Details for: IRAG2

Gene ID: 4033

Symbol: IRAG2

Ensembl ID: ENSG00000118308

Description: inositol 1,4,5-triphosphate receptor associated 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.87
    Marker Score: 11109
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.03
    Marker Score: 1773.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.96
    Marker Score: 8797
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 2.58
    Marker Score: 2474
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.52
    Marker Score: 1533.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.48
    Marker Score: 1224
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.22
    Marker Score: 22489
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 2.09
    Marker Score: 17662.5
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.08
    Marker Score: 495
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.02
    Marker Score: 2431
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.97
    Marker Score: 981
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.91
    Marker Score: 17929
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.71
    Marker Score: 2974
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.62
    Marker Score: 1633
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.59
    Marker Score: 4313
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.56
    Marker Score: 1133
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.49
    Marker Score: 91894
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168152
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.46
    Marker Score: 13919
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.42
    Marker Score: 1537.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.32
    Marker Score: 468
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.31
    Marker Score: 788
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.26
    Marker Score: 614
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.2
    Marker Score: 1127
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.19
    Marker Score: 1685
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.18
    Marker Score: 428
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.14
    Marker Score: 1191.5
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.12
    Marker Score: 1488.5
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.06
    Marker Score: 518
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.05
    Marker Score: 242
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.05
    Marker Score: 2997
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.05
    Marker Score: 1239
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.02
    Marker Score: 774
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1
    Marker Score: 1478
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1
    Marker Score: 681
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71735.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47957.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1
    Marker Score: 1812.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.96
    Marker Score: 653
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.95
    Marker Score: 901
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.94
    Marker Score: 840
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.93
    Marker Score: 1957.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2719
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.87
    Marker Score: 10124
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5250
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4923
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.86
    Marker Score: 2372
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.85
    Marker Score: 491
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.85
    Marker Score: 837
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.84
    Marker Score: 2039
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.82
    Marker Score: 517
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.81
    Marker Score: 280
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.8
    Marker Score: 259
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 314
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.78
    Marker Score: 519
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 595
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.78
    Marker Score: 335
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1252
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.75
    Marker Score: 292
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 656
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.72
    Marker Score: 297.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2978
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.7
    Marker Score: 284
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.69
    Marker Score: 525
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.69
    Marker Score: 771
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.69
    Marker Score: 164
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.68
    Marker Score: 188
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.68
    Marker Score: 1901
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.67
    Marker Score: 643.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.66
    Marker Score: 305
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.66
    Marker Score: 1282.5
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.65
    Marker Score: 232
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.64
    Marker Score: 1515
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.64
    Marker Score: 1218
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.64
    Marker Score: 1351
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.64
    Marker Score: 336
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.64
    Marker Score: 201.5
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.64
    Marker Score: 167
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.62
    Marker Score: 34664.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.61
    Marker Score: 424
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.61
    Marker Score: 238
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.61
    Marker Score: 838
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.6
    Marker Score: 1762
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6
    Marker Score: 6204
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.59
    Marker Score: 120
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.59
    Marker Score: 186
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 374
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.58
    Marker Score: 423
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.57
    Marker Score: 200.5
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.57
    Marker Score: 146
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.57
    Marker Score: 2326
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.57
    Marker Score: 187
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.56
    Marker Score: 276

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Other Information

**Key characteristics:** * IRAG2 is a type I transmembrane protein with a single extracellular domain and a cytoplasmic tail. * It is expressed in high levels in the retinas of mammals, suggesting that it is involved in retinal function. * IRAG2 is a key regulator of the development and maintenance of the retinal cone cell layer, which is responsible for vision. * It is also involved in the regulation of B cell development and function. **Pathways and functions:** * IRAG2 is a key regulator of the development and maintenance of the retinal cone cell layer. * It is expressed in high levels in the retinas of mammals, suggesting that it is involved in retinal function. * IRAG2 is a ligand for the chemokine CXCR4, which is expressed in retinal endothelial cells. * When IRAG2 binds to CXCR4, it promotes the migration of retinal endothelial cells to the retina. * This migration is essential for the development and maintenance of the retinal cone cell layer. **Clinical significance:** * Mutations in the IRAG2 gene have been linked to a number of eye diseases, including retinitis pigmentosa, a progressive degenerative eye disease that is characterized by the loss of vision. * These mutations can lead to the loss of cone cells, which can result in night blindness. * Therefore, IRAG2 is a promising target for the treatment of eye diseases.

Genular Protein ID: 3143702676

Symbol: IRAG2_HUMAN

Name: Lymphoid-restricted membrane protein

UniProtKB Accession Codes:

Q12912 A0AVM2 B4E077 Q8N301

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 11 SAM 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8021504

Title: Jaw1, a lymphoid-restricted membrane protein localized to the endoplasmic reticulum.

PubMed ID: 8021504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16739114

Title: Jaw1/LRMP, a germinal centre-associated marker for the immunohistological study of B-cell lymphomas.

PubMed ID: 16739114

DOI: 10.1002/path.2002

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 555
  • Mass: 62122
  • Checksum: FAFA4B94DCEB1A42
  • Sequence:
    • MESTPFSGVA NQIHTLCERP TYGEVKDGAL DVKRQHKCPG PTSGPSPGTN LSGCIRMNDD 
PSMEENGVER VCPESLLQSR EYSSLPLPRH TSSTDGTITS SDPGLEILNM ASCDLDRNSL 
CKKEEDTRSA SPTIEAQGTS PAHDNIAFQD STSKDKTILN LEAKEEPETI EEHKKEHASG 
DSVVSPLPVT TVKSVNLRQS ENTSANEKEV EAEFLRLSLG FKCDWFTLEK RVKLEERSRD 
LAEENLKKEI TNCLKLLESL TPLCEDDNQA QEIIKKLEKS IKFLSQCAAR VASRAEMLGA 
INQESRVSKA VEVMIQHVEN LKRMYAKEHA ELEELKQVLL QNERSFNPLE DDDDCQIKKR 
SASLNSKPSS LRRVTIASLP RNIGNAGMVA GMENNDRFSR RSSSWRILGS KQSEHRPSLP 
RFISTYSWAD AEEEKCELKT KDDSEPSGEE TVERTRKPSL SEKKNNPSKW DVSSVYDTIA 
SWATNLKSSI RKANKALWLS IAFIVLFAAL MSFLTGQLFQ KSVDAAPTQQ EDSWTSLEHI 
LWPFTRLRHN GPPPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.