Details for: ID3

Gene ID: 3399

Symbol: ID3

Ensembl ID: ENSG00000117318

Description: inhibitor of DNA binding 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.6
    Marker Score: 3599
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.96
    Marker Score: 10077
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.64
    Marker Score: 5264
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.31
    Marker Score: 1871
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.19
    Marker Score: 6380
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.04
    Marker Score: 103586
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.03
    Marker Score: 3236
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 3.02
    Marker Score: 1634
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.99
    Marker Score: 2124
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.91
    Marker Score: 4480
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.91
    Marker Score: 4115
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.9
    Marker Score: 2499
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.84
    Marker Score: 5929.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.76
    Marker Score: 4818
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.54
    Marker Score: 1819
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.53
    Marker Score: 1687
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.5
    Marker Score: 4248
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.47
    Marker Score: 2352
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.44
    Marker Score: 21457
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.42
    Marker Score: 3521
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.38
    Marker Score: 2240
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.36
    Marker Score: 3993
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.33
    Marker Score: 3030
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.31
    Marker Score: 1969
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.3
    Marker Score: 672
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.26
    Marker Score: 639
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.25
    Marker Score: 5114
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.23
    Marker Score: 2402.5
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.22
    Marker Score: 1048
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.21
    Marker Score: 2119
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.21
    Marker Score: 5783
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.2
    Marker Score: 1968
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.19
    Marker Score: 8096
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.17
    Marker Score: 4076
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.16
    Marker Score: 1355
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.15
    Marker Score: 2074
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.12
    Marker Score: 3124
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.1
    Marker Score: 705
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.1
    Marker Score: 902
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.09
    Marker Score: 940
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.07
    Marker Score: 27309
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.06
    Marker Score: 1229
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.06
    Marker Score: 6462
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.05
    Marker Score: 497
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.05
    Marker Score: 4816
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.04
    Marker Score: 22938
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.01
    Marker Score: 2424
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.99
    Marker Score: 436
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.97
    Marker Score: 457
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.96
    Marker Score: 2701
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.96
    Marker Score: 717
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.93
    Marker Score: 378
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.93
    Marker Score: 3160.5
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.92
    Marker Score: 1142
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.91
    Marker Score: 3321
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.9
    Marker Score: 980
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.88
    Marker Score: 1698
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.87
    Marker Score: 2083
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.87
    Marker Score: 530
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.86
    Marker Score: 395
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.85
    Marker Score: 7758
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.84
    Marker Score: 592
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.84
    Marker Score: 2273
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 1.83
    Marker Score: 1032
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.83
    Marker Score: 8762
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.79
    Marker Score: 419
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.78
    Marker Score: 4231
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.78
    Marker Score: 2953
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.76
    Marker Score: 4780
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.76
    Marker Score: 1768
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.75
    Marker Score: 932.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.75
    Marker Score: 402
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.72
    Marker Score: 2033
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.71
    Marker Score: 1702
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.69
    Marker Score: 10787
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.69
    Marker Score: 4255
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.67
    Marker Score: 1046
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.66
    Marker Score: 968
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.65
    Marker Score: 587
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.64
    Marker Score: 1839
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.64
    Marker Score: 1078
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.63
    Marker Score: 2974
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.62
    Marker Score: 1950.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.61
    Marker Score: 671
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.61
    Marker Score: 4449
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.6
    Marker Score: 407
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.59
    Marker Score: 458
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.57
    Marker Score: 2263
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.56
    Marker Score: 647
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.55
    Marker Score: 585
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.54
    Marker Score: 1445
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.53
    Marker Score: 1639
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.47
    Marker Score: 1720
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.46
    Marker Score: 8662
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166040
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.45
    Marker Score: 3749
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.43
    Marker Score: 457
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.42
    Marker Score: 2290
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.42
    Marker Score: 342
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.42
    Marker Score: 757

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Other Information

## Summary ID3 is a protein that acts as an inhibitor of DNA binding. It is involved in various cellular processes, including neural development, cardiovascular development, and tissue regeneration. ## Key characteristics * ID3 is a protein of the Bhlh family of transcription factors. * It is expressed in a variety of cell types, including endothelial cells, fibroblasts, and stem cells. * ID3 inhibits the binding of DNA binding proteins to DNA sequences. * It is involved in the regulation of gene expression through negative regulation of transcription by RNA polymerase II. * It is also involved in the signaling pathways of NTKRs and NRKs. ## Pathways and functions * ID3 inhibits the binding of DNA binding proteins to DNA sequences, thereby blocking their ability to regulate gene expression. * It is involved in the development and maintenance of the central nervous system. * It is also involved in the development and maintenance of the heart, vascular system, and other tissues. * It is involved in tissue regeneration by promoting the proliferation and differentiation of stem cells. ## Clinical significance ID3 is a potential therapeutic target for a variety of diseases, including heart disease, cancer, and neurodegenerative disorders. By blocking ID3 signaling, it may be possible to treat these diseases.

Genular Protein ID: 1905076350

Symbol: ID3_HUMAN

Name: DNA-binding protein inhibitor ID-3

UniProtKB Accession Codes:

Q02535 A8K1T8 O75641

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 2 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1628620

Title: Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development.

PubMed ID: 1628620

DOI: 10.1002/j.1460-2075.1992.tb05321.x

PubMed ID: 8437843

Title: An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types.

PubMed ID: 8437843

PubMed ID: 7828896

Title: Structural organisation and chromosomal mapping of the human Id-3 gene.

PubMed ID: 7828896

DOI: 10.1016/0378-1119(94)90676-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20861012

Title: The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression.

PubMed ID: 20861012

DOI: 10.1074/jbc.m110.175182

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 119
  • Mass: 12999
  • Checksum: 7FC38B56B4DCEFBC
  • Sequence:
    • MKALSPVRGC YEAVCCLSER SLAIARGRGK GPAAEEPLSL LDDMNHCYSR LRELVPGVPR 
GTQLSQVEIL QRVIDYILDL QVVLAEPAPG PPDGPHLPIQ TAELTPELVI SNDKRSFCH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.