Gene IGKC - ENSG00000211592 | NCBI Gene ID: 3514

Details for: IGKC

Gene ID: 3514

Symbol: IGKC

Ensembl ID: ENSG00000211592

Description: immunoglobulin kappa constant

Associated with

Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Iga immunoglobulin complex
(GO:0071745)
Igd immunoglobulin complex
(GO:0071738)
Ige immunoglobulin complex
(GO:0071742)
Igg immunoglobulin complex
(GO:0071735)
Igm immunoglobulin complex
(GO:0071753)
Immune response
(GO:0006955)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: respiratory basal cell (CL0002633)
Fold Change: 6.93
Marker Score: 9955
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 5.49
Marker Score: 4672
Cell Name: germinal center B cell (CL0000844)
Fold Change: 3.73
Marker Score: 2267.5
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.36
Marker Score: 1680
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.1
Marker Score: 3057
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.98
Marker Score: 925
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 2.9
Marker Score: 7518
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.84
Marker Score: 979
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.76
Marker Score: 17581
Cell Name: memory T cell (CL0000813)
Fold Change: 2.72
Marker Score: 1171
Cell Name: neutrophil (CL0000775)
Fold Change: 2.69
Marker Score: 1641
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 2.5
Marker Score: 939
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 2.48
Marker Score: 5207
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.44
Marker Score: 5539
Cell Name: exhausted T cell (CL0011025)
Fold Change: 2.42
Marker Score: 1390
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 2.4
Marker Score: 781
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.36
Marker Score: 1421
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 2.35
Marker Score: 1702
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 2.32
Marker Score: 1191
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 2.29
Marker Score: 608
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 2.21
Marker Score: 1143
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.16
Marker Score: 766
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 2.15
Marker Score: 939
Cell Name: follicular B cell (CL0000843)
Fold Change: 2.06
Marker Score: 2229
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.05
Marker Score: 3582
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.05
Marker Score: 2820
Cell Name: naive B cell (CL0000788)
Fold Change: 2.01
Marker Score: 1797
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.01
Marker Score: 938
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2
Marker Score: 861
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 1.89
Marker Score: 429
Cell Name: peptic cell (CL0000155)
Fold Change: 1.88
Marker Score: 789
Cell Name: plasmablast (CL0000980)
Fold Change: 1.84
Marker Score: 2453
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.8
Marker Score: 647
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.79
Marker Score: 4452
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 1.79
Marker Score: 622
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.77
Marker Score: 4952
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 1.75
Marker Score: 483
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 1.64
Marker Score: 963
Cell Name: mature B cell (CL0000785)
Fold Change: 1.64
Marker Score: 1199
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.63
Marker Score: 516
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.63
Marker Score: 8554
Cell Name: ionocyte (CL0005006)
Fold Change: 1.59
Marker Score: 484
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.57
Marker Score: 4271.5
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 1.5
Marker Score: 1159
Cell Name: immature B cell (CL0000816)
Fold Change: 1.49
Marker Score: 989
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 169071
Cell Name: memory B cell (CL0000787)
Fold Change: 1.44
Marker Score: 1091
Cell Name: blood cell (CL0000081)
Fold Change: 1.42
Marker Score: 16553
Cell Name: keratocyte (CL0002363)
Fold Change: 1.42
Marker Score: 326
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.4
Marker Score: 1176
Cell Name: mature T cell (CL0002419)
Fold Change: 1.35
Marker Score: 13379
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 1.34
Marker Score: 1260
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.33
Marker Score: 3490
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 1.33
Marker Score: 350
Cell Name: fibroblast (CL0000057)
Fold Change: 1.3
Marker Score: 1255
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.28
Marker Score: 2161
Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.25
Marker Score: 288
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 1.24
Marker Score: 837
Cell Name: B cell (CL0000236)
Fold Change: 1.24
Marker Score: 1176
Cell Name: megakaryocyte (CL0000556)
Fold Change: 1.21
Marker Score: 690
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 1.21
Marker Score: 1215
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1.2
Marker Score: 449
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 1.18
Marker Score: 310
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.17
Marker Score: 850
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.17
Marker Score: 229
Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 1.16
Marker Score: 334
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.15
Marker Score: 904
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 1.15
Marker Score: 348
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.13
Marker Score: 248
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.12
Marker Score: 4682.5
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.1
Marker Score: 384
Cell Name: goblet cell (CL0000160)
Fold Change: 1.09
Marker Score: 7236
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 1.08
Marker Score: 915.5
Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.06
Marker Score: 214
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 1.05
Marker Score: 229
Cell Name: plasma cell (CL0000786)
Fold Change: 1.05
Marker Score: 1172
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.03
Marker Score: 698.5
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.03
Marker Score: 928
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 1.02
Marker Score: 882
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.02
Marker Score: 246
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 1.02
Marker Score: 424
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.02
Marker Score: 4183
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1
Marker Score: 659
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71623
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47854
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.99
Marker Score: 460
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 0.99
Marker Score: 385.5
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.99
Marker Score: 4095
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.98
Marker Score: 220
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 0.98
Marker Score: 229
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30394
Cell Name: enterocyte (CL0000584)
Fold Change: 0.98
Marker Score: 4697
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.98
Marker Score: 215
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.97
Marker Score: 6328
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 499
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 455
Cell Name: stem cell (CL0000034)
Fold Change: 0.96
Marker Score: 2275
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.96
Marker Score: 240
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.95
Marker Score: 296
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2399

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Other Information

Description

**Key characteristics** - IGKC is a glycoprotein with a molecular weight of approximately 110 kDa. - It is a member of the immunoglobulin superfamily. - It is expressed in the plasma membrane of B cells. - It is involved in the activation of B cells and the production of antibodies. **Pathways and functions** - IGKC is involved in the adaptive immune response. - It is expressed on the surface of B cells and is important for the recognition of antigens by B cells. - It is also involved in the activation of B cells and the production of antibodies. - IGKC is a key regulator of the adaptive immune response. **Clinical significance** - Mutations in the IGKC gene have been linked to several human diseases, including autoimmune disorders such as rheumatoid arthritis, lupus, and multiple sclerosis. - In rheumatoid arthritis, mutations in the IGKC gene are associated with the development of autoantibodies that target the joints. - In lupus, mutations in the IGKC gene are associated with the development of autoantibodies that target various organs in the body, including the skin, joints, and kidneys. - In multiple sclerosis, mutations in the IGKC gene are associated with the development of relapsing-remitting multiple sclerosis (RRMS), a chronic autoimmune disease that affects the central nervous system.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.