Details for: UCP2
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 76.05rCSI 73.13%PRS 82.75
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CSI 61.08rCSI 53.1%PRS 72.37
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CSI 58.93rCSI 58.81%PRS 54.87
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CSI 57.18rCSI 39.92%PRS 64.42
-
CSI 56.79rCSI 43.76%PRS 62.1
-
CSI 53.08rCSI 35.38%PRS 81.24
-
CSI 50.52rCSI 44.42%PRS 49.44
-
CSI 44.17rCSI 45.02%PRS 74.45
-
CSI 40.28rCSI 38.77%PRS 61.67
-
CSI 39.82rCSI 39.11%PRS 77.28
-
CSI 36.93rCSI 38.53%PRS 61.86
-
CSI 36.19rCSI 27.02%PRS 78.18
-
CSI 35.71rCSI 33.74%PRS 61.22
-
CSI 34.7rCSI 29.76%PRS 69.88
-
CSI 34.26rCSI 31.61%PRS 63.01
-
CSI 33.37rCSI 27.86%PRS 72.19
-
CSI 31.1rCSI 24.46%PRS 68.35
-
CSI 30.51rCSI 39.97%PRS 75.23
-
CSI 29.87rCSI 22.19%PRS 74.92
-
CSI 29.41rCSI 33.1%PRS 77.77
-
CSI 28.1rCSI 20.17%PRS 75.9
-
CSI 27.32rCSI 20.49%PRS 87.2
-
CSI 27.13rCSI 26.79%PRS 84.56
-
CSI 26.88rCSI 20.84%PRS 63.48
-
CSI 26.08rCSI 33.47%PRS 58.74
-
CSI 25.96rCSI 59.36%PRS 61.48
-
CSI 24.64rCSI 24.96%PRS 87
-
CSI 24.26rCSI 69.25%PRS 73.06
-
CSI 23.86rCSI 19.28%PRS 72.13
-
CSI 23.08rCSI 24.73%PRS 60.98
-
CSI 23.02rCSI 16.17%PRS 79.86
-
CSI 22.76rCSI 57.03%PRS 85.07
-
CSI 21rCSI 24.6%PRS 78.07
-
CSI 20.95rCSI 21.55%PRS 77.99
-
CSI 20.32rCSI 12%PRS 78.93
-
CSI 20.28rCSI 23.42%PRS 54.72
-
CSI 20.27rCSI 60.46%PRS 78.67
-
CSI 20.26rCSI 14.1%PRS 76.82
-
CSI 19.5rCSI 31.26%PRS 82.17
-
CSI 19.4rCSI 14.76%PRS 74.67
-
CSI 19.18rCSI 23.17%PRS 70.5
-
CSI 18.42rCSI 17.03%PRS 80.88
-
CSI 18.38rCSI 28.23%PRS 70.62
-
CSI 18.26rCSI 15.12%PRS 63.8
-
CSI 17.62rCSI 22.15%PRS 87.57
-
CSI 17.6rCSI 18.4%PRS 59.63
-
CSI 17.6rCSI 16.16%PRS 70.46
-
CSI 17.06rCSI 57.69%PRS 65.57
-
CSI 16.95rCSI 16.66%PRS 82.63
-
CSI 16.86rCSI 14.77%PRS 71.32
-
CSI 16.57rCSI 54.25%PRS 86.44
-
CSI 15.78rCSI 13.67%PRS 66.6
-
CSI 15.77rCSI 14%PRS 59.61
-
CSI 15.74rCSI 19.39%PRS 75.19
-
CSI 15.52rCSI 25.15%PRS 58.21
-
CSI 15.14rCSI 18.86%PRS 72.46
-
CSI 15.06rCSI 11.27%PRS 76.73
-
CSI 14.9rCSI 20.36%PRS 63.32
-
CSI 14.71rCSI 33.52%PRS 57.99
-
CSI 14.4rCSI 14.16%PRS 64.21
-
CSI 14.16rCSI 20.76%PRS 73.18
-
CSI 14.08rCSI 16.54%PRS 86.51
-
CSI 14.07rCSI 16.31%PRS 69.17
-
CSI 13.82rCSI 30.43%PRS 65.88
-
CSI 13.59rCSI 14.19%PRS 83.63
-
CSI 13.42rCSI 22.99%PRS 70.42
-
CSI 13.12rCSI 16.83%PRS 66.35
-
CSI 12.95rCSI 9.73%PRS 67.1
-
CSI 12.85rCSI 17.19%PRS 79.92
-
CSI 12.75rCSI 10.73%PRS 78.59
-
CSI 12.47rCSI 8.29%PRS 64.72
-
CSI 12.33rCSI 15.77%PRS 82.18
-
CSI 12.3rCSI 18.79%PRS 70.97
-
CSI 12.03rCSI 13.94%PRS 72.39
-
CSI 11.84rCSI 22.96%PRS 84.83
-
CSI 11.67rCSI 14.68%PRS 73.47
-
CSI 11.65rCSI 9.33%PRS 81.7
-
CSI 11.64rCSI 10.6%PRS 76.15
-
CSI 11.42rCSI 13.63%PRS 81.08
-
CSI 11.41rCSI 45.59%PRS 77.29
-
CSI 11.18rCSI 29.66%PRS 73.07
-
CSI 11.03rCSI 12.76%PRS 51.65
-
CSI 11rCSI 16.81%PRS 77.09
-
CSI 10.84rCSI 14.76%PRS 85.48
-
CSI 10.7rCSI 7.44%PRS 72.79
-
CSI 10.63rCSI 23.85%PRS 79.05
-
CSI 10.61rCSI 9.58%PRS 58.49
-
CSI 10.59rCSI 9.3%PRS 67.15
-
CSI 10.56rCSI 49.52%PRS 78.93
-
CSI 9.73rCSI 14.25%PRS 57.57
-
CSI 9.57rCSI 51.61%PRS 73.88
-
CSI 9.24rCSI 13.67%PRS 66.91
-
CSI 9.1rCSI 21.6%PRS 65.29
-
CSI 8.82rCSI 13.49%PRS 74.98
-
CSI 8.8rCSI 6.84%PRS 79.35
-
CSI 8.72rCSI 9.99%PRS 80.08
-
CSI 8.72rCSI 15.87%PRS 78.95
-
CSI 8.37rCSI 18.99%PRS 65.57
-
CSI 8.22rCSI 44.48%PRS 88.69
-
CSI 8.13rCSI 6.74%PRS 60.82
-
CSI 0.3rCSI 1.5%PRS 83.0%
-
CSI 0.4rCSI 1.6%PRS 78.3%
-
CSI 0.4rCSI 11.6%PRS 92.3%
-
CSI 0.6rCSI 2.5%PRS 81.6%
-
CSI 0.9rCSI 15.5%PRS 89.2%
-
CSI 0.9rCSI 1.7%PRS 72.0%
-
CSI 1.0rCSI 4.3%PRS 90.0%
-
CSI 1.0rCSI 1.9%PRS 78.9%
-
CSI 1.1rCSI 2.9%PRS 89.3%
-
CSI 1.2rCSI 7.6%PRS 87.2%
-
CSI 1.2rCSI 1.5%PRS 63.3%
-
CSI 1.4rCSI 8.6%PRS 88.0%
-
CSI 1.4rCSI 3.4%PRS 90.9%
-
CSI 1.5rCSI 6.4%PRS 91.9%
-
CSI 1.7rCSI 2.0%PRS 78.2%
-
CSI 1.7rCSI 18.0%PRS 81.8%
-
CSI 1.7rCSI 22.8%PRS 87.4%
-
CSI 1.9rCSI 2.3%PRS 48.8%
-
CSI 1.9rCSI 10.8%PRS 71.0%
-
CSI 1.9rCSI 3.7%PRS 87.1%
-
CSI 1.9rCSI 13.6%PRS 75.8%
-
CSI 1.9rCSI 12.8%PRS 86.4%
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CSI 2.0rCSI 4.2%PRS 72.8%
-
CSI 2.2rCSI 5.7%PRS 79.9%
-
CSI 2.2rCSI 5.6%PRS 60.0%
-
CSI 2.3rCSI 13.7%PRS 80.1%
-
CSI 2.3rCSI 9.9%PRS 74.2%
-
CSI 2.4rCSI 4.5%PRS 81.1%
-
CSI 2.5rCSI 4.4%PRS 83.3%
-
CSI 2.5rCSI 4.6%PRS 76.7%
-
CSI 2.6rCSI 66.2%PRS 89.2%
-
CSI 2.6rCSI 4.9%PRS 89.1%
-
CSI 2.6rCSI 15.0%PRS 70.8%
-
CSI 2.8rCSI 32.2%PRS 86.6%
-
CSI 2.9rCSI 5.8%PRS 78.3%
-
CSI 3.0rCSI 4.1%PRS 82.1%
-
CSI 3.2rCSI 13.7%PRS 74.0%
-
CSI 3.2rCSI 67.6%PRS 88.4%
-
CSI 3.2rCSI 61.5%PRS 89.8%
-
CSI 3.3rCSI 7.6%PRS 73.8%
-
CSI 3.3rCSI 7.9%PRS 79.3%
-
CSI 3.5rCSI 2.3%PRS 74.8%
-
CSI 3.7rCSI 5.4%PRS 77.4%
-
CSI 3.7rCSI 6.3%PRS 79.5%
-
CSI 3.9rCSI 8.6%PRS 74.3%
-
CSI 4.1rCSI 8.5%PRS 79.8%
-
CSI 4.2rCSI 3.3%PRS 82.7%
-
CSI 4.2rCSI 6.6%PRS 84.9%
-
CSI 4.3rCSI 18.7%PRS 52.0%
-
CSI 4.5rCSI 16.3%PRS 85.9%
-
CSI 4.5rCSI 4.9%PRS 65.4%
-
CSI 4.5rCSI 6.9%PRS 65.8%
-
CSI 4.7rCSI 17.1%PRS 81.0%
-
CSI 4.8rCSI 18.5%PRS 76.2%
-
CSI 4.8rCSI 52.2%PRS 76.5%
-
CSI 4.8rCSI 24.2%PRS 74.1%
-
CSI 4.8rCSI 5.9%PRS 69.1%
-
CSI 4.9rCSI 8.3%PRS 84.1%
-
CSI 4.9rCSI 7.1%PRS 71.2%
-
CSI 5.0rCSI 7.3%PRS 66.3%
-
CSI 5.0rCSI 7.3%PRS 77.6%
-
CSI 5.2rCSI 5.5%PRS 72.0%
-
CSI 5.3rCSI 7.6%PRS 72.4%
-
CSI 5.3rCSI 24.0%PRS 88.3%
-
CSI 5.3rCSI 8.4%PRS 72.7%
-
CSI 5.3rCSI 18.8%PRS 70.5%
-
CSI 5.3rCSI 15.3%PRS 81.3%
-
CSI 5.5rCSI 18.8%PRS 83.9%
-
CSI 5.6rCSI 31.4%PRS 84.2%
-
CSI 6.0rCSI 8.0%PRS 68.1%
-
CSI 6.1rCSI 6.3%PRS 67.3%
-
CSI 6.2rCSI 12.8%PRS 63.4%
-
CSI 6.3rCSI 9.6%PRS 65.8%
-
CSI 6.3rCSI 10.4%PRS 66.8%
-
CSI 7.0rCSI 9.6%PRS 81.0%
-
CSI 7.0rCSI 38.1%PRS 77.2%
-
CSI 7.1rCSI 5.7%PRS 63.1%
-
CSI 7.2rCSI 33.2%PRS 80.1%
-
CSI 7.3rCSI 9.1%PRS 72.0%
-
CSI 7.3rCSI 5.5%PRS 75.4%
-
CSI 7.3rCSI 47.2%PRS 79.2%
-
CSI 7.4rCSI 16.5%PRS 69.4%
-
CSI 7.5rCSI 13.6%PRS 75.4%
-
CSI 7.6rCSI 7.7%PRS 75.9%
-
CSI 7.8rCSI 17.0%PRS 75.1%
-
CSI 7.9rCSI 14.3%PRS 76.8%
-
CSI 7.9rCSI 10.8%PRS 53.4%
-
CSI 8.0rCSI 33.2%PRS 65.1%
-
CSI 8.1rCSI 7.8%PRS 52.2%
-
CSI 8.1rCSI 6.7%PRS 60.8%
-
CSI 8.2rCSI 44.5%PRS 88.7%
-
CSI 8.4rCSI 19.0%PRS 65.6%
-
CSI 8.7rCSI 15.9%PRS 79.0%
-
CSI 8.7rCSI 10.0%PRS 80.1%
-
CSI 8.8rCSI 6.8%PRS 79.4%
-
CSI 8.8rCSI 13.5%PRS 75.0%
-
CSI 9.1rCSI 21.6%PRS 65.3%
-
CSI 9.2rCSI 13.7%PRS 66.9%
-
CSI 9.6rCSI 51.6%PRS 73.9%
-
CSI 9.7rCSI 14.3%PRS 57.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 517509895
Symbol: UCP2_HUMAN
Name: Mitochondrial uncoupling protein 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9180264
Title: Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression.
PubMed ID: 9180264
PubMed ID: 9054939
Title: Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia.
PubMed ID: 9054939
DOI: 10.1038/ng0397-269
PubMed ID: 9133562
Title: Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis.
PubMed ID: 9133562
PubMed ID: 9568704
Title: Structure and organization of the human uncoupling protein 2 gene and identification of a common biallelic variant in Caucasian and African-American subjects.
PubMed ID: 9568704
PubMed ID: 10082652
Title: Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene.
PubMed ID: 10082652
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11171965
Title: Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone).
PubMed ID: 11171965
PubMed ID: 11278935
Title: Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria.
PubMed ID: 11278935
PubMed ID: 22524567
Title: Toward understanding the mechanism of ion transport activity of neuronal uncoupling proteins UCP2, UCP4, and UCP5.
PubMed ID: 22524567
DOI: 10.1021/bi3003378
PubMed ID: 24395786
Title: UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation.
PubMed ID: 24395786
PubMed ID: 26182433
Title: A biophysical study on molecular physiology of the uncoupling proteins of the central nervous system.
PubMed ID: 26182433
DOI: 10.1042/bsr20150130
PubMed ID: 33798544
Title: Mitochondrial proton leaks and uncoupling proteins.
PubMed ID: 33798544
PubMed ID: 33373220
Title: Functional Oligomeric Forms of Uncoupling Protein 2: Strong Evidence for Asymmetry in Protein and Lipid Bilayer Systems.
PubMed ID: 33373220
PubMed ID: 11381268
Title: A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans.
PubMed ID: 11381268
DOI: 10.1038/88911
Sequence Information:
- Length: 309
- Mass: 33229
- Checksum: 2E1741391621E3D9
- Sequence:
MVGFKATDVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGESQGP VRATASAQYR GVMGTILTMV RTEGPRSLYN GLVAGLQRQM SFASVRIGLY DSVKQFYTKG SEHASIGSRL LAGSTTGALA VAVAQPTDVV KVRFQAQARA GGGRRYQSTV NAYKTIAREE GFRGLWKGTS PNVARNAIVN CAELVTYDLI KDALLKANLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT RYMNSALGQY SSAGHCALTM LQKEGPRAFY KGFMPSFLRL GSWNVVMFVT YEQLKRALMA ACTSREAPF