Details for: HLA DRB5

Gene ID: 3127

Symbol: HLA DRB5

Ensembl ID: ENSG00000198502

Description: major histocompatibility complex, class II, DR beta 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 204.5386
    Cell Significance Index: -31.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 80.3678
    Cell Significance Index: -41.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 57.7385
    Cell Significance Index: -14.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.0837
    Cell Significance Index: -32.1600
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 16.7349
    Cell Significance Index: 69.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.6747
    Cell Significance Index: -31.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.2855
    Cell Significance Index: -32.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.1037
    Cell Significance Index: -24.8900
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 7.9058
    Cell Significance Index: 20.8600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 6.4772
    Cell Significance Index: 114.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.7751
    Cell Significance Index: 106.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.3688
    Cell Significance Index: -11.7500
  • Cell Name: centroblast (CL0009112)
    Fold Change: 4.9463
    Cell Significance Index: 11.5400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.7340
    Cell Significance Index: 53.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.5941
    Cell Significance Index: 541.7800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 4.0874
    Cell Significance Index: 70.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.0124
    Cell Significance Index: 117.8400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 3.8708
    Cell Significance Index: 27.8000
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 3.8020
    Cell Significance Index: 14.1700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.7433
    Cell Significance Index: 56.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.9242
    Cell Significance Index: 132.5500
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.4301
    Cell Significance Index: 10.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.4292
    Cell Significance Index: 167.9900
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.3612
    Cell Significance Index: 7.2800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.3508
    Cell Significance Index: 36.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.0124
    Cell Significance Index: 53.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0964
    Cell Significance Index: 65.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9554
    Cell Significance Index: 862.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7586
    Cell Significance Index: 82.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5276
    Cell Significance Index: 18.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5255
    Cell Significance Index: 85.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4555
    Cell Significance Index: 12.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3378
    Cell Significance Index: 255.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2703
    Cell Significance Index: 51.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2478
    Cell Significance Index: 15.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2040
    Cell Significance Index: 20.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1998
    Cell Significance Index: 20.4100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1016
    Cell Significance Index: 2.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0485
    Cell Significance Index: 21.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0214
    Cell Significance Index: 2.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0172
    Cell Significance Index: -32.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0218
    Cell Significance Index: -40.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0240
    Cell Significance Index: -0.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0256
    Cell Significance Index: -39.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0294
    Cell Significance Index: -40.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0374
    Cell Significance Index: -20.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0396
    Cell Significance Index: -11.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0420
    Cell Significance Index: -31.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0525
    Cell Significance Index: -38.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0575
    Cell Significance Index: -32.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0612
    Cell Significance Index: -38.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0805
    Cell Significance Index: -3.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0809
    Cell Significance Index: -4.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0876
    Cell Significance Index: -39.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0878
    Cell Significance Index: -17.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0927
    Cell Significance Index: -33.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1059
    Cell Significance Index: -13.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1396
    Cell Significance Index: -15.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1444
    Cell Significance Index: -4.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1487
    Cell Significance Index: -31.3100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1523
    Cell Significance Index: -3.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1576
    Cell Significance Index: -3.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1603
    Cell Significance Index: -28.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1639
    Cell Significance Index: -32.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1892
    Cell Significance Index: -32.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2002
    Cell Significance Index: -8.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2226
    Cell Significance Index: -13.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2232
    Cell Significance Index: -27.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2411
    Cell Significance Index: -33.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2450
    Cell Significance Index: -28.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2609
    Cell Significance Index: -37.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3162
    Cell Significance Index: -32.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3214
    Cell Significance Index: -22.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4023
    Cell Significance Index: -29.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4215
    Cell Significance Index: -11.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4312
    Cell Significance Index: -33.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4965
    Cell Significance Index: -39.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5186
    Cell Significance Index: -16.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5210
    Cell Significance Index: -35.0400
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.6006
    Cell Significance Index: -4.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6007
    Cell Significance Index: -36.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6097
    Cell Significance Index: -12.9900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6206
    Cell Significance Index: -26.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6538
    Cell Significance Index: -36.6900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.7020
    Cell Significance Index: -6.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7129
    Cell Significance Index: -37.4300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7606
    Cell Significance Index: -27.9200
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.7796
    Cell Significance Index: -3.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7823
    Cell Significance Index: -40.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8052
    Cell Significance Index: -37.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8240
    Cell Significance Index: -21.1800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.8255
    Cell Significance Index: -16.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8732
    Cell Significance Index: -38.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9571
    Cell Significance Index: -28.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9574
    Cell Significance Index: -33.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9748
    Cell Significance Index: -34.1500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.9892
    Cell Significance Index: -20.5200
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.9958
    Cell Significance Index: -10.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0196
    Cell Significance Index: -38.6100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -1.0398
    Cell Significance Index: -15.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HLA-DRB5 is a non-essential MHC class II gene, which is expressed on the surface of antigen-presenting cells (APCs) such as dendritic cells, B cells, and monocytes. It is a part of the HLA class II gene complex and is encoded by the DRB1 locus. HLA-DRB5 is characterized by its ability to present a wide range of peptides to T-cells, including antigens from pathogens, tumor cells, and self-proteins. This diversity in peptide presentation allows HLA-DRB5 to regulate immune responses and prevent autoimmunity. **Pathways and Functions:** HLA-DRB5 is involved in several key immune pathways, including: 1. **Antigen Processing and Presentation**: HLA-DRB5 processes exogenous peptides from pathogens, tumor cells, and self-proteins and presents them to T-cells via the MHC class II molecule. 2. **T-Cell Activation**: The presentation of peptides by HLA-DRB5 to T-cells activates T-cell responses, which are essential for immune defense against pathogens and tumor cells. 3. **Cytokine Signaling**: HLA-DRB5 is involved in cytokine signaling pathways, including the production of cytokines such as IL-2 and IFN-γ, which regulate immune responses. 4. **Endocytic Vesicle Membrane**: HLA-DRB5 is also involved in the regulation of endocytic vesicle membrane trafficking, which is essential for the presentation of peptides to T-cells. **Clinical Significance:** HLA-DRB5 has significant implications in various immune-related disorders, including: 1. **Autoimmune Diseases**: HLA-DRB5 has been associated with several autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and lupus. 2. **Transplantation**: HLA-DRB5 is a critical factor in transplantation, as it determines the compatibility of organ donors and recipients. 3. **Cancer**: HLA-DRB5 has been implicated in the regulation of tumor immune responses, and its expression is often altered in cancer patients. 4. **Infectious Diseases**: HLA-DRB5 is involved in the regulation of immune responses to pathogens, and its expression is often altered in patients with infectious diseases. In conclusion, HLA-DRB5 is a crucial gene in the immune system, playing a pivotal role in the presentation of exogenous peptides to T-cells and the regulation of immune responses. Its clinical significance extends to various immune-related disorders, including autoimmune diseases, transplantation, cancer, and infectious diseases. Further research into the function and regulation of HLA-DRB5 is necessary to fully understand its role in the immune system and to develop new therapeutic strategies for immune-related disorders.

Genular Protein ID: 4103405283

Symbol: DRB5_HUMAN

Name: HLA class II histocompatibility antigen, DR beta 5 chain

UniProtKB Accession Codes:

Q30154 B2RBV6 C7C4X3 O00157 O00283 O46700 Q29703 Q29787 Q29788 Q30126 Q30150 Q30199 Q6SJR2 Q7M2H9 Q8HWS7 Q8WLR5 Q9MY54 Q9XRX6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 21 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 4 PDBsum 4 PIR 9 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3099214

Title: Polymorphism of human Ia antigens generated by reciprocal intergenic exchange between two DR beta loci.

PubMed ID: 3099214

DOI: 10.1038/324676a0

PubMed ID: 3571980

Title: cDNA cloning and sequencing reveals that the electrophoretically constant DR beta 2 molecules, as well as the variable DR beta 1 molecules, from HLA-DR2 subtypes have different amino acid sequences including a hypervariable region for a functionally important epitope.

PubMed ID: 3571980

PubMed ID: 3259543

Title: MHC class II sequences of an HLA-DR2 narcoleptic.

PubMed ID: 3259543

DOI: 10.1007/bf00364432

PubMed ID: 2001975

Title: A novel DRB1 allele in DR2-positive American blacks.

PubMed ID: 2001975

DOI: 10.1016/0198-8859(91)90069-l

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9162096

Title: Diversity associated with the second expressed HLA-DRB locus in the human population.

PubMed ID: 9162096

DOI: 10.1007/s002510050248

PubMed ID: 2885840

Title: HLA-DR2 subtypes form an additional supertypic family of DR beta alleles.

PubMed ID: 2885840

DOI: 10.1073/pnas.84.13.4591

PubMed ID: 3476943

Title: Allelic variation in the DR subregion of the human major histocompatibility complex.

PubMed ID: 3476943

DOI: 10.1073/pnas.84.17.6234

PubMed ID: 6576979

Title: Primary structure of human class II histocompatibility antigens 3rd communication. Amino acid sequence comparison between DR and DC subclass antigens derived from a lymphoblastoid B cell line homozygous at the HLA loci (HLA-A3,3; B7,7; Dw2,2; DR2,2: MT1,1; Dc1,1: MB1,1).

PubMed ID: 6576979

DOI: 10.1515/bchm2.1983.364.1.749

PubMed ID: 8773325

Title: Characterization of a new HLA-DRB5 allele (DRB5*0105) by PCR-SSP and direct sequencing.

PubMed ID: 8773325

DOI: 10.1111/j.1399-0039.1996.tb02563.x

PubMed ID: 9226128

Title: Sequence of a new HLA-DR allele, DRB5*0106.

PubMed ID: 9226128

DOI: 10.1111/j.1365-2370.1997.00267.x

PubMed ID: 14617041

Title: Identification of a new HLA-DRB5 allele, DRB5*0112, by routine PCR-SSP.

PubMed ID: 14617041

DOI: 10.1046/j.1399-0039.2003.00124.x

PubMed ID: 16671952

Title: Identification of a new allele, HLA-DRB5*0113, through three different molecular biology techniques.

PubMed ID: 16671952

DOI: 10.1111/j.1399-0039.2006.00588.x

PubMed ID: 9458128

Title: Identification of novel DRB1*11 (DRB1*11013, DRB1*1129), DRB1*08 (DRB1*0816) and DRB5* (DRB5*0107) alleles.

PubMed ID: 9458128

DOI: 10.1111/j.1399-0039.1997.tb02933.x

PubMed ID: 9694360

Title: Identification of novel DRB1*13 (DRB1*1333), DRB1*04 (DRB1*0426) and DRB5* (DRB5*0109) alleles.

PubMed ID: 9694360

DOI: 10.1111/j.1399-0039.1998.tb03010.x

PubMed ID: 1471145

Title: DRB5*HK: a new HLA-DRB5 allele in Cantonese.

PubMed ID: 1471145

DOI: 10.1111/j.1399-0039.1992.tb02047.x

PubMed ID: 8598037

Title: Invariant chain structure and MHC class II function.

PubMed ID: 8598037

DOI: 10.1016/s0092-8674(00)81025-9

PubMed ID: 11684289

Title: Presentation of antigens by MHC class II molecules: getting the most out of them.

PubMed ID: 11684289

DOI: 10.1016/s0161-5890(01)00069-4

PubMed ID: 17241953

Title: Autophagy in MHC class II presentation: sampling from within.

PubMed ID: 17241953

DOI: 10.1016/j.immuni.2007.01.005

PubMed ID: 18046453

Title: MHC class II molecules on the move for successful antigen presentation.

PubMed ID: 18046453

DOI: 10.1038/sj.emboj.7601945

PubMed ID: 18305173

Title: MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation.

PubMed ID: 18305173

DOI: 10.1073/pnas.0708874105

PubMed ID: 19092054

Title: MHC class II transport at a glance.

PubMed ID: 19092054

DOI: 10.1242/jcs.035089

PubMed ID: 19533806

Title: CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.

PubMed ID: 19533806

DOI: 10.3748/wjg.15.2855

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 11080454

Title: Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins.

PubMed ID: 11080454

DOI: 10.1006/jmbi.2000.4198

PubMed ID: 11163233

Title: Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II.

PubMed ID: 11163233

DOI: 10.1016/s1074-7613(01)00092-9

PubMed ID: 12244309

Title: A functional and structural basis for TCR cross-reactivity in multiple sclerosis.

PubMed ID: 12244309

DOI: 10.1038/ni835

PubMed ID: 16079912

Title: Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule.

PubMed ID: 16079912

DOI: 10.1038/sj.emboj.7600771

Sequence Information:

  • Length: 266
  • Mass: 30056
  • Checksum: 0D4335BAEEA6AF22
  • Sequence:
    • MVCLKLPGGS YMAKLTVTLM VLSSPLALAG DTRPRFLQQD KYECHFFNGT ERVRFLHRDI 
YNQEEDLRFD SDVGEYRAVT ELGRPDAEYW NSQKDFLEDR RAAVDTYCRH NYGVGESFTV 
QRRVEPKVTV YPARTQTLQH HNLLVCSVNG FYPGSIEVRW FRNSQEEKAG VVSTGLIQNG 
DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAQ SESAQSKMLS GVGGFVLGLL 
FLGAGLFIYF KNQKGHSGLH PTGLVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.