Details for: BLNK

Gene ID: 29760

Symbol: BLNK

Ensembl ID: ENSG00000095585

Description: B cell linker

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 105.7570
    Cell Significance Index: -16.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 64.2240
    Cell Significance Index: -16.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 39.6547
    Cell Significance Index: -16.1100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 25.0960
    Cell Significance Index: -16.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.3500
    Cell Significance Index: -16.4600
  • Cell Name: centroblast (CL0009112)
    Fold Change: 8.9282
    Cell Significance Index: 20.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1865
    Cell Significance Index: -16.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.6154
    Cell Significance Index: 497.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.1151
    Cell Significance Index: 249.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3413
    Cell Significance Index: 29.0600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.3277
    Cell Significance Index: 18.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3017
    Cell Significance Index: 17.7600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2266
    Cell Significance Index: 11.3000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.1926
    Cell Significance Index: 20.0900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.0631
    Cell Significance Index: 13.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9064
    Cell Significance Index: 58.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8832
    Cell Significance Index: 797.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8823
    Cell Significance Index: 25.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7890
    Cell Significance Index: 22.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7558
    Cell Significance Index: 122.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5430
    Cell Significance Index: 53.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4747
    Cell Significance Index: 24.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4412
    Cell Significance Index: 30.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4208
    Cell Significance Index: 11.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3720
    Cell Significance Index: 67.0700
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.3439
    Cell Significance Index: 4.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2784
    Cell Significance Index: 6.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2601
    Cell Significance Index: 5.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2531
    Cell Significance Index: 31.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2393
    Cell Significance Index: 47.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2026
    Cell Significance Index: 7.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1699
    Cell Significance Index: 7.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1465
    Cell Significance Index: 3.9200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1170
    Cell Significance Index: 2.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1082
    Cell Significance Index: 47.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1002
    Cell Significance Index: 3.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0337
    Cell Significance Index: 18.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0276
    Cell Significance Index: 3.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0175
    Cell Significance Index: 32.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0085
    Cell Significance Index: 6.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0062
    Cell Significance Index: 3.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0045
    Cell Significance Index: 0.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0013
    Cell Significance Index: 0.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0002
    Cell Significance Index: 0.3500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0031
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0038
    Cell Significance Index: -5.1900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0039
    Cell Significance Index: -0.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0046
    Cell Significance Index: -7.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0056
    Cell Significance Index: -0.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0068
    Cell Significance Index: -4.6900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0095
    Cell Significance Index: -0.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0101
    Cell Significance Index: -1.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0124
    Cell Significance Index: -4.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0133
    Cell Significance Index: -10.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0169
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0269
    Cell Significance Index: -16.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0291
    Cell Significance Index: -21.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0335
    Cell Significance Index: -15.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0381
    Cell Significance Index: -21.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0614
    Cell Significance Index: -17.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0760
    Cell Significance Index: -11.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0959
    Cell Significance Index: -11.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1049
    Cell Significance Index: -22.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1079
    Cell Significance Index: -13.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1135
    Cell Significance Index: -14.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1212
    Cell Significance Index: -16.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1290
    Cell Significance Index: -7.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1362
    Cell Significance Index: -9.6300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1408
    Cell Significance Index: -1.2500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1542
    Cell Significance Index: -2.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1610
    Cell Significance Index: -16.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1864
    Cell Significance Index: -14.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1943
    Cell Significance Index: -9.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2053
    Cell Significance Index: -9.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2208
    Cell Significance Index: -14.8500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2249
    Cell Significance Index: -6.6300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2264
    Cell Significance Index: -3.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2276
    Cell Significance Index: -17.4700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2329
    Cell Significance Index: -3.3100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2575
    Cell Significance Index: -2.1000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.2682
    Cell Significance Index: -1.0100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2755
    Cell Significance Index: -11.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2971
    Cell Significance Index: -18.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3034
    Cell Significance Index: -4.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3035
    Cell Significance Index: -15.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3209
    Cell Significance Index: -18.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3301
    Cell Significance Index: -14.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3331
    Cell Significance Index: -6.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3337
    Cell Significance Index: -15.5600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.3405
    Cell Significance Index: -2.2600
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.3548
    Cell Significance Index: -3.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3753
    Cell Significance Index: -14.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3754
    Cell Significance Index: -13.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3871
    Cell Significance Index: -9.9500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3980
    Cell Significance Index: -4.6800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3998
    Cell Significance Index: -16.3800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4421
    Cell Significance Index: -16.2300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4438
    Cell Significance Index: -11.0900
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.4468
    Cell Significance Index: -4.8800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4597
    Cell Significance Index: -14.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BLNK is a cytoplasmic adaptor protein that belongs to the SH2 domain-containing family of proteins. It consists of two SH2 domains, two SH3 domains, and a proline-rich region, which enable it to interact with a variety of signaling molecules. BLNK is specifically expressed in hematopoietic cells, including B cells, macrophages, and dendritic cells. Its expression is tightly regulated during B cell development, with high levels of expression observed in mature B cells. **Pathways and Functions:** BLNK is a central hub in the BCR signaling pathway, facilitating the transmission of signals from the BCR to downstream effectors. The BCR signaling pathway involves the activation of phospholipase C (PLC) upon BCR engagement, leading to the generation of second messengers such as inositol trisphosphate (IP3) and diacylglycerol (DAG). BLNK interacts with PLC-γ2, facilitating its activation and subsequent signaling. BLNK also interacts with other key signaling molecules, including the tyrosine kinase Syk, which phosphorylates and activates downstream effectors such as PLC-γ2 and the adaptor protein SLP-95. In addition to its role in BCR signaling, BLNK also participates in other immune-related pathways, including cytokine signaling, inflammatory response, and viral infection pathways. BLNK interacts with various cytokine receptors, including those for IL-3, IL-5, and GM-CSF, facilitating the activation of downstream signaling pathways. **Clinical Significance:** Dysregulation of BLNK has been implicated in various immune-related disorders, including autoimmune diseases such as rheumatoid arthritis and lupus. BLNK mutations have also been associated with X-linked agammaglobulinemia (XLA), a condition characterized by impaired B cell development and function. Furthermore, BLNK has been identified as a potential therapeutic target for the treatment of SARS-CoV-2 infections. In conclusion, BLNK is a critical adaptor protein that plays a pivotal role in the signaling cascade of B cell receptors. Its dysregulation has been implicated in various immune-related disorders, and it has emerged as a potential therapeutic target for the treatment of SARS-CoV-2 infections. Further research is necessary to fully elucidate the molecular mechanisms of BLNK and its role in immune response and disease. **Key Proteins:** * BLNK_HUMAN (B-cell linker protein) * Q2MD54_HUMAN * Q2MD59_HUMAN **Significantly Expressed Cells:** * Central nervous system macrophage * OFF-bipolar cell * B-1 B cell * Renal principal cell * Corneal epithelial cell * Mature microglial cell * Tonsil germinal center B cell * Retina horizontal cell * Late pro-B cell * Centroblast

Genular Protein ID: 3834846812

Symbol: BLNK_HUMAN

Name: B-cell linker protein

UniProtKB Accession Codes:

Q8WV28 O75498 O75499 Q2MD49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 38 Ensembl 3 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9697839

Title: BLNK: a central linker protein in B cell activation.

PubMed ID: 9697839

DOI: 10.1016/s1074-7613(00)80591-9

PubMed ID: 10583958

Title: An essential role for BLNK in human B cell development.

PubMed ID: 10583958

DOI: 10.1126/science.286.5446.1954

PubMed ID: 16636677

Title: SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells.

PubMed ID: 16636677

DOI: 10.1038/sj.onc.1209520

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9341187

Title: Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation.

PubMed ID: 9341187

DOI: 10.1074/jbc.272.43.27362

PubMed ID: 12456653

Title: BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins.

PubMed ID: 12456653

DOI: 10.1093/emboj/cdf658

PubMed ID: 15270728

Title: Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells.

PubMed ID: 15270728

DOI: 10.1111/j.1365-2567.2004.01918.x

PubMed ID: 16912232

Title: Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes.

PubMed ID: 16912232

DOI: 10.1182/blood-2006-02-005397

PubMed ID: 18369315

Title: The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development.

PubMed ID: 18369315

DOI: 10.1038/emboj.2008.62

PubMed ID: 21930792

Title: SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.

PubMed ID: 21930792

DOI: 10.1128/mcb.05817-11

Sequence Information:

  • Length: 456
  • Mass: 50466
  • Checksum: 95F1D5485D03D397
  • Sequence:
    • MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR DYASESPADE 
EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP VEQETRPVHP ALPFARGEYI 
DNRSSQRHSP PFSKTLPSKP SWPSEKARLT STLPALTALQ KPQVPPKPKG LLEDEADYVV 
PVEDNDENYI HPTESSSPPP EKAPMVNRST KPNSSTPASP PGTASGRNSG AWETKSPPPA 
APSPLPRAGK KPTTPLKTTP VASQQNASSV CEEKPIPAER HRGSSHRQEA VQSPVFPPAQ 
KQIHQKPIPL PRFTEGGNPT VDGPLPSFSS NSTISEQEAG VLCKPWYAGA CDRKSAEEAL 
HRSNKDGSFL IRKSSGHDSK QPYTLVVFFN KRVYNIPVRF IEATKQYALG RKKNGEEYFG 
SVAEIIRNHQ HSPLVLIDSQ NNTKDSTRLK YAVKVS

Genular Protein ID: 801511517

Symbol: Q2MD59_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q2MD59 F5GXS1

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 2 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16568084

Title: The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells.

PubMed ID: 16568084

DOI: 10.1038/sj.onc.1209510

Sequence Information:

  • Length: 299
  • Mass: 32998
  • Checksum: 827C7D4AD2FB5048
  • Sequence:
    • MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR DYASESPADE 
EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP VEQETRPVHP ALPFARGTAS 
GRNSGAWETK SPPPAAPSPL PRAGKKPTTP LKTTPVASQQ NASSVCEEKP IPAERHRGSS 
HRQEAVQSPV FPPAQKQIHQ KPIPLPRFTE GGNPTVDGPL PSFSSNSTIS EQEAGVLCKP 
WYAGACDRKS AEEALHRSNK YFGSVAEIIR NHQHSPLVLI DSQNNTKDST RLKYAVKVS

Genular Protein ID: 539731031

Symbol: Q2MD54_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q2MD54

Database IDs:

BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 2 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16568084

Title: The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells.

PubMed ID: 16568084

DOI: 10.1038/sj.onc.1209510

PubMed ID: 16636677

Title: SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells.

PubMed ID: 16636677

DOI: 10.1038/sj.onc.1209520

Sequence Information:

  • Length: 381
  • Mass: 42213
  • Checksum: BCB444129B6FE88A
  • Sequence:
    • MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR DYASESPADE 
EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP VEQETRPVHP ALPFARGEYI 
DNRSSQRHSP PFSKTLPSKP SWPSEKARLT STLPALTALQ KPQVPPKPKG LLEDEADYVV 
PVEDNDENYI HPTESSSPPP EKGRNSGAWE TKSPPPAAPS PLPRAGKKPT TPLKTTPVAS 
QQNASSVCEE KPIPAERHRG SSHRQEAVQS PVFPPAQKQI HQKPIPLPRF TEGGNPTVDG 
PLPSFSSNST ISEQEAGVLC KPWYAGACDR KSAEEALHRS NKYFGSVAEI IRNHQHSPLV 
LIDSQNNTKD STRLKYAVKV S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.