Details for: HLA DMA
Gene ID: 3108
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: HLA DMA
Ensembl ID: ENSG00000204257
Description: major histocompatibility complex, class II, DM alpha
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 75.19rCSI 52.5%PRS 90.06
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CSI 58.03rCSI 49.77%PRS 90.84
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CSI 47.81rCSI 35.69%PRS 94.9
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CSI 46.85rCSI 39.11%PRS 83.23
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CSI 46.23rCSI 55.84%PRS 92.42
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CSI 42.82rCSI 42.28%PRS 94.12
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CSI 42.06rCSI 52.88%PRS 93.24
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CSI 38.92rCSI 56.38%PRS 95.45
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CSI 38.36rCSI 47.27%PRS 87.46
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CSI 37.36rCSI 35.92%PRS 95.18
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CSI 35.88rCSI 59.1%PRS 89.28
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CSI 34.63rCSI 43.46%PRS 92.78
-
CSI 33.93rCSI 29.5%PRS 93.63
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CSI 33.61rCSI 31.01%PRS 87.77
-
CSI 31.6rCSI 48.27%PRS 94.31
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CSI 28.54rCSI 28.03%PRS 95.95
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CSI 28.18rCSI 43.27%PRS 93.02
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CSI 28.05rCSI 36.75%PRS 94.19
-
CSI 26.82rCSI 59.04%PRS 89.49
-
CSI 26.09rCSI 19.38%PRS 94.12
-
CSI 25.78rCSI 17.14%PRS 88.57
-
CSI 24.94rCSI 25.26%PRS 93.78
-
CSI 24.68rCSI 20.76%PRS 95.73
-
CSI 24.27rCSI 17.42%PRS 95.96
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CSI 22.65rCSI 17.45%PRS 89.77
-
CSI 22.04rCSI 50.01%PRS 85.94
-
CSI 21.61rCSI 39.31%PRS 89.11
-
CSI 19.6rCSI 64.16%PRS 96.1
-
CSI 19.18rCSI 15.9%PRS 87.76
-
CSI 19.12rCSI 24.53%PRS 88.86
-
CSI 18.71rCSI 55.79%PRS 92.53
-
CSI 18.32rCSI 45.91%PRS 95.19
-
CSI 16.83rCSI 13.93%PRS 88.59
-
CSI 16.16rCSI 21.62%PRS 89.7
-
CSI 16.1rCSI 23.21%PRS 90.8
-
CSI 15.45rCSI 34.52%PRS 92.02
-
CSI 15.36rCSI 31.86%PRS 84.23
-
CSI 15.31rCSI 14.73%PRS 85.78
-
CSI 15.24rCSI 19.49%PRS 91.98
-
CSI 15.19rCSI 20.2%PRS 90.71
-
CSI 15.18rCSI 13.83%PRS 95.26
-
CSI 14.99rCSI 21.94%PRS 90.6
-
CSI 14.72rCSI 68%PRS 94.81
-
CSI 14.51rCSI 26.22%PRS 88.97
-
CSI 14.39rCSI 9.69%PRS 95.96
-
CSI 14.05rCSI 51.08%PRS 95.31
-
CSI 13.95rCSI 12.22%PRS 91.66
-
CSI 13.66rCSI 14.52%PRS 89.63
-
CSI 13.37rCSI 19.59%PRS 90.17
-
CSI 13.21rCSI 13.79%PRS 85.75
-
CSI 12.95rCSI 19.19%PRS 93.66
-
CSI 12.58rCSI 15.67%PRS 93.21
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CSI 12.19rCSI 8.47%PRS 95.34
-
CSI 12.16rCSI 19.49%PRS 92.79
-
CSI 11.64rCSI 25.42%PRS 90.68
-
CSI 10.8rCSI 28.16%PRS 87.87
-
CSI 10.79rCSI 20.58%PRS 93.52
-
CSI 10.56rCSI 23.72%PRS 94.83
-
CSI 10.48rCSI 7.97%PRS 95.95
-
CSI 10.34rCSI 16.75%PRS 81.34
-
CSI 10.29rCSI 23.54%PRS 87.61
-
CSI 10.2rCSI 10.49%PRS 94.07
-
CSI 10.16rCSI 29%PRS 88.88
-
CSI 9.94rCSI 19.33%PRS 89
-
CSI 9.59rCSI 53.99%PRS 95.34
-
CSI 8.85rCSI 6.62%PRS 95.46
-
CSI 8.61rCSI 13.88%PRS 84.33
-
CSI 8.01rCSI 8.2%PRS 90.53
-
CSI 7.99rCSI 21.81%PRS 90.91
-
CSI 7.93rCSI 6.24%PRS 90.06
-
CSI 7.76rCSI 6.82%PRS 77.31
-
CSI 7.68rCSI 46.46%PRS 93.74
-
CSI 7.56rCSI 6.64%PRS 90.4
-
CSI 7.48rCSI 21.45%PRS 97.58
-
CSI 7.3rCSI 18.51%PRS 78.83
-
CSI 7.29rCSI 5.67%PRS 95.8
-
CSI 7.17rCSI 7.16%PRS 80.98
-
CSI 7.05rCSI 12.04%PRS 95.98
-
CSI 7.03rCSI 10.61%PRS 91.12
-
CSI 6.96rCSI 7.97%PRS 92.82
-
CSI 6.95rCSI 6.83%PRS 95.48
-
CSI 6.68rCSI 17.6%PRS 94.33
-
CSI 6.68rCSI 11.96%PRS 85.84
-
CSI 6.45rCSI 12.19%PRS 93.32
-
CSI 6.42rCSI 7.81%PRS 91.4
-
CSI 6.21rCSI 4.67%PRS 90.94
-
CSI 6.09rCSI 10.43%PRS 90.16
-
CSI 5.73rCSI 7.94%PRS 83.23
-
CSI 5.64rCSI 22.71%PRS 86.14
-
CSI 5.24rCSI 4.73%PRS 85.33
-
CSI 5.24rCSI 23.57%PRS 95.68
-
CSI 5.17rCSI 17.8%PRS 92.38
-
CSI 5.03rCSI 6.84%PRS 92.29
-
CSI 5.01rCSI 9.99%PRS 94.71
-
CSI 4.82rCSI 7.67%PRS 81.03
-
CSI 4.79rCSI 52.08%PRS 92.9
-
CSI 4.76rCSI 5.7%PRS 92.87
-
CSI 4.69rCSI 3.79%PRS 88.43
-
CSI 4.56rCSI 11.79%PRS 83.1
-
CSI 4.38rCSI 5.31%PRS 67.05
-
CSI 0.3rCSI 1.7%PRS 89.8%
-
CSI 0.5rCSI 3.1%PRS 87.5%
-
CSI 0.6rCSI 11.2%PRS 92.2%
-
CSI 1.0rCSI 19.2%PRS 91.8%
-
CSI 1.0rCSI 23.9%PRS 91.7%
-
CSI 1.0rCSI 3.6%PRS 91.9%
-
CSI 1.1rCSI 6.0%PRS 90.3%
-
CSI 1.2rCSI 8.1%PRS 88.9%
-
CSI 1.3rCSI 2.3%PRS 56.6%
-
CSI 1.4rCSI 4.7%PRS 82.4%
-
CSI 1.5rCSI 6.3%PRS 90.6%
-
CSI 1.6rCSI 2.1%PRS 96.4%
-
CSI 1.7rCSI 6.4%PRS 96.7%
-
CSI 1.8rCSI 3.4%PRS 97.1%
-
CSI 2.0rCSI 51.2%PRS 95.9%
-
CSI 2.2rCSI 11.1%PRS 95.2%
-
CSI 2.3rCSI 4.9%PRS 90.1%
-
CSI 2.3rCSI 4.5%PRS 95.2%
-
CSI 2.3rCSI 30.9%PRS 96.4%
-
CSI 2.4rCSI 50.9%PRS 95.7%
-
CSI 2.7rCSI 29.1%PRS 91.2%
-
CSI 2.7rCSI 3.2%PRS 96.5%
-
CSI 3.0rCSI 4.9%PRS 89.7%
-
CSI 3.0rCSI 20.9%PRS 90.8%
-
CSI 3.1rCSI 11.3%PRS 97.3%
-
CSI 3.2rCSI 14.4%PRS 91.5%
-
CSI 3.2rCSI 2.8%PRS 89.6%
-
CSI 3.5rCSI 17.9%PRS 96.2%
-
CSI 3.6rCSI 6.2%PRS 94.8%
-
CSI 3.7rCSI 4.4%PRS 87.6%
-
CSI 3.8rCSI 9.1%PRS 95.2%
-
CSI 3.9rCSI 5.6%PRS 90.3%
-
CSI 3.9rCSI 6.4%PRS 78.1%
-
CSI 3.9rCSI 17.0%PRS 89.5%
-
CSI 4.0rCSI 4.6%PRS 80.4%
-
CSI 4.0rCSI 22.5%PRS 85.3%
-
CSI 4.1rCSI 5.9%PRS 85.9%
-
CSI 4.3rCSI 26.3%PRS 91.5%
-
CSI 4.4rCSI 34.9%PRS 92.1%
-
CSI 4.4rCSI 5.3%PRS 67.1%
-
CSI 4.6rCSI 11.8%PRS 83.1%
-
CSI 4.7rCSI 3.8%PRS 88.4%
-
CSI 4.8rCSI 5.7%PRS 92.9%
-
CSI 4.8rCSI 52.1%PRS 92.9%
-
CSI 4.8rCSI 7.7%PRS 81.0%
-
CSI 5.0rCSI 10.0%PRS 94.7%
-
CSI 5.0rCSI 6.8%PRS 92.3%
-
CSI 5.2rCSI 17.8%PRS 92.4%
-
CSI 5.2rCSI 23.6%PRS 95.7%
-
CSI 5.2rCSI 4.7%PRS 85.3%
-
CSI 5.6rCSI 22.7%PRS 86.1%
-
CSI 5.7rCSI 7.9%PRS 83.2%
-
CSI 6.1rCSI 10.4%PRS 90.2%
-
CSI 6.2rCSI 4.7%PRS 90.9%
-
CSI 6.4rCSI 7.8%PRS 91.4%
-
CSI 6.5rCSI 12.2%PRS 93.3%
-
CSI 6.7rCSI 12.0%PRS 85.8%
-
CSI 6.7rCSI 17.6%PRS 94.3%
-
CSI 7.0rCSI 6.8%PRS 95.5%
-
CSI 7.0rCSI 8.0%PRS 92.8%
-
CSI 7.0rCSI 10.6%PRS 91.1%
-
CSI 7.1rCSI 12.0%PRS 96.0%
-
CSI 7.2rCSI 7.2%PRS 81.0%
-
CSI 7.3rCSI 5.7%PRS 95.8%
-
CSI 7.3rCSI 18.5%PRS 78.8%
-
CSI 7.5rCSI 21.5%PRS 97.6%
-
CSI 7.6rCSI 6.6%PRS 90.4%
-
CSI 7.7rCSI 46.5%PRS 93.7%
-
CSI 7.8rCSI 6.8%PRS 77.3%
-
CSI 7.9rCSI 6.2%PRS 90.1%
-
CSI 8.0rCSI 21.8%PRS 90.9%
-
CSI 8.0rCSI 8.2%PRS 90.5%
-
CSI 8.6rCSI 13.9%PRS 84.3%
-
CSI 8.9rCSI 6.6%PRS 95.5%
-
CSI 9.6rCSI 54.0%PRS 95.3%
-
CSI 9.9rCSI 19.3%PRS 89.0%
-
CSI 10.2rCSI 29.0%PRS 88.9%
-
CSI 10.2rCSI 10.5%PRS 94.1%
-
CSI 10.3rCSI 23.5%PRS 87.6%
-
CSI 10.3rCSI 16.8%PRS 81.3%
-
CSI 10.5rCSI 8.0%PRS 96.0%
-
CSI 10.6rCSI 23.7%PRS 94.8%
-
CSI 10.8rCSI 20.6%PRS 93.5%
-
CSI 10.8rCSI 28.2%PRS 87.9%
-
CSI 11.6rCSI 25.4%PRS 90.7%
-
CSI 12.2rCSI 19.5%PRS 92.8%
-
CSI 12.2rCSI 8.5%PRS 95.3%
-
CSI 12.6rCSI 15.7%PRS 93.2%
-
CSI 13.0rCSI 19.2%PRS 93.7%
-
CSI 13.2rCSI 13.8%PRS 85.8%
-
CSI 13.4rCSI 19.6%PRS 90.2%
-
CSI 13.7rCSI 14.5%PRS 89.6%
-
CSI 14.0rCSI 12.2%PRS 91.7%
-
CSI 14.1rCSI 51.1%PRS 95.3%
-
CSI 14.4rCSI 9.7%PRS 96.0%
-
CSI 14.5rCSI 26.2%PRS 89.0%
-
CSI 14.7rCSI 68.0%PRS 94.8%
-
CSI 15.0rCSI 21.9%PRS 90.6%
-
CSI 15.2rCSI 13.8%PRS 95.3%
-
CSI 15.2rCSI 20.2%PRS 90.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 3786305756
Symbol: Q6ICR9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 23222639
Title: HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.
PubMed ID: 23222639
DOI: 10.1038/nsmb.2460
Sequence Information:
- Length: 261
- Mass: 29207
- Checksum: BAAB2528874DFFC6
- Sequence:
MGHEQNQGAA LLQMLPLLWL LPHSWAVPEA PTPMWPDDLQ NHTFLHTVYC QDGSPSVGLS EAYDEDQLFF FDFSQNTRVP RLPEFADWAQ EQGDAPAILF DKEFCEWMIQ QIGPKLDGKI PVSRGFPIAE VFTLKPLEFG KPNTLVCFVS NLFPPMLTVN WQHHSVPVEG FGPTFVSAVD GLSFQAFSYL NFTPEPSDIF SCIVTHEIDR YTAIAYWVPR NALPSDLLEN VLCGVAFGLG VLGIIVGIVL IIYFRKPCSG D