Details for: BLNK
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.9
Marker Score: 1,442 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 2.43
Marker Score: 7,192 - Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.35
Marker Score: 4,093 - Cell Name: renal principal cell (CL0005009)
Fold Change: 2.15
Marker Score: 1,659 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.13
Marker Score: 2,350 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 2.05
Marker Score: 741 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.03
Marker Score: 6,022 - Cell Name: retina horizontal cell (CL0000745)
Fold Change: 2.01
Marker Score: 1,923 - Cell Name: late pro-B cell (CL0002048)
Fold Change: 1.97
Marker Score: 2,325 - Cell Name: centroblast (CL0009112)
Fold Change: 1.96
Marker Score: 967 - Cell Name: germinal center B cell (CL0000844)
Fold Change: 1.86
Marker Score: 1,132 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 1.68
Marker Score: 14,246 - Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 1.66
Marker Score: 4,837 - Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.62
Marker Score: 374 - Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.59
Marker Score: 4,326 - Cell Name: naive B cell (CL0000788)
Fold Change: 1.56
Marker Score: 1,393 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.54
Marker Score: 1,552 - Cell Name: class switched memory B cell (CL0000972)
Fold Change: 1.48
Marker Score: 1,389 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.47
Marker Score: 774 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168,471 - Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 1.27
Marker Score: 621 - Cell Name: memory B cell (CL0000787)
Fold Change: 1.24
Marker Score: 938 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.22
Marker Score: 1,279 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.21
Marker Score: 3,043 - Cell Name: centrocyte (CL0009111)
Fold Change: 1.21
Marker Score: 287 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.19
Marker Score: 234 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.16
Marker Score: 2,353 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.15
Marker Score: 4,967 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.13
Marker Score: 9,706 - Cell Name: immature B cell (CL0000816)
Fold Change: 1.12
Marker Score: 743 - Cell Name: IgM plasma cell (CL0000986)
Fold Change: 1.12
Marker Score: 390 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.07
Marker Score: 6,897 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.06
Marker Score: 248 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.04
Marker Score: 624 - Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 1.03
Marker Score: 2,149 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.01
Marker Score: 926 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.98
Marker Score: 670 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,406 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.98
Marker Score: 5,273 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 502 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 456 - Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.96
Marker Score: 341 - Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.96
Marker Score: 230 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.95
Marker Score: 848 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,410 - Cell Name: eurydendroid cell (CL0000253)
Fold Change: 0.95
Marker Score: 386 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.94
Marker Score: 926 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.94
Marker Score: 9,479 - Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.91
Marker Score: 536 - Cell Name: follicular B cell (CL0000843)
Fold Change: 0.91
Marker Score: 990 - Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 0.91
Marker Score: 573 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,730 - Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.91
Marker Score: 552 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.9
Marker Score: 223 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 323 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.89
Marker Score: 1,444 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.89
Marker Score: 2,381 - Cell Name: plasmablast (CL0000980)
Fold Change: 0.89
Marker Score: 1,181 - Cell Name: thymocyte (CL0000893)
Fold Change: 0.88
Marker Score: 921 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.87
Marker Score: 927 - Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.87
Marker Score: 223 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,273 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.87
Marker Score: 4,940 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.82
Marker Score: 1,348 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.81
Marker Score: 12,669 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.81
Marker Score: 1,338 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.81
Marker Score: 616 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.8
Marker Score: 322 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.78
Marker Score: 252 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.78
Marker Score: 1,474 - Cell Name: keratinocyte (CL0000312)
Fold Change: 0.77
Marker Score: 643 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.77
Marker Score: 155 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.77
Marker Score: 827 - Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.77
Marker Score: 653 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.76
Marker Score: 1,076 - Cell Name: brush cell (CL0002204)
Fold Change: 0.74
Marker Score: 679 - Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.74
Marker Score: 279 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.74
Marker Score: 276 - Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.74
Marker Score: 194 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 464 - Cell Name: stem cell (CL0000034)
Fold Change: 0.72
Marker Score: 1,705 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.72
Marker Score: 1,057 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.72
Marker Score: 636 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.71
Marker Score: 266 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.7
Marker Score: 385 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.7
Marker Score: 5,447 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.69
Marker Score: 2,883 - Cell Name: renal intercalated cell (CL0005010)
Fold Change: 0.68
Marker Score: 365 - Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.66
Marker Score: 1,898 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.66
Marker Score: 748 - Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.64
Marker Score: 280 - Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.62
Marker Score: 336 - Cell Name: mature B cell (CL0000785)
Fold Change: 0.62
Marker Score: 458 - Cell Name: enterocyte (CL0000584)
Fold Change: 0.62
Marker Score: 2,986 - Cell Name: B cell (CL0000236)
Fold Change: 0.62
Marker Score: 587 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.62
Marker Score: 409 - Cell Name: lymphocyte (CL0000542)
Fold Change: 0.61
Marker Score: 310 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.61
Marker Score: 655 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.61
Marker Score: 587
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3834846812
Symbol: BLNK_HUMAN
Name: B-cell linker protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9697839
Title: BLNK: a central linker protein in B cell activation.
PubMed ID: 9697839
PubMed ID: 10583958
Title: An essential role for BLNK in human B cell development.
PubMed ID: 10583958
PubMed ID: 16636677
Title: SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells.
PubMed ID: 16636677
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9341187
Title: Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation.
PubMed ID: 9341187
PubMed ID: 12456653
Title: BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins.
PubMed ID: 12456653
DOI: 10.1093/emboj/cdf658
PubMed ID: 15270728
Title: Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells.
PubMed ID: 15270728
PubMed ID: 16912232
Title: Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes.
PubMed ID: 16912232
PubMed ID: 18369315
Title: The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development.
PubMed ID: 18369315
PubMed ID: 21930792
Title: SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.
PubMed ID: 21930792
DOI: 10.1128/mcb.05817-11
Sequence Information:
- Length: 456
- Mass: 50466
- Checksum: 95F1D5485D03D397
- Sequence:
MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR DYASESPADE EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP VEQETRPVHP ALPFARGEYI DNRSSQRHSP PFSKTLPSKP SWPSEKARLT STLPALTALQ KPQVPPKPKG LLEDEADYVV PVEDNDENYI HPTESSSPPP EKAPMVNRST KPNSSTPASP PGTASGRNSG AWETKSPPPA APSPLPRAGK KPTTPLKTTP VASQQNASSV CEEKPIPAER HRGSSHRQEA VQSPVFPPAQ KQIHQKPIPL PRFTEGGNPT VDGPLPSFSS NSTISEQEAG VLCKPWYAGA CDRKSAEEAL HRSNKDGSFL IRKSSGHDSK QPYTLVVFFN KRVYNIPVRF IEATKQYALG RKKNGEEYFG SVAEIIRNHQ HSPLVLIDSQ NNTKDSTRLK YAVKVS
Genular Protein ID: 539731031
Symbol: Q2MD54_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 16568084
Title: The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells.
PubMed ID: 16568084
PubMed ID: 16636677
Title: SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells.
PubMed ID: 16636677
Sequence Information:
- Length: 381
- Mass: 42213
- Checksum: BCB444129B6FE88A
- Sequence:
MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR DYASESPADE EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP VEQETRPVHP ALPFARGEYI DNRSSQRHSP PFSKTLPSKP SWPSEKARLT STLPALTALQ KPQVPPKPKG LLEDEADYVV PVEDNDENYI HPTESSSPPP EKGRNSGAWE TKSPPPAAPS PLPRAGKKPT TPLKTTPVAS QQNASSVCEE KPIPAERHRG SSHRQEAVQS PVFPPAQKQI HQKPIPLPRF TEGGNPTVDG PLPSFSSNST ISEQEAGVLC KPWYAGACDR KSAEEALHRS NKYFGSVAEI IRNHQHSPLV LIDSQNNTKD STRLKYAVKV S
Genular Protein ID: 801511517
Symbol: Q2MD59_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 16568084
Title: The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells.
PubMed ID: 16568084
Sequence Information:
- Length: 299
- Mass: 32998
- Checksum: 827C7D4AD2FB5048
- Sequence:
MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR DYASESPADE EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP VEQETRPVHP ALPFARGTAS GRNSGAWETK SPPPAAPSPL PRAGKKPTTP LKTTPVASQQ NASSVCEEKP IPAERHRGSS HRQEAVQSPV FPPAQKQIHQ KPIPLPRFTE GGNPTVDGPL PSFSSNSTIS EQEAGVLCKP WYAGACDRKS AEEALHRSNK YFGSVAEIIR NHQHSPLVLI DSQNNTKDST RLKYAVKVS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.