Details for: BLNK

Gene ID: 29760

Symbol: BLNK

Ensembl ID: ENSG00000095585

Description: B cell linker

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.9
    Marker Score: 1,442
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 2.43
    Marker Score: 7,192
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.35
    Marker Score: 4,093
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.15
    Marker Score: 1,659
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.13
    Marker Score: 2,350
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.05
    Marker Score: 741
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.03
    Marker Score: 6,022
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 2.01
    Marker Score: 1,923
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.97
    Marker Score: 2,325
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.96
    Marker Score: 967
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.86
    Marker Score: 1,132
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.68
    Marker Score: 14,246
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 1.66
    Marker Score: 4,837
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.62
    Marker Score: 374
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.59
    Marker Score: 4,326
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.56
    Marker Score: 1,393
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.54
    Marker Score: 1,552
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.48
    Marker Score: 1,389
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.47
    Marker Score: 774
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,471
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.27
    Marker Score: 621
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.24
    Marker Score: 938
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.22
    Marker Score: 1,279
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.21
    Marker Score: 3,043
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.21
    Marker Score: 287
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.19
    Marker Score: 234
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.16
    Marker Score: 2,353
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.15
    Marker Score: 4,967
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.13
    Marker Score: 9,706
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.12
    Marker Score: 743
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.12
    Marker Score: 390
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.07
    Marker Score: 6,897
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.06
    Marker Score: 248
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.04
    Marker Score: 624
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.03
    Marker Score: 2,149
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.01
    Marker Score: 926
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.98
    Marker Score: 670
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.98
    Marker Score: 5,273
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.96
    Marker Score: 341
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.96
    Marker Score: 230
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.95
    Marker Score: 848
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.95
    Marker Score: 386
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.94
    Marker Score: 926
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.94
    Marker Score: 9,479
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.91
    Marker Score: 536
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.91
    Marker Score: 990
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.91
    Marker Score: 573
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,730
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.91
    Marker Score: 552
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9
    Marker Score: 223
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1,444
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.89
    Marker Score: 2,381
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.89
    Marker Score: 1,181
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.88
    Marker Score: 921
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.87
    Marker Score: 927
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.87
    Marker Score: 223
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,273
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,940
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.82
    Marker Score: 1,348
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.81
    Marker Score: 12,669
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.81
    Marker Score: 1,338
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 616
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 322
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.78
    Marker Score: 252
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.78
    Marker Score: 1,474
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.77
    Marker Score: 643
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.77
    Marker Score: 155
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.77
    Marker Score: 827
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.77
    Marker Score: 653
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.76
    Marker Score: 1,076
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 679
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.74
    Marker Score: 279
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.74
    Marker Score: 276
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.74
    Marker Score: 194
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.72
    Marker Score: 1,705
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.72
    Marker Score: 1,057
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.72
    Marker Score: 636
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.71
    Marker Score: 266
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.7
    Marker Score: 385
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.7
    Marker Score: 5,447
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,883
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.68
    Marker Score: 365
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.66
    Marker Score: 1,898
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.66
    Marker Score: 748
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.64
    Marker Score: 280
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.62
    Marker Score: 336
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.62
    Marker Score: 458
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.62
    Marker Score: 2,986
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.62
    Marker Score: 587
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.62
    Marker Score: 409
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.61
    Marker Score: 310
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.61
    Marker Score: 655
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.61
    Marker Score: 587

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BLNK is a cytoplasmic adaptor protein that belongs to the SH2 domain-containing family of proteins. It consists of two SH2 domains, two SH3 domains, and a proline-rich region, which enable it to interact with a variety of signaling molecules. BLNK is specifically expressed in hematopoietic cells, including B cells, macrophages, and dendritic cells. Its expression is tightly regulated during B cell development, with high levels of expression observed in mature B cells. **Pathways and Functions:** BLNK is a central hub in the BCR signaling pathway, facilitating the transmission of signals from the BCR to downstream effectors. The BCR signaling pathway involves the activation of phospholipase C (PLC) upon BCR engagement, leading to the generation of second messengers such as inositol trisphosphate (IP3) and diacylglycerol (DAG). BLNK interacts with PLC-γ2, facilitating its activation and subsequent signaling. BLNK also interacts with other key signaling molecules, including the tyrosine kinase Syk, which phosphorylates and activates downstream effectors such as PLC-γ2 and the adaptor protein SLP-95. In addition to its role in BCR signaling, BLNK also participates in other immune-related pathways, including cytokine signaling, inflammatory response, and viral infection pathways. BLNK interacts with various cytokine receptors, including those for IL-3, IL-5, and GM-CSF, facilitating the activation of downstream signaling pathways. **Clinical Significance:** Dysregulation of BLNK has been implicated in various immune-related disorders, including autoimmune diseases such as rheumatoid arthritis and lupus. BLNK mutations have also been associated with X-linked agammaglobulinemia (XLA), a condition characterized by impaired B cell development and function. Furthermore, BLNK has been identified as a potential therapeutic target for the treatment of SARS-CoV-2 infections. In conclusion, BLNK is a critical adaptor protein that plays a pivotal role in the signaling cascade of B cell receptors. Its dysregulation has been implicated in various immune-related disorders, and it has emerged as a potential therapeutic target for the treatment of SARS-CoV-2 infections. Further research is necessary to fully elucidate the molecular mechanisms of BLNK and its role in immune response and disease. **Key Proteins:** * BLNK_HUMAN (B-cell linker protein) * Q2MD54_HUMAN * Q2MD59_HUMAN **Significantly Expressed Cells:** * Central nervous system macrophage * OFF-bipolar cell * B-1 B cell * Renal principal cell * Corneal epithelial cell * Mature microglial cell * Tonsil germinal center B cell * Retina horizontal cell * Late pro-B cell * Centroblast

Genular Protein ID: 3834846812

Symbol: BLNK_HUMAN

Name: B-cell linker protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9697839

Title: BLNK: a central linker protein in B cell activation.

PubMed ID: 9697839

DOI: 10.1016/s1074-7613(00)80591-9

PubMed ID: 10583958

Title: An essential role for BLNK in human B cell development.

PubMed ID: 10583958

DOI: 10.1126/science.286.5446.1954

PubMed ID: 16636677

Title: SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells.

PubMed ID: 16636677

DOI: 10.1038/sj.onc.1209520

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9341187

Title: Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation.

PubMed ID: 9341187

DOI: 10.1074/jbc.272.43.27362

PubMed ID: 12456653

Title: BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins.

PubMed ID: 12456653

DOI: 10.1093/emboj/cdf658

PubMed ID: 15270728

Title: Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells.

PubMed ID: 15270728

DOI: 10.1111/j.1365-2567.2004.01918.x

PubMed ID: 16912232

Title: Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes.

PubMed ID: 16912232

DOI: 10.1182/blood-2006-02-005397

PubMed ID: 18369315

Title: The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development.

PubMed ID: 18369315

DOI: 10.1038/emboj.2008.62

PubMed ID: 21930792

Title: SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.

PubMed ID: 21930792

DOI: 10.1128/mcb.05817-11

Sequence Information:

  • Length: 456
  • Mass: 50466
  • Checksum: 95F1D5485D03D397
  • Sequence:
  • MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR DYASESPADE 
    EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP VEQETRPVHP ALPFARGEYI 
    DNRSSQRHSP PFSKTLPSKP SWPSEKARLT STLPALTALQ KPQVPPKPKG LLEDEADYVV 
    PVEDNDENYI HPTESSSPPP EKAPMVNRST KPNSSTPASP PGTASGRNSG AWETKSPPPA 
    APSPLPRAGK KPTTPLKTTP VASQQNASSV CEEKPIPAER HRGSSHRQEA VQSPVFPPAQ 
    KQIHQKPIPL PRFTEGGNPT VDGPLPSFSS NSTISEQEAG VLCKPWYAGA CDRKSAEEAL 
    HRSNKDGSFL IRKSSGHDSK QPYTLVVFFN KRVYNIPVRF IEATKQYALG RKKNGEEYFG 
    SVAEIIRNHQ HSPLVLIDSQ NNTKDSTRLK YAVKVS

Genular Protein ID: 539731031

Symbol: Q2MD54_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 16568084

Title: The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells.

PubMed ID: 16568084

DOI: 10.1038/sj.onc.1209510

PubMed ID: 16636677

Title: SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells.

PubMed ID: 16636677

DOI: 10.1038/sj.onc.1209520

Sequence Information:

  • Length: 381
  • Mass: 42213
  • Checksum: BCB444129B6FE88A
  • Sequence:
  • MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR DYASESPADE 
    EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP VEQETRPVHP ALPFARGEYI 
    DNRSSQRHSP PFSKTLPSKP SWPSEKARLT STLPALTALQ KPQVPPKPKG LLEDEADYVV 
    PVEDNDENYI HPTESSSPPP EKGRNSGAWE TKSPPPAAPS PLPRAGKKPT TPLKTTPVAS 
    QQNASSVCEE KPIPAERHRG SSHRQEAVQS PVFPPAQKQI HQKPIPLPRF TEGGNPTVDG 
    PLPSFSSNST ISEQEAGVLC KPWYAGACDR KSAEEALHRS NKYFGSVAEI IRNHQHSPLV 
    LIDSQNNTKD STRLKYAVKV S

Genular Protein ID: 801511517

Symbol: Q2MD59_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 16568084

Title: The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells.

PubMed ID: 16568084

DOI: 10.1038/sj.onc.1209510

Sequence Information:

  • Length: 299
  • Mass: 32998
  • Checksum: 827C7D4AD2FB5048
  • Sequence:
  • MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR DYASESPADE 
    EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP VEQETRPVHP ALPFARGTAS 
    GRNSGAWETK SPPPAAPSPL PRAGKKPTTP LKTTPVASQQ NASSVCEEKP IPAERHRGSS 
    HRQEAVQSPV FPPAQKQIHQ KPIPLPRFTE GGNPTVDGPL PSFSSNSTIS EQEAGVLCKP 
    WYAGACDRKS AEEALHRSNK YFGSVAEIIR NHQHSPLVLI DSQNNTKDST RLKYAVKVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.