Details for: HSPA6

Gene ID: 3310

Symbol: HSPA6

Ensembl ID: ENSG00000173110

Description: heat shock protein family A (Hsp70) member 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 151.8529
    Cell Significance Index: -23.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 94.0691
    Cell Significance Index: -23.8600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 49.2432
    Cell Significance Index: -25.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.4573
    Cell Significance Index: -23.9900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 11.5472
    Cell Significance Index: 67.8400
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 11.4756
    Cell Significance Index: 43.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.2315
    Cell Significance Index: -24.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 7.9363
    Cell Significance Index: 227.5000
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 7.4511
    Cell Significance Index: 27.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1124
    Cell Significance Index: -24.1200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 4.8081
    Cell Significance Index: 37.0600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.3510
    Cell Significance Index: 26.7600
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.2780
    Cell Significance Index: 8.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1475
    Cell Significance Index: 60.2500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.0556
    Cell Significance Index: 8.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7805
    Cell Significance Index: 148.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6999
    Cell Significance Index: 18.4100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.6899
    Cell Significance Index: -1.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5696
    Cell Significance Index: 19.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5607
    Cell Significance Index: 55.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5351
    Cell Significance Index: 483.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5122
    Cell Significance Index: 60.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2912
    Cell Significance Index: 57.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2456
    Cell Significance Index: 12.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2041
    Cell Significance Index: 33.2000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1968
    Cell Significance Index: 2.5200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1863
    Cell Significance Index: 0.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1157
    Cell Significance Index: 7.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0877
    Cell Significance Index: 11.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0739
    Cell Significance Index: 8.0400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0706
    Cell Significance Index: 1.3100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0640
    Cell Significance Index: 0.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0564
    Cell Significance Index: 0.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0341
    Cell Significance Index: 21.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0247
    Cell Significance Index: 2.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0235
    Cell Significance Index: 10.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0207
    Cell Significance Index: 15.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0174
    Cell Significance Index: 1.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0170
    Cell Significance Index: 2.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0012
    Cell Significance Index: 0.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0046
    Cell Significance Index: -0.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0076
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0133
    Cell Significance Index: -9.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0137
    Cell Significance Index: -7.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0313
    Cell Significance Index: -9.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0344
    Cell Significance Index: -25.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0352
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0375
    Cell Significance Index: -6.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0411
    Cell Significance Index: -22.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0417
    Cell Significance Index: -8.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0479
    Cell Significance Index: -17.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0692
    Cell Significance Index: -3.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0797
    Cell Significance Index: -5.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0805
    Cell Significance Index: -14.5100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.0933
    Cell Significance Index: -0.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0939
    Cell Significance Index: -4.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0997
    Cell Significance Index: -4.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1002
    Cell Significance Index: -11.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1069
    Cell Significance Index: -21.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1152
    Cell Significance Index: -3.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1163
    Cell Significance Index: -2.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1191
    Cell Significance Index: -14.6400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1356
    Cell Significance Index: -5.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1362
    Cell Significance Index: -3.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1515
    Cell Significance Index: -22.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1654
    Cell Significance Index: -21.3700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1845
    Cell Significance Index: -21.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2083
    Cell Significance Index: -14.7300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2390
    Cell Significance Index: -3.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2573
    Cell Significance Index: -19.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2608
    Cell Significance Index: -15.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2711
    Cell Significance Index: -3.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3066
    Cell Significance Index: -18.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3199
    Cell Significance Index: -24.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3199
    Cell Significance Index: -5.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3315
    Cell Significance Index: -20.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3692
    Cell Significance Index: -23.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3744
    Cell Significance Index: -10.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3825
    Cell Significance Index: -14.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3949
    Cell Significance Index: -24.2700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4011
    Cell Significance Index: -5.7100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.4157
    Cell Significance Index: -5.8400
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.4402
    Cell Significance Index: -3.0700
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.4472
    Cell Significance Index: -4.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4551
    Cell Significance Index: -25.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4673
    Cell Significance Index: -12.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4743
    Cell Significance Index: -15.1900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.4897
    Cell Significance Index: -7.1100
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.4984
    Cell Significance Index: -2.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5433
    Cell Significance Index: -24.0300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5446
    Cell Significance Index: -3.6900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.5582
    Cell Significance Index: -2.4300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5810
    Cell Significance Index: -3.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5981
    Cell Significance Index: -15.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6101
    Cell Significance Index: -12.7700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.6121
    Cell Significance Index: -19.3600
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.6170
    Cell Significance Index: -4.4400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6234
    Cell Significance Index: -21.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6362
    Cell Significance Index: -24.0900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6434
    Cell Significance Index: -11.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HSPA6 is a 76 kDa protein that belongs to the Hsp70 family, characterized by its ability to bind to unfolded or misfolded proteins, preventing their aggregation and promoting their proper folding. It has a high affinity for hydrophobic regions of proteins and can interact with various molecular chaperones, including Hsp90 and Hsp70. HSPA6 is also a substrate of the heat shock transcription factor 1 (HSF1), which regulates its expression in response to heat shock and other stress stimuli. Its expression is induced by various stressors, including heat, oxidative stress, and inflammatory signals. **Pathways and Functions** HSPA6 is involved in several cellular pathways, including: 1. **ATP-dependent protein folding chaperone pathway**: HSPA6 assists in the proper folding of proteins by binding to unfolded or misfolded proteins and promoting their refolding. 2. **Cellular responses to stimuli pathway**: HSPA6 is induced by various stressors, including heat shock, oxidative stress, and inflammatory signals, and plays a crucial role in regulating the heat shock response. 3. **Regulation of HSF1-mediated heat shock response pathway**: HSPA6 is a substrate of HSF1, which regulates its expression in response to heat shock and other stress stimuli. 4. **Protein refolding pathway**: HSPA6 participates in the refolding of proteins that have been denatured or misfolded due to various stressors. **Clinical Significance** HSPA6 has been implicated in various diseases and disorders, including: 1. **Cancer**: HSPA6 overexpression has been observed in several types of cancer, including breast, lung, and colon cancer, suggesting its potential role in tumorigenesis and cancer progression. 2. **Neurodegenerative diseases**: HSPA6 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where its dysregulation may contribute to protein misfolding and aggregation. 3. **Inflammatory disorders**: HSPA6 has been shown to play a role in regulating the inflammatory response, and its dysregulation may contribute to the development of inflammatory disorders, such as arthritis and atherosclerosis. 4. **Stress response**: HSPA6 is a key regulator of the cellular stress response, and its dysregulation may contribute to the development of stress-related disorders, such as heat shock and oxidative stress. In conclusion, HSPA6 is a crucial molecular chaperone that plays a vital role in maintaining protein homeostasis and cellular stress resistance. Its dysregulation has been implicated in various diseases and disorders, highlighting its potential as a therapeutic target for the treatment of various diseases and disorders.

Genular Protein ID: 3366780090

Symbol: HSP76_HUMAN

Name: Heat shock 70 kDa protein 6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2327978

Title: The human heat-shock protein family. Expression of a novel heat-inducible HSP70 (HSP70B') and isolation of its cDNA and genomic DNA.

PubMed ID: 2327978

DOI: 10.1042/bj2670125

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1346391

Title: The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1.

PubMed ID: 1346391

DOI: 10.1016/0888-7543(92)90409-l

PubMed ID: 3184191

Title: Cis-acting elements involved in the regulated expression of a human HSP70 gene.

PubMed ID: 3184191

DOI: 10.1016/0022-2836(88)90094-0

PubMed ID: 23921388

Title: Identification and characterization of a novel human methyltransferase modulating Hsp70 function through lysine methylation.

PubMed ID: 23921388

DOI: 10.1074/jbc.m113.483248

PubMed ID: 26865365

Title: The human HSP70 family of chaperones: where do we stand?

PubMed ID: 26865365

DOI: 10.1007/s12192-016-0676-6

PubMed ID: 20072699

Title: Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78.

PubMed ID: 20072699

DOI: 10.1371/journal.pone.0008625

Sequence Information:

  • Length: 643
  • Mass: 71028
  • Checksum: BCE348F0226DB70B
  • Sequence:
  • MQAPRELAVG IDLGTTYSCV GVFQQGRVEI LANDQGNRTT PSYVAFTDTE RLVGDAAKSQ 
    AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFRVVSEG GKPKVRVCYR GEDKTFYPEE 
    ISSMVLSKMK ETAEAYLGQP VKHAVITVPA YFNDSQRQAT KDAGAIAGLN VLRIINEPTA 
    AAIAYGLDRR GAGERNVLIF DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV 
    NHFMEEFRRK HGKDLSGNKR ALRRLRTACE RAKRTLSSST QATLEIDSLF EGVDFYTSIT 
    RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDVVLVG GSTRIPKVQK LLQDFFNGKE 
    LNKSINPDEA VAYGAAVQAA VLMGDKCEKV QDLLLLDVAP LSLGLETAGG VMTTLIQRNA 
    TIPTKQTQTF TTYSDNQPGV FIQVYEGERA MTKDNNLLGR FELSGIPPAP RGVPQIEVTF 
    DIDANGILSV TATDRSTGKA NKITITNDKG RLSKEEVERM VHEAEQYKAE DEAQRDRVAA 
    KNSLEAHVFH VKGSLQEESL RDKIPEEDRR KMQDKCREVL AWLEHNQLAE KEEYEHQKRE 
    LEQICRPIFS RLYGGPGVPG GSSCGTQARQ GDPSTGPIIE EVD

Genular Protein ID: 3866297538

Symbol: B3KSM6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 643
  • Mass: 70972
  • Checksum: E5121DEC9E04132D
  • Sequence:
  • MQAPRELAVG IDLGTTYSCA GVFQQGRVEI LANDQGNRTT PSYVAFTDTE RLVGDAAKSQ 
    AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFRVVSEG GKPKVRVCYR GEDKTFYPEE 
    ISSMVLSKMK ETAEAYLGQP VKHAVITVPA YFNDSQRQAT KDAGAIAGLN VLRIINEPTA 
    AAIAYGLDRR GAGERNVLIF DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV 
    NHFMEEFRRK HGKDLSGNKR ALRRLRTACE RAKRTLSSST QATLEIDSLF EGVDFYTSIT 
    RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDVVLVG GSTRIPKVQK LLQDFFNGKE 
    LNKSINPDEA VAYGAAAQAA VLMGDKCEKV QDLLLLDVAP LSLGLETAGG VMTTLIQRNA 
    TIPTKQTQTF TTYSDNQPGV FIQVYEGERA MTKDNNLLGR FELSGIPPAP RGVPQIEVTF 
    DIDANGILSV TATDRSTGKA NKITITNDKG RLSKEEVERM VHEAEQYKAE DEAQRDRVAA 
    KNSLEAHVFH VKGSLQEESL RDKIPEEDRR KMQDKCREVL AWLEHNQLAE KEEYEHQKRE 
    LEQICRPIFS RLYGGPGVPG GSSCGTQARQ GDPSTGPIIE EVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.