Details for: BLNK

Gene ID: 29760

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: BLNK

Ensembl ID: ENSG00000095585

Description: B cell linker

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • central nervous system macrophage CL0000878
    CSI 16.85
    rCSI 55.86%
    PRS 88.01
  • late pro-B cell CL0002048
    CSI 15.7
    rCSI 39.35%
    PRS 94.11
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 10.54
    rCSI 12.73%
    PRS 90.63
  • mature B cell CL0000785
    CSI 8.88
    rCSI 7.72%
    PRS 91.9
  • pro-B cell CL0000826
    CSI 8.28
    rCSI 6.86%
    PRS 86.22
  • intestine goblet cell CL0019031
    CSI 7.87
    rCSI 6.98%
    PRS 81.76
  • innate lymphoid cell CL0001065
    CSI 7.15
    rCSI 14.76%
    PRS 80.16
  • common dendritic progenitor CL0001029
    CSI 7.07
    rCSI 8.87%
    PRS 91.06
  • fraction A pre-pro B cell CL0002045
    CSI 6.89
    rCSI 7.89%
    PRS 92.06
  • placental villous trophoblast CL2000060
    CSI 6.18
    rCSI 9.54%
    PRS 82.92
  • hepatocyte CL0000182
    CSI 5.51
    rCSI 9.87%
    PRS 83.18
  • transit amplifying cell of colon CL0009011
    CSI 5.36
    rCSI 6.3%
    PRS 85.4
  • plasmacytoid dendritic cell, human CL0001058
    CSI 5.3
    rCSI 3.7%
    PRS 87.4
  • IgG plasma cell CL0000985
    CSI 5.29
    rCSI 6.33%
    PRS 91.61
  • corneal epithelial cell CL0000575
    CSI 5.16
    rCSI 14.75%
    PRS 88.5
  • naive B cell CL0000788
    CSI 4.87
    rCSI 4.17%
    PRS 89.33
  • microglial cell CL0000129
    CSI 4.78
    rCSI 19.26%
    PRS 84.52
  • plasmablast CL0000980
    CSI 4.69
    rCSI 3.69%
    PRS 88.18
  • large pre-B-II cell CL0000957
    CSI 4.47
    rCSI 12.76%
    PRS 87.73
  • renal alpha-intercalated cell CL0005011
    CSI 4.33
    rCSI 5.78%
    PRS 89.14
  • kidney connecting tubule epithelial cell CL1000768
    CSI 4.3
    rCSI 10.91%
    PRS 75.35
  • myeloid leukocyte CL0000766
    CSI 4.26
    rCSI 3.93%
    PRS 85.37
  • memory B cell CL0000787
    CSI 4.22
    rCSI 4.17%
    PRS 93.46
  • early lymphoid progenitor CL0000936
    CSI 3.99
    rCSI 3.5%
    PRS 88.46
  • renal beta-intercalated cell CL0002201
    CSI 3.59
    rCSI 8.55%
    PRS 83.8
  • squamous epithelial cell CL0000076
    CSI 3.55
    rCSI 8.44%
    PRS 83.15
  • immature B cell CL0000816
    CSI 3.51
    rCSI 2.61%
    PRS 92.61
  • IgA plasma cell CL0000987
    CSI 3.46
    rCSI 3.54%
    PRS 89.56
  • B cell CL0000236
    CSI 3.45
    rCSI 4.62%
    PRS 88.89
  • secretory cell CL0000151
    CSI 3.42
    rCSI 3.57%
    PRS 83.31
  • unswitched memory B cell CL0000970
    CSI 3.4
    rCSI 2.86%
    PRS 94.42
  • midzonal region hepatocyte CL0019028
    CSI 3.28
    rCSI 7.7%
    PRS 82.99
  • goblet cell CL0000160
    CSI 3.23
    rCSI 3.05%
    PRS 82.25
  • precursor B cell CL0000817
    CSI 3.14
    rCSI 2.75%
    PRS 90.01
  • choroid plexus epithelial cell CL0000706
    CSI 3.06
    rCSI 5.01%
    PRS 74.44
  • stem cell CL0000034
    CSI 3.03
    rCSI 2.92%
    PRS 78.39
  • colonocyte CL1000347
    CSI 2.96
    rCSI 4.25%
    PRS 83.8
  • small pre-B-II cell CL0000954
    CSI 2.92
    rCSI 2.81%
    PRS 94.16
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 2.89
    rCSI 7.54%
    PRS 84.98
  • M cell of gut CL0000682
    CSI 2.87
    rCSI 3.04%
    PRS 87.9
  • conjunctival epithelial cell CL1000432
    CSI 2.79
    rCSI 4.27%
    PRS 83.91
  • class switched memory B cell CL0000972
    CSI 2.74
    rCSI 2.05%
    PRS 93.72
  • mature microglial cell CL0002629
    CSI 2.72
    rCSI 11.29%
    PRS 84.18
  • regulatory T cell CL0000815
    CSI 2.68
    rCSI 3.11%
    PRS 82.53
  • helper T cell CL0000912
    CSI 2.68
    rCSI 3.79%
    PRS 82.1
  • plasmacytoid dendritic cell CL0000784
    CSI 2.6
    rCSI 2.63%
    PRS 93.33
  • Kupffer cell CL0000091
    CSI 2.47
    rCSI 5.64%
    PRS 84.87
  • periportal region hepatocyte CL0019026
    CSI 2.37
    rCSI 9.23%
    PRS 82.4
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 2.29
    rCSI 5.91%
    PRS 79.98
  • dendritic cell CL0000451
    CSI 2.24
    rCSI 2.76%
    PRS 85.92
  • BEST4+ enteroycte CL4030026
    CSI 2.21
    rCSI 2.75%
    PRS 84.59
  • transitional stage B cell CL0000818
    CSI 2.13
    rCSI 6.99%
    PRS 95.61
  • pulmonary ionocyte CL0017000
    CSI 2.12
    rCSI 2.58%
    PRS 89.59
  • intestinal epithelial cell CL0002563
    CSI 2.08
    rCSI 2.18%
    PRS 81.58
  • common lymphoid progenitor CL0000051
    CSI 2.06
    rCSI 2.75%
    PRS 95.37
  • mononuclear phagocyte CL0000113
    CSI 2.03
    rCSI 4.47%
    PRS 87.27
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 1.94
    rCSI 2.75%
    PRS 81.18
  • ionocyte CL0005006
    CSI 1.92
    rCSI 2.05%
    PRS 85.83
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 1.89
    rCSI 2.29%
    PRS 64.58
  • centrilobular region hepatocyte CL0019029
    CSI 1.74
    rCSI 4.54%
    PRS 81.56
  • intrahepatic cholangiocyte CL0002538
    CSI 1.71
    rCSI 4.09%
    PRS 86.4
  • renal principal cell CL0005009
    CSI 1.7
    rCSI 4.43%
    PRS 83.84
  • enterocyte CL0000584
    CSI 1.4
    rCSI 2.26%
    PRS 82.42
  • suprabasal keratinocyte CL4033013
    CSI 1.37
    rCSI 2.24%
    PRS 52.01
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 1.34
    rCSI 3.61%
    PRS 87.62
  • kidney epithelial cell CL0002518
    CSI 1.27
    rCSI 2.42%
    PRS 94.42
  • basal cell of epidermis CL0002187
    CSI 1.25
    rCSI 2.22%
    PRS 53.28
  • melanocyte of skin CL1000458
    CSI 1.19
    rCSI 1.62%
    PRS 51.8
  • pancreatic ductal cell CL0002079
    CSI 1.16
    rCSI 2.25%
    PRS 86.82
  • germinal center B cell CL0000844
    CSI 1.11
    rCSI 3.32%
    PRS 91.43
  • small intestine goblet cell CL1000495
    CSI 1.02
    rCSI 2.23%
    PRS 88.25
  • follicular B cell CL0000843
    CSI 1
    rCSI 3.65%
    PRS 94.49
  • paneth cell of epithelium of small intestine CL1000343
    CSI 0.95
    rCSI 2.66%
    PRS 89.32
  • cholangiocyte CL1000488
    CSI 0.94
    rCSI 5.63%
    PRS 85.02
  • B-1 B cell CL0000819
    CSI 0.91
    rCSI 23.5%
    PRS 95.29
  • IgM plasma cell CL0000986
    CSI 0.72
    rCSI 3.23%
    PRS 95.22
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.42
    rCSI 4.5%
    PRS 80.2

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [BLNK](/details-gene/29760), or B-cell linker protein, is an essential intracellular signaling adaptor protein located on chromosome 10. As its name suggests, [BLNK](/details-gene/29760) is a cornerstone of B-cell biology, functioning as a central scaffold that organizes signaling complexes downstream of the B-cell receptor (BCR) ([Link](https://doi.org/10.1016/s1074-7613(00)80591-9)). Its critical importance is highlighted by its involvement in the '[B cell receptor signaling pathway](https://www.ebi.ac.uk/QuickGO/term/GO:0050853)' ([GO:0050853](https://www.ebi.ac.uk/QuickGO/term/GO:0050853)) and its requirement for normal [B cell](/details-cell/CL0000236) development ([Link](https://doi.org/10.1126/science.286.5446.1954)). **Overall**, expression data confirms its primary role within the B-lymphocyte lineage, showing high significance in various developmental stages including [late pro-B cell](/details-cell/CL0002048), [pro-B cell](/details-cell/CL0000826), and [mature B cell](/details-cell/CL0000785). However, its notable expression in other immune cells, such as [central nervous system macrophage](/details-cell/CL0000878) and [CD1c-positive myeloid dendritic cell](/details-cell/CL0002399), suggests a broader role in adaptive and innate immune responses. ## Cellular Roles and Expression Landscape The expression profile of [BLNK](/details-gene/29760) firmly establishes it as a key component of the hematopoietic system, particularly within the B-cell lineage. **Overall**, it demonstrates high significance across multiple stages of [B cell](/details-cell/CL0000236) development, from early precursors like [fraction A pre-pro B cell](/details-cell/CL0002045) and [pro-B cell](/details-cell/CL0000826) to [mature B cell](/details-cell/CL0000785), underscoring its fundamental role in B-cell maturation and function. Beyond the B-cell lineage, [BLNK](/details-gene/29760) is also highly significant in other professional antigen-presenting cells. It is the top marker in [central nervous system macrophage](/details-cell/CL0000878) (microglia) and shows high expression in [CD1c-positive myeloid dendritic cell](/details-cell/CL0002399) and [plasmacytoid dendritic cell, human](/details-cell/CL0001058). This pattern suggests that [BLNK](/details-gene/29760) may function as an adaptor protein in signaling pathways common to various immune surveillance cells. Interestingly, [BLNK](/details-gene/29760) also shows significant expression in several non-hematopoietic cell types, including [intestine goblet cell](/details-cell/CL0019031), [placental villous trophoblast](/details-cell/CL2000060), and [hepatocyte](/details-cell/CL0000182). This may indicate uncharacterized roles for [BLNK](/details-gene/29760) in mucosal barrier function, placental biology, or liver homeostasis, potentially by transducing signals from surface receptors in these specialized contexts. ## Pathways and Molecular Function [BLNK](/details-gene/29760) functions primarily as a scaffold protein, possessing '[Signaling adaptor activity](https://www.ebi.ac.uk/QuickGO/term/GO:0035591)' ([GO:0035591](https://www.ebi.ac.uk/QuickGO/term/GO:0035591)) and '[Molecular condensate scaffold activity](https://www.ebi.ac.uk/QuickGO/term/GO:0140693)' ([GO:0140693](https://www.ebi.ac.uk/QuickGO/term/GO:0140693)). Upon B-cell receptor activation, [BLNK](/details-gene/29760) becomes phosphorylated and recruits a variety of signaling molecules to the plasma membrane, facilitating signal transduction ([Link](https://doi.org/10.1093/emboj/cdf658)). This is reflected in its annotation for binding numerous key signaling components, including '[Protein tyrosine kinase binding](https://www.ebi.ac.uk/QuickGO/term/GO:1990782)' ([GO:1990782](https://www.ebi.ac.uk/QuickGO/term/GO:1990782)), '[Sh2 domain binding](https://www.ebi.ac.uk/QuickGO/term/GO:0042169)' ([GO:0042169](https://www.ebi.ac.uk/QuickGO/term/GO:0042169)), and '[Phospholipase binding](https://www.ebi.ac.uk/QuickGO/term/GO:0043274)' ([GO:0043274](https://www.ebi.ac.uk/QuickGO/term/GO:0043274)). Its central role is well-defined within the Reactome pathway '[Signaling by the b cell receptor (bcr)](https://reactome.org/content/detail/R-HSA-983705)' ([R-HSA-983705](https://reactome.org/content/detail/R-HSA-983705)), where it connects the receptor to downstream effectors that regulate gene expression, proliferation, and differentiation. The protein's function extends to broader immune processes, as shown by its involvement in the '[Adaptive immune system](https://reactome.org/content/detail/R-HSA-1280218)' ([R-HSA-1280218](https://reactome.org/content/detail/R-HSA-1280218)) and '[Cytokine signaling in immune system](https://reactome.org/content/detail/R-HSA-1280215)' ([R-HSA-1280215](https://reactome.org/content/detail/R-HSA-1280215)). Furthermore, its annotation in pathways related to '[Infectious disease](https://reactome.org/content/detail/R-HSA-5663205)' ([R-HSA-5663205](https://reactome.org/content/detail/R-HSA-5663205)) suggests its function is co-opted or essential during host-pathogen interactions. ## Research Directions The well-established role of [BLNK](/details-gene/29760) in B-cell signaling contrasts with its high expression in less-studied cellular contexts, opening up several avenues for future research. **Proposed Hypotheses:** 1. The high significance of [BLNK](/details-gene/29760) in [central nervous system macrophage](/details-cell/CL0000878) (microglia) suggests it functions as a critical adaptor downstream of receptors involved in neuroinflammation and phagocytosis (e.g., TREM2 or Toll-like receptors), modulating microglial activation states in response to neuronal damage or pathogens. 2. In [intestine goblet cell](/details-cell/CL0019031), [BLNK](/details-gene/29760) may integrate signals from the gut lumen, such as microbial products, to regulate the production and secretion of mucins, thereby playing a direct role in maintaining the intestinal mucosal barrier. 3. Given that deficiencies in [BLNK](/details-gene/29760) can lead to aberrant V(D)J recombination and are linked to leukemia ([Link](https://doi.org/10.1038/sj.onc.1209520)), specific post-translational modifications or expression levels of [BLNK](/details-gene/29760) isoforms may serve as biomarkers for B-cell malignancies and predict response to targeted therapies that inhibit BCR signaling. **Experimental Approach:** To test the role of [BLNK](/details-gene/29760) in microglial function (Hypothesis 1), a conditional knockout mouse model using *Cx3cr1*-Cre drivers to specifically delete [BLNK](/details-gene/29760) in microglia could be employed. Primary microglia isolated from these mice and wild-type controls would be stimulated *in vitro* with lipopolysaccharide (LPS) or aggregated amyloid-beta. The functional consequences of [BLNK](/details-gene/29760) deletion would be assessed by measuring changes in phagocytic capacity using fluorescently labeled substrates, cytokine profiles via multiplex ELISA, and transcriptional reprogramming through RNA sequencing. **Therapeutic Potential:** As an intracellular adaptor protein, [BLNK](/details-gene/29760) is not a conventional drug target for antibodies. However, its central position in BCR signaling makes the pathways it regulates highly relevant for therapeutic intervention, particularly in B-cell cancers. The expression level or mutational status of [BLNK](/details-gene/29760) could serve as a predictive biomarker for patient response to existing drugs that target downstream kinases like BTK or SYK. Therefore, the therapeutic strategy would focus on the **inhibition** of the signaling cascade that [BLNK](/details-gene/29760) orchestrates. Developing small molecules to disrupt specific protein-protein interactions involving [BLNK](/details-gene/29760) could represent a future, more targeted approach for treating certain B-cell malignancies or autoimmune diseases.

Genular Protein ID: 3834846812

Symbol: BLNK_HUMAN

Name: B-cell linker protein

UniProtKB Accession Codes:

Q8WV28 O75498 O75499 Q2MD49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 38 Ensembl 3 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9697839

Title: BLNK: a central linker protein in B cell activation.

PubMed ID: 9697839

DOI: 10.1016/s1074-7613(00)80591-9

PubMed ID: 10583958

Title: An essential role for BLNK in human B cell development.

PubMed ID: 10583958

DOI: 10.1126/science.286.5446.1954

PubMed ID: 16636677

Title: SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells.

PubMed ID: 16636677

DOI: 10.1038/sj.onc.1209520

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9341187

Title: Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation.

PubMed ID: 9341187

DOI: 10.1074/jbc.272.43.27362

PubMed ID: 12456653

Title: BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins.

PubMed ID: 12456653

DOI: 10.1093/emboj/cdf658

PubMed ID: 15270728

Title: Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells.

PubMed ID: 15270728

DOI: 10.1111/j.1365-2567.2004.01918.x

PubMed ID: 16912232

Title: Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes.

PubMed ID: 16912232

DOI: 10.1182/blood-2006-02-005397

PubMed ID: 18369315

Title: The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development.

PubMed ID: 18369315

DOI: 10.1038/emboj.2008.62

PubMed ID: 21930792

Title: SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.

PubMed ID: 21930792

DOI: 10.1128/mcb.05817-11

Sequence Information:

  • Length: 456
  • Mass: 50466
  • Checksum: 95F1D5485D03D397
  • Sequence:
    • MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR DYASESPADE 
EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP VEQETRPVHP ALPFARGEYI 
DNRSSQRHSP PFSKTLPSKP SWPSEKARLT STLPALTALQ KPQVPPKPKG LLEDEADYVV 
PVEDNDENYI HPTESSSPPP EKAPMVNRST KPNSSTPASP PGTASGRNSG AWETKSPPPA 
APSPLPRAGK KPTTPLKTTP VASQQNASSV CEEKPIPAER HRGSSHRQEA VQSPVFPPAQ 
KQIHQKPIPL PRFTEGGNPT VDGPLPSFSS NSTISEQEAG VLCKPWYAGA CDRKSAEEAL 
HRSNKDGSFL IRKSSGHDSK QPYTLVVFFN KRVYNIPVRF IEATKQYALG RKKNGEEYFG 
SVAEIIRNHQ HSPLVLIDSQ NNTKDSTRLK YAVKVS

Genular Protein ID: 801511517

Symbol: Q2MD59_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q2MD59 F5GXS1

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 2 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16568084

Title: The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells.

PubMed ID: 16568084

DOI: 10.1038/sj.onc.1209510

Sequence Information:

  • Length: 299
  • Mass: 32998
  • Checksum: 827C7D4AD2FB5048
  • Sequence:
    • MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR DYASESPADE 
EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP VEQETRPVHP ALPFARGTAS 
GRNSGAWETK SPPPAAPSPL PRAGKKPTTP LKTTPVASQQ NASSVCEEKP IPAERHRGSS 
HRQEAVQSPV FPPAQKQIHQ KPIPLPRFTE GGNPTVDGPL PSFSSNSTIS EQEAGVLCKP 
WYAGACDRKS AEEALHRSNK YFGSVAEIIR NHQHSPLVLI DSQNNTKDST RLKYAVKVS

Genular Protein ID: 539731031

Symbol: Q2MD54_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q2MD54

Database IDs:

BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 2 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16568084

Title: The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells.

PubMed ID: 16568084

DOI: 10.1038/sj.onc.1209510

PubMed ID: 16636677

Title: SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells.

PubMed ID: 16636677

DOI: 10.1038/sj.onc.1209520

Sequence Information:

  • Length: 381
  • Mass: 42213
  • Checksum: BCB444129B6FE88A
  • Sequence:
    • MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR DYASESPADE 
EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP VEQETRPVHP ALPFARGEYI 
DNRSSQRHSP PFSKTLPSKP SWPSEKARLT STLPALTALQ KPQVPPKPKG LLEDEADYVV 
PVEDNDENYI HPTESSSPPP EKGRNSGAWE TKSPPPAAPS PLPRAGKKPT TPLKTTPVAS 
QQNASSVCEE KPIPAERHRG SSHRQEAVQS PVFPPAQKQI HQKPIPLPRF TEGGNPTVDG 
PLPSFSSNST ISEQEAGVLC KPWYAGACDR KSAEEALHRS NKYFGSVAEI IRNHQHSPLV 
LIDSQNNTKD STRLKYAVKV S