Details for: FCER2

Gene ID: 2208

Symbol: FCER2

Ensembl ID: ENSG00000104921

Description: Fc epsilon receptor II

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 26.8732
    Cell Significance Index: -4.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.9924
    Cell Significance Index: -4.3100
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 5.1968
    Cell Significance Index: 23.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.3253
    Cell Significance Index: -4.1000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.1234
    Cell Significance Index: 17.3800
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.7757
    Cell Significance Index: 3.8800
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.6843
    Cell Significance Index: 2.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4357
    Cell Significance Index: 51.3800
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.3908
    Cell Significance Index: 1.9600
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.1540
    Cell Significance Index: 0.9300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1115
    Cell Significance Index: 2.7800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0849
    Cell Significance Index: 1.0500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0352
    Cell Significance Index: 0.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0333
    Cell Significance Index: 0.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0039
    Cell Significance Index: 0.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0040
    Cell Significance Index: -7.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0050
    Cell Significance Index: -3.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0050
    Cell Significance Index: -7.6400
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.0052
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0055
    Cell Significance Index: -4.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0057
    Cell Significance Index: -3.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0058
    Cell Significance Index: -7.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0067
    Cell Significance Index: -4.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0069
    Cell Significance Index: -2.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0070
    Cell Significance Index: -3.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0071
    Cell Significance Index: -0.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0072
    Cell Significance Index: -1.4200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0080
    Cell Significance Index: -0.3500
  • Cell Name: centroblast (CL0009112)
    Fold Change: -0.0086
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0105
    Cell Significance Index: -1.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0108
    Cell Significance Index: -4.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0123
    Cell Significance Index: -2.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0129
    Cell Significance Index: -3.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0158
    Cell Significance Index: -1.0200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0190
    Cell Significance Index: -0.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0197
    Cell Significance Index: -2.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0197
    Cell Significance Index: -4.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0296
    Cell Significance Index: -3.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0312
    Cell Significance Index: -3.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0355
    Cell Significance Index: -4.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0368
    Cell Significance Index: -4.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0419
    Cell Significance Index: -4.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0440
    Cell Significance Index: -4.4900
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.0524
    Cell Significance Index: -0.4600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0540
    Cell Significance Index: -0.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0552
    Cell Significance Index: -3.7100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0667
    Cell Significance Index: -0.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0669
    Cell Significance Index: -5.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0690
    Cell Significance Index: -1.8500
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0700
    Cell Significance Index: -0.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0702
    Cell Significance Index: -1.4700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0718
    Cell Significance Index: -1.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0768
    Cell Significance Index: -3.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0809
    Cell Significance Index: -4.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0814
    Cell Significance Index: -2.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0831
    Cell Significance Index: -4.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0841
    Cell Significance Index: -2.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0863
    Cell Significance Index: -4.0600
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.0875
    Cell Significance Index: -0.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0925
    Cell Significance Index: -4.3200
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0956
    Cell Significance Index: -0.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0973
    Cell Significance Index: -3.4100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0983
    Cell Significance Index: -1.6700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1004
    Cell Significance Index: -1.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1030
    Cell Significance Index: -5.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1049
    Cell Significance Index: -4.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1052
    Cell Significance Index: -3.3500
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1083
    Cell Significance Index: -1.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1085
    Cell Significance Index: -6.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1103
    Cell Significance Index: -3.6100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1104
    Cell Significance Index: -2.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1212
    Cell Significance Index: -4.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1250
    Cell Significance Index: -3.6700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1286
    Cell Significance Index: -1.5200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1286
    Cell Significance Index: -1.4100
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.1301
    Cell Significance Index: -1.3600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1308
    Cell Significance Index: -5.3600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1348
    Cell Significance Index: -1.4700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1359
    Cell Significance Index: -3.6300
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1389
    Cell Significance Index: -1.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1402
    Cell Significance Index: -4.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1414
    Cell Significance Index: -3.8500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1450
    Cell Significance Index: -4.2700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1467
    Cell Significance Index: -3.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1468
    Cell Significance Index: -3.8600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1495
    Cell Significance Index: -3.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1526
    Cell Significance Index: -2.1900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1615
    Cell Significance Index: -2.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1619
    Cell Significance Index: -3.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1633
    Cell Significance Index: -4.6800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1685
    Cell Significance Index: -3.6400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1710
    Cell Significance Index: -3.6300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1742
    Cell Significance Index: -2.9300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1759
    Cell Significance Index: -4.4800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1780
    Cell Significance Index: -1.5400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1800
    Cell Significance Index: -3.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1804
    Cell Significance Index: -6.3400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1808
    Cell Significance Index: -2.4600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1814
    Cell Significance Index: -6.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FCER2 is a low-affinity IgE receptor that is characterized by its ability to bind to IgE antibodies in a non-covalent manner. The receptor is composed of two subunits, alpha and beta, which are linked by a disulfide bond. The alpha subunit contains the Ig-binding site, while the beta subunit is involved in signal transduction. FCER2 is expressed on the surface of various immune cells, including B cells, macrophages, and follicular dendritic cells, and is involved in the regulation of immune responses in a range of contexts, including allergic reactions, immune responses to pathogens, and the regulation of humoral immunity. **Pathways and Functions:** FCER2 is involved in a range of immune processes, including: 1. **Antigen processing and presentation:** FCER2 is involved in the processing and presentation of antigens to T cells, which is critical for the activation of immune responses. 2. **Cytokine signaling:** FCER2 is involved in the signaling of cytokines, including IL-4, IL-13, and IL-10, which are critical for the regulation of immune responses. 3. **Fc-ε receptor signaling pathway:** FCER2 is involved in the signaling pathway that is activated by the binding of IgE to Fc receptors, which is critical for the regulation of immune responses in allergic reactions. 4. **Immune response:** FCER2 is involved in the regulation of immune responses, including the regulation of humoral immunity and the activation of immune cells. 5. **Interspecies interaction:** FCER2 is involved in the regulation of interspecies interactions, including the regulation of immune responses to pathogens. **Clinical Significance:** The dysregulation of FCER2 has been implicated in a range of clinical disorders, including: 1. **Allergic reactions:** The dysregulation of FCER2 is involved in the pathogenesis of allergic reactions, including asthma and atopic dermatitis. 2. **Autoimmune diseases:** The dysregulation of FCER2 has been implicated in the pathogenesis of autoimmune diseases, including rheumatoid arthritis and lupus. 3. **Immunodeficiency disorders:** The dysregulation of FCER2 is involved in the pathogenesis of immunodeficiency disorders, including X-linked agammaglobulinemia. 4. **Cancer:** The dysregulation of FCER2 has been implicated in the pathogenesis of certain types of cancer, including breast cancer and lung cancer. In conclusion, FCER2 is a critical component of the immune system that plays a pivotal role in the regulation of immune responses. The dysregulation of FCER2 has been implicated in a range of clinical disorders, and further research is needed to fully understand the role of this receptor in the regulation of immune responses.

Genular Protein ID: 1313073264

Symbol: FCER2_HUMAN

Name: Low affinity immunoglobulin epsilon Fc receptor

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2949326

Title: Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins.

PubMed ID: 2949326

DOI: 10.1073/pnas.84.3.819

PubMed ID: 2877743

Title: Molecular structure of human lymphocyte receptor for immunoglobulin E.

PubMed ID: 2877743

DOI: 10.1016/0092-8674(86)90508-8

PubMed ID: 3034567

Title: Cloning and expression of the cDNA coding for a human lymphocyte IgE receptor.

PubMed ID: 3034567

DOI: 10.1002/j.1460-2075.1987.tb04726.x

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2972386

Title: Two species of human Fc epsilon receptor II (Fc epsilon RII/CD23): tissue-specific and IL-4-specific regulation of gene expression.

PubMed ID: 2972386

DOI: 10.1016/0092-8674(88)90219-x

PubMed ID: 1417742

Title: Partial characterization of natural and recombinant human soluble CD23.

PubMed ID: 1417742

DOI: 10.1042/bj2860819

PubMed ID: 2167225

Title: IgE-dependent antigen focusing by human B lymphocytes is mediated by the low-affinity receptor for IgE.

PubMed ID: 2167225

DOI: 10.1002/eji.1830200721

PubMed ID: 1386409

Title: CD21 is a ligand for CD23 and regulates IgE production.

PubMed ID: 1386409

DOI: 10.1038/358505a0

PubMed ID: 7544003

Title: The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen.

PubMed ID: 7544003

DOI: 10.1073/pnas.92.17.7804

PubMed ID: 17389606

Title: The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10.

PubMed ID: 17389606

DOI: 10.1074/jbc.m608414200

PubMed ID: 22615937

Title: Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.

PubMed ID: 22615937

DOI: 10.1371/journal.pone.0037187

PubMed ID: 37453717

Title: Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.

PubMed ID: 37453717

DOI: 10.1016/j.mcpro.2023.100617

PubMed ID: 8142907

Title: Modeling of the lectin-homology domains of the human and murine low-affinity Fc epsilon receptor (Fc epsilon RII/CD23).

PubMed ID: 8142907

PubMed ID: 8745401

Title: Structure-based modeling of the ligand binding domain of the human cell surface receptor CD23 and comparison of two independently derived molecular models.

PubMed ID: 8745401

DOI: 10.1002/pro.5560050207

PubMed ID: 16172256

Title: The structure of human CD23 and its interactions with IgE and CD21.

PubMed ID: 16172256

DOI: 10.1084/jem.20050811

PubMed ID: 16765898

Title: Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding.

PubMed ID: 16765898

DOI: 10.1016/j.str.2006.03.017

PubMed ID: 23424103

Title: Mutations in the autoregulatory domain of beta-tubulin 4a cause hereditary dystonia.

PubMed ID: 23424103

DOI: 10.1002/ana.23832

Sequence Information:

  • Length: 321
  • Mass: 36469
  • Checksum: F86708C0E6515B87
  • Sequence:
  • MEEGQYSEIE ELPRRRCCRR GTQIVLLGLV TAALWAGLLT LLLLWHWDTT QSLKQLEERA 
    ARNVSQVSKN LESHHGDQMA QKSQSTQISQ ELEELRAEQQ RLKSQDLELS WNLNGLQADL 
    SSFKSQELNE RNEASDLLER LREEVTKLRM ELQVSSGFVC NTCPEKWINF QRKCYYFGKG 
    TKQWVHARYA CDDMEGQLVS IHSPEEQDFL TKHASHTGSW IGLRNLDLKG EFIWVDGSHV 
    DYSNWAPGEP TSRSQGEDCV MMRGSGRWND AFCDRKLGAW VCDRLATCTP PASEGSAESM 
    GPDSRPDPDG RLPTPSAPLH S

Genular Protein ID: 2792490569

Symbol: K3W4U1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 320
  • Mass: 36299
  • Checksum: 7BAE201DC57FCF85
  • Sequence:
  • MNPPSQEIEE LPRRRCCRRG TQIVLLGLVT AALWAGLLTL LLLWHWDTTQ SLKQLEERAA 
    RNVSQVSKNL ESHHGDQMAQ KSQSTQISQE LEELRAEQQR LKSQDLELSW NLNGLQADLS 
    SFKSQELNER NEASDLLERL REEVTKLRME LQVSSGFVCN TCPEKWINFQ RKCYYFGKGT 
    KQWVHARYAC DDMEGQLVSI HSPEEQDFLT KHASHTGSWI GLRNLDLKGE FIWVDGSHVD 
    YSNWAPGEPT SRSQGEDCVM MRGSGRWNDA FCDRKLGAWV CDRLATCTPP ASEGSAESMG 
    PDSRPDPDGR LPTPSAPLHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.