Details for: TCL1A

Gene ID: 8115

Symbol: TCL1A

Ensembl ID: ENSG00000100721

Description: TCL1 family AKT coactivator A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: centroblast (CL0009112)
    Fold Change: 49.3214
    Cell Significance Index: 115.0700
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 30.0234
    Cell Significance Index: -4.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.1320
    Cell Significance Index: -5.3600
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 5.7759
    Cell Significance Index: 25.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.6203
    Cell Significance Index: 662.8100
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 4.7774
    Cell Significance Index: 14.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.6417
    Cell Significance Index: -4.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.6247
    Cell Significance Index: 233.8500
  • Cell Name: germ cell (CL0000586)
    Fold Change: 3.5030
    Cell Significance Index: 26.4500
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 2.1094
    Cell Significance Index: 10.5800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.9274
    Cell Significance Index: 29.8200
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.8776
    Cell Significance Index: 8.8200
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.5613
    Cell Significance Index: 7.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7417
    Cell Significance Index: 19.8400
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.5778
    Cell Significance Index: 3.0700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0029
    Cell Significance Index: -5.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0030
    Cell Significance Index: -0.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0040
    Cell Significance Index: -0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0067
    Cell Significance Index: -5.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0098
    Cell Significance Index: -6.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0146
    Cell Significance Index: -0.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0153
    Cell Significance Index: -6.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0266
    Cell Significance Index: -5.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0306
    Cell Significance Index: -6.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0444
    Cell Significance Index: -1.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0470
    Cell Significance Index: -1.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0483
    Cell Significance Index: -1.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0507
    Cell Significance Index: -6.9600
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0622
    Cell Significance Index: -0.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0623
    Cell Significance Index: -6.3600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0672
    Cell Significance Index: -0.8700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0684
    Cell Significance Index: -2.9800
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0703
    Cell Significance Index: -0.6700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0707
    Cell Significance Index: -1.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0889
    Cell Significance Index: -5.4500
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.0920
    Cell Significance Index: -0.6500
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0946
    Cell Significance Index: -0.7000
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1039
    Cell Significance Index: -1.3300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1067
    Cell Significance Index: -1.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1121
    Cell Significance Index: -6.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1121
    Cell Significance Index: -1.2700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1207
    Cell Significance Index: -2.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1261
    Cell Significance Index: -6.5700
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.1343
    Cell Significance Index: -1.2600
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1374
    Cell Significance Index: -1.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1408
    Cell Significance Index: -6.2300
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1441
    Cell Significance Index: -1.6700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1515
    Cell Significance Index: -1.7900
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.1562
    Cell Significance Index: -1.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1624
    Cell Significance Index: -4.2700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1632
    Cell Significance Index: -1.0000
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.1663
    Cell Significance Index: -1.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1718
    Cell Significance Index: -6.0200
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1772
    Cell Significance Index: -1.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1786
    Cell Significance Index: -5.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1817
    Cell Significance Index: -6.3200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1859
    Cell Significance Index: -2.3000
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1884
    Cell Significance Index: -1.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1906
    Cell Significance Index: -6.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1966
    Cell Significance Index: -5.2500
  • Cell Name: lymphocyte of B lineage (CL0000945)
    Fold Change: -0.1979
    Cell Significance Index: -1.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2000
    Cell Significance Index: -6.3700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2021
    Cell Significance Index: -7.4200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2066
    Cell Significance Index: -2.8100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2073
    Cell Significance Index: -5.1700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2080
    Cell Significance Index: -3.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2082
    Cell Significance Index: -5.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2183
    Cell Significance Index: -6.4300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2186
    Cell Significance Index: -5.5700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2343
    Cell Significance Index: -3.9400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2386
    Cell Significance Index: -4.9800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2387
    Cell Significance Index: -4.7600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2484
    Cell Significance Index: -5.4400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2495
    Cell Significance Index: -1.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2538
    Cell Significance Index: -7.2800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.2573
    Cell Significance Index: -1.5900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2615
    Cell Significance Index: -5.6500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2675
    Cell Significance Index: -3.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2681
    Cell Significance Index: -5.6900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2682
    Cell Significance Index: -5.3900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2709
    Cell Significance Index: -3.8800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2718
    Cell Significance Index: -5.3500
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.2735
    Cell Significance Index: -1.7800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2785
    Cell Significance Index: -6.7500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2992
    Cell Significance Index: -5.8500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3033
    Cell Significance Index: -7.5800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3090
    Cell Significance Index: -7.5400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3129
    Cell Significance Index: -5.4100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3171
    Cell Significance Index: -6.2700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3198
    Cell Significance Index: -5.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3209
    Cell Significance Index: -5.3700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3263
    Cell Significance Index: -4.5800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3280
    Cell Significance Index: -4.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3322
    Cell Significance Index: -6.1400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3364
    Cell Significance Index: -4.5400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3460
    Cell Significance Index: -3.7200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3525
    Cell Significance Index: -3.7500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.3570
    Cell Significance Index: -3.9900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.3578
    Cell Significance Index: -4.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TCL1A exhibits several key characteristics that make it a significant player in B cell biology. These include: 1. **AKT coactivator activity**: TCL1A acts as a coactivator for AKT, a serine/threonine kinase that regulates cell survival, proliferation, and metabolism. 2. **High expression in B cells**: TCL1A is highly expressed in various B cell subsets, including germinal center B cells, centroblasts, and memory B cells. 3. **Regulation of peptidyl-serine phosphorylation**: TCL1A is involved in the regulation of peptidyl-serine phosphorylation, a post-translational modification that plays a critical role in cell signaling. 4. **Protein binding and interaction**: TCL1A interacts with various proteins, including AKT, protein kinases, and other signaling molecules, to regulate cell signaling pathways. **Pathways and Functions:** TCL1A is involved in several key signaling pathways that regulate B cell development and function. These include: 1. **AKT signaling pathway**: TCL1A acts as a coactivator for AKT, which regulates cell survival, proliferation, and metabolism. 2. **Peptidyl-serine phosphorylation pathway**: TCL1A regulates peptidyl-serine phosphorylation, a post-translational modification that plays a critical role in cell signaling. 3. **Protein kinase signaling pathway**: TCL1A interacts with protein kinases to regulate cell signaling pathways. 4. **Intracellular signaling pathway**: TCL1A is involved in regulating intracellular signaling pathways that control cell growth, differentiation, and survival. **Clinical Significance:** TCL1A has significant implications for understanding B cell development and function, as well as its role in various diseases. Some potential clinical applications of TCL1A include: 1. **B cell malignancies**: TCL1A may play a role in the development of B cell malignancies, such as B cell chronic lymphocytic leukemia (B-CLL). 2. **Autoimmune diseases**: TCL1A may be involved in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Immunotherapy**: TCL1A may be a target for immunotherapy strategies aimed at modulating B cell function and immune responses. In conclusion, TCL1A is a critical gene involved in B cell development and function. Its regulation of AKT signaling pathways, peptidyl-serine phosphorylation, and protein kinase signaling pathways highlights its importance in B cell biology. Further research on TCL1A may reveal new insights into B cell development and function, as well as its role in various diseases.

Genular Protein ID: 3631146338

Symbol: TCL1A_HUMAN

Name: T-cell leukemia/lymphoma protein 1A

UniProtKB Accession Codes:

P56279 Q6IBK7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7809072

Title: Identification of the TCL1 gene involved in T-cell malignancies.

PubMed ID: 7809072

DOI: 10.1073/pnas.91.26.12530

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7987816

Title: Characterization and localization of the TCL-1 oncogene product.

PubMed ID: 7987816

PubMed ID: 10983986

Title: The protooncogene TCL1 is an Akt kinase coactivator.

PubMed ID: 10983986

DOI: 10.1016/s1097-2765(00)00039-3

PubMed ID: 10716693

Title: Tcl1 enhances Akt kinase activity and mediates its nuclear translocation.

PubMed ID: 10716693

DOI: 10.1073/pnas.97.7.3028

PubMed ID: 11707444

Title: Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family.

PubMed ID: 11707444

DOI: 10.1074/jbc.m107069200

PubMed ID: 11839817

Title: Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1.

PubMed ID: 11839817

DOI: 10.1128/mcb.22.5.1513-1525.2002

PubMed ID: 16934922

Title: The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity.

PubMed ID: 16934922

DOI: 10.1016/j.canlet.2006.07.006

PubMed ID: 9519406

Title: Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology.

PubMed ID: 9519406

DOI: 10.1016/s0969-2126(98)00017-3

Sequence Information:

  • Length: 114
  • Mass: 13460
  • Checksum: 90D55ABC97C36D04
  • Sequence:
    • MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR 
PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.