Details for: IMPDH2

Gene ID: 3615

Symbol: IMPDH2

Ensembl ID: ENSG00000178035

Description: inosine monophosphate dehydrogenase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.11
    Marker Score: 20250
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.84
    Marker Score: 37457
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.56
    Marker Score: 2732
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.51
    Marker Score: 10266
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.45
    Marker Score: 1846
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.44
    Marker Score: 10506
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.39
    Marker Score: 5836
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.39
    Marker Score: 2549.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.37
    Marker Score: 5630
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.35
    Marker Score: 1476
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.3
    Marker Score: 1668
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.3
    Marker Score: 2160
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.29
    Marker Score: 1644
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.28
    Marker Score: 2422
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.27
    Marker Score: 6182
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.24
    Marker Score: 77654
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.24
    Marker Score: 16674
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.23
    Marker Score: 1272
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.22
    Marker Score: 2239
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.2
    Marker Score: 2296.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.18
    Marker Score: 3803
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.15
    Marker Score: 8274
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.14
    Marker Score: 24145
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.14
    Marker Score: 4464
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.12
    Marker Score: 3761
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.12
    Marker Score: 4986
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.12
    Marker Score: 8320
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.09
    Marker Score: 3422
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.01
    Marker Score: 2168
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.99
    Marker Score: 638
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.97
    Marker Score: 4464
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.94
    Marker Score: 19653
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.94
    Marker Score: 2852
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.92
    Marker Score: 1284
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.92
    Marker Score: 939
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.9
    Marker Score: 19108
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.9
    Marker Score: 2005
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.89
    Marker Score: 1040
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.88
    Marker Score: 3190
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.85
    Marker Score: 649
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.81
    Marker Score: 2787
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.81
    Marker Score: 15595
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8
    Marker Score: 5343
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.8
    Marker Score: 6664
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.78
    Marker Score: 3766
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.78
    Marker Score: 13884
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.76
    Marker Score: 2821
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.74
    Marker Score: 1484
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.73
    Marker Score: 3935
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.7
    Marker Score: 2403
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.7
    Marker Score: 4444
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.68
    Marker Score: 406
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.68
    Marker Score: 2416
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.67
    Marker Score: 1132
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.64
    Marker Score: 3085
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.62
    Marker Score: 599
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.62
    Marker Score: 4409.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.62
    Marker Score: 459
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.61
    Marker Score: 1581
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.61
    Marker Score: 605
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.59
    Marker Score: 457
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.58
    Marker Score: 1248
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.58
    Marker Score: 1184
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.57
    Marker Score: 1973
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.56
    Marker Score: 500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.55
    Marker Score: 1293
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.55
    Marker Score: 520
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.55
    Marker Score: 52640
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.54
    Marker Score: 1125
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.53
    Marker Score: 1975
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.52
    Marker Score: 1709
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.51
    Marker Score: 1352
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.51
    Marker Score: 355
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.51
    Marker Score: 1868
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.5
    Marker Score: 294
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.5
    Marker Score: 433
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.49
    Marker Score: 767
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.49
    Marker Score: 703
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.49
    Marker Score: 994
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.47
    Marker Score: 1727
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.47
    Marker Score: 498
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.47
    Marker Score: 611
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.44
    Marker Score: 2633
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.44
    Marker Score: 624
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.43
    Marker Score: 708
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.43
    Marker Score: 848
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.43
    Marker Score: 759
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.42
    Marker Score: 2262
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.42
    Marker Score: 895
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.42
    Marker Score: 337
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.41
    Marker Score: 325
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.41
    Marker Score: 533
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.4
    Marker Score: 696
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.4
    Marker Score: 1855
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.38
    Marker Score: 8838
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.38
    Marker Score: 2338.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.38
    Marker Score: 437
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.37
    Marker Score: 1291
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.37
    Marker Score: 8945
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.37
    Marker Score: 935

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Other Information

**Key characteristics:** - It is a protein with a molecular weight of approximately 150 kDa. - It is a flavoprotein with a conserved active site. - It is involved in the regulation of inflammation and immune responses. **Pathways and functions:** - It is involved in the regulation of innate immune responses. - It is a key regulator of dendritic cell activation. - It is involved in the regulation of macrophage infiltration. - It is involved in the regulation of neutrophil degranulation. - It is involved in the regulation of purine ribonucleoside monophosphate biosynthesis. - It helps to maintain immune homeostasis by regulating the inflammatory response. **Clinical significance:** IMPDH2 is a potential therapeutic target for a variety of diseases, including inflammatory diseases, autoimmune diseases, and cancer. It is a target for the treatment of sars and other viral infections. **Additional notes:** - It is a key regulator of the innate immune response. - It is involved in the regulation of inflammation. - It is a potential therapeutic target for a variety of diseases.

Genular Protein ID: 1852624224

Symbol: IMDH2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P12268 Q6LEF3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 20 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 DrugCentral 1 EC 1 EMBL 7 EMDB 17 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HAMAP 1 HAMAP-Rule 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 30 PDBsum 22 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 4 RefSeq 1 Rhea 1 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2902093

Title: Cloning and sequence analysis of the human and Chinese hamster inosine-5'-monophosphate dehydrogenase cDNAs.

PubMed ID: 2902093

DOI: 10.1016/s0021-9258(19)37654-9

PubMed ID: 1969416

Title: Two distinct cDNAs for human IMP dehydrogenase.

PubMed ID: 1969416

DOI: 10.1016/s0021-9258(19)34120-1

PubMed ID: 7999076

Title: Cloning and sequence of the human type II IMP dehydrogenase gene.

PubMed ID: 7999076

DOI: 10.1006/bbrc.1994.2698

PubMed ID: 7896827

Title: Characterization of the human inosine-5'-monophosphate dehydrogenase type II gene.

PubMed ID: 7896827

DOI: 10.1074/jbc.270.12.6808

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8098009

Title: Chromosomal localization and structure of the human type II IMP dehydrogenase gene.

PubMed ID: 8098009

DOI: 10.1006/geno.1993.1177

PubMed ID: 7903306

Title: Characterization of human type I and type II IMP dehydrogenases.

PubMed ID: 7903306

DOI: 10.1016/s0021-9258(19)74247-1

PubMed ID: 7763314

Title: Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding.

PubMed ID: 7763314

DOI: 10.1016/0006-2952(95)00026-v

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 14766016

Title: Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo.

PubMed ID: 14766016

DOI: 10.1042/bj20031585

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17496727

Title: A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity.

PubMed ID: 17496727

DOI: 10.1097/fpc.0b013e328012b8cf

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28985504

Title: CLOCK acetylates ASS1 to drive circadian rhythm of ureagenesis.

PubMed ID: 28985504

DOI: 10.1016/j.molcel.2017.09.008

PubMed ID: 24477477

Title: Glutamine deprivation initiates reversible assembly of mammalian rods and rings.

PubMed ID: 24477477

DOI: 10.1007/s00018-014-1567-6

PubMed ID: 30293565

Title: ANKRD9 is associated with tumor suppression as a substrate receptor subunit of ubiquitin ligase.

PubMed ID: 30293565

DOI: 10.1016/j.bbadis.2018.07.001

PubMed ID: 31337707

Title: ANKRD9 is a metabolically-controlled regulator of IMPDH2 abundance and macro-assembly.

PubMed ID: 31337707

DOI: 10.1074/jbc.ra119.008231

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10097070

Title: Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design.

PubMed ID: 10097070

DOI: 10.1073/pnas.96.7.3531

Sequence Information:

  • Length: 514
  • Mass: 55805
  • Checksum: 876BEA0EC1DDBEE9
  • Sequence:
    • MADYLISGGT SYVPDDGLTA QQLFNCGDGL TYNDFLILPG YIDFTADQVD LTSALTKKIT 
LKTPLVSSPM DTVTEAGMAI AMALTGGIGF IHHNCTPEFQ ANEVRKVKKY EQGFITDPVV 
LSPKDRVRDV FEAKARHGFC GIPITDTGRM GSRLVGIISS RDIDFLKEEE HDCFLEEIMT 
KREDLVVAPA GITLKEANEI LQRSKKGKLP IVNEDDELVA IIARTDLKKN RDYPLASKDA 
KKQLLCGAAI GTHEDDKYRL DLLAQAGVDV VVLDSSQGNS IFQINMIKYI KDKYPNLQVI 
GGNVVTAAQA KNLIDAGVDA LRVGMGSGSI CITQEVLACG RPQATAVYKV SEYARRFGVP 
VIADGGIQNV GHIAKALALG ASTVMMGSLL AATTEAPGEY FFSDGIRLKK YRGMGSLDAM 
DKHLSSQNRY FSEADKIKVA QGVSGAVQDK GSIHKFVPYL IAGIQHSCQD IGAKSLTQVR 
AMMYSGELKF EKRTSSAQVE GGVHSLHSYE KRLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.