Details for: TCF4

Gene ID: 6925

Symbol: TCF4

Ensembl ID: ENSG00000196628

Description: transcription factor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1021.8250
    Cell Significance Index: -158.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 568.5147
    Cell Significance Index: -144.2000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 328.5163
    Cell Significance Index: -155.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 296.4133
    Cell Significance Index: -120.4200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 278.0018
    Cell Significance Index: -143.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 129.5505
    Cell Significance Index: -159.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 126.3167
    Cell Significance Index: -120.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 50.6628
    Cell Significance Index: -110.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 40.5469
    Cell Significance Index: -160.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 11.7423
    Cell Significance Index: 281.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 10.4575
    Cell Significance Index: 642.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 7.7546
    Cell Significance Index: 435.1500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 7.5070
    Cell Significance Index: 107.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 6.1922
    Cell Significance Index: 2221.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 5.8241
    Cell Significance Index: 113.6700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 5.0178
    Cell Significance Index: 85.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.5603
    Cell Significance Index: 237.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.8007
    Cell Significance Index: 255.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.6934
    Cell Significance Index: 193.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.5792
    Cell Significance Index: 102.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.2214
    Cell Significance Index: 646.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.2451
    Cell Significance Index: 308.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.2259
    Cell Significance Index: 1539.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.7385
    Cell Significance Index: 36.3900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.3731
    Cell Significance Index: 29.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.8441
    Cell Significance Index: 5.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5821
    Cell Significance Index: 68.6500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5574
    Cell Significance Index: 8.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4616
    Cell Significance Index: 204.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4097
    Cell Significance Index: 260.1900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.4093
    Cell Significance Index: 3.1600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.3596
    Cell Significance Index: 5.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3569
    Cell Significance Index: 322.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2204
    Cell Significance Index: 406.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1785
    Cell Significance Index: 274.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1533
    Cell Significance Index: 18.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1447
    Cell Significance Index: 26.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1216
    Cell Significance Index: 66.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0877
    Cell Significance Index: 2.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0182
    Cell Significance Index: 8.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0397
    Cell Significance Index: -74.7200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0528
    Cell Significance Index: -0.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0801
    Cell Significance Index: -108.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1177
    Cell Significance Index: -22.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1509
    Cell Significance Index: -111.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1613
    Cell Significance Index: -100.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1782
    Cell Significance Index: -130.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1853
    Cell Significance Index: -36.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1997
    Cell Significance Index: -112.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.2169
    Cell Significance Index: -164.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2743
    Cell Significance Index: -4.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4335
    Cell Significance Index: -27.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.4618
    Cell Significance Index: -75.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4702
    Cell Significance Index: -99.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4993
    Cell Significance Index: -143.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5125
    Cell Significance Index: -18.0100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5455
    Cell Significance Index: -9.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.5699
    Cell Significance Index: -73.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7399
    Cell Significance Index: -56.7800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.7403
    Cell Significance Index: -9.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.8082
    Cell Significance Index: -79.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.8389
    Cell Significance Index: -143.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.8760
    Cell Significance Index: -127.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8864
    Cell Significance Index: -103.3000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.9404
    Cell Significance Index: -13.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.9865
    Cell Significance Index: -107.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -1.0178
    Cell Significance Index: -131.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -1.0429
    Cell Significance Index: -106.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.3039
    Cell Significance Index: -45.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.3430
    Cell Significance Index: -139.8400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.4654
    Cell Significance Index: -167.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.4773
    Cell Significance Index: -66.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.4874
    Cell Significance Index: -170.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.6967
    Cell Significance Index: -134.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.7397
    Cell Significance Index: -120.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.7978
    Cell Significance Index: -133.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.8866
    Cell Significance Index: -54.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.9026
    Cell Significance Index: -116.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.9603
    Cell Significance Index: -138.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.1406
    Cell Significance Index: -128.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.1415
    Cell Significance Index: -134.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -2.2354
    Cell Significance Index: -58.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.2470
    Cell Significance Index: -56.1700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -2.2910
    Cell Significance Index: -45.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -2.3029
    Cell Significance Index: -108.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.3395
    Cell Significance Index: -67.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.3972
    Cell Significance Index: -61.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -2.6528
    Cell Significance Index: -37.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -2.7258
    Cell Significance Index: -127.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -2.9243
    Cell Significance Index: -151.9100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -3.2336
    Cell Significance Index: -68.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -3.2337
    Cell Significance Index: -103.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -3.3272
    Cell Significance Index: -89.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -3.3521
    Cell Significance Index: -106.7600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -3.4483
    Cell Significance Index: -69.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.6170
    Cell Significance Index: -159.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -3.8976
    Cell Significance Index: -99.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -3.9861
    Cell Significance Index: -139.6400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.9905
    Cell Significance Index: -146.4900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -4.0551
    Cell Significance Index: -132.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TCF4 is a transcription factor that belongs to the TCF/LEF family, which consists of four members: TCF1, TCF3, TCF4, and LEF1. TCF4 is specifically expressed in neuronal cells and is involved in the regulation of gene expression through the Wnt/β-catenin signaling pathway. The gene is characterized by its ability to bind to specific DNA sequences, known as E-boxes, which are involved in the regulation of transcription. TCF4 is also capable of forming heterodimers with other transcription factors, such as TCF7L2, to regulate gene expression. **Pathways and Functions** TCF4 is involved in several signaling pathways, including: 1. **Wnt/β-catenin pathway**: TCF4 is a key component of the Wnt/β-catenin signaling pathway, which plays a crucial role in cell differentiation, proliferation, and survival. 2. **Cell differentiation**: TCF4 regulates the expression of genes involved in neuronal differentiation, including genes involved in the development of synapses and axons. 3. **Developmental biology**: TCF4 is involved in the regulation of gene expression during embryonic development, particularly in the development of the CNS. 4. **Chromatin regulation**: TCF4 regulates the expression of genes by interacting with chromatin, which is a complex of DNA, histone proteins, and other proteins that regulate gene expression. **Clinical Significance** Aberrant expression of TCF4 has been implicated in several diseases, including: 1. **Cancer**: TCF4 is overexpressed in various types of cancer, including colon, breast, and lung cancer, and is involved in the regulation of gene expression that promotes tumor growth and metastasis. 2. **Neurodevelopmental disorders**: TCF4 mutations have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 3. **Autoimmune diseases**: TCF4 has been implicated in the regulation of immune responses and has been associated with autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, TCF4 is a crucial transcription factor involved in various cellular processes, including cell differentiation, development, and signaling pathways. Its aberrant expression has been implicated in several diseases, highlighting the importance of TCF4 in human health and disease. Further research is necessary to fully understand the mechanisms by which TCF4 regulates gene expression and its role in disease.

Genular Protein ID: 970332304

Symbol: ITF2_HUMAN

Name: Transcription factor 4

UniProtKB Accession Codes:

P15884 B3KT62 B3KUC0 B4DT37 B4DUG3 B7Z5M6 B7Z6Y1 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU4 G0LNU5 G0LNU8 G0LNU9 G0LNV0 G0LNV1 G0LNV2 H3BPQ1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 12 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 37 Ensembl 23 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 14 Pumba 1 RNAct 1 Reactome 2 RefSeq 32 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1681116

Title: Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers.

PubMed ID: 1681116

DOI: 10.1128/jvi.65.11.6084-6093.1991

PubMed ID: 21789225

Title: Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5' exon usage and splicing.

PubMed ID: 21789225

DOI: 10.1371/journal.pone.0022138

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9302263

Title: A novel, heritable, expanding CTG repeat in an intron of the SEF2-1 gene on chromosome 18q21.1.

PubMed ID: 9302263

DOI: 10.1093/hmg/6.11.1855

PubMed ID: 2308860

Title: Sequence of the cDNA encoding ITF-2, a positive-acting transcription factor.

PubMed ID: 2308860

DOI: 10.1093/nar/18.3.678

PubMed ID: 2105528

Title: Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif.

PubMed ID: 2105528

DOI: 10.1126/science.2105528

PubMed ID: 17467953

Title: Nine-amino-acid transactivation domain: establishment and prediction utilities.

PubMed ID: 17467953

DOI: 10.1016/j.ygeno.2007.02.003

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22777675

Title: Functional analysis of TCF4 missense mutations that cause Pitt-Hopkins syndrome.

PubMed ID: 22777675

DOI: 10.1002/humu.22160

PubMed ID: 24094747

Title: Mutations in AGBL1 cause dominant late-onset Fuchs corneal dystrophy and alter protein-protein interaction with TCF4.

PubMed ID: 24094747

DOI: 10.1016/j.ajhg.2013.08.010

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25466284

Title: Mutations affecting the BHLHA9 DNA-binding domain cause MSSD, mesoaxial synostotic syndactyly with phalangeal reduction, Malik-Percin type.

PubMed ID: 25466284

DOI: 10.1016/j.ajhg.2014.10.012

PubMed ID: 24255041

Title: Association and familial segregation of CTG18.1 trinucleotide repeat expansion of TCF4 gene in Fuchs' endothelial corneal dystrophy.

PubMed ID: 24255041

DOI: 10.1167/iovs.13-12611

PubMed ID: 25168903

Title: Comprehensive assessment of genetic variants within TCF4 in Fuchs' endothelial corneal dystrophy.

PubMed ID: 25168903

DOI: 10.1167/iovs.14-14958

PubMed ID: 25593321

Title: RNA toxicity and missplicing in the common eye disease fuchs endothelial corneal dystrophy.

PubMed ID: 25593321

DOI: 10.1074/jbc.m114.621607

PubMed ID: 28921696

Title: Exome sequencing identifies a TCF4 mutation in a Chinese pedigree with symmetrical acral keratoderma.

PubMed ID: 28921696

DOI: 10.1111/jdv.14591

PubMed ID: 17436254

Title: Mutations in TCF4, encoding a class I basic helix-loop-helix transcription factor, are responsible for Pitt-Hopkins syndrome, a severe epileptic encephalopathy associated with autonomic dysfunction.

PubMed ID: 17436254

DOI: 10.1086/515582

PubMed ID: 17436255

Title: Haploinsufficiency of TCF4 causes syndromal mental retardation with intermittent hyperventilation (Pitt-Hopkins syndrome).

PubMed ID: 17436255

DOI: 10.1086/515583

PubMed ID: 18728071

Title: Further delineation of Pitt-Hopkins syndrome: phenotypic and genotypic description of 16 novel patients.

PubMed ID: 18728071

DOI: 10.1136/jmg.2008.060129

PubMed ID: 19235238

Title: Mutational, functional, and expression studies of the TCF4 gene in Pitt-Hopkins syndrome.

PubMed ID: 19235238

DOI: 10.1002/humu.20935

PubMed ID: 20184619

Title: Two percent of patients suspected of having Angelman syndrome have TCF4 mutations.

PubMed ID: 20184619

DOI: 10.1111/j.1399-0004.2010.01380.x

PubMed ID: 22045651

Title: Novel comprehensive diagnostic strategy in Pitt-Hopkins syndrome: clinical score and further delineation of the TCF4 mutational spectrum.

PubMed ID: 22045651

DOI: 10.1002/humu.21639

PubMed ID: 25356899

Title: De novo mutations in moderate or severe intellectual disability.

PubMed ID: 25356899

DOI: 10.1371/journal.pgen.1004772

Sequence Information:

  • Length: 667
  • Mass: 71308
  • Checksum: 53459FC7989D9487
  • Sequence:
    • MHHQQRMAAL GTDKELSDLL DFSAMFSPPV SSGKNGPTSL ASGHFTGSNV EDRSSSGSWG 
NGGHPSPSRN YGDGTPYDHM TSRDLGSHDN LSPPFVNSRI QSKTERGSYS SYGRESNLQG 
CHQQSLLGGD MDMGNPGTLS PTKPGSQYYQ YSSNNPRRRP LHSSAMEVQT KKVRKVPPGL 
PSSVYAPSAS TADYNRDSPG YPSSKPATST FPSSFFMQDG HHSSDPWSSS SGMNQPGYAG 
MLGNSSHIPQ SSSYCSLHPH ERLSYPSHSS ADINSSLPPM STFHRSGTNH YSTSSCTPPA 
NGTDSIMANR GSGAAGSSQT GDALGKALAS IYSPDHTNNS FSSNPSTPVG SPPSLSAGTA 
VWSRNGGQAS SSPNYEGPLH SLQSRIEDRL ERLDDAIHVL RNHAVGPSTA MPGGHGDMHG 
IIGPSHNGAM GGLGSGYGTG LLSANRHSLM VGTHREDGVA LRGSHSLLPN QVPVPQLPVQ 
SATSPDLNPP QDPYRGMPPG LQGQSVSSGS SEIKSDDEGD ENLQDTKSSE DKKLDDDKKD 
IKSITSNNDD EDLTPEQKAE REKERRMANN ARERLRVRDI NEAFKELGRM VQLHLKSDKP 
QTKLLILHQA VAVILSLEQQ VRERNLNPKA ACLKRREEEK VSSEPPPLSL AGPHPGMGDA 
SNHMGQM

Genular Protein ID: 2636073906

Symbol: H3BPJ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

H3BPJ7

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 3 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 642
  • Mass: 68483
  • Checksum: 3FB2B751A05C33A6
  • Sequence:
    • MFSPPVSSGK NGPTSLASGH FTGSNVEDRS SSGSWGNGGH PSPSRNYGDG TPYDHMTSRD 
LGSHDNLSPP FVNSRIQSKT ERGSYSSYGR ESNLQGCHQS LLGGDMDMGN PGTLSPTKPG 
SQYYQYSSNN PRRRPLHSSA MEVQTKKVRK VPPGLPSSVY APSASTADYN RDSPGYPSSK 
PATSTFPSSF FMQDGHHSSD PWSSSSGMNQ PGYAGMLGNS SHIPQSSSYC SLHPHERLSY 
PSHSSADINS SLPPMSTFHR SGTNHYSTSS CTPPANGTDS IMANRGSGAA GSSQTGDALG 
KALASIYSPD HTNNSFSSNP STPVGSPPSL SAGTAVWSRN GGQASSSPNY EGPLHSLQSR 
IEDRLERLDD AIHVLRNHAV GPSTAMPGGH GDMHGIIGPS HNGAMGGLGS GYGTGLLSAN 
RHSLMVGTHR EDGVALRGSH SLLPNQVPVP QLPVQSATSP DLNPPQDPYR GMPPGLQGQS 
VSSGSSEIKS DDEGDENLQD TKSSEDKKLD DDKKDIKSIT SNNDDEDLTP EQKAEREKER 
RMANNARERL RVRDINEAFK ELGRMVQLHL KSDKPQTKLL ILHQAVAVIL SLEQQVRERN 
LNPKAACLKR REEEKVSSEP PPLSLAGPHP GMGDASNHMG QM

Genular Protein ID: 179835081

Symbol: A0A1B0GW91_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1B0GW91

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 455
  • Mass: 48584
  • Checksum: CBBB0CBE9630F7EE
  • Sequence:
    • MQDGHHSSDP WSSSSGMNQP GYAGMLGNSS HIPQSSSYCS LHPHERLSYP SHSSADINSS 
LPPMSTFHRS GTNHYSTSSC TPPANGTDSI MANRGSGAAG SSQTGDALGK ALASIYSPDH 
TNNSFSSNPS TPVGSPPSLS AGTAVWSRNG GQASSSPNYE GPLHSLQSRI EDRLERLDDA 
IHVLRNHAVG PSTAMPGGHG DMHGIIGPSH NGAMGGLGSG YGTGLLSANR HSLMVGTHRE 
DGVALRGSHS LLPNQVPVPQ LPVQSATSPD LNPPQDPYRG MPPGLQGQSV SSGSSEIKSD 
DEGDENLQDT KSSEDKKLDD DKKDIKSITR SRSSNNDDED LTPEQKAERE KERRMANNAR 
ERLRVRDINE AFKELGRMVQ LHLKSDKPQT KLLILHQAVA VILSLEQQVR ERNLNPKAAC 
LKRREEEKVS SEPPPLSLAG PHPGMGDASN HMGQM

Genular Protein ID: 779406676

Symbol: A0A1B0GWD5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1B0GWD5

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 4 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 5 SAM 1 SMART 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 541
  • Mass: 57912
  • Checksum: CC36A3491449ACC4
  • Sequence:
    • MDMGNPGTLS PTKPGSQYYQ YSSNNPRRRP LHSSAMEVQT KKVRKVPPGL PSSVYAPSAS 
TADYNRDSPG YPSSKPATST FPSSFFMQDG HHSSDPWSSS SGMNQPGYAG MLGNSSHIPQ 
SSSYCSLHPH ERLSYPSHSS ADINSSLPPM STFHRSGTNH YSTSSCTPPA NGTDSIMANR 
GSGAAGSSQT GDALGKALAS IYSPDHTNNS FSSNPSTPVG SPPSLSAGTA VWSRNGGQAS 
SSPNYEGPLH SLQSRIEDRL ERLDDAIHVL RNHAVGPSTA MPGGHGDMHG IIGPSHNGAM 
GGLGSGYGTG LLSANRHSLM VGTHREDGVA LRGSHSLLPN QVPVPQLPVQ SATSPDLNPP 
QDPYRGMPPG LQGQSVSSGS SEIKSDDEGD ENLQDTKSSE DKKLDDDKKD IKSITRSRSS 
NNDDEDLTPE QKAEREKERR MANNARERLR VRDINEAFKE LGRMVQLHLK SDKPQTKLLI 
LHQAVAVILS LEQQVRERNL NPKAACLKRR EEEKVSSEPP PLSLAGPHPG MGDASNHMGQ 
M

Genular Protein ID: 1947753056

Symbol: B3KVA4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KVA4

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 3 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 667
  • Mass: 71278
  • Checksum: 8A93DE8A5E3F4C0F
  • Sequence:
    • MHHQQRMAAL GTDKELSDLL DFSAMFSPPV SSGKNGPTSL ASGHFTGSNV EDRSSSGSWG 
NGGHPSPSRN YGDGTPYDHM TSRDLGSHDN LSPPFVNSRI QSKTERGSYS SYGRESNLQG 
CHQQSLLGGD MDMGNPGTLS PTKPGSQYYQ YSSNNPRRRP LHSSAMEVQT KKVRKVPPGL 
PSSVYAPSAS TADYNRDSPG YPSSKPATST FPSSFFMQDG HHSSDPWSSS GGMNQPGYAG 
MLGNSSHIPQ SSSYCSLHPH ERLSYPSHSS ADINSSLPPM STFHRSGTNH YSTSSCTPPA 
NGTDSIMANR GSGAAGSSQT GDALGKALAS IYSPDHTNNS FSSNPSTPVG SPPSLSAGTA 
VWSRNGGQAS SSPNYEGPLH SLQSRIEDRL ERLDDAIHVL RNHAVGPSTA MPGGHGDMHG 
IIGPSHNGAM GGLGSGYGTG LLSANRHSLM VGTHREDGVA LRGSHSLLPN QVPVPQLPVQ 
SATSPDLNPP QDPYRGMPPG LQGQSVSSGS SEIKSDDEGD ENLQDTKSSE DKKLDDDKKD 
IKSITSNNDD EDLTPEQKAE REKERRMANN ARERLRVRDI NEAFKELGRM VQLHLKSDKP 
QTKLLILHQA VAVILSLEQQ VRERNLNPKA ACLKRREEEK VSSEPPPLSL AGPHPGMGDA 
SNHMGQM

Genular Protein ID: 3895121247

Symbol: E9PH57_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PH57

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 773
  • Mass: 83426
  • Checksum: 18FDDD76D52E62AC
  • Sequence:
    • MFSKRLEKIP QVPLLFPFIF IILTNYSKME GAVESQPSFF KTSQDIVTCT WVENCYSSFS 
RRPLEQMFCK HQSKNIISWT GMVAHTCNPS TLGGQGLCDF AKMHHQQRMA ALGTDKELSD 
LLDFSAMFSP PVSSGKNGPT SLASGHFTGS NVEDRSSSGS WGNGGHPSPS RNYGDGTPYD 
HMTSRDLGSH DNLSPPFVNS RIQSKTERGS YSSYGRESNL QGCHQQSLLG GDMDMGNPGT 
LSPTKPGSQY YQYSSNNPRR RPLHSSAMEV QTKKVRKVPP GLPSSVYAPS ASTADYNRDS 
PGYPSSKPAT STFPSSFFMQ DGHHSSDPWS SSSGMNQPGY AGMLGNSSHI PQSSSYCSLH 
PHERLSYPSH SSADINSSLP PMSTFHRSGT NHYSTSSCTP PANGTDSIMA NRGSGAAGSS 
QTGDALGKAL ASIYSPDHTN NSFSSNPSTP VGSPPSLSAG TAVWSRNGGQ ASSSPNYEGP 
LHSLQSRIED RLERLDDAIH VLRNHAVGPS TAMPGGHGDM HGIIGPSHNG AMGGLGSGYG 
TGLLSANRHS LMVGTHREDG VALRGSHSLL PNQVPVPQLP VQSATSPDLN PPQDPYRGMP 
PGLQGQSVSS GSSEIKSDDE GDENLQDTKS SEDKKLDDDK KDIKSITRSR SSNNDDEDLT 
PEQKAEREKE RRMANNARER LRVRDINEAF KELGRMVQLH LKSDKPQTKL LILHQAVAVI 
LSLEQQVRER NLNPKAACLK RREEEKVSSE PPPLSLAGPH PGMGDASNHM GQM

Genular Protein ID: 3067058147

Symbol: H3BTP3_HUMAN

Name: N/A

UniProtKB Accession Codes:

H3BTP3

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 677
  • Mass: 72432
  • Checksum: C2ED30EC6BF74EF1
  • Sequence:
    • MHHQQRMAAL GTDKELSDLL DFSAMFSPPV SSGKNGPTSL ASGHFTGSNV EDRSSSGSWG 
NGGHPSPSRN YGDGTPYDHM TSRDLGSHDN LSPPFVNSRI QSKTERGSYS SYGRESNLQG 
CHQQSLLGGD MDMGNPGTLS PTKPGSQYYQ YSSNNPRRRP LHSSAMEVQT KKVRKVPPGL 
PSSLVLSPQV YAPSASTADY NRDSPGYPSS KPATSTFPSS FFMQDGHHSS DPWSSSSGMN 
QPGYAGMLGN SSHIPQSSSY CSLHPHERLS YPSHSSADIN SSLPPMSTFH RSGTNHYSTS 
SCTPPANGTD SIMANRGSGA AGSSQTGDAL GKALASIYSP DHTNNSFSSN PSTPVGSPPS 
LSAGTAVWSR NGGQASSSPN YEGPLHSLQS RIEDRLERLD DAIHVLRNHA VGPSTAMPGG 
HGDMHGIIGP SHNGAMGGLG SGYGTGLLSA NRHSLMVGTH REDGVALRGS HSLLPNQVPV 
PQLPVQSATS PDLNPPQDPY RGMPPGLQGQ SVSSGSSEIK SDDEGDENLQ DTKSSEDKKL 
DDDKKDIKSI TRSRSSNNDD EDLTPEQKAE REKERRMANN ARERLRVRDI NEAFKELGRM 
VQLHLKSDKP QTKLLILHQA VAVILSLEQQ VRERNLNPKA ACLKRREEEK VSSEPPPLSL 
AGPHPGMGDA SNHMGQM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.