Details for: IRF8

Gene ID: 3394

Symbol: IRF8

Ensembl ID: ENSG00000140968

Description: interferon regulatory factor 8

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.95
    Marker Score: 1456
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.66
    Marker Score: 5567
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.65
    Marker Score: 7867.5
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.56
    Marker Score: 2526
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.51
    Marker Score: 6920.5
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.48
    Marker Score: 1510
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.98
    Marker Score: 1190.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.97
    Marker Score: 3439
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.97
    Marker Score: 1756
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.9
    Marker Score: 671
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.88
    Marker Score: 1426
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.77
    Marker Score: 421
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.76
    Marker Score: 762
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.76
    Marker Score: 2119
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.68
    Marker Score: 1820
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.65
    Marker Score: 1555
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.64
    Marker Score: 3341
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.62
    Marker Score: 787
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.59
    Marker Score: 367
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.56
    Marker Score: 39991
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.55
    Marker Score: 1554
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.52
    Marker Score: 620
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.51
    Marker Score: 750
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.48
    Marker Score: 2883
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.31
    Marker Score: 906
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.3
    Marker Score: 72806
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.2
    Marker Score: 434
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.2
    Marker Score: 703
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.18
    Marker Score: 1418.5
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.15
    Marker Score: 1096
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.12
    Marker Score: 1280
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.11
    Marker Score: 2760
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.1
    Marker Score: 1799
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.08
    Marker Score: 2610
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.06
    Marker Score: 2871
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.05
    Marker Score: 6391
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.04
    Marker Score: 273
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.01
    Marker Score: 348
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71762
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47988
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.97
    Marker Score: 473
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.96
    Marker Score: 3968
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 492
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.95
    Marker Score: 11066
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.95
    Marker Score: 2463
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.95
    Marker Score: 3517
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 446
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.92
    Marker Score: 9338
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.92
    Marker Score: 631
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.92
    Marker Score: 607
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5210
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2723
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.91
    Marker Score: 2647
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5262
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.87
    Marker Score: 549
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.85
    Marker Score: 275
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.85
    Marker Score: 212
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.82
    Marker Score: 1547
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.81
    Marker Score: 1844
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.81
    Marker Score: 594.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.79
    Marker Score: 12371
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.78
    Marker Score: 431
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 592
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.77
    Marker Score: 513
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.77
    Marker Score: 615
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.76
    Marker Score: 517
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.75
    Marker Score: 835
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 301
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.74
    Marker Score: 758
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.74
    Marker Score: 474
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.72
    Marker Score: 250
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.72
    Marker Score: 364
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.72
    Marker Score: 800
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 637
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.7
    Marker Score: 1118
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.69
    Marker Score: 166
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2889.5
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.68
    Marker Score: 282
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.66
    Marker Score: 449
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.65
    Marker Score: 467
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.64
    Marker Score: 344
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.64
    Marker Score: 239
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.62
    Marker Score: 1481
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.62
    Marker Score: 139
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.61
    Marker Score: 264
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.6
    Marker Score: 780
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.6
    Marker Score: 1089.5
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.58
    Marker Score: 172
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.57
    Marker Score: 196
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.57
    Marker Score: 197
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.56
    Marker Score: 135
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 438
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.55
    Marker Score: 2631.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.54
    Marker Score: 2199

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Other Information

**Key characteristics:** - IRF8 is a member of the interferon regulatory factor family of transcription factors. - It is expressed in high levels in cells that are involved in immune surveillance, such as dendritic cells and macrophages. - IRF8 is a key regulator of the immune response. - It is involved in the regulation of inflammation, tolerance, and cell death. **Pathways and functions:** - IRF8 is a key regulator of autophagy, a process by which cells break down and recycle their own components. - It is also involved in the regulation of cytokine signaling, DNA-binding transcription factor activity, and rna polymerase ii-specific transcription. - IRF8 is essential for the differentiation of plasma cells and memory B cells. - It is also involved in the regulation of B-1 B cell activation. **Clinical significance:** Mutations in the IRF8 gene have been linked to a number of autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. These mutations can lead to the overactivation of the immune system, resulting in inflammation and tissue damage. **Conclusion:** IRF8 is an essential transcription factor that plays a critical role in regulating the immune response. Its overexpression is associated with a number of autoimmune diseases, highlighting its importance in maintaining immune homeostasis.

Genular Protein ID: 4111121968

Symbol: IRF8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q02556 A0AV82

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 3 ExpressionAtlas 1 GO 29 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1460054

Title: Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes.

PubMed ID: 1460054

DOI: 10.1016/s0021-9258(19)74081-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10991940

Title: Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome.

PubMed ID: 10991940

DOI: 10.1074/jbc.m004900200

PubMed ID: 23166356

Title: BCL6 positively regulates AID and germinal center gene expression via repression of miR-155.

PubMed ID: 23166356

DOI: 10.1084/jem.20121387

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 21524210

Title: IRF8 mutations and human dendritic-cell immunodeficiency.

PubMed ID: 21524210

DOI: 10.1056/nejmoa1100066

PubMed ID: 25122610

Title: Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8(K108E) mutation.

PubMed ID: 25122610

DOI: 10.1182/blood-2014-04-570879

PubMed ID: 29434592

Title: Signaling lymphocyte activation molecule family 5 enhances autophagy and fine-tunes cytokine response in monocyte-derived dendritic cells via stabilization of interferon regulatory factor 8.

PubMed ID: 29434592

DOI: 10.3389/fimmu.2018.00062

PubMed ID: 33951726

Title: Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients.

PubMed ID: 33951726

DOI: 10.1084/jem.20201750

Sequence Information:

  • Length: 426
  • Mass: 48356
  • Checksum: 1535D1B7C83E0355
  • Sequence:
    • MCDRNGGRRL RQWLIEQIDS SMYPGLIWEN EEKSMFRIPW KHAGKQDYNQ EVDASIFKAW 
AVFKGKFKEG DKAEPATWKT RLRCALNKSP DFEEVTDRSQ LDISEPYKVY RIVPEEEQKC 
KLGVATAGCV NEVTEMECGR SEIDELIKEP SVDDYMGMIK RSPSPPEACR SQLLPDWWAQ 
QPSTGVPLVT GYTTYDAHHS AFSQMVISFY YGGKLVGQAT TTCPEGCRLS LSQPGLPGTK 
LYGPEGLELV RFPPADAIPS ERQRQVTRKL FGHLERGVLL HSSRQGVFVK RLCQGRVFCS 
GNAVVCKGRP NKLERDEVVQ VFDTSQFFRE LQQFYNSQGR LPDGRVVLCF GEEFPDMAPL 
RSKLILVQIE QLYVRQLAEE AGKSCGAGSV MQAPEEPPPD QVFRMFPDIC ASHQRSFFRE 
NQQITV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.