Details for: POU2AF1

Gene ID: 5450

Symbol: POU2AF1

Ensembl ID: ENSG00000110777

Description: POU class 2 homeobox associating factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 39.9884
    Cell Significance Index: -6.2200
  • Cell Name: centroblast (CL0009112)
    Fold Change: 29.7077
    Cell Significance Index: 69.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.8774
    Cell Significance Index: -6.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.0367
    Cell Significance Index: -6.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.9722
    Cell Significance Index: 468.4400
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.2476
    Cell Significance Index: 6.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.5940
    Cell Significance Index: -6.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3450
    Cell Significance Index: 60.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0358
    Cell Significance Index: 197.1200
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.9548
    Cell Significance Index: 4.2700
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.6813
    Cell Significance Index: 4.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6561
    Cell Significance Index: 64.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.6378
    Cell Significance Index: 22.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5877
    Cell Significance Index: 530.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4876
    Cell Significance Index: 10.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3611
    Cell Significance Index: 58.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3412
    Cell Significance Index: 37.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2616
    Cell Significance Index: 16.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2557
    Cell Significance Index: 29.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2204
    Cell Significance Index: 13.2300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2077
    Cell Significance Index: 14.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1534
    Cell Significance Index: 7.9700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1331
    Cell Significance Index: 2.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0580
    Cell Significance Index: 1.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0524
    Cell Significance Index: 1.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0463
    Cell Significance Index: 29.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0260
    Cell Significance Index: 4.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0223
    Cell Significance Index: 2.7500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0086
    Cell Significance Index: 0.1300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0078
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0034
    Cell Significance Index: -6.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0052
    Cell Significance Index: -8.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0065
    Cell Significance Index: -3.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0067
    Cell Significance Index: -9.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0068
    Cell Significance Index: -5.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0097
    Cell Significance Index: -3.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0107
    Cell Significance Index: -7.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0112
    Cell Significance Index: -8.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0128
    Cell Significance Index: -7.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0131
    Cell Significance Index: -2.5900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0153
    Cell Significance Index: -0.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0176
    Cell Significance Index: -7.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0178
    Cell Significance Index: -3.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0179
    Cell Significance Index: -0.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0180
    Cell Significance Index: -5.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0286
    Cell Significance Index: -3.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0293
    Cell Significance Index: -0.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0336
    Cell Significance Index: -4.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0374
    Cell Significance Index: -0.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0377
    Cell Significance Index: -0.5400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0412
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0454
    Cell Significance Index: -7.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0455
    Cell Significance Index: -6.6200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0493
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0494
    Cell Significance Index: -10.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0586
    Cell Significance Index: -6.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0632
    Cell Significance Index: -1.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0641
    Cell Significance Index: -3.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0665
    Cell Significance Index: -6.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0689
    Cell Significance Index: -7.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0707
    Cell Significance Index: -9.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0843
    Cell Significance Index: -1.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0860
    Cell Significance Index: -4.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0873
    Cell Significance Index: -5.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0882
    Cell Significance Index: -5.9300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0897
    Cell Significance Index: -3.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0926
    Cell Significance Index: -7.1100
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1081
    Cell Significance Index: -0.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1107
    Cell Significance Index: -1.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1200
    Cell Significance Index: -6.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1226
    Cell Significance Index: -9.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1322
    Cell Significance Index: -6.9400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1422
    Cell Significance Index: -1.5400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1438
    Cell Significance Index: -1.5300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1447
    Cell Significance Index: -3.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1448
    Cell Significance Index: -8.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1463
    Cell Significance Index: -6.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1563
    Cell Significance Index: -8.1400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1580
    Cell Significance Index: -1.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1614
    Cell Significance Index: -7.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1624
    Cell Significance Index: -5.6900
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1706
    Cell Significance Index: -2.1300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1727
    Cell Significance Index: -1.6900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1741
    Cell Significance Index: -5.7000
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1751
    Cell Significance Index: -1.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1755
    Cell Significance Index: -5.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1758
    Cell Significance Index: -4.7100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1778
    Cell Significance Index: -4.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1819
    Cell Significance Index: -4.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1846
    Cell Significance Index: -8.6800
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1882
    Cell Significance Index: -1.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1892
    Cell Significance Index: -6.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1908
    Cell Significance Index: -7.2300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1924
    Cell Significance Index: -2.4900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1956
    Cell Significance Index: -3.2900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1969
    Cell Significance Index: -2.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2026
    Cell Significance Index: -4.2400
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.2041
    Cell Significance Index: -1.6400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2053
    Cell Significance Index: -2.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The POU2AF1 gene belongs to the POU family of transcription factors, which are characterized by the presence of a POU domain. This domain is responsible for the recognition and binding to specific DNA sequences, allowing the gene to regulate the transcription of target genes. The POU2AF1 gene is specifically expressed in B cells, where it plays a critical role in the regulation of gene expression. The gene's product, OBF1_HUMAN, is a coactivator that enhances the transcriptional activity of RNA polymerase II, a key enzyme involved in the transcription of genes. **Pathways and Functions:** The POU2AF1 gene is involved in several key pathways that regulate immune cell development and function. These include: 1. **Germinal center B cell differentiation**: The POU2AF1 gene regulates the expression of genes involved in the differentiation of B cells into germinal center B cells, a critical step in the humoral immune response. 2. **Humoral immune response**: The gene's product, OBF1_HUMAN, enhances the transcriptional activity of RNA polymerase II, leading to the increased production of immunoglobulins, which are essential for the humoral immune response. 3. **Positive regulation of interleukin-6 production**: The POU2AF1 gene is involved in the regulation of interleukin-6 (IL-6) production, a cytokine that plays a crucial role in the activation and proliferation of B cells. 4. **Transcription coactivator activity**: The gene's product, OBF1_HUMAN, acts as a coactivator, enhancing the transcriptional activity of RNA polymerase II and promoting the expression of genes involved in immune cell development and function. **Clinical Significance:** The POU2AF1 gene has significant clinical implications, particularly in the context of immune-related disorders. Dysregulation of the POU2AF1 gene has been implicated in various autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. Additionally, the gene's product, OBF1_HUMAN, has been shown to be a potential therapeutic target for the treatment of autoimmune diseases. In conclusion, the POU2AF1 gene is a critical component of the immune system, playing a pivotal role in the development and function of immune cells. Further research is needed to fully understand the mechanisms by which this gene regulates immune cell development and function, and to explore its potential as a therapeutic target for the treatment of immune-related disorders.

Genular Protein ID: 1335844590

Symbol: OBF1_HUMAN

Name: B-cell-specific coactivator OBF-1

UniProtKB Accession Codes:

Q16633 B2R8Z9 Q14983

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7859290

Title: OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins.

PubMed ID: 7859290

DOI: 10.1016/0092-8674(95)90500-6

PubMed ID: 7779176

Title: A B-cell coactivator of octamer-binding transcription factors.

PubMed ID: 7779176

DOI: 10.1038/373360a0

PubMed ID: 8574789

Title: Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3; 11) (q27; q23) chromosomal translocation.

PubMed ID: 8574789

PubMed ID: 7623806

Title: Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B.

PubMed ID: 7623806

DOI: 10.1128/mcb.15.8.4115

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11483517

Title: The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1.

PubMed ID: 11483517

DOI: 10.1093/emboj/20.15.4143

PubMed ID: 11483518

Title: Regulation of BOB.1/OBF.1 stability by SIAH.

PubMed ID: 11483518

DOI: 10.1093/emboj/20.15.4153

PubMed ID: 10541551

Title: Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface.

PubMed ID: 10541551

DOI: 10.1101/gad.13.20.2650

PubMed ID: 35576971

Title: OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage.

PubMed ID: 35576971

DOI: 10.1038/s41586-022-04842-7

Sequence Information:

  • Length: 256
  • Mass: 27436
  • Checksum: 2C46F1796774D614
  • Sequence:
    • MLWQKPTAPE QAPAPARPYQ GVRVKEPVKE LLRRKRGHAS SGAAPAPTAV VLPHQPLATY 
TTVGPSCLDM EGSVSAVTEE AALCAGWLSQ PTPATLQPLA PWTPYTEYVP HEAVSCPYSA 
DMYVQPVCPS YTVVGPSSVL TYASPPLITN VTTRSSATPA VGPPLEGPEH QAPLTYFPWP 
QPLSTLPTST LQYQPPAPAL PGPQFVQLPI SIPEPVLQDM EDPRRAASSL TIDKLLLEEE 
DSDAYALNHT LSVEGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.