Gene IGHM - ENSG00000211899 | NCBI Gene ID: 3507

Details for: IGHM

Gene ID: 3507

Symbol: IGHM

Ensembl ID: ENSG00000211899

Description: immunoglobulin heavy constant mu

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Disease
(R-HSA-1643685)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Potential therapeutics for sars
(R-HSA-9679191)
Sars-cov infections
(R-HSA-9679506)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antibacterial humoral response
(GO:0019731)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Cell surface
(GO:0009986)
Complement activation, classical pathway
(GO:0006958)
Defense response to gram-negative bacterium
(GO:0050829)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Hexameric igm immunoglobulin complex
(GO:0071757)
Igm immunoglobulin complex
(GO:0071753)
Immunoglobulin complex, circulating
(GO:0042571)
Immunoglobulin receptor binding
(GO:0034987)
Innate immune response
(GO:0045087)
Pentameric igm immunoglobulin complex
(GO:0071756)
Peptidoglycan binding
(GO:0042834)
Phosphatidylcholine binding
(GO:0031210)
Plasma membrane
(GO:0005886)
Single-stranded dna binding
(GO:0003697)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 15.98
Marker Score: 162005
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 4.25
Marker Score: 4187
Cell Name: germinal center B cell (CL0000844)
Fold Change: 3.7
Marker Score: 2252.5
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 3.65
Marker Score: 7642
Cell Name: B-1 B cell (CL0000819)
Fold Change: 3.16
Marker Score: 5509
Cell Name: naive B cell (CL0000788)
Fold Change: 3.03
Marker Score: 2704
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 3.02
Marker Score: 1052
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.91
Marker Score: 1030
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.86
Marker Score: 28949
Cell Name: late pro-B cell (CL0002048)
Fold Change: 2.33
Marker Score: 2746.5
Cell Name: follicular B cell (CL0000843)
Fold Change: 2.32
Marker Score: 2509
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 2.3
Marker Score: 1687
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 2.24
Marker Score: 6092
Cell Name: B-1b B cell (CL0000821)
Fold Change: 2.23
Marker Score: 514
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.96
Marker Score: 1956
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 1.95
Marker Score: 539
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 1.86
Marker Score: 475
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.82
Marker Score: 1242.5
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.8
Marker Score: 1085
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 1.68
Marker Score: 1435
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 1.49
Marker Score: 872
Cell Name: memory B cell (CL0000787)
Fold Change: 1.48
Marker Score: 1118
Cell Name: early promyelocyte (CL0002154)
Fold Change: 1.46
Marker Score: 1165
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.45
Marker Score: 708
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.43
Marker Score: 4229
Cell Name: plasmablast (CL0000980)
Fold Change: 1.39
Marker Score: 1846.5
Cell Name: centroblast (CL0009112)
Fold Change: 1.37
Marker Score: 674
Cell Name: immature B cell (CL0000816)
Fold Change: 1.26
Marker Score: 833
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 1.25
Marker Score: 547
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 1.22
Marker Score: 321
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 1.19
Marker Score: 316
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.13
Marker Score: 4760
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.13
Marker Score: 822
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.12
Marker Score: 2784
Cell Name: goblet cell (CL0000160)
Fold Change: 1.12
Marker Score: 7413
Cell Name: B-1a B cell (CL0000820)
Fold Change: 1.07
Marker Score: 256
Cell Name: blood cell (CL0000081)
Fold Change: 1.05
Marker Score: 12193
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 1.01
Marker Score: 949
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 1
Marker Score: 490
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71753
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47980
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 0.99
Marker Score: 749
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30402
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.96
Marker Score: 508
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 490
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2407
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 445
Cell Name: B cell (CL0000236)
Fold Change: 0.94
Marker Score: 893
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.94
Marker Score: 633.5
Cell Name: centrocyte (CL0009111)
Fold Change: 0.92
Marker Score: 219
Cell Name: mature B cell (CL0000785)
Fold Change: 0.92
Marker Score: 672
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2732
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.91
Marker Score: 658
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5182
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.9
Marker Score: 360
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.89
Marker Score: 307
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 314
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5275
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.85
Marker Score: 319
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.81
Marker Score: 2106
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1262
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 587
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 0.76
Marker Score: 247
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 690
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 381
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 0.7
Marker Score: 159
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.69
Marker Score: 417
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: plasma cell (CL0000786)
Fold Change: 0.65
Marker Score: 730
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.64
Marker Score: 267
Cell Name: neutrophil (CL0000775)
Fold Change: 0.63
Marker Score: 384
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.62
Marker Score: 2575
Cell Name: thymocyte (CL0000893)
Fold Change: 0.62
Marker Score: 644
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.6
Marker Score: 215
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.58
Marker Score: 374
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.58
Marker Score: 335
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.57
Marker Score: 921
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.56
Marker Score: 369
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.56
Marker Score: 1563
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.55
Marker Score: 237
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.53
Marker Score: 264
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.52
Marker Score: 265
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.51
Marker Score: 398
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.51
Marker Score: 134
Cell Name: naive T cell (CL0000898)
Fold Change: 0.49
Marker Score: 316
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.48
Marker Score: 127
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.48
Marker Score: 169
Cell Name: fibroblast (CL0000057)
Fold Change: 0.48
Marker Score: 466
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.48
Marker Score: 302
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.47
Marker Score: 93
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.46
Marker Score: 381.5
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.46
Marker Score: 246
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.45
Marker Score: 268
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.44
Marker Score: 252
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.44
Marker Score: 422
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.43
Marker Score: 197
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 0.42
Marker Score: 306
Cell Name: mast cell (CL0000097)
Fold Change: 0.42
Marker Score: 244
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 0.42
Marker Score: 97

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Other Information

Description

**Key characteristics:** - IGHM is a member of the immunoglobulin heavy chain family. - It is responsible for the production of antibodies that are produced by B cells. - IGHM is expressed in high levels in germinal center B cells, which are responsible for the production of antibodies in response to an infection. - IGHM is also expressed in B cells that have switched from the naïve to the memory cell stage. **Pathways and functions:** - IGHM is expressed in B cells and is responsible for the production of antibodies. - Antibodies are proteins that are produced by B cells in response to an infection. - Antibodies bind to specific antigens, which can trigger an immune response. - Antibodies can neutralize viruses, bacteria, and other pathogens. **Clinical significance:** - Mutations in the IGHM gene can lead to the development of immunodeficiency diseases, such as severe combined immunodeficiency (SCID). - IGHM is a potential target for immunotherapy of cancer and autoimmune diseases. - Antibodies produced by IGHM can be used to treat cancer and autoimmune diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.