Details for: IGKC

Gene ID: 3514

Symbol: IGKC

Ensembl ID: ENSG00000211592

Description: immunoglobulin kappa constant

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 105.8740
    Cell Significance Index: -54.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 91.4593
    Cell Significance Index: -43.1800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 65.2139
    Cell Significance Index: -43.7600
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 41.4350
    Cell Significance Index: 429.1600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.6431
    Cell Significance Index: -55.3000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 14.1674
    Cell Significance Index: 121.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.3422
    Cell Significance Index: -40.9800
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 9.6971
    Cell Significance Index: 68.2400
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 8.6091
    Cell Significance Index: 38.5000
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 3.8879
    Cell Significance Index: 31.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9800
    Cell Significance Index: 195.8700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.7214
    Cell Significance Index: 22.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.6231
    Cell Significance Index: 165.8000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.5320
    Cell Significance Index: 31.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3697
    Cell Significance Index: 260.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1956
    Cell Significance Index: 1079.5700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.8706
    Cell Significance Index: 13.4700
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.8130
    Cell Significance Index: 4.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7133
    Cell Significance Index: 116.0200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4058
    Cell Significance Index: 4.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3952
    Cell Significance Index: 42.9900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.3573
    Cell Significance Index: 4.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1379
    Cell Significance Index: 10.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0932
    Cell Significance Index: 12.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0284
    Cell Significance Index: 21.5000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0232
    Cell Significance Index: 0.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0128
    Cell Significance Index: -0.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0241
    Cell Significance Index: -3.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0252
    Cell Significance Index: -1.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0603
    Cell Significance Index: -26.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0609
    Cell Significance Index: -33.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0680
    Cell Significance Index: -49.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0813
    Cell Significance Index: -2.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0833
    Cell Significance Index: -2.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0896
    Cell Significance Index: -4.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0926
    Cell Significance Index: -1.5900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0959
    Cell Significance Index: -3.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1078
    Cell Significance Index: -79.8500
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.1080
    Cell Significance Index: -0.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1083
    Cell Significance Index: -21.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1192
    Cell Significance Index: -2.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1392
    Cell Significance Index: -9.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1422
    Cell Significance Index: -80.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1566
    Cell Significance Index: -7.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1638
    Cell Significance Index: -29.5300
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1895
    Cell Significance Index: -2.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1987
    Cell Significance Index: -11.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2226
    Cell Significance Index: -4.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2385
    Cell Significance Index: -32.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2714
    Cell Significance Index: -33.3700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2803
    Cell Significance Index: -7.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2944
    Cell Significance Index: -59.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3026
    Cell Significance Index: -43.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3360
    Cell Significance Index: -57.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4062
    Cell Significance Index: -8.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4136
    Cell Significance Index: -26.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4565
    Cell Significance Index: -32.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5010
    Cell Significance Index: -57.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5448
    Cell Significance Index: -41.8100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5789
    Cell Significance Index: -25.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6046
    Cell Significance Index: -37.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6301
    Cell Significance Index: -49.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6451
    Cell Significance Index: -20.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6545
    Cell Significance Index: -41.2500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6742
    Cell Significance Index: -10.1600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7416
    Cell Significance Index: -13.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8200
    Cell Significance Index: -18.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8205
    Cell Significance Index: -38.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9338
    Cell Significance Index: -49.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.9425
    Cell Significance Index: -48.9600
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -1.0151
    Cell Significance Index: -6.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0303
    Cell Significance Index: -63.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1131
    Cell Significance Index: -49.2400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1234
    Cell Significance Index: -41.2400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -1.1278
    Cell Significance Index: -12.6000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.2419
    Cell Significance Index: -33.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4506
    Cell Significance Index: -46.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.4843
    Cell Significance Index: -51.5800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -1.5071
    Cell Significance Index: -20.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.5583
    Cell Significance Index: -51.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.6174
    Cell Significance Index: -46.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.6216
    Cell Significance Index: -42.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.6439
    Cell Significance Index: -44.0500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.6753
    Cell Significance Index: -40.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.7352
    Cell Significance Index: -51.1100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -1.9348
    Cell Significance Index: -32.8600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.9688
    Cell Significance Index: -33.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.9711
    Cell Significance Index: -43.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.9814
    Cell Significance Index: -49.4100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -2.0047
    Cell Significance Index: -29.1100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -2.0048
    Cell Significance Index: -33.7700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -2.0813
    Cell Significance Index: -33.0200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -2.0825
    Cell Significance Index: -28.3300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -2.0840
    Cell Significance Index: -52.0500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -2.0929
    Cell Significance Index: -21.7000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -2.1026
    Cell Significance Index: -53.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -2.1494
    Cell Significance Index: -58.5100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -2.1880
    Cell Significance Index: -37.5900
  • Cell Name: B cell (CL0000236)
    Fold Change: -2.2552
    Cell Significance Index: -26.6500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -2.2604
    Cell Significance Index: -46.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGKC gene is a member of the immunoglobulin superfamily, which encodes for the constant regions of the heavy and light chains of antibodies. The kappa constant region (IGKC) is specifically associated with the kappa light chain, which is one of the two chains that make up the B-cell receptor complex. The IGKC gene undergoes somatic recombination during B-cell development, resulting in the creation of a diverse repertoire of kappa light chains. The IGKC gene is highly expressed in various immune cells, including B cells, T cells, and dendritic cells, highlighting its central role in the adaptive immune response. **Pathways and Functions:** The IGKC gene is involved in several key pathways, including: 1. **Adaptive Immune Response:** The IGKC gene plays a crucial role in the adaptive immune response by enabling B cells to recognize and bind to antigens. This binding event triggers a series of signaling cascades that ultimately lead to the activation of B cells and the production of antibodies. 2. **Antigen Binding:** The IGKC gene is essential for the formation of the B-cell receptor complex, which recognizes and binds to antigens. This binding event is critical for the activation of B cells and the initiation of the immune response. 3. **B Cell Receptor Signaling Pathway:** The IGKC gene is involved in the signaling pathway that follows antigen binding. This pathway involves the activation of various kinases and transcription factors, leading to the expression of genes involved in the immune response. **Clinical Significance:** The IGKC gene has significant clinical implications in various immune-related disorders, including: 1. **Immunodeficiency Disorders:** Mutations in the IGKC gene can lead to immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA), characterized by a lack of antibodies and impaired immune function. 2. **Autoimmune Diseases:** Dysregulation of the IGKC gene has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where the immune system attacks the body's own tissues. 3. **Cancer:** The IGKC gene has been shown to be involved in the development of certain types of cancer, such as multiple myeloma, where abnormal kappa light chains can contribute to tumor growth and progression. In conclusion, the IGKC gene plays a critical role in the adaptive immune response, enabling B cells to recognize and bind to antigens. Its dysregulation has significant clinical implications in various immune-related disorders, highlighting the importance of further research into the IGKC gene and its functions in the immune system.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.