Details for: HLA DPB1

Gene ID: 3115

Symbol: HLA DPB1

Ensembl ID: ENSG00000223865

Description: major histocompatibility complex, class II, DP beta 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 316.1138
    Cell Significance Index: -49.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 121.6403
    Cell Significance Index: -62.5700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 118.1473
    Cell Significance Index: -55.7800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 83.3057
    Cell Significance Index: -55.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.3750
    Cell Significance Index: -12.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.5959
    Cell Significance Index: -48.8200
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 34.7432
    Cell Significance Index: 144.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.6667
    Cell Significance Index: -39.2900
  • Cell Name: centroblast (CL0009112)
    Fold Change: 14.6031
    Cell Significance Index: 34.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.4160
    Cell Significance Index: -52.9400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.1716
    Cell Significance Index: -24.4500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.1808
    Cell Significance Index: -31.2700
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 7.7124
    Cell Significance Index: 34.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 6.3268
    Cell Significance Index: 746.1200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 6.3227
    Cell Significance Index: 111.7300
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 6.1217
    Cell Significance Index: 105.1700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.8790
    Cell Significance Index: 108.6600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 5.0060
    Cell Significance Index: 56.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.0452
    Cell Significance Index: 260.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.4380
    Cell Significance Index: 71.6000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.3828
    Cell Significance Index: 36.8700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.3385
    Cell Significance Index: 16.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.0443
    Cell Significance Index: 389.0400
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 1.7293
    Cell Significance Index: 6.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.2778
    Cell Significance Index: 34.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8779
    Cell Significance Index: 112.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7531
    Cell Significance Index: 17.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6319
    Cell Significance Index: 102.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3483
    Cell Significance Index: 37.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3126
    Cell Significance Index: 236.5900
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.2997
    Cell Significance Index: 1.8100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.2183
    Cell Significance Index: 2.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1680
    Cell Significance Index: 17.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1150
    Cell Significance Index: 13.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0961
    Cell Significance Index: 13.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0871
    Cell Significance Index: 38.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0589
    Cell Significance Index: 5.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0276
    Cell Significance Index: 3.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0023
    Cell Significance Index: -1.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0149
    Cell Significance Index: -1.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0167
    Cell Significance Index: -31.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0289
    Cell Significance Index: -53.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0319
    Cell Significance Index: -23.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0354
    Cell Significance Index: -54.5500
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: -0.0379
    Cell Significance Index: -0.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0437
    Cell Significance Index: -59.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0593
    Cell Significance Index: -33.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0611
    Cell Significance Index: -1.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0776
    Cell Significance Index: -13.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0807
    Cell Significance Index: -59.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0835
    Cell Significance Index: -45.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0869
    Cell Significance Index: -55.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1047
    Cell Significance Index: -47.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1093
    Cell Significance Index: -21.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1270
    Cell Significance Index: -45.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1438
    Cell Significance Index: -6.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1465
    Cell Significance Index: -18.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1494
    Cell Significance Index: -5.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1602
    Cell Significance Index: -33.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1628
    Cell Significance Index: -7.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1714
    Cell Significance Index: -19.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1754
    Cell Significance Index: -4.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1970
    Cell Significance Index: -39.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2014
    Cell Significance Index: -34.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2035
    Cell Significance Index: -12.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2048
    Cell Significance Index: -10.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3018
    Cell Significance Index: -15.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3126
    Cell Significance Index: -45.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3354
    Cell Significance Index: -25.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3834
    Cell Significance Index: -43.7600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4217
    Cell Significance Index: -17.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4245
    Cell Significance Index: -30.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4757
    Cell Significance Index: -11.8900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.4869
    Cell Significance Index: -3.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5035
    Cell Significance Index: -52.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6326
    Cell Significance Index: -48.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6668
    Cell Significance Index: -14.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7303
    Cell Significance Index: -44.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7422
    Cell Significance Index: -16.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7770
    Cell Significance Index: -61.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7787
    Cell Significance Index: -49.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7794
    Cell Significance Index: -40.4900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7989
    Cell Significance Index: -34.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8414
    Cell Significance Index: -39.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8770
    Cell Significance Index: -49.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9210
    Cell Significance Index: -29.5000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.9212
    Cell Significance Index: -11.6400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -1.0167
    Cell Significance Index: -6.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0421
    Cell Significance Index: -17.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0438
    Cell Significance Index: -29.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1168
    Cell Significance Index: -49.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1368
    Cell Significance Index: -41.7300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -1.1695
    Cell Significance Index: -16.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2130
    Cell Significance Index: -31.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.2374
    Cell Significance Index: -25.9000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -1.2724
    Cell Significance Index: -19.3300
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -1.3053
    Cell Significance Index: -13.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.3333
    Cell Significance Index: -50.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.3685
    Cell Significance Index: -39.2300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.3798
    Cell Significance Index: -26.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The HLA DPB1 gene has several key characteristics that make it an essential component of the immune system: 1. **MHC class II**: The DPB1 gene is part of the MHC class II region, which is located on chromosome 6p21.3 in humans. MHC class II molecules are responsible for presenting antigens to CD4+ T cells, which is crucial for the activation of immune responses. 2. **Antigen presentation**: The DPB1 protein complex presents peptides from extracellular pathogens to CD4+ T cells, which is essential for the activation of immune responses. 3. **T-cell activation**: The DPB1 protein complex is necessary for the activation of CD4+ T cells, which is critical for the development of immune responses. 4. **Polygenic**: The DPB1 gene is part of a polygenic region, meaning that multiple genes within the MHC class II region contribute to the function of the DPB1 protein complex. 5. **High polymorphism**: The DPB1 gene exhibits high polymorphism, meaning that there are many different alleles of the gene that can encode for different DPB1 protein complexes. **Pathways and Functions** The HLA DPB1 gene is involved in several pathways and functions, including: 1. **Adaptive immune response**: The DPB1 protein complex plays a crucial role in the adaptive immune response, specifically in the activation of CD4+ T cells. 2. **Antigen processing and presentation**: The DPB1 protein complex is responsible for presenting peptides from extracellular pathogens to CD4+ T cells. 3. **Cytokine signaling**: The DPB1 protein complex is involved in cytokine signaling, which is critical for the activation of immune responses. 4. **T-cell receptor signaling pathway**: The DPB1 protein complex is necessary for the activation of CD4+ T cells, which is critical for the development of immune responses. 5. **Immune system regulation**: The DPB1 protein complex plays a role in regulating the immune system, including the activation of CD4+ T cells and the production of cytokines. **Clinical Significance** The HLA DPB1 gene has significant clinical implications, including: 1. **Transplantation**: The DPB1 protein complex plays a crucial role in transplantation, as mismatched DPB1 alleles can lead to rejection of transplanted organs. 2. **Autoimmune diseases**: Variations in the DPB1 gene have been associated with autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Infectious diseases**: The DPB1 protein complex is involved in the presentation of antigens from extracellular pathogens, which is critical for the activation of immune responses against infectious diseases. 4. **Cancer**: The DPB1 protein complex has been implicated in cancer, as variations in the DPB1 gene have been associated with an increased risk of certain types of cancer. 5. **Immune system disorders**: The DPB1 protein complex plays a role in regulating the immune system, and variations in the DPB1 gene have been associated with immune system disorders, such as immunodeficiency diseases. In conclusion, the HLA DPB1 gene is a critical component of the immune system, playing a pivotal role in antigen presentation, T-cell activation, and immune system regulation. Its clinical significance is evident in transplantation, autoimmune diseases, infectious diseases, cancer, and immune system disorders. Further research is needed to fully understand the functions and clinical implications of the HLA DPB1 gene.

Genular Protein ID: 374868705

Symbol: DPB1_HUMAN

Name: HLA class II histocompatibility antigen, DP beta 1 chain

UniProtKB Accession Codes:

P04440 A0PFJ7 A5I886 A8YPB3 B5U8B4 B7VF80 B7VF87 B8ZX68 B8ZYT0 B9W5S8 B9W6F7 B9W6F9 C0MPP5 C0MPQ2 C0MPQ3 C0MPQ5 C0MPQ6 C0MPQ7 C4R9J5 C5IZL1 O00259 O19698 O19700 O19702 O19749 O46884 O77952 O98215 O98216 O98217 O98218 O98219 O98222 O98223 P01916 P04232 P13763 P79493 P79608 Q0P0L4 Q0ZFN3 Q14279 Q27S71 Q29682 Q29684 Q29698 Q29714 Q29775 Q29776 Q29778 Q29779 Q29781 Q29827 Q29828 Q29879 Q29880 Q29898 Q29977 Q2MGW3 Q30015 Q30031 Q30032 Q30033 Q30034 Q30050 Q30051 Q30052 Q30053 Q30054 Q30055 Q30174 Q4GY31 Q4JHD8 Q5ENE0 Q5ENE1 Q5ENW3 Q5EP46 Q5EP47 Q5EP49 Q5EP51 Q5EP52 Q5EP53 Q5EP56 Q5I4H8 Q5I4H9 Q5ISH4 Q5ISH5 Q5SQ73 Q5STP2 Q5YLA6 Q6IVX1 Q6LBX2 Q6LBX3 Q6LBX4 Q6LBX5 Q6LBX6 Q6LBX7 Q6PWX6 Q6TAS4 Q714U1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 100 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 17 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6098459

Title: Structure and polymorphism of the HLA class II SB light chain genes.

PubMed ID: 6098459

DOI: 10.1002/j.1460-2075.1984.tb02245.x

PubMed ID: 2998758

Title: DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression.

PubMed ID: 2998758

DOI: 10.1002/j.1460-2075.1985.tb04012.x

PubMed ID: 2987832

Title: Complete nucleotide sequence of a functional HLA-DP beta gene and the region between the DP beta 1 and DP alpha 1 genes: comparison of the 5' ends of HLA class II genes.

PubMed ID: 2987832

DOI: 10.1093/nar/13.5.1607

PubMed ID: 3036829

Title: Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes.

PubMed ID: 3036829

DOI: 10.1016/s0021-9258(18)47483-2

PubMed ID: 2838415

Title: The beta-chains of DP4 molecules from different haplotypes are encoded by the same gene.

PubMed ID: 2838415

DOI: 10.1016/0888-7543(88)90103-6

PubMed ID: 1529429

Title: A new HLA-DPB1 allele from a patient with systemic lupus erythematosus.

PubMed ID: 1529429

DOI: 10.1111/j.1399-0039.1992.tb01938.x

PubMed ID: 16189666

Title: Extended HLA-DPB1 polymorphism: an RNA approach for HLA-DPB1 typing.

PubMed ID: 16189666

DOI: 10.1007/s00251-005-0043-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2714855

Title: Sequence polymorphism of HLA-DP beta chains.

PubMed ID: 2714855

DOI: 10.1007/bf00352845

PubMed ID: 7638863

Title: HLA-DPB1 alleles in a population from north India and description of a new variant (DPB1*5601).

PubMed ID: 7638863

DOI: 10.1111/j.1399-0039.1995.tb02450.x

PubMed ID: 1481203

Title: Characterization of novel HLA-DPB1 alleles by oligotyping and nucleotide sequencing.

PubMed ID: 1481203

DOI: 10.1111/j.1399-0039.1992.tb02055.x

PubMed ID: 8896187

Title: DPB1*TF, a novel HLA class II DPB1 allele (DPB1*6701) identified in a Turkish family.

PubMed ID: 8896187

DOI: 10.1111/j.1399-0039.1996.tb02637.x

PubMed ID: 9756410

Title: Identification of two new DPB1 alleles, DPB1*7701 and *7801, by sequence-based typing.

PubMed ID: 9756410

DOI: 10.1111/j.1399-0039.1998.tb02285.x

PubMed ID: 9756411

Title: Identification of a new DPB1 allele (DPB1*7901) by sequence-based typing.

PubMed ID: 9756411

DOI: 10.1111/j.1399-0039.1998.tb02286.x

PubMed ID: 16147881

Title: DNA-sequence determination of exon 2 of a novel HLA-DPB1 allele, HLA-DPB1*0403.

PubMed ID: 16147881

DOI: 10.1080/10425170500061442

PubMed ID: 1440570

Title: Genetic diversity within the HLA class II region: ten new DPB1 alleles and their population distribution.

PubMed ID: 1440570

DOI: 10.1111/j.1399-0039.1992.tb02109.x

PubMed ID: 7806296

Title: Identification of the novel HLA-DPB1*5801 allele detected by sequenced based typing.

PubMed ID: 7806296

DOI: 10.1007/bf00182337

PubMed ID: 8773318

Title: Three new DPB1 alleles identified in a Bantu-speaking population from central Cameroon.

PubMed ID: 8773318

DOI: 10.1111/j.1399-0039.1996.tb02556.x

PubMed ID: 6330724

Title: Molecular organization of the HLA-SB region of the human major histocompatibility complex and evidence for two SB beta-chain genes.

PubMed ID: 6330724

DOI: 10.1073/pnas.81.13.3934

PubMed ID: 19775376

Title: In a study for acne vulgaris, sequence-based HLA typing showed a novel DPB1 allele, DPB1*2402.

PubMed ID: 19775376

DOI: 10.1111/j.1399-0039.2009.01325.x

PubMed ID: 2460556

Title: Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta loci.

PubMed ID: 2460556

PubMed ID: 2242906

Title: Rapid HLA-DPB typing using enzymatically amplified DNA and nonradioactive sequence-specific oligonucleotide probes.

PubMed ID: 2242906

DOI: 10.1007/bf00187094

PubMed ID: 8344726

Title: Novel class II HLA-DRB4 and DPB1 alleles found in the Belgian population.

PubMed ID: 8344726

DOI: 10.1007/bf00210483

PubMed ID: 7901923

Title: Identification of a new HLA-DPB1 allele detected by PCR-RFLP and its nucleotide sequence determination by direct sequencing after PCR amplification.

PubMed ID: 7901923

DOI: 10.1111/j.1399-0039.1993.tb02016.x

PubMed ID: 7912859

Title: A new HLA-DPB1 allele, DPB1*SUT (DPB1*4701).

PubMed ID: 7912859

DOI: 10.1111/j.1399-0039.1994.tb02297.x

PubMed ID: 7839356

Title: Direct sequencing of a novel DPB1 allele (DPB1*5101) of the heterozygote from the membrane of reverse dot blot analysis.

PubMed ID: 7839356

DOI: 10.1111/j.1399-0039.1994.tb02382.x

PubMed ID: 8781129

Title: DPB1*BR: an Mhc class II DPB1 allele (DPB1*6601) of negroid origin.

PubMed ID: 8781129

DOI: 10.1007/s002510050145

PubMed ID: 8824162

Title: Identification of a new HLA-DPB1*6501 allele in a Caucasian individual.

PubMed ID: 8824162

DOI: 10.1007/bf02602812

PubMed ID: 11169249

Title: Two new HLA DPB1 alleles identified by sequence-based typing: DPB1*8201 and DPB1*8301.

PubMed ID: 11169249

DOI: 10.1034/j.1399-0039.2000.560613.x

PubMed ID: 11556983

Title: DPB1*8601, a previously unrecognized DPB1 variant in the Caucasoid population.

PubMed ID: 11556983

DOI: 10.1034/j.1399-0039.2001.057006536.x

PubMed ID: 11782281

Title: Three new DP alleles identified in a study of 800 unrelated bone marrow donor-recipient pairs.

PubMed ID: 11782281

DOI: 10.1034/j.1399-0039.2001.580410.x

PubMed ID: 12135440

Title: Identification of a new HLA-DPB1 allele,HLA-DPB1*9001.

PubMed ID: 12135440

DOI: 10.1034/j.1399-0039.2002.590419.x

PubMed ID: 12694578

Title: Identification of a novel DPB1 allele, DPB1*9301, by sequence-based typing in a Lahu ethnic minority of China.

PubMed ID: 12694578

DOI: 10.1046/j.0001-2815.2002.00143.x

PubMed ID: 12890000

Title: High resolution sequence-based DPB1 typing identified two novel DPB1 alleles, DPB1*9401 and DPB1*9501, from a Kenyan population.

PubMed ID: 12890000

DOI: 10.1034/j.1399-0039.2003.00066.x

PubMed ID: 12890001

Title: Sequence-based typing identifies a novel HLA-DPB1 allele, DPB1*9601.

PubMed ID: 12890001

DOI: 10.1034/j.1399-0039.2003.00081.x

PubMed ID: 15361132

Title: Identification of a novel HLA-DPB1 allele--DPB1*0102.

PubMed ID: 15361132

DOI: 10.1111/j.1399-0039.2004.00276.x

PubMed ID: 16866899

Title: Identification of a novel HLA-DPB1 allele, DPB1*1702.

PubMed ID: 16866899

DOI: 10.1111/j.1399-0039.2006.00630.x

PubMed ID: 8085260

Title: Seven new DPB1 alleles and their population distribution.

PubMed ID: 8085260

DOI: 10.1111/j.1399-0039.1994.tb02333.x

PubMed ID: 9174146

Title: Six new DPB1 alleles identified in a study of 1,302 unrelated bone marrow donor-recipient pairs.

PubMed ID: 9174146

DOI: 10.1111/j.1399-0039.1997.tb02788.x

PubMed ID: 10090623

Title: Four new DP alleles identified in a study of 500 unrelated bone marrow donor-recipient pairs.

PubMed ID: 10090623

DOI: 10.1034/j.1399-0039.1999.530213.x

PubMed ID: 15140044

Title: Identification of a novel HLA-DPB1 allele, DPB1*9701, by sequence-based typing.

PubMed ID: 15140044

DOI: 10.1111/j.0001-2815.2004.00198.x

PubMed ID: 7744621

Title: Novel HLA-DPB1 alleles detected in the Ethiopian population.

PubMed ID: 7744621

DOI: 10.1016/0198-8859(94)00100-5

PubMed ID: 8851734

Title: DPB1*5901a: a novel HLA-DPB1 allele from a Caucasian family with insulin-dependent diabetes mellitus.

PubMed ID: 8851734

DOI: 10.1111/j.1399-0039.1996.tb02533.x

PubMed ID: 15982263

Title: Identification of a new allele in a Sicilian individual: HLA-DPB1*0302.

PubMed ID: 15982263

DOI: 10.1111/j.1399-0039.2005.00429.x

PubMed ID: 1412421

Title: DPB1*WA4 - an additional HLA class II allele identified in west Africa.

PubMed ID: 1412421

DOI: 10.1111/j.1399-0039.1992.tb01966.x

PubMed ID: 1358867

Title: Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-DR/DQ and two 'new' alleles.

PubMed ID: 1358867

DOI: 10.1016/0198-8859(92)90113-2

PubMed ID: 7817379

Title: A novel HLA-DPB1 allele, DPB1*3601 (DPB1*KT).

PubMed ID: 7817379

DOI: 10.1111/j.1399-0039.1994.tb02370.x

PubMed ID: 9694359

Title: Three new DP alleles identified in sub-Saharan Africa: DPB1*7401, DPA1*02013, and DPA1*0302.

PubMed ID: 9694359

DOI: 10.1111/j.1399-0039.1998.tb03009.x

PubMed ID: 8525482

Title: Characterization of a new DPB1 allele (DPB1*5701) isolated from a Caucasian individual.

PubMed ID: 8525482

DOI: 10.1111/j.1399-0039.1995.tb03122.x

PubMed ID: 10958363

Title: The nucleotide sequence of two new DP alleles, DPA1*02015 and DPB1*8401, identified in a Chinese subject.

PubMed ID: 10958363

DOI: 10.1034/j.1399-0039.2000.560114.x

PubMed ID: 6310612

Title: Genetic mapping of a human class II antigen beta-chain cDNA clone to the SB region of the HLA complex.

PubMed ID: 6310612

DOI: 10.1073/pnas.80.19.6036

PubMed ID: 8598037

Title: Invariant chain structure and MHC class II function.

PubMed ID: 8598037

DOI: 10.1016/s0092-8674(00)81025-9

PubMed ID: 11684289

Title: Presentation of antigens by MHC class II molecules: getting the most out of them.

PubMed ID: 11684289

DOI: 10.1016/s0161-5890(01)00069-4

PubMed ID: 18046453

Title: MHC class II molecules on the move for successful antigen presentation.

PubMed ID: 18046453

DOI: 10.1038/sj.emboj.7601945

PubMed ID: 17241953

Title: Autophagy in MHC class II presentation: sampling from within.

PubMed ID: 17241953

DOI: 10.1016/j.immuni.2007.01.005

PubMed ID: 19092054

Title: MHC class II transport at a glance.

PubMed ID: 19092054

DOI: 10.1242/jcs.035089

PubMed ID: 19533806

Title: CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.

PubMed ID: 19533806

DOI: 10.3748/wjg.15.2855

Sequence Information:

  • Length: 258
  • Mass: 29159
  • Checksum: E74777D438DE9C41
  • Sequence:
    • MMVLQVSAAP RTVALTALLM VLLTSVVQGR ATPENYLFQG RQECYAFNGT QRFLERYIYN 
REEFARFDSD VGEFRAVTEL GRPAAEYWNS QKDILEEKRA VPDRMCRHNY ELGGPMTLQR 
RVQPRVNVSP SKKGPLQHHN LLVCHVTDFY PGSIQVRWFL NGQEETAGVV STNLIRNGDW 
TFQILVMLEM TPQQGDVYTC QVEHTSLDSP VTVEWKAQSD SARSKTLTGA GGFVLGLIIC 
GVGIFMHRRS KKVQRGSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.