Details for: HILPDA

Gene ID: 29923

Symbol: HILPDA

Ensembl ID: ENSG00000135245

Description: hypoxia inducible lipid droplet associated

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 156.6747
    Cell Significance Index: -24.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 95.0941
    Cell Significance Index: -24.1200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 67.7028
    Cell Significance Index: -27.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 55.1763
    Cell Significance Index: -26.0500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 38.9108
    Cell Significance Index: -26.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.3576
    Cell Significance Index: -25.1000
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 13.1626
    Cell Significance Index: 17.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 10.1586
    Cell Significance Index: 271.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.4313
    Cell Significance Index: -25.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.3836
    Cell Significance Index: -25.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.2061
    Cell Significance Index: 114.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.0690
    Cell Significance Index: 393.7500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 2.0161
    Cell Significance Index: 23.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4495
    Cell Significance Index: 143.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0873
    Cell Significance Index: 65.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9594
    Cell Significance Index: 523.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9430
    Cell Significance Index: 102.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8632
    Cell Significance Index: 779.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7877
    Cell Significance Index: 128.1100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.6840
    Cell Significance Index: 4.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5010
    Cell Significance Index: 68.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4974
    Cell Significance Index: 17.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4928
    Cell Significance Index: 88.8400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.4578
    Cell Significance Index: 7.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4503
    Cell Significance Index: 31.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4185
    Cell Significance Index: 28.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3366
    Cell Significance Index: 3.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3302
    Cell Significance Index: 21.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2803
    Cell Significance Index: 7.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2320
    Cell Significance Index: 102.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2097
    Cell Significance Index: 4.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1844
    Cell Significance Index: 9.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1609
    Cell Significance Index: 19.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1599
    Cell Significance Index: 7.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1349
    Cell Significance Index: 17.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1007
    Cell Significance Index: 1.2000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0944
    Cell Significance Index: 0.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0851
    Cell Significance Index: 24.4800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0778
    Cell Significance Index: 0.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0679
    Cell Significance Index: 13.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0567
    Cell Significance Index: 39.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0514
    Cell Significance Index: 10.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0342
    Cell Significance Index: 0.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0100
    Cell Significance Index: 0.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0044
    Cell Significance Index: 0.2700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0044
    Cell Significance Index: 0.0500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0105
    Cell Significance Index: -0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0135
    Cell Significance Index: -25.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0160
    Cell Significance Index: -1.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0186
    Cell Significance Index: -34.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0208
    Cell Significance Index: -7.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0211
    Cell Significance Index: -15.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0221
    Cell Significance Index: -33.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0238
    Cell Significance Index: -17.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0253
    Cell Significance Index: -34.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0347
    Cell Significance Index: -22.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0381
    Cell Significance Index: -28.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0384
    Cell Significance Index: -4.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0406
    Cell Significance Index: -22.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0526
    Cell Significance Index: -1.4700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0530
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0541
    Cell Significance Index: -33.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0546
    Cell Significance Index: -24.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0642
    Cell Significance Index: -1.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0645
    Cell Significance Index: -3.6200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0740
    Cell Significance Index: -1.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1084
    Cell Significance Index: -12.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1101
    Cell Significance Index: -18.8000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1109
    Cell Significance Index: -0.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1208
    Cell Significance Index: -1.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1239
    Cell Significance Index: -16.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1359
    Cell Significance Index: -6.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1405
    Cell Significance Index: -10.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1489
    Cell Significance Index: -31.3700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1524
    Cell Significance Index: -3.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1597
    Cell Significance Index: -4.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1607
    Cell Significance Index: -10.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1622
    Cell Significance Index: -12.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1707
    Cell Significance Index: -24.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1963
    Cell Significance Index: -22.4900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1969
    Cell Significance Index: -5.0300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1993
    Cell Significance Index: -0.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2155
    Cell Significance Index: -4.5900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2579
    Cell Significance Index: -4.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2679
    Cell Significance Index: -13.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2762
    Cell Significance Index: -4.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2792
    Cell Significance Index: -22.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3126
    Cell Significance Index: -19.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3171
    Cell Significance Index: -9.0900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.3193
    Cell Significance Index: -1.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3507
    Cell Significance Index: -16.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3602
    Cell Significance Index: -24.2200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3790
    Cell Significance Index: -4.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5124
    Cell Significance Index: -22.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5153
    Cell Significance Index: -15.1300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.5207
    Cell Significance Index: -3.0900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.5264
    Cell Significance Index: -5.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5312
    Cell Significance Index: -14.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5383
    Cell Significance Index: -17.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The HILPDA gene encodes a protein that is specifically associated with lipid droplets, which are organelles involved in lipid storage and metabolism. The HILPDA protein is induced under hypoxic conditions, suggesting its role in cellular adaptation to low oxygen levels. The gene is expressed in various cell types, including fibroblasts, epithelial cells, and endothelial cells, which are all involved in tissue repair, growth, and maintenance. The HILPDA protein is also involved in autocrine signaling, positive regulation of cell population proliferation, and positive regulation of cytokine production, highlighting its potential role in immune responses and inflammation. **Pathways and Functions:** The HILPDA gene is involved in several cellular pathways, including autocrine signaling, cellular response to hypoxia, and lipid droplet organization. The HILPDA protein is thought to play a key role in lipid droplet formation and organization, which is essential for lipid storage and metabolism. The gene is also involved in positive regulation of cell population proliferation, cytokine production, and lipid storage, suggesting its role in tissue repair and maintenance. Furthermore, the HILPDA protein is associated with the regulation of cellular metabolism, including the metabolism of lipids and other biomolecules. **Clinical Significance:** The HILPDA gene has significant implications for various diseases, including cancer, cardiovascular disease, and metabolic disorders. Under hypoxic conditions, the HILPDA protein can promote tumor growth and metastasis by regulating lipid droplet formation and organization. In cardiovascular disease, the HILPDA protein may contribute to endothelial dysfunction and atherosclerosis by regulating lipid metabolism and storage. Additionally, the HILPDA gene may play a role in metabolic disorders, such as obesity and type 2 diabetes, by regulating lipid metabolism and storage. Further research is needed to fully understand the clinical significance of the HILPDA gene and its potential therapeutic applications. In conclusion, the HILPDA gene is a novel player in cellular adaptation and metabolic regulation, with significant implications for various diseases. Further research is needed to fully understand the mechanisms by which the HILPDA protein regulates lipid droplet formation and organization, as well as its role in immune responses and inflammation.

Genular Protein ID: 3475617994

Symbol: HLPDA_HUMAN

Name: Hypoxia-inducible lipid droplet-associated protein

UniProtKB Accession Codes:

Q9Y5L2 A4D0Z5 Q52LY5 Q53HJ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 GO 13 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10690527

Title: Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment.

PubMed ID: 10690527

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15930302

Title: Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for renal cell carcinoma and potential target for molecular therapy.

PubMed ID: 15930302

DOI: 10.1158/0008-5472.can-05-0120

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20624928

Title: Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1.

PubMed ID: 20624928

DOI: 10.1096/fj.10-159806

PubMed ID: 21614900

Title: Expression of hypoxia-inducible 2 (HIG2) protein in uterine cancer.

PubMed ID: 21614900

Sequence Information:

  • Length: 63
  • Mass: 6950
  • Checksum: 91EA626A511FC8B7
  • Sequence:
    • MKHVLNLYLL GVVLTLLSIF VRVMESLEGL LESPSPGTSW TTRSQLANTE PTKGLPDHPS 
RSM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.