Gene HLA DRB5 - ENSG00000198502 | NCBI Gene ID: 3127

Details for: HLA DRB5

Gene ID: 3127

Symbol: HLA DRB5

Ensembl ID: ENSG00000198502

Description: major histocompatibility complex, class II, DR beta 5

Associated with

Adaptive immune system
(R-HSA-1280218)
Costimulation by the cd28 family
(R-HSA-388841)
Cytokine signaling in immune system
(R-HSA-1280215)
Downstream tcr signaling
(R-HSA-202424)
Generation of second messenger molecules
(R-HSA-202433)
Immune system
(R-HSA-168256)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Mhc class ii antigen presentation
(R-HSA-2132295)
Pd-1 signaling
(R-HSA-389948)
Phosphorylation of cd3 and tcr zeta chains
(R-HSA-202427)
Tcr signaling
(R-HSA-202403)
Translocation of zap-70 to immunological synapse
(R-HSA-202430)
Adaptive immune response
(GO:0002250)
Antigen processing and presentation of exogenous peptide antigen via mhc class ii
(GO:0019886)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Endocytic vesicle membrane
(GO:0030666)
Er to golgi transport vesicle membrane
(GO:0012507)
Extracellular exosome
(GO:0070062)
Golgi membrane
(GO:0000139)
Late endosome membrane
(GO:0031902)
Lumenal side of endoplasmic reticulum membrane
(GO:0098553)
Lysosomal membrane
(GO:0005765)
Mhc class ii protein complex
(GO:0042613)
Mhc class ii protein complex binding
(GO:0023026)
Peptide antigen assembly with mhc class ii protein complex
(GO:0002503)
Peptide antigen binding
(GO:0042605)
Plasma membrane
(GO:0005886)
Positive regulation of immune response
(GO:0050778)
Positive regulation of t cell activation
(GO:0050870)
Trans-golgi network membrane
(GO:0032588)
Transport vesicle membrane
(GO:0030658)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: thymocyte (CL0000893)
Fold Change: 5.37
Marker Score: 5627
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 4.36
Marker Score: 9141
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.52
Marker Score: 6859
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.13
Marker Score: 174863
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.12
Marker Score: 3571
Cell Name: naive B cell (CL0000788)
Fold Change: 2.8
Marker Score: 2497
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 2.76
Marker Score: 2717
Cell Name: blood cell (CL0000081)
Fold Change: 2.75
Marker Score: 31960
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.74
Marker Score: 8135
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 2.72
Marker Score: 3268
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.68
Marker Score: 68736
Cell Name: pneumocyte (CL0000322)
Fold Change: 2.68
Marker Score: 4309
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.56
Marker Score: 3701
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 2.56
Marker Score: 6622.5
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.54
Marker Score: 4430
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 2.44
Marker Score: 6211
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.31
Marker Score: 15077
Cell Name: centrocyte (CL0009111)
Fold Change: 2.31
Marker Score: 550
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.19
Marker Score: 6923.5
Cell Name: B-1b B cell (CL0000821)
Fold Change: 2.18
Marker Score: 503
Cell Name: follicular B cell (CL0000843)
Fold Change: 2.15
Marker Score: 2330
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.12
Marker Score: 5109
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 2.11
Marker Score: 821
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.11
Marker Score: 5260
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.11
Marker Score: 1269
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 2.1
Marker Score: 1808
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 2.09
Marker Score: 1967
Cell Name: myelocyte (CL0002193)
Fold Change: 2.09
Marker Score: 902
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.09
Marker Score: 975
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 2.05
Marker Score: 3161
Cell Name: microglial cell (CL0000129)
Fold Change: 2.05
Marker Score: 3725
Cell Name: centroblast (CL0009112)
Fold Change: 2.03
Marker Score: 998
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.98
Marker Score: 3243
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.95
Marker Score: 3304
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.91
Marker Score: 11625
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.89
Marker Score: 12087
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 1.85
Marker Score: 1082
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.83
Marker Score: 1325
Cell Name: late pro-B cell (CL0002048)
Fold Change: 1.8
Marker Score: 2120
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 1.79
Marker Score: 1237
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.75
Marker Score: 9212
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 1.68
Marker Score: 1689
Cell Name: immature B cell (CL0000816)
Fold Change: 1.67
Marker Score: 1104
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.66
Marker Score: 587
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 1.62
Marker Score: 412
Cell Name: mature T cell (CL0002419)
Fold Change: 1.6
Marker Score: 15866
Cell Name: dendritic cell (CL0000451)
Fold Change: 1.58
Marker Score: 1082
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.57
Marker Score: 3142
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.54
Marker Score: 1566
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.53
Marker Score: 4155
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 1.52
Marker Score: 634
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.52
Marker Score: 890
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.47
Marker Score: 1461
Cell Name: mural cell (CL0008034)
Fold Change: 1.45
Marker Score: 166881
Cell Name: club cell (CL0000158)
Fold Change: 1.45
Marker Score: 1692
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.43
Marker Score: 713
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 1.42
Marker Score: 364
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 1.42
Marker Score: 373
Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.41
Marker Score: 354
Cell Name: lactocyte (CL0002325)
Fold Change: 1.41
Marker Score: 22591
Cell Name: Langerhans cell (CL0000453)
Fold Change: 1.4
Marker Score: 418
Cell Name: memory B cell (CL0000787)
Fold Change: 1.38
Marker Score: 1041
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.35
Marker Score: 3072
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.34
Marker Score: 895
Cell Name: germinal center B cell (CL0000844)
Fold Change: 1.33
Marker Score: 810
Cell Name: mature B cell (CL0000785)
Fold Change: 1.33
Marker Score: 975
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.31
Marker Score: 1909
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 1.31
Marker Score: 721
Cell Name: osteoclast (CL0000092)
Fold Change: 1.26
Marker Score: 629
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.25
Marker Score: 1123
Cell Name: ciliated cell (CL0000064)
Fold Change: 1.25
Marker Score: 4293.5
Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 1.24
Marker Score: 346
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.23
Marker Score: 1232
Cell Name: vasa recta ascending limb cell (CL1001131)
Fold Change: 1.23
Marker Score: 325
Cell Name: B cell (CL0000236)
Fold Change: 1.23
Marker Score: 1168
Cell Name: macrophage (CL0000235)
Fold Change: 1.21
Marker Score: 1347
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 1.2
Marker Score: 419
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.18
Marker Score: 444
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 1.15
Marker Score: 397
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 1.13
Marker Score: 469
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 1.12
Marker Score: 1079
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.12
Marker Score: 1008
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.1
Marker Score: 579
Cell Name: monocyte (CL0000576)
Fold Change: 1.1
Marker Score: 1429
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.08
Marker Score: 9377
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.07
Marker Score: 524.5
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.05
Marker Score: 435
Cell Name: classical monocyte (CL0000860)
Fold Change: 1.03
Marker Score: 4281
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 1.03
Marker Score: 554
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.02
Marker Score: 358
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.02
Marker Score: 326
Cell Name: B-1a B cell (CL0000820)
Fold Change: 1.02
Marker Score: 243
Cell Name: plasmablast (CL0000980)
Fold Change: 1.01
Marker Score: 1340
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.01
Marker Score: 579
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71670
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47898
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.99
Marker Score: 2013
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30392
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.98
Marker Score: 1857
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 495

Hover over a box to see details here...

**Key characteristics:** * DRB5 is a type I transmembrane protein with a molecular weight of approximately 110 kDa. * It is expressed on the surface of professional antigen-presenting cells, such as macrophages and dendritic cells. * DRB5 is classified as a member of the HLA class II histocompatibility complex, which is responsible for presenting antigens to T cells. * The DRB5 gene is highly conserved across different species. **Pathways and functions:** * DRB5 is expressed on the surface of professional antigen-presenting cells. * Upon antigen binding, DRB5 complex is presented on the surface of antigen-presenting cells. * This allows T cells to recognize and interact with antigen-presenting cells. * DRB5 is involved in the adaptive immune response, helping to regulate the activation and differentiation of T cells. * It plays a role in the generation of second messenger molecules, such as cytokines, which can influence the immune response. **Clinical significance:** * Mutations in the DRB5 gene have been linked to several autoimmune disorders, including systemic sclerosis, rheumatoid arthritis, and lupus. * DRB5 is a potential target for immunotherapy in these diseases. * DRB5 inhibitors are being investigated as a therapeutic approach to autoimmune diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

HLA class II histocompatibility antigen, DR beta 5 chain

Genular Protein ID: 4103405283

Symbol: DRB5_HUMAN

Name: HLA class II histocompatibility antigen, DR beta 5 chain

UniProtKB Accession Codes:

Q30154 B2RBV6 C7C4X3 O00157 O00283 O46700 Q29703 Q29787 Q29788 Q30126 Q30150 Q30199 Q6SJR2 Q7M2H9 Q8HWS7 Q8WLR5 Q9MY54 Q9XRX6

Database IDs:

Citations:

PubMed ID: 3099214

Title: Polymorphism of human Ia antigens generated by reciprocal intergenic exchange between two DR beta loci.

PubMed ID: 3099214

DOI: 10.1038/324676a0

PubMed ID: 3571980

Title: cDNA cloning and sequencing reveals that the electrophoretically constant DR beta 2 molecules, as well as the variable DR beta 1 molecules, from HLA-DR2 subtypes have different amino acid sequences including a hypervariable region for a functionally important epitope.

PubMed ID: 3571980

PubMed ID: 3259543

Title: MHC class II sequences of an HLA-DR2 narcoleptic.

PubMed ID: 3259543

DOI: 10.1007/bf00364432

PubMed ID: 2001975

Title: A novel DRB1 allele in DR2-positive American blacks.

PubMed ID: 2001975

DOI: 10.1016/0198-8859(91)90069-l

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9162096

Title: Diversity associated with the second expressed HLA-DRB locus in the human population.

PubMed ID: 9162096

DOI: 10.1007/s002510050248

PubMed ID: 2885840

Title: HLA-DR2 subtypes form an additional supertypic family of DR beta alleles.

PubMed ID: 2885840

DOI: 10.1073/pnas.84.13.4591

PubMed ID: 3476943

Title: Allelic variation in the DR subregion of the human major histocompatibility complex.

PubMed ID: 3476943

DOI: 10.1073/pnas.84.17.6234

PubMed ID: 6576979

Title: Primary structure of human class II histocompatibility antigens 3rd communication. Amino acid sequence comparison between DR and DC subclass antigens derived from a lymphoblastoid B cell line homozygous at the HLA loci (HLA-A3,3; B7,7; Dw2,2; DR2,2: MT1,1; Dc1,1: MB1,1).

PubMed ID: 6576979

DOI: 10.1515/bchm2.1983.364.1.749

PubMed ID: 8773325

Title: Characterization of a new HLA-DRB5 allele (DRB5*0105) by PCR-SSP and direct sequencing.

PubMed ID: 8773325

DOI: 10.1111/j.1399-0039.1996.tb02563.x

PubMed ID: 9226128

Title: Sequence of a new HLA-DR allele, DRB5*0106.

PubMed ID: 9226128

DOI: 10.1111/j.1365-2370.1997.00267.x

PubMed ID: 14617041

Title: Identification of a new HLA-DRB5 allele, DRB5*0112, by routine PCR-SSP.

PubMed ID: 14617041

DOI: 10.1046/j.1399-0039.2003.00124.x

PubMed ID: 16671952

Title: Identification of a new allele, HLA-DRB5*0113, through three different molecular biology techniques.

PubMed ID: 16671952

DOI: 10.1111/j.1399-0039.2006.00588.x

PubMed ID: 9458128

Title: Identification of novel DRB1*11 (DRB1*11013, DRB1*1129), DRB1*08 (DRB1*0816) and DRB5* (DRB5*0107) alleles.

PubMed ID: 9458128

DOI: 10.1111/j.1399-0039.1997.tb02933.x

PubMed ID: 9694360

Title: Identification of novel DRB1*13 (DRB1*1333), DRB1*04 (DRB1*0426) and DRB5* (DRB5*0109) alleles.

PubMed ID: 9694360

DOI: 10.1111/j.1399-0039.1998.tb03010.x

PubMed ID: 1471145

Title: DRB5*HK: a new HLA-DRB5 allele in Cantonese.

PubMed ID: 1471145

DOI: 10.1111/j.1399-0039.1992.tb02047.x

PubMed ID: 8598037

Title: Invariant chain structure and MHC class II function.

PubMed ID: 8598037

DOI: 10.1016/s0092-8674(00)81025-9

PubMed ID: 11684289

Title: Presentation of antigens by MHC class II molecules: getting the most out of them.

PubMed ID: 11684289

DOI: 10.1016/s0161-5890(01)00069-4

PubMed ID: 17241953

Title: Autophagy in MHC class II presentation: sampling from within.

PubMed ID: 17241953

DOI: 10.1016/j.immuni.2007.01.005

PubMed ID: 18046453

Title: MHC class II molecules on the move for successful antigen presentation.

PubMed ID: 18046453

DOI: 10.1038/sj.emboj.7601945

PubMed ID: 18305173

Title: MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation.

PubMed ID: 18305173

DOI: 10.1073/pnas.0708874105

PubMed ID: 19092054

Title: MHC class II transport at a glance.

PubMed ID: 19092054

DOI: 10.1242/jcs.035089

PubMed ID: 19533806

Title: CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.

PubMed ID: 19533806

DOI: 10.3748/wjg.15.2855

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 11080454

Title: Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins.

PubMed ID: 11080454

DOI: 10.1006/jmbi.2000.4198

PubMed ID: 11163233

Title: Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II.

PubMed ID: 11163233

DOI: 10.1016/s1074-7613(01)00092-9

PubMed ID: 12244309

Title: A functional and structural basis for TCR cross-reactivity in multiple sclerosis.

PubMed ID: 12244309

DOI: 10.1038/ni835

PubMed ID: 16079912

Title: Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule.

PubMed ID: 16079912

DOI: 10.1038/sj.emboj.7600771

Sequence Information:

Length: 266
Mass: 30056
Checksum: 0D4335BAEEA6AF22
Sequence:

MVCLKLPGGS YMAKLTVTLM VLSSPLALAG DTRPRFLQQD KYECHFFNGT ERVRFLHRDI 
YNQEEDLRFD SDVGEYRAVT ELGRPDAEYW NSQKDFLEDR RAAVDTYCRH NYGVGESFTV 
QRRVEPKVTV YPARTQTLQH HNLLVCSVNG FYPGSIEVRW FRNSQEEKAG VVSTGLIQNG 
DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAQ SESAQSKMLS GVGGFVLGLL 
FLGAGLFIYF KNQKGHSGLH PTGLVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: HLA DRB5

Associated with

Cells (max top 100)

Other Information

Polymorphism of human Ia antigens generated by reciprocal intergenic exchange between two DR beta loci. PubMed ID: 3099214

cDNA cloning and sequencing reveals that the electrophoretically constant DR beta 2 molecules, as well as the variable DR beta 1 molecules, from HLA-DR2 subtypes have different amino acid sequences including a hypervariable region for a functionally important epitope. PubMed ID: 3571980

MHC class II sequences of an HLA-DR2 narcoleptic. PubMed ID: 3259543

A novel DRB1 allele in DR2-positive American blacks. PubMed ID: 2001975

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Diversity associated with the second expressed HLA-DRB locus in the human population. PubMed ID: 9162096

HLA-DR2 subtypes form an additional supertypic family of DR beta alleles. PubMed ID: 2885840

Allelic variation in the DR subregion of the human major histocompatibility complex. PubMed ID: 3476943

Primary structure of human class II histocompatibility antigens 3rd communication. Amino acid sequence comparison between DR and DC subclass antigens derived from a lymphoblastoid B cell line homozygous at the HLA loci (HLA-A3,3; B7,7; Dw2,2; DR2,2: MT1,1; Dc1,1: MB1,1). PubMed ID: 6576979

Characterization of a new HLA-DRB5 allele (DRB5*0105) by PCR-SSP and direct sequencing. PubMed ID: 8773325

Sequence of a new HLA-DR allele, DRB5*0106. PubMed ID: 9226128

Identification of a new HLA-DRB5 allele, DRB5*0112, by routine PCR-SSP. PubMed ID: 14617041

Identification of a new allele, HLA-DRB5*0113, through three different molecular biology techniques. PubMed ID: 16671952

Identification of novel DRB1*11 (DRB1*11013, DRB1*1129), DRB1*08 (DRB1*0816) and DRB5* (DRB5*0107) alleles. PubMed ID: 9458128

Identification of novel DRB1*13 (DRB1*1333), DRB1*04 (DRB1*0426) and DRB5* (DRB5*0109) alleles. PubMed ID: 9694360

DRB5*HK: a new HLA-DRB5 allele in Cantonese. PubMed ID: 1471145

Invariant chain structure and MHC class II function. PubMed ID: 8598037

Presentation of antigens by MHC class II molecules: getting the most out of them. PubMed ID: 11684289

Autophagy in MHC class II presentation: sampling from within. PubMed ID: 17241953

MHC class II molecules on the move for successful antigen presentation. PubMed ID: 18046453

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. PubMed ID: 18305173

MHC class II transport at a glance. PubMed ID: 19092054

CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract. PubMed ID: 19533806

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Initial characterization of the human central proteome. PubMed ID: 21269460

Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins. PubMed ID: 11080454

Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II. PubMed ID: 11163233

A functional and structural basis for TCR cross-reactivity in multiple sclerosis. PubMed ID: 12244309

Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule. PubMed ID: 16079912