Details for: ID3

Gene ID: 3399

Symbol: ID3

Ensembl ID: ENSG00000117318

Description: inhibitor of DNA binding 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 435.4039
    Cell Significance Index: -67.7300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 268.7632
    Cell Significance Index: -68.1700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 150.8566
    Cell Significance Index: -62.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 141.2345
    Cell Significance Index: -66.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 138.3607
    Cell Significance Index: -56.2100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 99.5198
    Cell Significance Index: -66.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 59.5029
    Cell Significance Index: -56.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 54.9817
    Cell Significance Index: -67.7900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 18.8596
    Cell Significance Index: 150.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.1108
    Cell Significance Index: -67.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.9831
    Cell Significance Index: -46.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.2706
    Cell Significance Index: -35.5500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 9.7361
    Cell Significance Index: 57.2000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.8633
    Cell Significance Index: 156.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 7.6761
    Cell Significance Index: 266.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.9432
    Cell Significance Index: 890.0800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.3350
    Cell Significance Index: 68.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.7379
    Cell Significance Index: 156.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.7162
    Cell Significance Index: 163.8600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 5.5561
    Cell Significance Index: 63.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.9585
    Cell Significance Index: 103.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.1783
    Cell Significance Index: 217.6400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.3119
    Cell Significance Index: 20.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.7201
    Cell Significance Index: 373.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.5711
    Cell Significance Index: 316.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.0521
    Cell Significance Index: 369.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8257
    Cell Significance Index: 180.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7679
    Cell Significance Index: 80.1300
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 1.5321
    Cell Significance Index: 5.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.4045
    Cell Significance Index: 620.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4032
    Cell Significance Index: 72.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1507
    Cell Significance Index: 33.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0962
    Cell Significance Index: 28.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9945
    Cell Significance Index: 21.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8643
    Cell Significance Index: 780.3900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.7768
    Cell Significance Index: 8.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6071
    Cell Significance Index: 71.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5653
    Cell Significance Index: 359.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4788
    Cell Significance Index: 901.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4496
    Cell Significance Index: 31.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3446
    Cell Significance Index: 65.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3078
    Cell Significance Index: 35.8700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2698
    Cell Significance Index: 1.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1890
    Cell Significance Index: 103.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1592
    Cell Significance Index: 2.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0661
    Cell Significance Index: 11.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0626
    Cell Significance Index: 47.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0240
    Cell Significance Index: 0.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0237
    Cell Significance Index: 36.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0206
    Cell Significance Index: 0.9700
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.0174
    Cell Significance Index: 0.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0051
    Cell Significance Index: 2.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0163
    Cell Significance Index: -30.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0183
    Cell Significance Index: -13.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0203
    Cell Significance Index: -12.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0290
    Cell Significance Index: -21.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0493
    Cell Significance Index: -5.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0538
    Cell Significance Index: -3.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0562
    Cell Significance Index: -76.4000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0607
    Cell Significance Index: -0.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0770
    Cell Significance Index: -3.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0855
    Cell Significance Index: -48.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1146
    Cell Significance Index: -22.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1238
    Cell Significance Index: -4.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1364
    Cell Significance Index: -10.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1499
    Cell Significance Index: -1.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1743
    Cell Significance Index: -25.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1907
    Cell Significance Index: -68.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2028
    Cell Significance Index: -42.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2032
    Cell Significance Index: -58.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2149
    Cell Significance Index: -3.2200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2340
    Cell Significance Index: -3.6200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2517
    Cell Significance Index: -28.7300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2553
    Cell Significance Index: -3.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2680
    Cell Significance Index: -8.5900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2695
    Cell Significance Index: -11.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2780
    Cell Significance Index: -5.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2833
    Cell Significance Index: -36.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.3484
    Cell Significance Index: -69.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3697
    Cell Significance Index: -26.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3812
    Cell Significance Index: -43.6700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4248
    Cell Significance Index: -6.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.5368
    Cell Significance Index: -58.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5967
    Cell Significance Index: -62.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6209
    Cell Significance Index: -16.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6475
    Cell Significance Index: -41.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7135
    Cell Significance Index: -56.5100
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.8177
    Cell Significance Index: -5.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8567
    Cell Significance Index: -65.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9560
    Cell Significance Index: -58.6100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.9689
    Cell Significance Index: -13.5900
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.9977
    Cell Significance Index: -5.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0651
    Cell Significance Index: -26.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.1382
    Cell Significance Index: -53.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1902
    Cell Significance Index: -62.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.2030
    Cell Significance Index: -33.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.2828
    Cell Significance Index: -80.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.5216
    Cell Significance Index: -20.7600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.5285
    Cell Significance Index: -56.1100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.6335
    Cell Significance Index: -10.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ID3 is a 44-kDa protein that belongs to the ID family of proteins, which are known for their ability to inhibit the activity of DNA-binding transcription factors. ID3 is characterized by its ability to bind to and inhibit the activity of various transcription factors, including E2F, MyoD, and C/EBPα. ID3 is also known to interact with other proteins, including NTRK1 (TrkA) and NTRK3 (TrkC), which are receptor tyrosine kinases involved in cell signaling pathways. **Pathways and Functions:** ID3 is involved in various cellular processes, including: 1. **Cell differentiation**: ID3 regulates the expression of genes involved in cell differentiation, including myogenesis and osteogenesis. 2. **Apoptosis**: ID3 promotes apoptosis by inhibiting the expression of anti-apoptotic genes. 3. **Cell cycle regulation**: ID3 regulates the expression of genes involved in cell cycle progression, including E2F target genes. 4. **Signaling pathways**: ID3 interacts with NTRK1 and NTRK3 to modulate signaling pathways involved in cell growth and differentiation. 5. **Gene expression regulation**: ID3 regulates the expression of genes involved in various cellular processes, including metabolism, growth, and development. **Clinical Significance:** Dysregulation of ID3 has been implicated in several diseases, including: 1. **Cancer**: ID3 is often downregulated in cancer cells, leading to increased cell proliferation and survival. 2. **Cardiovascular disorders**: ID3 has been implicated in the regulation of cardiac development and function, and its dysregulation has been linked to cardiovascular disorders, including heart failure. 3. **Neurological disorders**: ID3 has been implicated in the regulation of neuronal development and function, and its dysregulation has been linked to neurological disorders, including Parkinson's disease and Alzheimer's disease. 4. **Metabolic disorders**: ID3 has been implicated in the regulation of glucose metabolism and insulin signaling, and its dysregulation has been linked to metabolic disorders, including type 2 diabetes. In conclusion, ID3 is a critical regulator of gene expression and cellular differentiation, and its dysregulation has been implicated in several diseases. Further research is needed to fully understand the mechanisms by which ID3 regulates gene expression and cellular processes, and to explore its potential as a therapeutic target for the treatment of diseases.

Genular Protein ID: 1905076350

Symbol: ID3_HUMAN

Name: DNA-binding protein inhibitor ID-3

UniProtKB Accession Codes:

Q02535 A8K1T8 O75641

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1628620

Title: Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development.

PubMed ID: 1628620

DOI: 10.1002/j.1460-2075.1992.tb05321.x

PubMed ID: 8437843

Title: An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types.

PubMed ID: 8437843

PubMed ID: 7828896

Title: Structural organisation and chromosomal mapping of the human Id-3 gene.

PubMed ID: 7828896

DOI: 10.1016/0378-1119(94)90676-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20861012

Title: The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression.

PubMed ID: 20861012

DOI: 10.1074/jbc.m110.175182

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 119
  • Mass: 12999
  • Checksum: 7FC38B56B4DCEFBC
  • Sequence:
    • MKALSPVRGC YEAVCCLSER SLAIARGRGK GPAAEEPLSL LDDMNHCYSR LRELVPGVPR 
GTQLSQVEIL QRVIDYILDL QVVLAEPAPG PPDGPHLPIQ TAELTPELVI SNDKRSFCH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.