Details for: IRAG2

Gene ID: 4033

Symbol: IRAG2

Ensembl ID: ENSG00000118308

Description: inositol 1,4,5-triphosphate receptor associated 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 72.0691
    Cell Significance Index: -11.2100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.5902
    Cell Significance Index: -13.2400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 29.0347
    Cell Significance Index: -14.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.2286
    Cell Significance Index: -7.1600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 27.8555
    Cell Significance Index: -11.4800
  • Cell Name: centroblast (CL0009112)
    Fold Change: 20.1323
    Cell Significance Index: 46.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.2866
    Cell Significance Index: -11.4500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 8.4210
    Cell Significance Index: 84.9500
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 5.5331
    Cell Significance Index: 17.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.1714
    Cell Significance Index: 609.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.6917
    Cell Significance Index: 238.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.0963
    Cell Significance Index: -9.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9751
    Cell Significance Index: -11.7400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.9338
    Cell Significance Index: 45.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.8974
    Cell Significance Index: 551.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.5639
    Cell Significance Index: 253.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.1201
    Cell Significance Index: -4.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3372
    Cell Significance Index: 217.4900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2210
    Cell Significance Index: 132.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9375
    Cell Significance Index: 48.7000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.8175
    Cell Significance Index: 2.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7381
    Cell Significance Index: 51.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5959
    Cell Significance Index: 12.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5750
    Cell Significance Index: 34.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5032
    Cell Significance Index: 100.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3944
    Cell Significance Index: 71.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3591
    Cell Significance Index: 9.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3536
    Cell Significance Index: 43.4800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2601
    Cell Significance Index: 3.7300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.2433
    Cell Significance Index: 3.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2213
    Cell Significance Index: 3.0200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2130
    Cell Significance Index: 2.9900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.2017
    Cell Significance Index: 3.0400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1925
    Cell Significance Index: 1.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1790
    Cell Significance Index: 35.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0809
    Cell Significance Index: 55.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0554
    Cell Significance Index: 9.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0510
    Cell Significance Index: 0.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0268
    Cell Significance Index: 0.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0242
    Cell Significance Index: 8.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0034
    Cell Significance Index: -0.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0074
    Cell Significance Index: -10.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0096
    Cell Significance Index: -0.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0151
    Cell Significance Index: -11.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0179
    Cell Significance Index: -9.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0182
    Cell Significance Index: -13.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0185
    Cell Significance Index: -11.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0196
    Cell Significance Index: -14.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0208
    Cell Significance Index: -9.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0238
    Cell Significance Index: -10.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0238
    Cell Significance Index: -13.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0251
    Cell Significance Index: -7.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0309
    Cell Significance Index: -0.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0315
    Cell Significance Index: -3.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0573
    Cell Significance Index: -7.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0635
    Cell Significance Index: -13.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0647
    Cell Significance Index: -8.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0651
    Cell Significance Index: -9.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0756
    Cell Significance Index: -1.8900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0815
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0986
    Cell Significance Index: -11.3000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1008
    Cell Significance Index: -3.2100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1042
    Cell Significance Index: -2.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1056
    Cell Significance Index: -13.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1103
    Cell Significance Index: -11.4900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1120
    Cell Significance Index: -2.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1242
    Cell Significance Index: -9.5300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1297
    Cell Significance Index: -5.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1396
    Cell Significance Index: -3.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1636
    Cell Significance Index: -10.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1675
    Cell Significance Index: -4.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1809
    Cell Significance Index: -14.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1817
    Cell Significance Index: -5.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1828
    Cell Significance Index: -8.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1830
    Cell Significance Index: -13.6400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1937
    Cell Significance Index: -3.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1957
    Cell Significance Index: -10.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1988
    Cell Significance Index: -12.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2010
    Cell Significance Index: -8.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2047
    Cell Significance Index: -10.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2107
    Cell Significance Index: -11.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2187
    Cell Significance Index: -8.2800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2201
    Cell Significance Index: -4.8200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2334
    Cell Significance Index: -4.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2481
    Cell Significance Index: -8.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2498
    Cell Significance Index: -6.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2524
    Cell Significance Index: -11.7700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2545
    Cell Significance Index: -8.0500
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.2623
    Cell Significance Index: -3.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2749
    Cell Significance Index: -9.0000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2872
    Cell Significance Index: -4.2000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2884
    Cell Significance Index: -3.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3065
    Cell Significance Index: -15.4900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3096
    Cell Significance Index: -3.6400
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.3148
    Cell Significance Index: -2.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3198
    Cell Significance Index: -11.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Lymphoid-restricted expression**: IRAG2 is primarily expressed in immune cells, including B cells, neutrophils, and other lymphoid cells. 2. **Intracellular calcium signaling**: IRAG2 is associated with the IP3R, which regulates calcium release from the endoplasmic reticulum, a critical step in intracellular signaling pathways. 3. **Vesicle fusion and targeting**: IRAG2 is involved in the regulation of vesicle fusion and targeting, which is essential for the release of immune-related molecules and the regulation of immune responses. 4. **Immune system processes**: IRAG2 is involved in various immune system processes, including neutrophil degranulation, immune system organization, and nuclear envelope organization. **Pathways and Functions** 1. **Calcium signaling pathway**: IRAG2 is involved in the regulation of intracellular calcium signaling through its association with the IP3R. This pathway is critical for various cellular processes, including cell signaling, metabolism, and gene expression. 2. **Vesicle fusion and targeting pathway**: IRAG2 regulates the fusion and targeting of vesicles, which is essential for the release of immune-related molecules and the regulation of immune responses. 3. **Immune system organization pathway**: IRAG2 is involved in the organization of the immune system, including the regulation of immune cell development, differentiation, and function. 4. **Innate immune system pathway**: IRAG2 is involved in the regulation of innate immune responses, including neutrophil degranulation and the release of immune-related molecules. **Clinical Significance** 1. **Immune system disorders**: IRAG2 dysregulation has been implicated in various immune system disorders, including autoimmune diseases, immunodeficiency disorders, and cancer. 2. **Cancer**: IRAG2 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma, suggesting its potential as a therapeutic target. 3. **Infectious diseases**: IRAG2 has been shown to play a critical role in the regulation of innate immune responses, making it a potential target for the treatment of infectious diseases. 4. **Neurological disorders**: IRAG2 has been implicated in various neurological disorders, including schizophrenia and autism, suggesting its potential as a therapeutic target for these conditions. In conclusion, the IRAG2 gene is a critical regulator of immune responses, and its dysregulation has been implicated in various immune system disorders and diseases. Further research is needed to fully understand the functions and clinical significance of IRAG2, but its potential as a therapeutic target for various diseases makes it an exciting area of investigation.

Genular Protein ID: 3143702676

Symbol: IRAG2_HUMAN

Name: Lymphoid-restricted membrane protein

UniProtKB Accession Codes:

Q12912 A0AVM2 B4E077 Q8N301

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 5 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 11 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8021504

Title: Jaw1, a lymphoid-restricted membrane protein localized to the endoplasmic reticulum.

PubMed ID: 8021504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16739114

Title: Jaw1/LRMP, a germinal centre-associated marker for the immunohistological study of B-cell lymphomas.

PubMed ID: 16739114

DOI: 10.1002/path.2002

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 555
  • Mass: 62122
  • Checksum: FAFA4B94DCEB1A42
  • Sequence:
    • MESTPFSGVA NQIHTLCERP TYGEVKDGAL DVKRQHKCPG PTSGPSPGTN LSGCIRMNDD 
PSMEENGVER VCPESLLQSR EYSSLPLPRH TSSTDGTITS SDPGLEILNM ASCDLDRNSL 
CKKEEDTRSA SPTIEAQGTS PAHDNIAFQD STSKDKTILN LEAKEEPETI EEHKKEHASG 
DSVVSPLPVT TVKSVNLRQS ENTSANEKEV EAEFLRLSLG FKCDWFTLEK RVKLEERSRD 
LAEENLKKEI TNCLKLLESL TPLCEDDNQA QEIIKKLEKS IKFLSQCAAR VASRAEMLGA 
INQESRVSKA VEVMIQHVEN LKRMYAKEHA ELEELKQVLL QNERSFNPLE DDDDCQIKKR 
SASLNSKPSS LRRVTIASLP RNIGNAGMVA GMENNDRFSR RSSSWRILGS KQSEHRPSLP 
RFISTYSWAD AEEEKCELKT KDDSEPSGEE TVERTRKPSL SEKKNNPSKW DVSSVYDTIA 
SWATNLKSSI RKANKALWLS IAFIVLFAAL MSFLTGQLFQ KSVDAAPTQQ EDSWTSLEHI 
LWPFTRLRHN GPPPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.