Details for: POLD4
Gene ID: 57804
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: POLD4
Ensembl ID: ENSG00000175482
Description: DNA polymerase delta 4, accessory subunit
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 53.68rCSI 41.36%PRS 65.38
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CSI 49.08rCSI 36.64%PRS 80.73
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CSI 47.86rCSI 50.14%PRS 61.01
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CSI 31.06rCSI 27%PRS 75.37
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CSI 30.62rCSI 49.38%PRS 67.58
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CSI 30.25rCSI 25.95%PRS 72.2
-
CSI 27.48rCSI 89.12%PRS 64.45
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CSI 27.26rCSI 24.83%PRS 78.87
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CSI 21.91rCSI 29.12%PRS 71.07
-
CSI 21.66rCSI 19.99%PRS 66.13
-
CSI 20.33rCSI 21.24%PRS 62.63
-
CSI 19.08rCSI 28.79%PRS 69.08
-
CSI 18.3rCSI 17.65%PRS 55.51
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CSI 18.07rCSI 13.42%PRS 77.93
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CSI 18rCSI 72.44%PRS 68.54
-
CSI 16.78rCSI 31.5%PRS 78.26
-
CSI 16.24rCSI 25.19%PRS 71.72
-
CSI 16.05rCSI 14.25%PRS 62.52
-
CSI 15.17rCSI 12.66%PRS 73.74
-
CSI 14.75rCSI 18.35%PRS 66.25
-
CSI 14.18rCSI 42.3%PRS 80.54
-
CSI 13.46rCSI 11.33%PRS 81.22
-
CSI 13.25rCSI 26.25%PRS 77.4
-
CSI 13.11rCSI 12.39%PRS 63.99
-
CSI 13.08rCSI 18.75%PRS 67.62
-
CSI 12.95rCSI 15.51%PRS 80.2
-
CSI 12.94rCSI 25.16%PRS 67.61
-
CSI 12.85rCSI 9.65%PRS 70.25
-
CSI 12.34rCSI 13.11%PRS 74.09
-
CSI 11.93rCSI 11.78%PRS 85.74
-
CSI 11.22rCSI 10.37%PRS 83.31
-
CSI 10.41rCSI 16.69%PRS 84.2
-
CSI 9.85rCSI 8.16%PRS 67.05
-
CSI 9.55rCSI 14.6%PRS 68.84
-
CSI 9.55rCSI 12%PRS 88.39
-
CSI 9rCSI 21.4%PRS 73.07
-
CSI 8.77rCSI 12.84%PRS 60.22
-
CSI 8.47rCSI 24.18%PRS 75.49
-
CSI 8.26rCSI 17.59%PRS 75.14
-
CSI 8.24rCSI 9.55%PRS 72.02
-
CSI 7.98rCSI 11.77%PRS 79.75
-
CSI 7.97rCSI 9.83%PRS 77.01
-
CSI 7.96rCSI 10.22%PRS 69.37
-
CSI 7.86rCSI 5.46%PRS 75.76
-
CSI 7.83rCSI 17.09%PRS 77.14
-
CSI 7.79rCSI 13.35%PRS 73.1
-
CSI 7.68rCSI 10.27%PRS 81.14
-
CSI 7.14rCSI 5.34%PRS 79.67
-
CSI 7.02rCSI 8.43%PRS 62.75
-
CSI 6.97rCSI 4.65%PRS 83.22
-
CSI 6.82rCSI 6.26%PRS 73.62
-
CSI 6.79rCSI 5.96%PRS 70.09
-
CSI 6.77rCSI 8.43%PRS 75.23
-
CSI 6.68rCSI 8.54%PRS 84.03
-
CSI 6.63rCSI 9.03%PRS 56.24
-
CSI 6.62rCSI 3.91%PRS 81.75
-
CSI 6.59rCSI 4.73%PRS 78.7
-
CSI 6.57rCSI 8.27%PRS 76.56
-
CSI 6.55rCSI 8.22%PRS 75.05
-
CSI 6.49rCSI 16.47%PRS 58.7
-
CSI 6.48rCSI 26.69%PRS 75
-
CSI 6.28rCSI 4.41%PRS 82.29
-
CSI 6.19rCSI 9.78%PRS 67.1
-
CSI 6.13rCSI 5.3%PRS 69.6
-
CSI 6.01rCSI 4.89%PRS 64.93
-
CSI 5.96rCSI 8.26%PRS 65.13
-
CSI 5.93rCSI 13.45%PRS 68.09
-
CSI 5.77rCSI 4.33%PRS 88.9
-
CSI 5.76rCSI 5.66%PRS 80.24
-
CSI 5.63rCSI 13.44%PRS 72.77
-
CSI 5.59rCSI 8.54%PRS 79.7
-
CSI 5.45rCSI 25.53%PRS 80.29
-
CSI 5.43rCSI 5.67%PRS 64.98
-
CSI 5.43rCSI 12.18%PRS 80.98
-
CSI 5.42rCSI 6.6%PRS 72.14
-
CSI 5.37rCSI 7.71%PRS 54.19
-
CSI 5.32rCSI 3.7%PRS 79.8
-
CSI 5.27rCSI 4.64%PRS 52.57
-
CSI 5.01rCSI 5.16%PRS 80.58
-
CSI 5.01rCSI 6.82%PRS 75.92
-
CSI 5.01rCSI 6.05%PRS 73.43
-
CSI 4.98rCSI 11.69%PRS 68.69
-
CSI 4.91rCSI 6.44%PRS 87.41
-
CSI 4.9rCSI 8.07%PRS 69.93
-
CSI 4.89rCSI 4.95%PRS 88.22
-
CSI 4.84rCSI 4.06%PRS 68.68
-
CSI 4.6rCSI 8.31%PRS 77.32
-
CSI 4.49rCSI 19.74%PRS 54.74
-
CSI 4.34rCSI 5.97%PRS 83.22
-
CSI 4.31rCSI 12.37%PRS 83.9
-
CSI 4.24rCSI 5.06%PRS 83.5
-
CSI 4.13rCSI 2.88%PRS 67.36
-
CSI 4.11rCSI 6.28%PRS 73.83
-
CSI 4.09rCSI 10.25%PRS 86.56
-
CSI 4.04rCSI 4.19%PRS 70.41
-
CSI 4rCSI 3.94%PRS 67.38
-
CSI 3.91rCSI 5.33%PRS 87.48
-
CSI 3.9rCSI 2.96%PRS 77.68
-
CSI 3.86rCSI 9.44%PRS 57.77
-
CSI 3.86rCSI 3.2%PRS 64.1
-
CSI 0.2rCSI 4.2%PRS 80.0%
-
CSI 0.2rCSI 1.2%PRS 73.3%
-
CSI 0.3rCSI 4.6%PRS 80.0%
-
CSI 0.6rCSI 0.7%PRS 50.5%
-
CSI 0.6rCSI 2.9%PRS 89.4%
-
CSI 0.7rCSI 2.4%PRS 72.6%
-
CSI 0.7rCSI 4.5%PRS 87.9%
-
CSI 0.7rCSI 3.4%PRS 82.3%
-
CSI 0.8rCSI 1.7%PRS 62.8%
-
CSI 0.8rCSI 8.8%PRS 82.9%
-
CSI 0.8rCSI 3.3%PRS 76.3%
-
CSI 0.9rCSI 2.1%PRS 81.9%
-
CSI 0.9rCSI 5.1%PRS 76.0%
-
CSI 1.0rCSI 5.8%PRS 73.0%
-
CSI 1.1rCSI 1.7%PRS 77.3%
-
CSI 1.1rCSI 2.5%PRS 76.5%
-
CSI 1.2rCSI 3.3%PRS 90.5%
-
CSI 1.2rCSI 5.1%PRS 67.0%
-
CSI 1.3rCSI 3.0%PRS 65.2%
-
CSI 1.3rCSI 1.0%PRS 85.0%
-
CSI 1.3rCSI 7.1%PRS 90.1%
-
CSI 1.4rCSI 1.2%PRS 61.6%
-
CSI 1.4rCSI 6.1%PRS 64.5%
-
CSI 1.5rCSI 2.7%PRS 79.2%
-
CSI 1.6rCSI 1.1%PRS 77.8%
-
CSI 1.6rCSI 4.2%PRS 87.6%
-
CSI 1.7rCSI 34.9%PRS 89.1%
-
CSI 1.7rCSI 10.1%PRS 82.1%
-
CSI 1.7rCSI 3.7%PRS 72.4%
-
CSI 1.7rCSI 1.9%PRS 80.8%
-
CSI 1.8rCSI 2.0%PRS 55.0%
-
CSI 1.9rCSI 2.9%PRS 73.8%
-
CSI 1.9rCSI 2.7%PRS 73.7%
-
CSI 1.9rCSI 2.5%PRS 84.3%
-
CSI 1.9rCSI 4.0%PRS 81.1%
-
CSI 2.0rCSI 4.7%PRS 68.0%
-
CSI 2.0rCSI 2.9%PRS 75.0%
-
CSI 2.0rCSI 2.1%PRS 76.9%
-
CSI 2.0rCSI 16.5%PRS 57.9%
-
CSI 2.0rCSI 52.5%PRS 90.2%
-
CSI 2.0rCSI 7.2%PRS 76.7%
-
CSI 2.1rCSI 2.4%PRS 82.2%
-
CSI 2.1rCSI 14.4%PRS 76.8%
-
CSI 2.2rCSI 3.7%PRS 81.7%
-
CSI 2.2rCSI 2.1%PRS 85.0%
-
CSI 2.2rCSI 2.3%PRS 68.1%
-
CSI 2.2rCSI 3.3%PRS 76.2%
-
CSI 2.3rCSI 4.6%PRS 81.2%
-
CSI 2.4rCSI 4.5%PRS 75.1%
-
CSI 2.4rCSI 1.9%PRS 81.9%
-
CSI 2.6rCSI 5.6%PRS 68.6%
-
CSI 2.6rCSI 7.4%PRS 61.1%
-
CSI 2.6rCSI 11.4%PRS 76.2%
-
CSI 2.7rCSI 2.9%PRS 64.5%
-
CSI 2.7rCSI 4.9%PRS 77.5%
-
CSI 2.8rCSI 12.2%PRS 76.6%
-
CSI 2.8rCSI 5.6%PRS 79.8%
-
CSI 2.9rCSI 3.9%PRS 70.5%
-
CSI 2.9rCSI 6.4%PRS 72.5%
-
CSI 2.9rCSI 28.4%PRS 80.2%
-
CSI 3.0rCSI 15.0%PRS 77.2%
-
CSI 3.1rCSI 3.5%PRS 73.6%
-
CSI 3.1rCSI 2.5%PRS 66.2%
-
CSI 3.2rCSI 2.5%PRS 67.1%
-
CSI 3.4rCSI 4.0%PRS 66.8%
-
CSI 3.4rCSI 3.5%PRS 78.1%
-
CSI 3.5rCSI 4.7%PRS 66.1%
-
CSI 3.5rCSI 37.6%PRS 78.5%
-
CSI 3.5rCSI 24.7%PRS 77.8%
-
CSI 3.5rCSI 5.2%PRS 69.7%
-
CSI 3.6rCSI 4.7%PRS 77.9%
-
CSI 3.7rCSI 2.9%PRS 71.4%
-
CSI 3.8rCSI 2.5%PRS 67.7%
-
CSI 3.8rCSI 2.9%PRS 78.3%
-
CSI 3.9rCSI 3.2%PRS 64.1%
-
CSI 3.9rCSI 9.4%PRS 57.8%
-
CSI 3.9rCSI 3.0%PRS 77.7%
-
CSI 3.9rCSI 5.3%PRS 87.5%
-
CSI 4.0rCSI 3.9%PRS 67.4%
-
CSI 4.0rCSI 4.2%PRS 70.4%
-
CSI 4.1rCSI 10.3%PRS 86.6%
-
CSI 4.1rCSI 6.3%PRS 73.8%
-
CSI 4.1rCSI 2.9%PRS 67.4%
-
CSI 4.2rCSI 5.1%PRS 83.5%
-
CSI 4.3rCSI 12.4%PRS 83.9%
-
CSI 4.3rCSI 6.0%PRS 83.2%
-
CSI 4.5rCSI 19.7%PRS 54.7%
-
CSI 4.6rCSI 8.3%PRS 77.3%
-
CSI 4.8rCSI 4.1%PRS 68.7%
-
CSI 4.9rCSI 5.0%PRS 88.2%
-
CSI 4.9rCSI 8.1%PRS 69.9%
-
CSI 4.9rCSI 6.4%PRS 87.4%
-
CSI 5.0rCSI 11.7%PRS 68.7%
-
CSI 5.0rCSI 6.1%PRS 73.4%
-
CSI 5.0rCSI 6.8%PRS 75.9%
-
CSI 5.0rCSI 5.2%PRS 80.6%
-
CSI 5.3rCSI 4.6%PRS 52.6%
-
CSI 5.3rCSI 3.7%PRS 79.8%
-
CSI 5.4rCSI 7.7%PRS 54.2%
-
CSI 5.4rCSI 6.6%PRS 72.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 172742314
Symbol: DPOD4_HUMAN
Name: DNA polymerase delta subunit 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10751307
Title: Identification of a fourth subunit of mammalian DNA polymerase delta.
PubMed ID: 10751307
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12403614
Title: Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme.
PubMed ID: 12403614
DOI: 10.1021/bi0262707
PubMed ID: 12522211
Title: Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen.
PubMed ID: 12522211
PubMed ID: 15670210
Title: Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta.
PubMed ID: 15670210
PubMed ID: 16934752
Title: The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins.
PubMed ID: 16934752
PubMed ID: 16510448
Title: Functional roles of p12, the fourth subunit of human DNA polymerase delta.
PubMed ID: 16510448
PubMed ID: 17317665
Title: A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta.
PubMed ID: 17317665
PubMed ID: 19074196
Title: DNA damage alters DNA polymerase delta to a form that exhibits increased discrimination against modified template bases and mismatched primers.
PubMed ID: 19074196
DOI: 10.1093/nar/gkn1000
PubMed ID: 20334433
Title: The p12 subunit of human polymerase delta modulates the rate and fidelity of DNA synthesis.
PubMed ID: 20334433
DOI: 10.1021/bi100042b
PubMed ID: 22801543
Title: Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage.
PubMed ID: 22801543
DOI: 10.4161/cc.21280
PubMed ID: 24035200
Title: Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase delta.
PubMed ID: 24035200
PubMed ID: 23233665
Title: Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase delta for degradation in response to DNA damage.
PubMed ID: 23233665
PubMed ID: 23913683
Title: A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase delta in response to DNA damage and during the S phase.
PubMed ID: 23913683
PubMed ID: 24022480
Title: Degradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damage.
PubMed ID: 24022480
PubMed ID: 24300032
Title: The tail that wags the dog: p12, the smallest subunit of DNA polymerase delta, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression.
PubMed ID: 24300032
DOI: 10.4161/cc.27407
PubMed ID: 24310611
Title: Break-induced replication repair of damaged forks induces genomic duplications in human cells.
PubMed ID: 24310611
Sequence Information:
- Length: 107
- Mass: 12433
- Checksum: 6F412738E4D9A19C
- Sequence:
MGRKRLITDS YPVVKRREGP AGHSKGELAP ELGEEPQPRD EEEAELELLR QFDLAWQYGP CTGITRLQRW CRAKQMGLEP PPEVWQVLKT HPGDPRFQCS LWHLYPL
Genular Protein ID: 2308432971
Symbol: Q6NSD7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 107
- Mass: 12442
- Checksum: 79034308E4D9A19C
- Sequence:
MGRKRLITDS YPVVKRREGP AGHSKGELAP ELGEEPQPRD EEEAELELLR QFDLAWQYGP CTGITRLQRW CRAKHMGLEP PPEVWQVLKT HPGDPRFQCS LWHLYPL