Details for: TCF4

Gene ID: 6925

Symbol: TCF4

Ensembl ID: ENSG00000196628

Description: transcription factor 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 7.98
    Marker Score: 41841
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 7.38
    Marker Score: 24739
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 7.18
    Marker Score: 10101
  • Cell Name: granule cell (CL0000120)
    Fold Change: 6.14
    Marker Score: 46307
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 6.03
    Marker Score: 32414
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 5.52
    Marker Score: 12698
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 5.4
    Marker Score: 1782.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.86
    Marker Score: 22493.5
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 4.36
    Marker Score: 2095
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 4.24
    Marker Score: 6165
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 4.15
    Marker Score: 2306.5
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 4.14
    Marker Score: 2405
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 4.09
    Marker Score: 9793
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.88
    Marker Score: 3356
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 3.84
    Marker Score: 2893
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 3.84
    Marker Score: 2151
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.76
    Marker Score: 4541
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 3.73
    Marker Score: 2022
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 3.69
    Marker Score: 2429
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 3.43
    Marker Score: 1792
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.42
    Marker Score: 3938.5
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.39
    Marker Score: 2231
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.33
    Marker Score: 3139
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.29
    Marker Score: 28870
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.25
    Marker Score: 8259.5
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 3.19
    Marker Score: 4424.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.16
    Marker Score: 67421.5
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 3.13
    Marker Score: 1821.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.1
    Marker Score: 40826
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.09
    Marker Score: 3854
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.07
    Marker Score: 54450.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.97
    Marker Score: 1775
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 2.96
    Marker Score: 2252
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.91
    Marker Score: 57849
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.9
    Marker Score: 5793
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.89
    Marker Score: 3405.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.88
    Marker Score: 2477
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.88
    Marker Score: 1806
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.86
    Marker Score: 21895.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.84
    Marker Score: 42490
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.83
    Marker Score: 5440
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.82
    Marker Score: 895
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.82
    Marker Score: 1393
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.79
    Marker Score: 3832
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.77
    Marker Score: 4655.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.76
    Marker Score: 2950
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.74
    Marker Score: 104161
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.73
    Marker Score: 1827
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.71
    Marker Score: 7741
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.67
    Marker Score: 693
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.66
    Marker Score: 2361.5
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.63
    Marker Score: 3803
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.59
    Marker Score: 2905
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.58
    Marker Score: 10707
  • Cell Name: glial cell (CL0000125)
    Fold Change: 2.55
    Marker Score: 2808
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.55
    Marker Score: 920
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.52
    Marker Score: 3388
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.51
    Marker Score: 975
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.51
    Marker Score: 2468
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.48
    Marker Score: 726
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.47
    Marker Score: 2328
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.47
    Marker Score: 2218
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.47
    Marker Score: 2644
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.45
    Marker Score: 90400
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.43
    Marker Score: 2293
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.43
    Marker Score: 2106
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.42
    Marker Score: 2736
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.41
    Marker Score: 6305
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.4
    Marker Score: 2580
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.39
    Marker Score: 1187
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.37
    Marker Score: 15446
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.37
    Marker Score: 2256.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.35
    Marker Score: 4096
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.34
    Marker Score: 2892
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.33
    Marker Score: 2817.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.33
    Marker Score: 8999
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.31
    Marker Score: 25966
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.29
    Marker Score: 1081
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.26
    Marker Score: 800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.26
    Marker Score: 4959
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.24
    Marker Score: 1328
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.21
    Marker Score: 1247.5
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.21
    Marker Score: 1329
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.16
    Marker Score: 20353
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.16
    Marker Score: 3656.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.14
    Marker Score: 1616
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.11
    Marker Score: 660
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.1
    Marker Score: 21113.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.09
    Marker Score: 2525
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.09
    Marker Score: 2015
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.09
    Marker Score: 480
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.07
    Marker Score: 127534
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 2.06
    Marker Score: 1859.5
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.06
    Marker Score: 499
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.03
    Marker Score: 2179
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 2.01
    Marker Score: 1254
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.01
    Marker Score: 467
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2
    Marker Score: 5428.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.99
    Marker Score: 2113
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.97
    Marker Score: 1103

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Other Information

**Key Characteristics** TCF4 is a transcription factor that belongs to the TCF/LEF family, which consists of four members: TCF1, TCF3, TCF4, and LEF1. TCF4 is specifically expressed in neuronal cells and is involved in the regulation of gene expression through the Wnt/β-catenin signaling pathway. The gene is characterized by its ability to bind to specific DNA sequences, known as E-boxes, which are involved in the regulation of transcription. TCF4 is also capable of forming heterodimers with other transcription factors, such as TCF7L2, to regulate gene expression. **Pathways and Functions** TCF4 is involved in several signaling pathways, including: 1. **Wnt/β-catenin pathway**: TCF4 is a key component of the Wnt/β-catenin signaling pathway, which plays a crucial role in cell differentiation, proliferation, and survival. 2. **Cell differentiation**: TCF4 regulates the expression of genes involved in neuronal differentiation, including genes involved in the development of synapses and axons. 3. **Developmental biology**: TCF4 is involved in the regulation of gene expression during embryonic development, particularly in the development of the CNS. 4. **Chromatin regulation**: TCF4 regulates the expression of genes by interacting with chromatin, which is a complex of DNA, histone proteins, and other proteins that regulate gene expression. **Clinical Significance** Aberrant expression of TCF4 has been implicated in several diseases, including: 1. **Cancer**: TCF4 is overexpressed in various types of cancer, including colon, breast, and lung cancer, and is involved in the regulation of gene expression that promotes tumor growth and metastasis. 2. **Neurodevelopmental disorders**: TCF4 mutations have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 3. **Autoimmune diseases**: TCF4 has been implicated in the regulation of immune responses and has been associated with autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, TCF4 is a crucial transcription factor involved in various cellular processes, including cell differentiation, development, and signaling pathways. Its aberrant expression has been implicated in several diseases, highlighting the importance of TCF4 in human health and disease. Further research is necessary to fully understand the mechanisms by which TCF4 regulates gene expression and its role in disease.

Genular Protein ID: 970332304

Symbol: ITF2_HUMAN

Name: Transcription factor 4

UniProtKB Accession Codes:

P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 12 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 37 EPD 1 Ensembl 23 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 14 Pumba 1 RNAct 1 Reactome 1 RefSeq 32 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1681116

Title: Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers.

PubMed ID: 1681116

DOI: 10.1128/jvi.65.11.6084-6093.1991

PubMed ID: 21789225

Title: Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5' exon usage and splicing.

PubMed ID: 21789225

DOI: 10.1371/journal.pone.0022138

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9302263

Title: A novel, heritable, expanding CTG repeat in an intron of the SEF2-1 gene on chromosome 18q21.1.

PubMed ID: 9302263

DOI: 10.1093/hmg/6.11.1855

PubMed ID: 2308860

Title: Sequence of the cDNA encoding ITF-2, a positive-acting transcription factor.

PubMed ID: 2308860

DOI: 10.1093/nar/18.3.678

PubMed ID: 2105528

Title: Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif.

PubMed ID: 2105528

DOI: 10.1126/science.2105528

PubMed ID: 17467953

Title: Nine-amino-acid transactivation domain: establishment and prediction utilities.

PubMed ID: 17467953

DOI: 10.1016/j.ygeno.2007.02.003

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22777675

Title: Functional analysis of TCF4 missense mutations that cause Pitt-Hopkins syndrome.

PubMed ID: 22777675

DOI: 10.1002/humu.22160

PubMed ID: 24094747

Title: Mutations in AGBL1 cause dominant late-onset Fuchs corneal dystrophy and alter protein-protein interaction with TCF4.

PubMed ID: 24094747

DOI: 10.1016/j.ajhg.2013.08.010

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25466284

Title: Mutations affecting the BHLHA9 DNA-binding domain cause MSSD, mesoaxial synostotic syndactyly with phalangeal reduction, Malik-Percin type.

PubMed ID: 25466284

DOI: 10.1016/j.ajhg.2014.10.012

PubMed ID: 24255041

Title: Association and familial segregation of CTG18.1 trinucleotide repeat expansion of TCF4 gene in Fuchs' endothelial corneal dystrophy.

PubMed ID: 24255041

DOI: 10.1167/iovs.13-12611

PubMed ID: 25168903

Title: Comprehensive assessment of genetic variants within TCF4 in Fuchs' endothelial corneal dystrophy.

PubMed ID: 25168903

DOI: 10.1167/iovs.14-14958

PubMed ID: 25593321

Title: RNA toxicity and missplicing in the common eye disease fuchs endothelial corneal dystrophy.

PubMed ID: 25593321

DOI: 10.1074/jbc.m114.621607

PubMed ID: 28921696

Title: Exome sequencing identifies a TCF4 mutation in a Chinese pedigree with symmetrical acral keratoderma.

PubMed ID: 28921696

DOI: 10.1111/jdv.14591

PubMed ID: 17436254

Title: Mutations in TCF4, encoding a class I basic helix-loop-helix transcription factor, are responsible for Pitt-Hopkins syndrome, a severe epileptic encephalopathy associated with autonomic dysfunction.

PubMed ID: 17436254

DOI: 10.1086/515582

PubMed ID: 17436255

Title: Haploinsufficiency of TCF4 causes syndromal mental retardation with intermittent hyperventilation (Pitt-Hopkins syndrome).

PubMed ID: 17436255

DOI: 10.1086/515583

PubMed ID: 18728071

Title: Further delineation of Pitt-Hopkins syndrome: phenotypic and genotypic description of 16 novel patients.

PubMed ID: 18728071

DOI: 10.1136/jmg.2008.060129

PubMed ID: 19235238

Title: Mutational, functional, and expression studies of the TCF4 gene in Pitt-Hopkins syndrome.

PubMed ID: 19235238

DOI: 10.1002/humu.20935

PubMed ID: 20184619

Title: Two percent of patients suspected of having Angelman syndrome have TCF4 mutations.

PubMed ID: 20184619

DOI: 10.1111/j.1399-0004.2010.01380.x

PubMed ID: 22045651

Title: Novel comprehensive diagnostic strategy in Pitt-Hopkins syndrome: clinical score and further delineation of the TCF4 mutational spectrum.

PubMed ID: 22045651

DOI: 10.1002/humu.21639

PubMed ID: 25356899

Title: De novo mutations in moderate or severe intellectual disability.

PubMed ID: 25356899

DOI: 10.1371/journal.pgen.1004772

Sequence Information:

  • Length: 667
  • Mass: 71308
  • Checksum: 53459FC7989D9487
  • Sequence:
    • MHHQQRMAAL GTDKELSDLL DFSAMFSPPV SSGKNGPTSL ASGHFTGSNV EDRSSSGSWG 
NGGHPSPSRN YGDGTPYDHM TSRDLGSHDN LSPPFVNSRI QSKTERGSYS SYGRESNLQG 
CHQQSLLGGD MDMGNPGTLS PTKPGSQYYQ YSSNNPRRRP LHSSAMEVQT KKVRKVPPGL 
PSSVYAPSAS TADYNRDSPG YPSSKPATST FPSSFFMQDG HHSSDPWSSS SGMNQPGYAG 
MLGNSSHIPQ SSSYCSLHPH ERLSYPSHSS ADINSSLPPM STFHRSGTNH YSTSSCTPPA 
NGTDSIMANR GSGAAGSSQT GDALGKALAS IYSPDHTNNS FSSNPSTPVG SPPSLSAGTA 
VWSRNGGQAS SSPNYEGPLH SLQSRIEDRL ERLDDAIHVL RNHAVGPSTA MPGGHGDMHG 
IIGPSHNGAM GGLGSGYGTG LLSANRHSLM VGTHREDGVA LRGSHSLLPN QVPVPQLPVQ 
SATSPDLNPP QDPYRGMPPG LQGQSVSSGS SEIKSDDEGD ENLQDTKSSE DKKLDDDKKD 
IKSITSNNDD EDLTPEQKAE REKERRMANN ARERLRVRDI NEAFKELGRM VQLHLKSDKP 
QTKLLILHQA VAVILSLEQQ VRERNLNPKA ACLKRREEEK VSSEPPPLSL AGPHPGMGDA 
SNHMGQM

Genular Protein ID: 179835081

Symbol: A0A1B0GW91_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1B0GW91

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 ChiTaRS 1 DNASU 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 455
  • Mass: 48584
  • Checksum: CBBB0CBE9630F7EE
  • Sequence:
    • MQDGHHSSDP WSSSSGMNQP GYAGMLGNSS HIPQSSSYCS LHPHERLSYP SHSSADINSS 
LPPMSTFHRS GTNHYSTSSC TPPANGTDSI MANRGSGAAG SSQTGDALGK ALASIYSPDH 
TNNSFSSNPS TPVGSPPSLS AGTAVWSRNG GQASSSPNYE GPLHSLQSRI EDRLERLDDA 
IHVLRNHAVG PSTAMPGGHG DMHGIIGPSH NGAMGGLGSG YGTGLLSANR HSLMVGTHRE 
DGVALRGSHS LLPNQVPVPQ LPVQSATSPD LNPPQDPYRG MPPGLQGQSV SSGSSEIKSD 
DEGDENLQDT KSSEDKKLDD DKKDIKSITR SRSSNNDDED LTPEQKAERE KERRMANNAR 
ERLRVRDINE AFKELGRMVQ LHLKSDKPQT KLLILHQAVA VILSLEQQVR ERNLNPKAAC 
LKRREEEKVS SEPPPLSLAG PHPGMGDASN HMGQM

Genular Protein ID: 779406676

Symbol: A0A1B0GWD5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1B0GWD5

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 ChiTaRS 1 DNASU 1 EMBL 6 EPD 1 Ensembl 4 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 Proteomes 2 RefSeq 5 SAM 1 SMART 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 541
  • Mass: 57912
  • Checksum: CC36A3491449ACC4
  • Sequence:
    • MDMGNPGTLS PTKPGSQYYQ YSSNNPRRRP LHSSAMEVQT KKVRKVPPGL PSSVYAPSAS 
TADYNRDSPG YPSSKPATST FPSSFFMQDG HHSSDPWSSS SGMNQPGYAG MLGNSSHIPQ 
SSSYCSLHPH ERLSYPSHSS ADINSSLPPM STFHRSGTNH YSTSSCTPPA NGTDSIMANR 
GSGAAGSSQT GDALGKALAS IYSPDHTNNS FSSNPSTPVG SPPSLSAGTA VWSRNGGQAS 
SSPNYEGPLH SLQSRIEDRL ERLDDAIHVL RNHAVGPSTA MPGGHGDMHG IIGPSHNGAM 
GGLGSGYGTG LLSANRHSLM VGTHREDGVA LRGSHSLLPN QVPVPQLPVQ SATSPDLNPP 
QDPYRGMPPG LQGQSVSSGS SEIKSDDEGD ENLQDTKSSE DKKLDDDKKD IKSITRSRSS 
NNDDEDLTPE QKAEREKERR MANNARERLR VRDINEAFKE LGRMVQLHLK SDKPQTKLLI 
LHQAVAVILS LEQQVRERNL NPKAACLKRR EEEKVSSEPP PLSLAGPHPG MGDASNHMGQ 
M

Genular Protein ID: 3067058147

Symbol: H3BTP3_HUMAN

Name: N/A

UniProtKB Accession Codes:

H3BTP3

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 677
  • Mass: 72432
  • Checksum: C2ED30EC6BF74EF1
  • Sequence:
    • MHHQQRMAAL GTDKELSDLL DFSAMFSPPV SSGKNGPTSL ASGHFTGSNV EDRSSSGSWG 
NGGHPSPSRN YGDGTPYDHM TSRDLGSHDN LSPPFVNSRI QSKTERGSYS SYGRESNLQG 
CHQQSLLGGD MDMGNPGTLS PTKPGSQYYQ YSSNNPRRRP LHSSAMEVQT KKVRKVPPGL 
PSSLVLSPQV YAPSASTADY NRDSPGYPSS KPATSTFPSS FFMQDGHHSS DPWSSSSGMN 
QPGYAGMLGN SSHIPQSSSY CSLHPHERLS YPSHSSADIN SSLPPMSTFH RSGTNHYSTS 
SCTPPANGTD SIMANRGSGA AGSSQTGDAL GKALASIYSP DHTNNSFSSN PSTPVGSPPS 
LSAGTAVWSR NGGQASSSPN YEGPLHSLQS RIEDRLERLD DAIHVLRNHA VGPSTAMPGG 
HGDMHGIIGP SHNGAMGGLG SGYGTGLLSA NRHSLMVGTH REDGVALRGS HSLLPNQVPV 
PQLPVQSATS PDLNPPQDPY RGMPPGLQGQ SVSSGSSEIK SDDEGDENLQ DTKSSEDKKL 
DDDKKDIKSI TRSRSSNNDD EDLTPEQKAE REKERRMANN ARERLRVRDI NEAFKELGRM 
VQLHLKSDKP QTKLLILHQA VAVILSLEQQ VRERNLNPKA ACLKRREEEK VSSEPPPLSL 
AGPHPGMGDA SNHMGQM

Genular Protein ID: 3895121247

Symbol: E9PH57_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PH57

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 8 EPD 1 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 773
  • Mass: 83426
  • Checksum: 18FDDD76D52E62AC
  • Sequence:
    • MFSKRLEKIP QVPLLFPFIF IILTNYSKME GAVESQPSFF KTSQDIVTCT WVENCYSSFS 
RRPLEQMFCK HQSKNIISWT GMVAHTCNPS TLGGQGLCDF AKMHHQQRMA ALGTDKELSD 
LLDFSAMFSP PVSSGKNGPT SLASGHFTGS NVEDRSSSGS WGNGGHPSPS RNYGDGTPYD 
HMTSRDLGSH DNLSPPFVNS RIQSKTERGS YSSYGRESNL QGCHQQSLLG GDMDMGNPGT 
LSPTKPGSQY YQYSSNNPRR RPLHSSAMEV QTKKVRKVPP GLPSSVYAPS ASTADYNRDS 
PGYPSSKPAT STFPSSFFMQ DGHHSSDPWS SSSGMNQPGY AGMLGNSSHI PQSSSYCSLH 
PHERLSYPSH SSADINSSLP PMSTFHRSGT NHYSTSSCTP PANGTDSIMA NRGSGAAGSS 
QTGDALGKAL ASIYSPDHTN NSFSSNPSTP VGSPPSLSAG TAVWSRNGGQ ASSSPNYEGP 
LHSLQSRIED RLERLDDAIH VLRNHAVGPS TAMPGGHGDM HGIIGPSHNG AMGGLGSGYG 
TGLLSANRHS LMVGTHREDG VALRGSHSLL PNQVPVPQLP VQSATSPDLN PPQDPYRGMP 
PGLQGQSVSS GSSEIKSDDE GDENLQDTKS SEDKKLDDDK KDIKSITRSR SSNNDDEDLT 
PEQKAEREKE RRMANNARER LRVRDINEAF KELGRMVQLH LKSDKPQTKL LILHQAVAVI 
LSLEQQVRER NLNPKAACLK RREEEKVSSE PPPLSLAGPH PGMGDASNHM GQM

Genular Protein ID: 1947753056

Symbol: B3KVA4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KVA4

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 3 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 667
  • Mass: 71278
  • Checksum: 8A93DE8A5E3F4C0F
  • Sequence:
    • MHHQQRMAAL GTDKELSDLL DFSAMFSPPV SSGKNGPTSL ASGHFTGSNV EDRSSSGSWG 
NGGHPSPSRN YGDGTPYDHM TSRDLGSHDN LSPPFVNSRI QSKTERGSYS SYGRESNLQG 
CHQQSLLGGD MDMGNPGTLS PTKPGSQYYQ YSSNNPRRRP LHSSAMEVQT KKVRKVPPGL 
PSSVYAPSAS TADYNRDSPG YPSSKPATST FPSSFFMQDG HHSSDPWSSS GGMNQPGYAG 
MLGNSSHIPQ SSSYCSLHPH ERLSYPSHSS ADINSSLPPM STFHRSGTNH YSTSSCTPPA 
NGTDSIMANR GSGAAGSSQT GDALGKALAS IYSPDHTNNS FSSNPSTPVG SPPSLSAGTA 
VWSRNGGQAS SSPNYEGPLH SLQSRIEDRL ERLDDAIHVL RNHAVGPSTA MPGGHGDMHG 
IIGPSHNGAM GGLGSGYGTG LLSANRHSLM VGTHREDGVA LRGSHSLLPN QVPVPQLPVQ 
SATSPDLNPP QDPYRGMPPG LQGQSVSSGS SEIKSDDEGD ENLQDTKSSE DKKLDDDKKD 
IKSITSNNDD EDLTPEQKAE REKERRMANN ARERLRVRDI NEAFKELGRM VQLHLKSDKP 
QTKLLILHQA VAVILSLEQQ VRERNLNPKA ACLKRREEEK VSSEPPPLSL AGPHPGMGDA 
SNHMGQM

Genular Protein ID: 2636073906

Symbol: H3BPJ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

H3BPJ7

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 ChiTaRS 1 DNASU 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 3 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 642
  • Mass: 68483
  • Checksum: 3FB2B751A05C33A6
  • Sequence:
    • MFSPPVSSGK NGPTSLASGH FTGSNVEDRS SSGSWGNGGH PSPSRNYGDG TPYDHMTSRD 
LGSHDNLSPP FVNSRIQSKT ERGSYSSYGR ESNLQGCHQS LLGGDMDMGN PGTLSPTKPG 
SQYYQYSSNN PRRRPLHSSA MEVQTKKVRK VPPGLPSSVY APSASTADYN RDSPGYPSSK 
PATSTFPSSF FMQDGHHSSD PWSSSSGMNQ PGYAGMLGNS SHIPQSSSYC SLHPHERLSY 
PSHSSADINS SLPPMSTFHR SGTNHYSTSS CTPPANGTDS IMANRGSGAA GSSQTGDALG 
KALASIYSPD HTNNSFSSNP STPVGSPPSL SAGTAVWSRN GGQASSSPNY EGPLHSLQSR 
IEDRLERLDD AIHVLRNHAV GPSTAMPGGH GDMHGIIGPS HNGAMGGLGS GYGTGLLSAN 
RHSLMVGTHR EDGVALRGSH SLLPNQVPVP QLPVQSATSP DLNPPQDPYR GMPPGLQGQS 
VSSGSSEIKS DDEGDENLQD TKSSEDKKLD DDKKDIKSIT SNNDDEDLTP EQKAEREKER 
RMANNARERL RVRDINEAFK ELGRMVQLHL KSDKPQTKLL ILHQAVAVIL SLEQQVRERN 
LNPKAACLKR REEEKVSSEP PPLSLAGPHP GMGDASNHMG QM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.