Details for: IRF8

Gene ID: 3394

Symbol: IRF8

Ensembl ID: ENSG00000140968

Description: interferon regulatory factor 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 82.9341
    Cell Significance Index: -12.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.0058
    Cell Significance Index: -12.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 41.0577
    Cell Significance Index: -16.6800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 38.8399
    Cell Significance Index: -16.0000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 34.8474
    Cell Significance Index: -17.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.5930
    Cell Significance Index: -15.8600
  • Cell Name: centroblast (CL0009112)
    Fold Change: 27.5303
    Cell Significance Index: 64.2300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 24.0081
    Cell Significance Index: -16.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.3978
    Cell Significance Index: -12.8200
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 6.6655
    Cell Significance Index: 44.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.4650
    Cell Significance Index: -14.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.7610
    Cell Significance Index: 443.5400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.4474
    Cell Significance Index: -7.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.3781
    Cell Significance Index: -13.3300
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.3117
    Cell Significance Index: 14.8100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.2363
    Cell Significance Index: 50.0700
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 2.0680
    Cell Significance Index: 5.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.8782
    Cell Significance Index: 50.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7979
    Cell Significance Index: 124.3400
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.7336
    Cell Significance Index: 5.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.3510
    Cell Significance Index: 24.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1920
    Cell Significance Index: 71.5600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.1830
    Cell Significance Index: 6.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9655
    Cell Significance Index: 95.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8825
    Cell Significance Index: 56.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8299
    Cell Significance Index: 90.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7308
    Cell Significance Index: 659.8200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.6623
    Cell Significance Index: 16.9200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.6517
    Cell Significance Index: 4.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5676
    Cell Significance Index: 16.3600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.5352
    Cell Significance Index: 4.3400
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.4037
    Cell Significance Index: 1.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3053
    Cell Significance Index: 13.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2802
    Cell Significance Index: 6.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2533
    Cell Significance Index: 48.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1892
    Cell Significance Index: 103.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1341
    Cell Significance Index: 26.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0490
    Cell Significance Index: 30.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0381
    Cell Significance Index: 5.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0060
    Cell Significance Index: -4.4400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0064
    Cell Significance Index: -0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0067
    Cell Significance Index: -12.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0087
    Cell Significance Index: -4.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0095
    Cell Significance Index: -17.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0104
    Cell Significance Index: -1.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0111
    Cell Significance Index: -17.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0113
    Cell Significance Index: -0.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0131
    Cell Significance Index: -17.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0164
    Cell Significance Index: -12.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0203
    Cell Significance Index: -14.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0245
    Cell Significance Index: -5.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0261
    Cell Significance Index: -16.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0341
    Cell Significance Index: -3.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0343
    Cell Significance Index: -1.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0367
    Cell Significance Index: -16.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0382
    Cell Significance Index: -6.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0387
    Cell Significance Index: -13.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0433
    Cell Significance Index: -12.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0452
    Cell Significance Index: -4.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0615
    Cell Significance Index: -7.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0663
    Cell Significance Index: -13.2900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0702
    Cell Significance Index: -1.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0756
    Cell Significance Index: -13.6300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1030
    Cell Significance Index: -11.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1048
    Cell Significance Index: -15.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1134
    Cell Significance Index: -5.7300
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -0.1209
    Cell Significance Index: -0.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1232
    Cell Significance Index: -15.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1296
    Cell Significance Index: -16.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1323
    Cell Significance Index: -8.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1390
    Cell Significance Index: -7.2400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1450
    Cell Significance Index: -2.1200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1596
    Cell Significance Index: -1.3200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1652
    Cell Significance Index: -1.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1752
    Cell Significance Index: -8.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1905
    Cell Significance Index: -14.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2106
    Cell Significance Index: -16.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2186
    Cell Significance Index: -16.2900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2238
    Cell Significance Index: -9.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2316
    Cell Significance Index: -15.5800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2504
    Cell Significance Index: -10.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2558
    Cell Significance Index: -13.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2596
    Cell Significance Index: -16.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2660
    Cell Significance Index: -16.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2708
    Cell Significance Index: -14.2200
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.2739
    Cell Significance Index: -1.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2787
    Cell Significance Index: -9.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2810
    Cell Significance Index: -15.7700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2849
    Cell Significance Index: -3.6000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2852
    Cell Significance Index: -3.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2991
    Cell Significance Index: -8.3600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3056
    Cell Significance Index: -5.1200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3112
    Cell Significance Index: -4.6900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3153
    Cell Significance Index: -3.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3288
    Cell Significance Index: -14.5500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.3397
    Cell Significance Index: -3.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3509
    Cell Significance Index: -12.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3571
    Cell Significance Index: -9.1800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3606
    Cell Significance Index: -6.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3608
    Cell Significance Index: -16.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation:** IRF8 acts as a transcription factor that regulates the expression of genes involved in immune responses, including cytokines, chemokines, and other immune-related genes. 2. **Cell-type specificity:** IRF8 expression is highly restricted to specific cell types, including dendritic cells, B cells, and natural killer cells, which highlights its importance in the immune system. 3. **Innate and adaptive immunity:** IRF8 plays a crucial role in both innate and adaptive immunity, regulating the response to pathogens, including bacteria and viruses. 4. **Cytokine production:** IRF8 is involved in the regulation of cytokine production, including the production of type I and type II interferons, which are critical for antiviral responses. **Pathways and Functions:** 1. **Interferon signaling:** IRF8 regulates the expression of interferon-stimulated genes (ISGs), which are critical for antiviral responses. 2. **Cytokine signaling:** IRF8 regulates the production of cytokines, including IL-12, which is essential for the development of T helper 1 (Th1) cells. 3. **Apoptosis:** IRF8 regulates the expression of pro-apoptotic genes, which are involved in the regulation of cell death. 4. **Cell differentiation:** IRF8 regulates the differentiation of dendritic cells, B cells, and natural killer cells, which are critical for the development of immune responses. **Clinical Significance:** 1. **Autoimmune disorders:** IRF8 has been implicated in the pathogenesis of autoimmune disorders, including rheumatoid arthritis and lupus. 2. **Cancer:** IRF8 has been shown to be involved in the development of various cancers, including leukemia and lymphoma. 3. **Infectious diseases:** IRF8 plays a crucial role in the regulation of immune responses to infectious diseases, including tuberculosis and HIV. 4. **Immunodeficiency diseases:** IRF8 has been implicated in the pathogenesis of immunodeficiency diseases, including severe combined immunodeficiency (SCID) and chronic granulomatous disease (CGD). In conclusion, IRF8 is a crucial regulator of immune responses and inflammation, with significant implications for the pathogenesis of various diseases. Further research is needed to fully understand the mechanisms by which IRF8 regulates immune responses and to identify potential therapeutic targets for the treatment of immune-related disorders.

Genular Protein ID: 4111121968

Symbol: IRF8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q02556 A0AV82

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 3 ExpressionAtlas 1 GO 29 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1460054

Title: Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes.

PubMed ID: 1460054

DOI: 10.1016/s0021-9258(19)74081-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10991940

Title: Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome.

PubMed ID: 10991940

DOI: 10.1074/jbc.m004900200

PubMed ID: 23166356

Title: BCL6 positively regulates AID and germinal center gene expression via repression of miR-155.

PubMed ID: 23166356

DOI: 10.1084/jem.20121387

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 21524210

Title: IRF8 mutations and human dendritic-cell immunodeficiency.

PubMed ID: 21524210

DOI: 10.1056/nejmoa1100066

PubMed ID: 25122610

Title: Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8(K108E) mutation.

PubMed ID: 25122610

DOI: 10.1182/blood-2014-04-570879

PubMed ID: 29434592

Title: Signaling lymphocyte activation molecule family 5 enhances autophagy and fine-tunes cytokine response in monocyte-derived dendritic cells via stabilization of interferon regulatory factor 8.

PubMed ID: 29434592

DOI: 10.3389/fimmu.2018.00062

PubMed ID: 33951726

Title: Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients.

PubMed ID: 33951726

DOI: 10.1084/jem.20201750

Sequence Information:

  • Length: 426
  • Mass: 48356
  • Checksum: 1535D1B7C83E0355
  • Sequence:
    • MCDRNGGRRL RQWLIEQIDS SMYPGLIWEN EEKSMFRIPW KHAGKQDYNQ EVDASIFKAW 
AVFKGKFKEG DKAEPATWKT RLRCALNKSP DFEEVTDRSQ LDISEPYKVY RIVPEEEQKC 
KLGVATAGCV NEVTEMECGR SEIDELIKEP SVDDYMGMIK RSPSPPEACR SQLLPDWWAQ 
QPSTGVPLVT GYTTYDAHHS AFSQMVISFY YGGKLVGQAT TTCPEGCRLS LSQPGLPGTK 
LYGPEGLELV RFPPADAIPS ERQRQVTRKL FGHLERGVLL HSSRQGVFVK RLCQGRVFCS 
GNAVVCKGRP NKLERDEVVQ VFDTSQFFRE LQQFYNSQGR LPDGRVVLCF GEEFPDMAPL 
RSKLILVQIE QLYVRQLAEE AGKSCGAGSV MQAPEEPPPD QVFRMFPDIC ASHQRSFFRE 
NQQITV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.