Details for: UBE2E2

Gene ID: 7325

Symbol: UBE2E2

Ensembl ID: ENSG00000182247

Description: ubiquitin conjugating enzyme E2 E2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 631.5848
    Cell Significance Index: -98.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 385.6793
    Cell Significance Index: -97.8300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 182.0078
    Cell Significance Index: -85.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 172.8708
    Cell Significance Index: -70.2300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 171.5267
    Cell Significance Index: -70.6600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 155.8365
    Cell Significance Index: -80.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 79.6703
    Cell Significance Index: -98.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.4495
    Cell Significance Index: -81.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 28.7994
    Cell Significance Index: -63.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 24.9490
    Cell Significance Index: -98.4500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 6.8768
    Cell Significance Index: 167.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 5.9283
    Cell Significance Index: 152.3900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 4.6329
    Cell Significance Index: 90.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 4.3910
    Cell Significance Index: 295.2500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 4.3714
    Cell Significance Index: 54.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.2084
    Cell Significance Index: 92.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.1645
    Cell Significance Index: 319.5800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 3.7317
    Cell Significance Index: 46.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.3359
    Cell Significance Index: 187.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.3126
    Cell Significance Index: 94.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.2813
    Cell Significance Index: 658.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.6146
    Cell Significance Index: 73.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.5935
    Cell Significance Index: 114.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.5797
    Cell Significance Index: 97.6900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.5584
    Cell Significance Index: 41.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1775
    Cell Significance Index: 781.0400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1.9526
    Cell Significance Index: 20.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.7599
    Cell Significance Index: 30.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.2570
    Cell Significance Index: 77.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0273
    Cell Significance Index: 195.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9042
    Cell Significance Index: 179.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7786
    Cell Significance Index: 20.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6442
    Cell Significance Index: 15.4500
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.5973
    Cell Significance Index: 2.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4876
    Cell Significance Index: 221.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4587
    Cell Significance Index: 414.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.4344
    Cell Significance Index: 590.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3968
    Cell Significance Index: 747.1300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3057
    Cell Significance Index: 4.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3042
    Cell Significance Index: 166.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2974
    Cell Significance Index: 188.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2885
    Cell Significance Index: 444.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2784
    Cell Significance Index: 4.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2725
    Cell Significance Index: 37.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2579
    Cell Significance Index: 30.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2399
    Cell Significance Index: 23.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2384
    Cell Significance Index: 12.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2375
    Cell Significance Index: 437.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1822
    Cell Significance Index: 21.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1026
    Cell Significance Index: 16.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0217
    Cell Significance Index: 9.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0422
    Cell Significance Index: -6.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0625
    Cell Significance Index: -1.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0835
    Cell Significance Index: -61.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0930
    Cell Significance Index: -68.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0981
    Cell Significance Index: -74.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1125
    Cell Significance Index: -11.7100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1166
    Cell Significance Index: -0.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1515
    Cell Significance Index: -85.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1602
    Cell Significance Index: -100.0200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1668
    Cell Significance Index: -1.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1823
    Cell Significance Index: -19.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1881
    Cell Significance Index: -24.3000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2205
    Cell Significance Index: -2.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2810
    Cell Significance Index: -50.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2827
    Cell Significance Index: -81.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3067
    Cell Significance Index: -52.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3486
    Cell Significance Index: -16.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.4319
    Cell Significance Index: -53.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4324
    Cell Significance Index: -44.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4621
    Cell Significance Index: -97.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4888
    Cell Significance Index: -36.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5345
    Cell Significance Index: -18.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6056
    Cell Significance Index: -37.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6530
    Cell Significance Index: -45.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6706
    Cell Significance Index: -40.2600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6874
    Cell Significance Index: -11.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7022
    Cell Significance Index: -31.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7034
    Cell Significance Index: -15.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7146
    Cell Significance Index: -46.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.7194
    Cell Significance Index: -92.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7557
    Cell Significance Index: -10.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8294
    Cell Significance Index: -38.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8345
    Cell Significance Index: -95.6100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.8581
    Cell Significance Index: -10.8300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.8936
    Cell Significance Index: -13.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9139
    Cell Significance Index: -72.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9218
    Cell Significance Index: -19.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9539
    Cell Significance Index: -15.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9705
    Cell Significance Index: -25.5200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.1766
    Cell Significance Index: -17.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.2528
    Cell Significance Index: -65.2600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -1.2714
    Cell Significance Index: -16.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2830
    Cell Significance Index: -37.7900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.2876
    Cell Significance Index: -25.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.3190
    Cell Significance Index: -37.8100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.3474
    Cell Significance Index: -14.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.3482
    Cell Significance Index: -95.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3825
    Cell Significance Index: -44.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.4386
    Cell Significance Index: -49.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UBE2E2 is a ubiquitin-conjugating enzyme E2, which is a key component of the ubiquitin-proteasome pathway (UPP). This pathway is essential for protein degradation, cell cycle regulation, and immune response. UBE2E2 is involved in the transfer of ubiquitin molecules to target proteins, marking them for degradation or modification. The gene is also involved in the regulation of the G1/S transition of the cell cycle, which is a critical checkpoint in the cell cycle. **Pathways and Functions:** UBE2E2 is involved in several key pathways, including: 1. **Adaptive Immune System:** UBE2E2 plays a crucial role in the adaptive immune response by regulating the processing and presentation of antigens to T-cells. 2. **Antigen Processing:** UBE2E2 is involved in the ubiquitination and proteasome degradation of antigens, which is essential for the presentation of antigens to T-cells. 3. **DNA Damage Response:** UBE2E2 is involved in the regulation of DNA damage response pathways, which are critical for maintaining genome stability. 4. **Protein Binding:** UBE2E2 interacts with various proteins, including ubiquitin, ubiquitin-conjugating enzymes, and transcription factors, to regulate protein function and stability. 5. **Cell Cycle Regulation:** UBE2E2 is involved in the regulation of the G1/S transition of the cell cycle, which is a critical checkpoint in the cell cycle. **Clinical Significance:** UBE2E2 has been implicated in various diseases and disorders, including: 1. **Autoimmune Diseases:** UBE2E2 has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where the immune system is dysregulated. 2. **Cancer:** UBE2E2 has been found to be overexpressed in various types of cancer, including breast and lung cancer, where it is involved in the regulation of cell growth and survival. 3. **Neurodegenerative Diseases:** UBE2E2 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it is involved in the regulation of protein aggregation and clearance. 4. **Infectious Diseases:** UBE2E2 has been found to be involved in the regulation of immune responses to infectious diseases, such as HIV and tuberculosis. In conclusion, UBE2E2 is a multifaceted gene involved in various cellular processes, including immune response, antigen processing, and regulation of the cell cycle. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of understanding its function and regulation in maintaining human health.

Genular Protein ID: 2766031178

Symbol: UB2E2_HUMAN

Name: Ubiquitin-conjugating enzyme E2 E2

UniProtKB Accession Codes:

Q96LR5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9371400

Title: cDNA cloning, characterization, and chromosome mapping of UBE2E2 encoding a human ubiquitin-conjugating E2 enzyme.

PubMed ID: 9371400

DOI: 10.1159/000134639

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 20133869

Title: ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells.

PubMed ID: 20133869

DOI: 10.1073/pnas.0909144107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 22496338

Title: A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

PubMed ID: 22496338

DOI: 10.1074/mcp.o111.013706

Sequence Information:

  • Length: 201
  • Mass: 22255
  • Checksum: 3286FB51E2B9CD3E
  • Sequence:
    • MSTEAQRVDD SPSTSGGSSD GDQRESVQQE PEREQVQPKK KEGKISSKTA AKLSTSAKRI 
QKELAEITLD PPPNCSAGPK GDNIYEWRST ILGPPGSVYE GGVFFLDITF SPDYPFKPPK 
VTFRTRIYHC NINSQGVICL DILKDNWSPA LTISKVLLSI CSLLTDCNPA DPLVGSIATQ 
YMTNRAEHDR MARQWTKRYA T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.