Details for: HLA DMA

Gene ID: 3108

Symbol: HLA DMA

Ensembl ID: ENSG00000204257

Description: major histocompatibility complex, class II, DM alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 165.4181
    Cell Significance Index: -25.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 65.2235
    Cell Significance Index: -33.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.0145
    Cell Significance Index: -25.9100
  • Cell Name: centroblast (CL0009112)
    Fold Change: 18.5979
    Cell Significance Index: 43.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 18.2540
    Cell Significance Index: -4.6300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.2697
    Cell Significance Index: -25.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.1229
    Cell Significance Index: -21.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9183
    Cell Significance Index: -27.3000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.6195
    Cell Significance Index: 85.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.4929
    Cell Significance Index: 529.8500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.0883
    Cell Significance Index: 72.2500
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.9669
    Cell Significance Index: 17.7400
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 3.2172
    Cell Significance Index: 13.3900
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 2.9260
    Cell Significance Index: 10.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.8857
    Cell Significance Index: 549.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.5704
    Cell Significance Index: 254.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.4934
    Cell Significance Index: 160.8600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.3124
    Cell Significance Index: 26.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.2036
    Cell Significance Index: 58.9500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.6743
    Cell Significance Index: 27.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.6374
    Cell Significance Index: 48.0900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.5767
    Cell Significance Index: 10.4600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.5041
    Cell Significance Index: 34.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3562
    Cell Significance Index: 220.5800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.0716
    Cell Significance Index: 16.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0111
    Cell Significance Index: 109.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9698
    Cell Significance Index: 113.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9458
    Cell Significance Index: 516.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8702
    Cell Significance Index: 785.7200
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.7165
    Cell Significance Index: 1.8900
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.6357
    Cell Significance Index: 1.9600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.5844
    Cell Significance Index: 10.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5498
    Cell Significance Index: 38.0200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.4149
    Cell Significance Index: 2.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3711
    Cell Significance Index: 17.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2802
    Cell Significance Index: 34.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2413
    Cell Significance Index: 43.5100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1937
    Cell Significance Index: 4.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1478
    Cell Significance Index: 111.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1329
    Cell Significance Index: 3.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1265
    Cell Significance Index: 5.9000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.1191
    Cell Significance Index: 0.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1074
    Cell Significance Index: 5.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1055
    Cell Significance Index: 10.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0870
    Cell Significance Index: 11.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0869
    Cell Significance Index: 38.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0868
    Cell Significance Index: 11.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0648
    Cell Significance Index: 7.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0452
    Cell Significance Index: 1.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0250
    Cell Significance Index: 8.9800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0053
    Cell Significance Index: 10.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0029
    Cell Significance Index: -5.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0074
    Cell Significance Index: -11.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0169
    Cell Significance Index: -22.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0170
    Cell Significance Index: -2.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0180
    Cell Significance Index: -13.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0203
    Cell Significance Index: -12.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0243
    Cell Significance Index: -13.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0346
    Cell Significance Index: -6.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0361
    Cell Significance Index: -1.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0365
    Cell Significance Index: -26.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0403
    Cell Significance Index: -25.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0492
    Cell Significance Index: -9.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0637
    Cell Significance Index: -28.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0649
    Cell Significance Index: -2.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0718
    Cell Significance Index: -15.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1351
    Cell Significance Index: -19.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1429
    Cell Significance Index: -19.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1452
    Cell Significance Index: -3.7100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1478
    Cell Significance Index: -16.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1777
    Cell Significance Index: -13.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1808
    Cell Significance Index: -3.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2239
    Cell Significance Index: -4.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2282
    Cell Significance Index: -11.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2438
    Cell Significance Index: -14.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2476
    Cell Significance Index: -7.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2507
    Cell Significance Index: -17.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2535
    Cell Significance Index: -26.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2561
    Cell Significance Index: -19.0900
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -0.2848
    Cell Significance Index: -1.7200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.3398
    Cell Significance Index: -3.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3457
    Cell Significance Index: -18.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4084
    Cell Significance Index: -25.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4167
    Cell Significance Index: -33.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4266
    Cell Significance Index: -23.9400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4285
    Cell Significance Index: -17.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4748
    Cell Significance Index: -13.2700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4930
    Cell Significance Index: -4.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4963
    Cell Significance Index: -13.5100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.5301
    Cell Significance Index: -5.9000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5399
    Cell Significance Index: -8.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5418
    Cell Significance Index: -19.8900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.5461
    Cell Significance Index: -11.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5667
    Cell Significance Index: -25.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6346
    Cell Significance Index: -22.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6660
    Cell Significance Index: -25.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6930
    Cell Significance Index: -22.0700
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.7043
    Cell Significance Index: -5.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7227
    Cell Significance Index: -9.8600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7247
    Cell Significance Index: -22.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** HLA-DMα is a 35-kDa protein that belongs to the HLA class II family. It is a transmembrane protein that localizes to the endosomal compartment, where it interacts with HLA-DMβ (DM beta) to facilitate the loading of antigens onto MHC class II molecules. 2. **Antigen Presentation:** HLA-DMα plays a critical role in the assembly of MHC class II-peptide complexes, ensuring that only high-affinity peptides are presented to T-cells. This process is essential for the initiation and regulation of immune responses. 3. **Cellular Expression:** HLA-DMα is predominantly expressed on antigen-presenting cells (APCs), including dendritic cells, macrophages, and B cells, which are responsible for processing and presenting antigens to T-cells. **Pathways and Functions:** 1. **Antigen Processing and Presentation:** HLA-DMα is involved in the processing and loading of antigens onto MHC class II molecules in the endosomal compartment. This process is essential for the presentation of antigens to T-cells, which is a critical step in the activation of immune responses. 2. **T-Cell Activation:** HLA-DMα facilitates the activation of T-cells by ensuring that only high-affinity peptides are presented to T-cells. This process is critical for the regulation of immune responses and the prevention of autoimmune diseases. 3. **Immune System Regulation:** HLA-DMα is involved in the regulation of immune responses, including the promotion of positive regulation of immune response and T-cell activation. **Clinical Significance:** 1. **Autoimmune Diseases:** Alterations in HLA-DMα expression have been associated with various autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. Understanding the role of HLA-DMα in these diseases can provide insights into the development of novel therapeutic strategies. 2. **Cancer Immunotherapy:** HLA-DMα plays a critical role in the presentation of tumor antigens to T-cells. Alterations in HLA-DMα expression can impact the efficacy of cancer immunotherapy, highlighting the need for targeted therapies that modulate HLA-DMα function. 3. **Infectious Diseases:** HLA-DMα is involved in the processing and presentation of antigens from pathogens, which is critical for the initiation of immune responses against infections. Understanding the role of HLA-DMα in infectious diseases can provide insights into the development of novel vaccines and therapeutic strategies. In conclusion, HLA-DMα is a critical accessory molecule that plays a pivotal role in the regulation of immune responses. Its involvement in antigen processing and presentation, T-cell activation, and immune system regulation makes it an essential component of the adaptive immune system. Further research on HLA-DMα is necessary to fully understand its role in various diseases and to develop novel therapeutic strategies that target this molecule.

Genular Protein ID: 3786305756

Symbol: Q6ICR9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6ICR9

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GlyCosmos 1 HOGENOM 1 InterPro 9 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PROSITE 3 Pfam 2 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 2 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 23222639

Title: HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.

PubMed ID: 23222639

DOI: 10.1038/nsmb.2460

Sequence Information:

  • Length: 261
  • Mass: 29207
  • Checksum: BAAB2528874DFFC6
  • Sequence:
    • MGHEQNQGAA LLQMLPLLWL LPHSWAVPEA PTPMWPDDLQ NHTFLHTVYC QDGSPSVGLS 
EAYDEDQLFF FDFSQNTRVP RLPEFADWAQ EQGDAPAILF DKEFCEWMIQ QIGPKLDGKI 
PVSRGFPIAE VFTLKPLEFG KPNTLVCFVS NLFPPMLTVN WQHHSVPVEG FGPTFVSAVD 
GLSFQAFSYL NFTPEPSDIF SCIVTHEIDR YTAIAYWVPR NALPSDLLEN VLCGVAFGLG 
VLGIIVGIVL IIYFRKPCSG D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.