IGHM | ENSG00000211899 | NCBI 3507

Details for: IGHM

Gene ID: 3507

Symbol: IGHM

Ensembl ID: ENSG00000211899

Description: immunoglobulin heavy constant mu

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Disease
(R-HSA-1643685)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Potential therapeutics for sars
(R-HSA-9679191)
Sars-cov infections
(R-HSA-9679506)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antibacterial humoral response
(GO:0019731)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Cell surface
(GO:0009986)
Complement activation, classical pathway
(GO:0006958)
Defense response to gram-negative bacterium
(GO:0050829)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Hexameric igm immunoglobulin complex
(GO:0071757)
Igm b cell receptor complex
(GO:0071755)
Igm immunoglobulin complex
(GO:0071753)
Immunoglobulin complex, circulating
(GO:0042571)
Immunoglobulin receptor binding
(GO:0034987)
Innate immune response
(GO:0045087)
Pentameric igm immunoglobulin complex
(GO:0071756)
Peptidoglycan binding
(GO:0042834)
Phosphatidylcholine binding
(GO:0031210)
Plasma membrane
(GO:0005886)
Pre-b cell allelic exclusion
(GO:0002331)
Protein binding
(GO:0005515)
Single-stranded dna binding
(GO:0003697)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 39.3101
Cell Significance Index: -15.9700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 34.1767
Cell Significance Index: -17.5800
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 25.8460
Cell Significance Index: -12.2000
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 18.7997
Cell Significance Index: -12.6200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 16.7270
Cell Significance Index: -15.9700
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 14.3538
Cell Significance Index: 64.1900
Cell Name: centroblast (CL0009112)
Fold Change: 9.5883
Cell Significance Index: 22.3700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 5.8534
Cell Significance Index: 377.6300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 5.8463
Cell Significance Index: 205.4300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 3.8010
Cell Significance Index: 109.5200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.2427
Cell Significance Index: 264.4800
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 2.1208
Cell Significance Index: 31.9600
Cell Name: early promyelocyte (CL0002154)
Fold Change: 2.1163
Cell Significance Index: 13.5100
Cell Name: follicular B cell (CL0000843)
Fold Change: 1.5853
Cell Significance Index: 7.9300
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.5382
Cell Significance Index: 9.2900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 1.2177
Cell Significance Index: -3.7400
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.0191
Cell Significance Index: 8.3100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8068
Cell Significance Index: 36.5700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.6888
Cell Significance Index: 18.4300
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.6636
Cell Significance Index: 4.6700
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.6323
Cell Significance Index: 5.5600
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.5484
Cell Significance Index: 11.6800
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.5170
Cell Significance Index: 3.4300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3665
Cell Significance Index: 22.0100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3062
Cell Significance Index: 276.5200
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.3050
Cell Significance Index: 1.5300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3038
Cell Significance Index: 33.0400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2437
Cell Significance Index: 39.6400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1467
Cell Significance Index: 14.5100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1314
Cell Significance Index: 9.0900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0737
Cell Significance Index: 14.0200
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0336
Cell Significance Index: 0.5200
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0215
Cell Significance Index: 2.2000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0046
Cell Significance Index: -3.3900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0052
Cell Significance Index: -9.7500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0055
Cell Significance Index: -3.0800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0063
Cell Significance Index: -4.7400
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0064
Cell Significance Index: -0.2800
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0101
Cell Significance Index: -1.2900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0195
Cell Significance Index: -12.3800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0235
Cell Significance Index: -2.7000
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0277
Cell Significance Index: -1.4000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0307
Cell Significance Index: -13.9300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0339
Cell Significance Index: -12.1600
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0377
Cell Significance Index: -7.4800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0380
Cell Significance Index: -0.9500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0415
Cell Significance Index: -1.0600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0472
Cell Significance Index: -13.5900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0572
Cell Significance Index: -11.4700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0619
Cell Significance Index: -1.3400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0658
Cell Significance Index: -9.5700
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0730
Cell Significance Index: -9.4300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0762
Cell Significance Index: -2.4400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0790
Cell Significance Index: -14.2400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0957
Cell Significance Index: -9.9600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0961
Cell Significance Index: -13.2000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1132
Cell Significance Index: -13.9200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1236
Cell Significance Index: -9.2100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1382
Cell Significance Index: -8.4700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1454
Cell Significance Index: -1.6500
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.1516
Cell Significance Index: -1.4400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1617
Cell Significance Index: -12.4100
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.1677
Cell Significance Index: -2.1700
Cell Name: thymocyte (CL0000893)
Fold Change: -0.1745
Cell Significance Index: -2.2100
Cell Name: naive B cell (CL0000788)
Fold Change: -0.1890
Cell Significance Index: -1.9900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1910
Cell Significance Index: -15.1300
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.1929
Cell Significance Index: -2.8000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2121
Cell Significance Index: -11.1400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2192
Cell Significance Index: -10.2200
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2254
Cell Significance Index: -8.2800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2255
Cell Significance Index: -11.7200
Cell Name: mature B cell (CL0000785)
Fold Change: -0.2320
Cell Significance Index: -1.5100
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.2403
Cell Significance Index: -3.0500
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2597
Cell Significance Index: -5.6100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2647
Cell Significance Index: -11.7100
Cell Name: memory B cell (CL0000787)
Fold Change: -0.2679
Cell Significance Index: -2.8500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2826
Cell Significance Index: -14.7200
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3050
Cell Significance Index: -11.5500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3071
Cell Significance Index: -14.4400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.3284
Cell Significance Index: -3.5700
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.3393
Cell Significance Index: -2.8500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3437
Cell Significance Index: -21.6600
Cell Name: B cell (CL0000236)
Fold Change: -0.3444
Cell Significance Index: -4.0700
Cell Name: leukocyte (CL0000738)
Fold Change: -0.3645
Cell Significance Index: -6.1900
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.3734
Cell Significance Index: -5.2400
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.3750
Cell Significance Index: -5.4900
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.3793
Cell Significance Index: -5.1600
Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.3803
Cell Significance Index: -5.4100
Cell Name: collagen secreting cell (CL0000667)
Fold Change: -0.4024
Cell Significance Index: -2.2400
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4404
Cell Significance Index: -11.5800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4406
Cell Significance Index: -11.7700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4426
Cell Significance Index: -15.3800
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.4440
Cell Significance Index: -5.3600
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: -0.4460
Cell Significance Index: -4.2700
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: -0.4494
Cell Significance Index: -3.5700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4549
Cell Significance Index: -13.4000
Cell Name: immature B cell (CL0000816)
Fold Change: -0.4550
Cell Significance Index: -4.3100
Cell Name: plasma cell (CL0000786)
Fold Change: -0.4556
Cell Significance Index: -5.0900
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.4727
Cell Significance Index: -4.7400
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: -0.4842
Cell Significance Index: -2.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** The IGHM gene is a single-copy gene located on chromosome 14q32.1. It is a transcribed gene that produces a heavy chain constant region, which is essential for the formation of IgM antibodies. The IGHM gene is highly expressed in B cells, particularly in the germinal center, where it plays a critical role in the selection and maturation of B cells. The gene is also expressed in other cell types, including glutamatergic neurons and plasma cells. **Pathways and Functions:** The IGHM gene is involved in multiple signaling pathways that regulate immune responses. These pathways include: 1. **Antigen-activated B cell receptor (BCR) signaling**: The IGHM gene is a key component of the BCR, which is responsible for recognizing and binding to antigens. Upon antigen binding, the BCR triggers a signaling cascade that activates various downstream pathways, including the activation of NF-κB and MAPK. 2. **Antibacterial humoral response**: The IGHM gene plays a crucial role in the early response to bacterial infections, particularly gram-negative bacteria. IgM antibodies produced from the IGHM gene are effective in neutralizing bacterial toxins and preventing infection. 3. **Complement activation**: The IGHM gene is involved in the activation of the complement system, which is a group of proteins that work together to eliminate pathogens from the body. 4. **Cell surface interactions**: The IGHM gene is involved in cell surface interactions at the vascular wall, where it regulates the adhesion of B cells to endothelial cells. **Clinical Significance:** The IGHM gene has significant clinical implications, particularly in the context of infections and autoimmune diseases. Dysregulation of the IGHM gene has been implicated in various diseases, including: 1. **Infectious diseases**: The IGHM gene plays a critical role in the early response to bacterial infections, particularly gram-negative bacteria. Dysregulation of the gene can lead to impaired immune responses and increased susceptibility to infection. 2. **Autoimmune diseases**: The IGHM gene has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. Dysregulation of the gene can lead to the production of autoantibodies and tissue damage. 3. **Cancer**: The IGHM gene has been implicated in cancer, particularly in the context of germinal center B cell-like lymphoma. Dysregulation of the gene can lead to the production of aberrant IgM antibodies and the development of cancer. In conclusion, the IGHM gene is a crucial component of the adaptive immune system, and its dysregulation can have significant clinical implications. Further research is needed to fully understand the mechanisms by which the IGHM gene regulates immune responses and to develop effective therapeutic strategies for related diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.