Details for: UBE2E2

Gene ID: 7325

Symbol: UBE2E2

Ensembl ID: ENSG00000182247

Description: ubiquitin conjugating enzyme E2 E2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 6.08
    Marker Score: 15213
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.15
    Marker Score: 173879
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 4.91
    Marker Score: 1774
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 4.26
    Marker Score: 2371
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 4.14
    Marker Score: 9904
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 3.95
    Marker Score: 1445
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.71
    Marker Score: 82881
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.53
    Marker Score: 1754
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 3.49
    Marker Score: 1891.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.29
    Marker Score: 15207
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 3.25
    Marker Score: 2447
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.04
    Marker Score: 5854
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.93
    Marker Score: 9605
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.86
    Marker Score: 1599
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.8
    Marker Score: 15020
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.79
    Marker Score: 1837
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.75
    Marker Score: 7836.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.73
    Marker Score: 2103
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.72
    Marker Score: 3082
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.6
    Marker Score: 2994
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.6
    Marker Score: 5708
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.59
    Marker Score: 51599
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.56
    Marker Score: 4303
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.53
    Marker Score: 37898
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.53
    Marker Score: 10501
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.51
    Marker Score: 5760
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.49
    Marker Score: 1310
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.48
    Marker Score: 3091
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.45
    Marker Score: 1026
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.44
    Marker Score: 12805
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.44
    Marker Score: 92511
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.42
    Marker Score: 18551
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.41
    Marker Score: 1408
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.41
    Marker Score: 1402
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.41
    Marker Score: 88774
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.38
    Marker Score: 1380
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.36
    Marker Score: 2036
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.36
    Marker Score: 2246
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.36
    Marker Score: 744
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.33
    Marker Score: 49834
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.3
    Marker Score: 36993
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.3
    Marker Score: 9584
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.28
    Marker Score: 8092
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.24
    Marker Score: 2479
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.22
    Marker Score: 2740
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.17
    Marker Score: 2705.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.15
    Marker Score: 20261
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.15
    Marker Score: 16179
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.12
    Marker Score: 7523.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.12
    Marker Score: 768
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.08
    Marker Score: 2520
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.07
    Marker Score: 127197
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.06
    Marker Score: 2955
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2
    Marker Score: 1644
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2
    Marker Score: 8368
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.99
    Marker Score: 7709
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.99
    Marker Score: 765
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.97
    Marker Score: 20301
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.96
    Marker Score: 725
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.96
    Marker Score: 7977
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.93
    Marker Score: 2602
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.92
    Marker Score: 475
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.89
    Marker Score: 2041
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.89
    Marker Score: 17953
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.89
    Marker Score: 551
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.88
    Marker Score: 513
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.87
    Marker Score: 1049
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.86
    Marker Score: 15943
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.86
    Marker Score: 563
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.84
    Marker Score: 3741
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.82
    Marker Score: 1579
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.82
    Marker Score: 583
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.8
    Marker Score: 459
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.77
    Marker Score: 563
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.75
    Marker Score: 454
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.72
    Marker Score: 1028
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.7
    Marker Score: 2473
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.7
    Marker Score: 2051
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.7
    Marker Score: 43472
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.69
    Marker Score: 2382
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.69
    Marker Score: 535
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.68
    Marker Score: 1104
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.66
    Marker Score: 2008
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.65
    Marker Score: 2876
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.64
    Marker Score: 620
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.62
    Marker Score: 844
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.61
    Marker Score: 2484
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.61
    Marker Score: 5384
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.6
    Marker Score: 1511
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.59
    Marker Score: 458
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.58
    Marker Score: 1590
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.56
    Marker Score: 1961
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.53
    Marker Score: 403
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.52
    Marker Score: 2762
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.47
    Marker Score: 2084
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.46
    Marker Score: 1538
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.44
    Marker Score: 693.5
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.44
    Marker Score: 475
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.43
    Marker Score: 9226
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1.43
    Marker Score: 432

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Other Information

**Key Characteristics:** UBE2E2 is a ubiquitin-conjugating enzyme E2, which is a key component of the ubiquitin-proteasome pathway (UPP). This pathway is essential for protein degradation, cell cycle regulation, and immune response. UBE2E2 is involved in the transfer of ubiquitin molecules to target proteins, marking them for degradation or modification. The gene is also involved in the regulation of the G1/S transition of the cell cycle, which is a critical checkpoint in the cell cycle. **Pathways and Functions:** UBE2E2 is involved in several key pathways, including: 1. **Adaptive Immune System:** UBE2E2 plays a crucial role in the adaptive immune response by regulating the processing and presentation of antigens to T-cells. 2. **Antigen Processing:** UBE2E2 is involved in the ubiquitination and proteasome degradation of antigens, which is essential for the presentation of antigens to T-cells. 3. **DNA Damage Response:** UBE2E2 is involved in the regulation of DNA damage response pathways, which are critical for maintaining genome stability. 4. **Protein Binding:** UBE2E2 interacts with various proteins, including ubiquitin, ubiquitin-conjugating enzymes, and transcription factors, to regulate protein function and stability. 5. **Cell Cycle Regulation:** UBE2E2 is involved in the regulation of the G1/S transition of the cell cycle, which is a critical checkpoint in the cell cycle. **Clinical Significance:** UBE2E2 has been implicated in various diseases and disorders, including: 1. **Autoimmune Diseases:** UBE2E2 has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where the immune system is dysregulated. 2. **Cancer:** UBE2E2 has been found to be overexpressed in various types of cancer, including breast and lung cancer, where it is involved in the regulation of cell growth and survival. 3. **Neurodegenerative Diseases:** UBE2E2 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it is involved in the regulation of protein aggregation and clearance. 4. **Infectious Diseases:** UBE2E2 has been found to be involved in the regulation of immune responses to infectious diseases, such as HIV and tuberculosis. In conclusion, UBE2E2 is a multifaceted gene involved in various cellular processes, including immune response, antigen processing, and regulation of the cell cycle. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of understanding its function and regulation in maintaining human health.

Genular Protein ID: 2766031178

Symbol: UB2E2_HUMAN

Name: Ubiquitin-conjugating enzyme E2 E2

UniProtKB Accession Codes:

Q96LR5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9371400

Title: cDNA cloning, characterization, and chromosome mapping of UBE2E2 encoding a human ubiquitin-conjugating E2 enzyme.

PubMed ID: 9371400

DOI: 10.1159/000134639

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 20133869

Title: ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells.

PubMed ID: 20133869

DOI: 10.1073/pnas.0909144107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 22496338

Title: A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

PubMed ID: 22496338

DOI: 10.1074/mcp.o111.013706

Sequence Information:

  • Length: 201
  • Mass: 22255
  • Checksum: 3286FB51E2B9CD3E
  • Sequence:
    • MSTEAQRVDD SPSTSGGSSD GDQRESVQQE PEREQVQPKK KEGKISSKTA AKLSTSAKRI 
QKELAEITLD PPPNCSAGPK GDNIYEWRST ILGPPGSVYE GGVFFLDITF SPDYPFKPPK 
VTFRTRIYHC NINSQGVICL DILKDNWSPA LTISKVLLSI CSLLTDCNPA DPLVGSIATQ 
YMTNRAEHDR MARQWTKRYA T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.