marker Score: 3436
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.46
    Marker Score: 3958
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 3.41
    Marker Score: 20749
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.27
    Marker Score: 3076
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.27
    Marker Score: 1988
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.91
    Marker Score: 2595
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.9
    Marker Score: 8599
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.83
    Marker Score: 72445
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.79
    Marker Score: 1376
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.78
    Marker Score: 1677
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.78
    Marker Score: 7201.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.73
    Marker Score: 5328
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.67
    Marker Score: 3865.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.63
    Marker Score: 930
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.6
    Marker Score: 4537.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.51
    Marker Score: 140399
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.37
    Marker Score: 2793
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.28
    Marker Score: 12004.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.26
    Marker Score: 1711
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.18
    Marker Score: 518
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.18
    Marker Score: 1576.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.08
    Marker Score: 24190
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.07
    Marker Score: 481
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 2.06
    Marker Score: 475
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.05
    Marker Score: 3289
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.03
    Marker Score: 8442
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.01
    Marker Score: 20392.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.01
    Marker Score: 5107
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.94
    Marker Score: 12648.5
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.91
    Marker Score: 2071
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.84
    Marker Score: 766.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.84
    Marker Score: 1837.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.81
    Marker Score: 1249
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.8
    Marker Score: 2175.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.76
    Marker Score: 2980
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.75
    Marker Score: 1161
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.71
    Marker Score: 1002
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.68
    Marker Score: 885
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.65
    Marker Score: 3746
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.65
    Marker Score: 500
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.6
    Marker Score: 824
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.58
    Marker Score: 2428.5
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.57
    Marker Score: 431
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.54
    Marker Score: 540
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.54
    Marker Score: 4180
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.53
    Marker Score: 6279.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.53
    Marker Score: 1314
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.52
    Marker Score: 1552
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.49
    Marker Score: 316
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.48
    Marker Score: 14645
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.47
    Marker Score: 2945
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.46
    Marker Score: 9340
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.46
    Marker Score: 682
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.45
    Marker Score: 836
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.45
    Marker Score: 367
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.43
    Marker Score: 1217
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.42
    Marker Score: 703
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.42
    Marker Score: 3530
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.4
    Marker Score: 450
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.36
    Marker Score: 470
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.34
    Marker Score: 1346
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.34
    Marker Score: 652
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.33
    Marker Score: 1219
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.33
    Marker Score: 383
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.32
    Marker Score: 338
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.31
    Marker Score: 991
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.31
    Marker Score: 872
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.31
    Marker Score: 45434
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.31
    Marker Score: 477.5
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.3
    Marker Score: 1618
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.28
    Marker Score: 3099
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.28
    Marker Score: 874
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.25
    Marker Score: 436
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.23
    Marker Score: 425
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.23
    Marker Score: 323
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.23
    Marker Score: 476
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.22
    Marker Score: 382
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.21
    Marker Score: 391
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.21
    Marker Score: 1215
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.2
    Marker Score: 1074
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.2
    Marker Score: 1142
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.2
    Marker Score: 596
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.19
    Marker Score: 10336
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 1.19
    Marker Score: 639
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.16
    Marker Score: 292
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.16
    Marker Score: 1116
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.16
    Marker Score: 1044
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 1.16
    Marker Score: 346
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.14
    Marker Score: 833
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.12
    Marker Score: 1242
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.1
    Marker Score: 2775
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.1
    Marker Score: 264
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.08
    Marker Score: 2048
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.07
    Marker Score: 2512
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.04
    Marker Score: 1702
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.02
    Marker Score: 260.5

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Other Information

**Key characteristics** * The HLA-DMA gene is located on chromosome 15q21.1. * It is a member of the HLA class II family. * It is expressed in high abundance in cells of the immune system, particularly in dendritic cells and macrophages. * It is responsible for the presentation of exogenous peptide antigens to T cells. **Pathways and functions** * The HLA-DMA gene is involved in the adaptive immune response. * It is expressed in cells of the immune system, where it is expressed on the surface of dendritic cells and macrophages. * When an antigen is presented on the MHC-DMA complex, it binds to MHC-DMA on the surface of an APC. * This binding triggers the activation of T cells, which can then recognize and respond to the antigen. **Clinical significance** The HLA-DMA gene is a key gene in the immune system. Mutations in the HLA-DMA gene can lead to a variety of autoimmune diseases, including rheumatoid arthritis, Crohn's disease, and melanoma. These diseases are characterized by the production of autoantibodies that target the MHC class II molecules. **Additional information** * The HLA-DMA gene is also known as CD155. * It is a highly conserved gene, with a similar sequence found in humans, mice, and rats. * It is expressed in high abundance in healthy adults, but its expression can be increased in response to infection or inflammation.

Genular Protein ID: 3786305756

Symbol: Q31604_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q31604 O02966 Q96FA1

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 16 ExpressionAtlas 1 GO 6 Gene3D 1 GenomeRNAi 1 HOGENOM 1 IntAct 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PROSITE 3 Pfam 2 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 2 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 8034636

Title: Genomic organization of HLA-DMA and HLA-DMB. Comparison of the gene organization of all six class II families in the human major histocompatibility complex.

PubMed ID: 8034636

PubMed ID: 8568858

Title: Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.

PubMed ID: 8568858

DOI: 10.1006/jmbi.1996.0001

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 261
  • Mass: 29207
  • Checksum: BAAB2528874DFFC6
  • Sequence:
    • MGHEQNQGAA LLQMLPLLWL LPHSWAVPEA PTPMWPDDLQ NHTFLHTVYC QDGSPSVGLS 
EAYDEDQLFF FDFSQNTRVP RLPEFADWAQ EQGDAPAILF DKEFCEWMIQ QIGPKLDGKI 
PVSRGFPIAE VFTLKPLEFG KPNTLVCFVS NLFPPMLTVN WQHHSVPVEG FGPTFVSAVD 
GLSFQAFSYL NFTPEPSDIF SCIVTHEIDR YTAIAYWVPR NALPSDLLEN VLCGVAFGLG 
VLGIIVGIVL IIYFRKPCSG D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.