Details for: HILPDA

Gene ID: 29923

Symbol: HILPDA

Ensembl ID: ENSG00000135245

Description: hypoxia inducible lipid droplet associated

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.81
    Marker Score: 2,250
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.16
    Marker Score: 3,835
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.01
    Marker Score: 1,146
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.59
    Marker Score: 6,247
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,944
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.38
    Marker Score: 391
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.29
    Marker Score: 44,656
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.29
    Marker Score: 11,079
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.27
    Marker Score: 2,415
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.25
    Marker Score: 1,513
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.2
    Marker Score: 4,449
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.2
    Marker Score: 9,356
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.18
    Marker Score: 18,540
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.12
    Marker Score: 626
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.11
    Marker Score: 751
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1
    Marker Score: 1,617
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.1
    Marker Score: 1,032
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.09
    Marker Score: 1,030
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.08
    Marker Score: 1,358
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.02
    Marker Score: 668
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.01
    Marker Score: 1,082
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,761
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1
    Marker Score: 549
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,986
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.99
    Marker Score: 11,102
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.95
    Marker Score: 306
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.95
    Marker Score: 4,084
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.94
    Marker Score: 1,600
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 441
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.93
    Marker Score: 1,947
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,312
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.92
    Marker Score: 19,720
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.91
    Marker Score: 2,247
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,737
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.91
    Marker Score: 455
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.9
    Marker Score: 176
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.9
    Marker Score: 748
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.9
    Marker Score: 7,776
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,262
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.84
    Marker Score: 11,126
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.84
    Marker Score: 506
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.84
    Marker Score: 571
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.83
    Marker Score: 524
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.82
    Marker Score: 492
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.82
    Marker Score: 301
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.81
    Marker Score: 1,418
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.81
    Marker Score: 386
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.8
    Marker Score: 1,637
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.8
    Marker Score: 10,792
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8
    Marker Score: 8,022
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.79
    Marker Score: 1,863
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.77
    Marker Score: 655
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.76
    Marker Score: 258
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.74
    Marker Score: 360
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 566
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.74
    Marker Score: 194
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.74
    Marker Score: 2,005
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 379
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.73
    Marker Score: 302
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.73
    Marker Score: 1,899
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.71
    Marker Score: 263
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,983
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.69
    Marker Score: 226
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.68
    Marker Score: 1,391
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.68
    Marker Score: 417
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 619
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.68
    Marker Score: 931
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.68
    Marker Score: 323
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.66
    Marker Score: 658
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.66
    Marker Score: 420
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.66
    Marker Score: 316
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.65
    Marker Score: 4,216
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.64
    Marker Score: 1,218
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.64
    Marker Score: 690
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.63
    Marker Score: 419
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.62
    Marker Score: 1,454
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.61
    Marker Score: 153
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.61
    Marker Score: 389
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.61
    Marker Score: 576
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.61
    Marker Score: 288
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.61
    Marker Score: 153
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.6
    Marker Score: 141
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.6
    Marker Score: 638
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.59
    Marker Score: 832
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 388
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.59
    Marker Score: 657
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.58
    Marker Score: 5,919
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.57
    Marker Score: 139
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.57
    Marker Score: 337
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.55
    Marker Score: 159
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.55
    Marker Score: 550
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.54
    Marker Score: 1,294

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The HILPDA gene encodes a protein that is specifically associated with lipid droplets, which are organelles involved in lipid storage and metabolism. The HILPDA protein is induced under hypoxic conditions, suggesting its role in cellular adaptation to low oxygen levels. The gene is expressed in various cell types, including fibroblasts, epithelial cells, and endothelial cells, which are all involved in tissue repair, growth, and maintenance. The HILPDA protein is also involved in autocrine signaling, positive regulation of cell population proliferation, and positive regulation of cytokine production, highlighting its potential role in immune responses and inflammation. **Pathways and Functions:** The HILPDA gene is involved in several cellular pathways, including autocrine signaling, cellular response to hypoxia, and lipid droplet organization. The HILPDA protein is thought to play a key role in lipid droplet formation and organization, which is essential for lipid storage and metabolism. The gene is also involved in positive regulation of cell population proliferation, cytokine production, and lipid storage, suggesting its role in tissue repair and maintenance. Furthermore, the HILPDA protein is associated with the regulation of cellular metabolism, including the metabolism of lipids and other biomolecules. **Clinical Significance:** The HILPDA gene has significant implications for various diseases, including cancer, cardiovascular disease, and metabolic disorders. Under hypoxic conditions, the HILPDA protein can promote tumor growth and metastasis by regulating lipid droplet formation and organization. In cardiovascular disease, the HILPDA protein may contribute to endothelial dysfunction and atherosclerosis by regulating lipid metabolism and storage. Additionally, the HILPDA gene may play a role in metabolic disorders, such as obesity and type 2 diabetes, by regulating lipid metabolism and storage. Further research is needed to fully understand the clinical significance of the HILPDA gene and its potential therapeutic applications. In conclusion, the HILPDA gene is a novel player in cellular adaptation and metabolic regulation, with significant implications for various diseases. Further research is needed to fully understand the mechanisms by which the HILPDA protein regulates lipid droplet formation and organization, as well as its role in immune responses and inflammation.

Genular Protein ID: 3475617994

Symbol: HLPDA_HUMAN

Name: Hypoxia-inducible lipid droplet-associated protein

UniProtKB Accession Codes:

Q9Y5L2 A4D0Z5 Q52LY5 Q53HJ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 GO 13 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10690527

Title: Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment.

PubMed ID: 10690527

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15930302

Title: Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for renal cell carcinoma and potential target for molecular therapy.

PubMed ID: 15930302

DOI: 10.1158/0008-5472.can-05-0120

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20624928

Title: Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1.

PubMed ID: 20624928

DOI: 10.1096/fj.10-159806

PubMed ID: 21614900

Title: Expression of hypoxia-inducible 2 (HIG2) protein in uterine cancer.

PubMed ID: 21614900

Sequence Information:

  • Length: 63
  • Mass: 6950
  • Checksum: 91EA626A511FC8B7
  • Sequence:
    • MKHVLNLYLL GVVLTLLSIF VRVMESLEGL LESPSPGTSW TTRSQLANTE PTKGLPDHPS 
RSM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.