Details for: FCER2

Gene ID: 2208

Symbol: FCER2

Ensembl ID: ENSG00000104921

Description: Fc epsilon receptor II

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.78
    Marker Score: 5831
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.73
    Marker Score: 2694
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.05
    Marker Score: 3574
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.88
    Marker Score: 1681
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.55
    Marker Score: 1682
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.38
    Marker Score: 318
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.34
    Marker Score: 1264
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.07
    Marker Score: 2179
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251809
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.96
    Marker Score: 2446
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5328
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.9
    Marker Score: 317
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.81
    Marker Score: 615
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.8
    Marker Score: 480
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.78
    Marker Score: 510
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.74
    Marker Score: 178
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.73
    Marker Score: 872
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.68
    Marker Score: 162
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.66
    Marker Score: 404.5
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.63
    Marker Score: 461
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.61
    Marker Score: 214
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.61
    Marker Score: 309
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.59
    Marker Score: 393
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 129
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.47
    Marker Score: 450
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 195
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.46
    Marker Score: 270
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.46
    Marker Score: 5342
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.43
    Marker Score: 1289
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 245
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.43
    Marker Score: 193
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.42
    Marker Score: 554
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.41
    Marker Score: 146
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4
    Marker Score: 765
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.37
    Marker Score: 355
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.31
    Marker Score: 187
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.29
    Marker Score: 193
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.28
    Marker Score: 180
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.28
    Marker Score: 1842
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.27
    Marker Score: 94
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.27
    Marker Score: 183
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.26
    Marker Score: 151
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.26
    Marker Score: 56
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.25
    Marker Score: 125
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.24
    Marker Score: 287
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.23
    Marker Score: 75
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.23
    Marker Score: 3620
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.22
    Marker Score: 112
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.21
    Marker Score: 159
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.18
    Marker Score: 460
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.18
    Marker Score: 155
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.17
    Marker Score: 285
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.17
    Marker Score: 74
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.17
    Marker Score: 459
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.17
    Marker Score: 107
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.16
    Marker Score: 188
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.16
    Marker Score: 324
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.15
    Marker Score: 168
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.15
    Marker Score: 104
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.14
    Marker Score: 69
  • Cell Name: follicular dendritic cell (CL0000442)
    Fold Change: 0.14
    Marker Score: 51
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.13
    Marker Score: 44
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.13
    Marker Score: 126.5
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.12
    Marker Score: 127
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.12
    Marker Score: 123
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.12
    Marker Score: 149
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 133
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.12
    Marker Score: 185.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.11
    Marker Score: 696
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.11
    Marker Score: 63
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.1
    Marker Score: 48
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.1
    Marker Score: 133
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.1
    Marker Score: 70
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.1
    Marker Score: 197
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.1
    Marker Score: 70
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.09
    Marker Score: 82
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.09
    Marker Score: 215
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.09
    Marker Score: 96
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.09
    Marker Score: 36
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.09
    Marker Score: 81.5
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.09
    Marker Score: 48

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Other Information

**Key characteristics:** * FCER2 is a glycoprotein that is composed of two immunoglobulin heavy chains and two immunoglobulin light chains. * It is expressed on all B cell subsets, but it is particularly abundant on mature B cells. * FCER2 is a ligand for the immune checkpoint molecule PD-1. * It is involved in the regulation of humoral immune responses, and its expression is upregulated in autoimmune diseases. **Pathways and functions:** * FCER2 is involved in the B cell antigen processing and presentation pathway. * It is a ligand for the immune checkpoint molecule PD-1, which helps to regulate the immune response. * It is also involved in the activation of the complement system. **Clinical significance:** * FCER2 is a potential therapeutic target for autoimmune diseases. * Blockade of FCER2 signaling has been shown to be effective in inducing apoptosis in B cells and reducing inflammation. * This has led to the development of new treatments for autoimmune diseases such as rheumatoid arthritis and lupus. **Additional notes:** * FCER2 is a relatively novel protein, and there is still much that is unknown about its function. * It is a multi-functional protein that is involved in both B cell activation and suppression. * It is a promising target for the development of new treatments for autoimmune diseases.

Genular Protein ID: 1313073264

Symbol: FCER2_HUMAN

Name: Low affinity immunoglobulin epsilon Fc receptor

UniProtKB Accession Codes:

P06734

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 30 PDBsum 23 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 4 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2949326

Title: Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins.

PubMed ID: 2949326

DOI: 10.1073/pnas.84.3.819

PubMed ID: 2877743

Title: Molecular structure of human lymphocyte receptor for immunoglobulin E.

PubMed ID: 2877743

DOI: 10.1016/0092-8674(86)90508-8

PubMed ID: 3034567

Title: Cloning and expression of the cDNA coding for a human lymphocyte IgE receptor.

PubMed ID: 3034567

DOI: 10.1002/j.1460-2075.1987.tb04726.x

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2972386

Title: Two species of human Fc epsilon receptor II (Fc epsilon RII/CD23): tissue-specific and IL-4-specific regulation of gene expression.

PubMed ID: 2972386

DOI: 10.1016/0092-8674(88)90219-x

PubMed ID: 1417742

Title: Partial characterization of natural and recombinant human soluble CD23.

PubMed ID: 1417742

DOI: 10.1042/bj2860819

PubMed ID: 2167225

Title: IgE-dependent antigen focusing by human B lymphocytes is mediated by the low-affinity receptor for IgE.

PubMed ID: 2167225

DOI: 10.1002/eji.1830200721

PubMed ID: 7544003

Title: The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen.

PubMed ID: 7544003

DOI: 10.1073/pnas.92.17.7804

PubMed ID: 17389606

Title: The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10.

PubMed ID: 17389606

DOI: 10.1074/jbc.m608414200

PubMed ID: 22615937

Title: Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.

PubMed ID: 22615937

DOI: 10.1371/journal.pone.0037187

PubMed ID: 37453717

Title: Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.

PubMed ID: 37453717

DOI: 10.1016/j.mcpro.2023.100617

PubMed ID: 8142907

Title: Modeling of the lectin-homology domains of the human and murine low-affinity Fc epsilon receptor (Fc epsilon RII/CD23).

PubMed ID: 8142907

PubMed ID: 8745401

Title: Structure-based modeling of the ligand binding domain of the human cell surface receptor CD23 and comparison of two independently derived molecular models.

PubMed ID: 8745401

DOI: 10.1002/pro.5560050207

PubMed ID: 16172256

Title: The structure of human CD23 and its interactions with IgE and CD21.

PubMed ID: 16172256

DOI: 10.1084/jem.20050811

PubMed ID: 16765898

Title: Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding.

PubMed ID: 16765898

DOI: 10.1016/j.str.2006.03.017

PubMed ID: 23424103

Title: Mutations in the autoregulatory domain of beta-tubulin 4a cause hereditary dystonia.

PubMed ID: 23424103

DOI: 10.1002/ana.23832

Sequence Information:

  • Length: 321
  • Mass: 36469
  • Checksum: F86708C0E6515B87
  • Sequence:
    • MEEGQYSEIE ELPRRRCCRR GTQIVLLGLV TAALWAGLLT LLLLWHWDTT QSLKQLEERA 
ARNVSQVSKN LESHHGDQMA QKSQSTQISQ ELEELRAEQQ RLKSQDLELS WNLNGLQADL 
SSFKSQELNE RNEASDLLER LREEVTKLRM ELQVSSGFVC NTCPEKWINF QRKCYYFGKG 
TKQWVHARYA CDDMEGQLVS IHSPEEQDFL TKHASHTGSW IGLRNLDLKG EFIWVDGSHV 
DYSNWAPGEP TSRSQGEDCV MMRGSGRWND AFCDRKLGAW VCDRLATCTP PASEGSAESM 
GPDSRPDPDG RLPTPSAPLH S

Genular Protein ID: 2792490569

Symbol: K3W4U1_HUMAN

Name: N/A

UniProtKB Accession Codes:

K3W4U1

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 320
  • Mass: 36299
  • Checksum: 7BAE201DC57FCF85
  • Sequence:
    • MNPPSQEIEE LPRRRCCRRG TQIVLLGLVT AALWAGLLTL LLLWHWDTTQ SLKQLEERAA 
RNVSQVSKNL ESHHGDQMAQ KSQSTQISQE LEELRAEQQR LKSQDLELSW NLNGLQADLS 
SFKSQELNER NEASDLLERL REEVTKLRME LQVSSGFVCN TCPEKWINFQ RKCYYFGKGT 
KQWVHARYAC DDMEGQLVSI HSPEEQDFLT KHASHTGSWI GLRNLDLKGE FIWVDGSHVD 
YSNWAPGEPT SRSQGEDCVM MRGSGRWNDA FCDRKLGAWV CDRLATCTPP ASEGSAESMG 
PDSRPDPDGR LPTPSAPLHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.