Details for: UCP2

Gene ID: 7351

Symbol: UCP2

Ensembl ID: ENSG00000175567

Description: uncoupling protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.39
    Marker Score: 39371
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.09
    Marker Score: 1883
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.08
    Marker Score: 3029
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.03
    Marker Score: 2847
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.02
    Marker Score: 1490
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.91
    Marker Score: 8497
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.91
    Marker Score: 9176.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.91
    Marker Score: 8627
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.86
    Marker Score: 2767
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.86
    Marker Score: 2859
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.81
    Marker Score: 5484
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.71
    Marker Score: 26857
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.68
    Marker Score: 11508
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.67
    Marker Score: 4661
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.64
    Marker Score: 1592
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.63
    Marker Score: 2350
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.62
    Marker Score: 16776
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.57
    Marker Score: 3780
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.56
    Marker Score: 88569.5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.54
    Marker Score: 4531.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.53
    Marker Score: 2225
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.53
    Marker Score: 133876
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.5
    Marker Score: 140017
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.48
    Marker Score: 3515
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.47
    Marker Score: 874
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.43
    Marker Score: 993
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.37
    Marker Score: 5768
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.36
    Marker Score: 4633.5
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.29
    Marker Score: 2701.5
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.26
    Marker Score: 4746
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.2
    Marker Score: 1212
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.2
    Marker Score: 19105
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.19
    Marker Score: 755
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.18
    Marker Score: 5265
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.1
    Marker Score: 1590
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 2.08
    Marker Score: 480
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.07
    Marker Score: 680
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.05
    Marker Score: 1916
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.04
    Marker Score: 1350
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.03
    Marker Score: 3481
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.02
    Marker Score: 5506
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.01
    Marker Score: 1156
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2
    Marker Score: 1170
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.99
    Marker Score: 1457
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.98
    Marker Score: 739
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.97
    Marker Score: 2058
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.95
    Marker Score: 465
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.95
    Marker Score: 2235
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.95
    Marker Score: 842
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.94
    Marker Score: 1073
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.89
    Marker Score: 1105
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.88
    Marker Score: 3565
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.88
    Marker Score: 2264
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.87
    Marker Score: 18936
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.86
    Marker Score: 777
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.85
    Marker Score: 5184
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.85
    Marker Score: 1642.5
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.84
    Marker Score: 2039
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.82
    Marker Score: 1320
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.82
    Marker Score: 584
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.81
    Marker Score: 1322
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.79
    Marker Score: 885
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.79
    Marker Score: 1468
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.78
    Marker Score: 4620
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.78
    Marker Score: 1475
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.76
    Marker Score: 1483
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.76
    Marker Score: 449
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.75
    Marker Score: 612
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.74
    Marker Score: 1257
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.7
    Marker Score: 432
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.66
    Marker Score: 2204
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.66
    Marker Score: 4575
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.64
    Marker Score: 5651
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.64
    Marker Score: 1132
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.62
    Marker Score: 430
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.6
    Marker Score: 1610
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.56
    Marker Score: 808
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.56
    Marker Score: 738
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.54
    Marker Score: 1169
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.54
    Marker Score: 645
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.54
    Marker Score: 540
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.54
    Marker Score: 2126
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.53
    Marker Score: 1559
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.52
    Marker Score: 531
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.51
    Marker Score: 1632
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.5
    Marker Score: 1097.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.5
    Marker Score: 432
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5
    Marker Score: 2203
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.49
    Marker Score: 6118
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.49
    Marker Score: 38221
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.49
    Marker Score: 916
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.46
    Marker Score: 321
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.45
    Marker Score: 725
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.45
    Marker Score: 798
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.44
    Marker Score: 437
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.43
    Marker Score: 960
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 1.42
    Marker Score: 709.5
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.42
    Marker Score: 490
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.41
    Marker Score: 1061
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.38
    Marker Score: 936

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Other Information

**Key Characteristics** UCP2 is a small, 33-kDa protein that is predominantly expressed in the mitochondria of various cell types, including blood cells, immune cells, and neuronal cells. It is a homodimeric protein that is composed of two identical subunits, each of which contains a transmembrane domain and a peroxisomal membrane domain. UCP2 is characterized by its ability to uncouple ATP synthesis from the respiratory chain activity, thereby reducing the energy expenditure of the cell. It also has a role in regulating the proton gradient across the mitochondrial inner membrane, which is essential for maintaining the proper functioning of the electron transport chain. **Pathways and Functions** UCP2 is involved in several signaling pathways that regulate energy metabolism and thermogenesis. Some of the key pathways and functions of UCP2 include: 1. **Adaptive thermogenesis**: UCP2 plays a crucial role in regulating thermogenesis, which is the process by which the body generates heat. This process is essential for maintaining energy homeostasis and regulating body temperature. 2. **Glucose and amino acid metabolism**: UCP2 is involved in regulating glucose and amino acid metabolism by modulating the activity of key enzymes and signaling pathways. 3. **Mitochondrial fission and fusion**: UCP2 is involved in regulating the dynamics of mitochondrial fission and fusion, which is essential for maintaining mitochondrial function and regulating cellular metabolism. 4. **Proton buffering**: UCP2 helps to regulate the proton gradient across the mitochondrial inner membrane, which is essential for maintaining the proper functioning of the electron transport chain. 5. **Oxidative stress response**: UCP2 has been implicated in regulating the response to oxidative stress, which is a condition characterized by the accumulation of reactive oxygen species (ROS) in the cell. **Clinical Significance** UCP2 has been implicated in several physiological and pathological processes, including: 1. **Obesity and diabetes**: UCP2 has been shown to play a role in regulating energy metabolism and thermogenesis, and its dysregulation has been implicated in the development of obesity and diabetes. 2. **Cancer**: UCP2 has been implicated in regulating the growth and proliferation of cancer cells, and its dysregulation has been associated with the development of various types of cancer. 3. **Neurodegenerative diseases**: UCP2 has been implicated in regulating the function of neurons and has been associated with the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Inflammatory diseases**: UCP2 has been implicated in regulating the immune response and has been associated with the development of inflammatory diseases, including rheumatoid arthritis and atherosclerosis. In conclusion, UCP2 is a critical regulator of energy metabolism and thermogenesis, and its dysregulation has been implicated in several physiological and pathological processes. Further research is needed to fully understand the role of UCP2 in regulating cellular metabolism and to explore its potential as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 517509895

Symbol: UCP2_HUMAN

Name: Mitochondrial uncoupling protein 2

UniProtKB Accession Codes:

P55851 Q4PJH8 Q53HM3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 20 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 2 ExpressionAtlas 1 GO 36 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 10 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9180264

Title: Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression.

PubMed ID: 9180264

DOI: 10.1016/s0014-5793(97)00384-0

PubMed ID: 9054939

Title: Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia.

PubMed ID: 9054939

DOI: 10.1038/ng0397-269

PubMed ID: 9133562

Title: Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis.

PubMed ID: 9133562

DOI: 10.2337/diab.46.5.900

PubMed ID: 9568704

Title: Structure and organization of the human uncoupling protein 2 gene and identification of a common biallelic variant in Caucasian and African-American subjects.

PubMed ID: 9568704

DOI: 10.2337/diabetes.47.4.685

PubMed ID: 10082652

Title: Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene.

PubMed ID: 10082652

DOI: 10.1006/bbrc.1998.0146

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11171965

Title: Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone).

PubMed ID: 11171965

DOI: 10.1073/pnas.98.4.1416

PubMed ID: 11278935

Title: Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria.

PubMed ID: 11278935

DOI: 10.1074/jbc.m011566200

PubMed ID: 22524567

Title: Toward understanding the mechanism of ion transport activity of neuronal uncoupling proteins UCP2, UCP4, and UCP5.

PubMed ID: 22524567

DOI: 10.1021/bi3003378

PubMed ID: 24395786

Title: UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation.

PubMed ID: 24395786

DOI: 10.1073/pnas.1317400111

PubMed ID: 26182433

Title: A biophysical study on molecular physiology of the uncoupling proteins of the central nervous system.

PubMed ID: 26182433

DOI: 10.1042/bsr20150130

PubMed ID: 33798544

Title: Mitochondrial proton leaks and uncoupling proteins.

PubMed ID: 33798544

DOI: 10.1016/j.bbabio.2021.148428

PubMed ID: 33373220

Title: Functional Oligomeric Forms of Uncoupling Protein 2: Strong Evidence for Asymmetry in Protein and Lipid Bilayer Systems.

PubMed ID: 33373220

DOI: 10.1021/acs.jpcb.0c09422

PubMed ID: 11381268

Title: A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans.

PubMed ID: 11381268

DOI: 10.1038/88911

Sequence Information:

  • Length: 309
  • Mass: 33229
  • Checksum: 2E1741391621E3D9
  • Sequence:
    • MVGFKATDVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGESQGP VRATASAQYR 
GVMGTILTMV RTEGPRSLYN GLVAGLQRQM SFASVRIGLY DSVKQFYTKG SEHASIGSRL 
LAGSTTGALA VAVAQPTDVV KVRFQAQARA GGGRRYQSTV NAYKTIAREE GFRGLWKGTS 
PNVARNAIVN CAELVTYDLI KDALLKANLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT 
RYMNSALGQY SSAGHCALTM LQKEGPRAFY KGFMPSFLRL GSWNVVMFVT YEQLKRALMA 
ACTSREAPF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.