Details for: HSPA6

Gene ID: 3310

Symbol: HSPA6

Ensembl ID: ENSG00000173110

Description: heat shock protein family A (Hsp70) member 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 4.18
    Marker Score: 5139
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 3.7
    Marker Score: 1325
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 3.64
    Marker Score: 1657
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.38
    Marker Score: 80868
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.02
    Marker Score: 1720
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 1.96
    Marker Score: 763
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.78
    Marker Score: 2559.5
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.72
    Marker Score: 1229
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.57
    Marker Score: 1175.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.57
    Marker Score: 1477
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.47
    Marker Score: 5425
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.43
    Marker Score: 1782.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.27
    Marker Score: 1334.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.22
    Marker Score: 1477
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.18
    Marker Score: 1812
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.18
    Marker Score: 2290
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.16
    Marker Score: 2365.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.14
    Marker Score: 2382
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.13
    Marker Score: 819
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.03
    Marker Score: 1796
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71760
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47985
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.95
    Marker Score: 2372
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.95
    Marker Score: 507
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.93
    Marker Score: 6198
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.93
    Marker Score: 627
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.92
    Marker Score: 1906
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2720
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 360
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9
    Marker Score: 599
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.89
    Marker Score: 1261
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5261
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.85
    Marker Score: 1026
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.84
    Marker Score: 470
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.83
    Marker Score: 568
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.81
    Marker Score: 1250
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.81
    Marker Score: 2092
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.8
    Marker Score: 284
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.78
    Marker Score: 785
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.77
    Marker Score: 385
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.77
    Marker Score: 1006
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.76
    Marker Score: 42473
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 568
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.74
    Marker Score: 174
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 674
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.74
    Marker Score: 307
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.74
    Marker Score: 500
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.73
    Marker Score: 833
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.71
    Marker Score: 473.5
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.71
    Marker Score: 500
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.7
    Marker Score: 437
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.69
    Marker Score: 689
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2875.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.68
    Marker Score: 1390
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.68
    Marker Score: 432
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.67
    Marker Score: 218
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.67
    Marker Score: 331
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.67
    Marker Score: 6607
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.66
    Marker Score: 1089.5
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.66
    Marker Score: 713
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.65
    Marker Score: 397
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.65
    Marker Score: 172
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.65
    Marker Score: 390
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.64
    Marker Score: 185
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.64
    Marker Score: 429
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.64
    Marker Score: 464
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.64
    Marker Score: 265
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.63
    Marker Score: 1156
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.63
    Marker Score: 2624
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.62
    Marker Score: 358.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.62
    Marker Score: 1688.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.62
    Marker Score: 1737
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.62
    Marker Score: 440
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.61
    Marker Score: 647
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.6
    Marker Score: 1190
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.58
    Marker Score: 262
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.57
    Marker Score: 676
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.57
    Marker Score: 480
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.56
    Marker Score: 8823.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.55
    Marker Score: 166
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.54
    Marker Score: 138
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.54
    Marker Score: 186
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.54
    Marker Score: 224
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.53
    Marker Score: 590
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.53
    Marker Score: 216
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.53
    Marker Score: 227
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.52
    Marker Score: 986
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.52
    Marker Score: 351
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.52
    Marker Score: 266
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.52
    Marker Score: 1264

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Other Information

**Key characteristics:** - HSPA6 is a chaperone that helps to prevent the aggregation and misfolding of proteins. - It is a key regulator of the heat shock response and is expressed in cells that are exposed to high temperatures. - HSPA6 is also involved in the regulation of inflammation and immune responses. **Pathways and functions:** - HSPA6 is involved in the folding and stability of various proteins, including those involved in the heat shock response, protein folding chaperones, and immune responses. - It is a key regulator of the heat shock response, which is a protective mechanism that helps cells to survive heat stress. - HSPA6 is also involved in the regulation of inflammation and immune responses. **Clinical significance:** - HSPA6 mutations can lead to the development of heat stress-related diseases, such as heat stroke and heat exhaustion. - Targeting HSPA6 has been investigated as a therapeutic strategy for these diseases. **Additional information:** - HSPA6 is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. - It is a member of the HSP70 family of chaperones, which are a large group of proteins that are involved in the folding and stability of proteins. - HSPA6 is a well-characterized protein that has been extensively studied for its role in heat stress response and protein folding.

Genular Protein ID: 3366780090

Symbol: HSP76_HUMAN

Name: Heat shock 70 kDa protein 6

UniProtKB Accession Codes:

P17066 Q1HBA8 Q8IYK7 Q9BT95

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2327978

Title: The human heat-shock protein family. Expression of a novel heat-inducible HSP70 (HSP70B') and isolation of its cDNA and genomic DNA.

PubMed ID: 2327978

DOI: 10.1042/bj2670125

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1346391

Title: The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1.

PubMed ID: 1346391

DOI: 10.1016/0888-7543(92)90409-l

PubMed ID: 3184191

Title: Cis-acting elements involved in the regulated expression of a human HSP70 gene.

PubMed ID: 3184191

DOI: 10.1016/0022-2836(88)90094-0

PubMed ID: 23921388

Title: Identification and characterization of a novel human methyltransferase modulating Hsp70 function through lysine methylation.

PubMed ID: 23921388

DOI: 10.1074/jbc.m113.483248

PubMed ID: 26865365

Title: The human HSP70 family of chaperones: where do we stand?

PubMed ID: 26865365

DOI: 10.1007/s12192-016-0676-6

PubMed ID: 20072699

Title: Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78.

PubMed ID: 20072699

DOI: 10.1371/journal.pone.0008625

Sequence Information:

  • Length: 643
  • Mass: 71028
  • Checksum: BCE348F0226DB70B
  • Sequence:
    • MQAPRELAVG IDLGTTYSCV GVFQQGRVEI LANDQGNRTT PSYVAFTDTE RLVGDAAKSQ 
AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFRVVSEG GKPKVRVCYR GEDKTFYPEE 
ISSMVLSKMK ETAEAYLGQP VKHAVITVPA YFNDSQRQAT KDAGAIAGLN VLRIINEPTA 
AAIAYGLDRR GAGERNVLIF DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV 
NHFMEEFRRK HGKDLSGNKR ALRRLRTACE RAKRTLSSST QATLEIDSLF EGVDFYTSIT 
RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDVVLVG GSTRIPKVQK LLQDFFNGKE 
LNKSINPDEA VAYGAAVQAA VLMGDKCEKV QDLLLLDVAP LSLGLETAGG VMTTLIQRNA 
TIPTKQTQTF TTYSDNQPGV FIQVYEGERA MTKDNNLLGR FELSGIPPAP RGVPQIEVTF 
DIDANGILSV TATDRSTGKA NKITITNDKG RLSKEEVERM VHEAEQYKAE DEAQRDRVAA 
KNSLEAHVFH VKGSLQEESL RDKIPEEDRR KMQDKCREVL AWLEHNQLAE KEEYEHQKRE 
LEQICRPIFS RLYGGPGVPG GSSCGTQARQ GDPSTGPIIE EVD

Genular Protein ID: 3866297538

Symbol: B3KSM6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KSM6

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 3 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 3

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 643
  • Mass: 70972
  • Checksum: E5121DEC9E04132D
  • Sequence:
    • MQAPRELAVG IDLGTTYSCA GVFQQGRVEI LANDQGNRTT PSYVAFTDTE RLVGDAAKSQ 
AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFRVVSEG GKPKVRVCYR GEDKTFYPEE 
ISSMVLSKMK ETAEAYLGQP VKHAVITVPA YFNDSQRQAT KDAGAIAGLN VLRIINEPTA 
AAIAYGLDRR GAGERNVLIF DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV 
NHFMEEFRRK HGKDLSGNKR ALRRLRTACE RAKRTLSSST QATLEIDSLF EGVDFYTSIT 
RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDVVLVG GSTRIPKVQK LLQDFFNGKE 
LNKSINPDEA VAYGAAAQAA VLMGDKCEKV QDLLLLDVAP LSLGLETAGG VMTTLIQRNA 
TIPTKQTQTF TTYSDNQPGV FIQVYEGERA MTKDNNLLGR FELSGIPPAP RGVPQIEVTF 
DIDANGILSV TATDRSTGKA NKITITNDKG RLSKEEVERM VHEAEQYKAE DEAQRDRVAA 
KNSLEAHVFH VKGSLQEESL RDKIPEEDRR KMQDKCREVL AWLEHNQLAE KEEYEHQKRE 
LEQICRPIFS RLYGGPGVPG GSSCGTQARQ GDPSTGPIIE EVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.