TRBC2 | ENSG00000211772 | NCBI 28638

Details for: TRBC2

Gene ID: 28638

Symbol: TRBC2

Ensembl ID: ENSG00000211772

Description: T cell receptor beta constant 2

Associated with

Adaptive immune response
(GO:0002250)
Alpha-beta t cell activation
(GO:0046631)
Alpha-beta t cell receptor complex
(GO:0042105)
Plasma membrane
(GO:0005886)
T cell receptor signaling pathway
(GO:0050852)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 4.68
Marker Score: 8,027
Cell Name: mature T cell (CL0002419)
Fold Change: 3.62
Marker Score: 35,835
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.5
Marker Score: 9,809
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 3.4
Marker Score: 6,071
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 3.39
Marker Score: 2,460
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 3.22
Marker Score: 2,737
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 3.19
Marker Score: 1,640
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.16
Marker Score: 2,779
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.09
Marker Score: 1,545
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.08
Marker Score: 2,590
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 3.01
Marker Score: 979
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2.95
Marker Score: 2,758
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.94
Marker Score: 2,843
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 2.85
Marker Score: 993
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.78
Marker Score: 3,937
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.77
Marker Score: 7,664
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 2.77
Marker Score: 8,097
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 2.76
Marker Score: 850
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.66
Marker Score: 826
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 2.59
Marker Score: 6,325
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 2.58
Marker Score: 684
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 2.54
Marker Score: 134,547
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.52
Marker Score: 10,819
Cell Name: memory T cell (CL0000813)
Fold Change: 2.43
Marker Score: 1,043
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.42
Marker Score: 1,044
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 2.4
Marker Score: 3,530
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 2.35
Marker Score: 1,698
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.34
Marker Score: 7,388
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.32
Marker Score: 9,499
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 2.25
Marker Score: 2,424
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 2.24
Marker Score: 4,390
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.18
Marker Score: 3,698
Cell Name: thymocyte (CL0000893)
Fold Change: 2.16
Marker Score: 2,258
Cell Name: blood cell (CL0000081)
Fold Change: 2.1
Marker Score: 24,449
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.1
Marker Score: 3,664
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 2.04
Marker Score: 1,548
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 2
Marker Score: 1,780
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 1.99
Marker Score: 1,651
Cell Name: naive B cell (CL0000788)
Fold Change: 1.98
Marker Score: 1,766
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 1.93
Marker Score: 1,900
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.9
Marker Score: 1,092
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 1.88
Marker Score: 572
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 1.87
Marker Score: 1,410
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 1.8
Marker Score: 1,693
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 1.8
Marker Score: 1,003
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 1.74
Marker Score: 3,651
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 1.73
Marker Score: 1,270
Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.71
Marker Score: 393
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 1.69
Marker Score: 383
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.65
Marker Score: 969
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.64
Marker Score: 987
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.62
Marker Score: 575
Cell Name: memory B cell (CL0000787)
Fold Change: 1.61
Marker Score: 1,220
Cell Name: ILC1, human (CL0001077)
Fold Change: 1.61
Marker Score: 408
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.57
Marker Score: 1,143
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 1.56
Marker Score: 764
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 1.52
Marker Score: 1,021
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.48
Marker Score: 1,480
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.48
Marker Score: 1,164
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167,672
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 1.46
Marker Score: 899
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 1.42
Marker Score: 3,192
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 1.41
Marker Score: 309
Cell Name: Unknown (CL0000548)
Fold Change: 1.34
Marker Score: 974
Cell Name: regulatory T cell (CL0000815)
Fold Change: 1.32
Marker Score: 1,462
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 1.27
Marker Score: 655
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.23
Marker Score: 835
Cell Name: naive T cell (CL0000898)
Fold Change: 1.21
Marker Score: 777
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 1.19
Marker Score: 700
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 1.19
Marker Score: 392
Cell Name: T follicular regulatory cell (CL0009113)
Fold Change: 1.17
Marker Score: 318
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 1.17
Marker Score: 264
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 1.13
Marker Score: 392
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 1.13
Marker Score: 929
Cell Name: goblet cell (CL0000160)
Fold Change: 1.11
Marker Score: 7,409
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 1.11
Marker Score: 505
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 1.05
Marker Score: 813
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.99
Marker Score: 1,072
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 497
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 452
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.95
Marker Score: 228
Cell Name: mature B cell (CL0000785)
Fold Change: 0.95
Marker Score: 697
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,408
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.94
Marker Score: 396
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.94
Marker Score: 1,016
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,289
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.91
Marker Score: 365
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,723
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 319
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.88
Marker Score: 1,431
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,276
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 0.87
Marker Score: 278
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.86
Marker Score: 433
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.83
Marker Score: 291
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.81
Marker Score: 712
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 0.78
Marker Score: 306
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,264
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.78
Marker Score: 472
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 592

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics** TRBC2 is a member of the TCR beta constant family, which is characterized by its ability to form a stable complex with the TCR alpha chain. This complex is essential for the recognition of antigens presented by major histocompatibility complex (MHC) molecules. TRBC2 is highly conserved across species, suggesting its critical role in T cell function. The gene is also highly expressed in T cell subsets, including naive and memory T cells, which are essential for immune responses. **Pathways and Functions** TRBC2 is involved in several key pathways, including: 1. **Adaptive immune response**: TRBC2 is essential for the recognition of antigens and the activation of T cells, which is a critical step in the adaptive immune response. 2. **Alpha-beta T cell activation**: TRBC2 plays a key role in the activation of alpha-beta T cells, which is a critical step in the immune response. 3. **T cell receptor signaling pathway**: TRBC2 is involved in the signaling pathway that occurs upon TCR engagement, which is essential for T cell activation and proliferation. 4. **Plasma membrane**: TRBC2 is embedded in the plasma membrane, where it interacts with other proteins and lipids to form a stable complex. **Functions** The primary function of TRBC2 is to form a stable complex with the TCR alpha chain, which is essential for T cell recognition and activation. TRBC2 also plays a role in the regulation of T cell function, including: 1. **T cell proliferation**: TRBC2 is involved in the regulation of T cell proliferation, which is critical for the expansion of activated T cells. 2. **T cell differentiation**: TRBC2 is involved in the regulation of T cell differentiation, which is critical for the development of effector T cells. 3. **T cell survival**: TRBC2 is involved in the regulation of T cell survival, which is critical for the maintenance of T cell populations. **Clinical Significance** Dysregulation of TRBC2 has been implicated in several immune-related disorders, including: 1. **Autoimmune diseases**: Dysregulation of TRBC2 has been implicated in autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Cancer**: Dysregulation of TRBC2 has been implicated in cancer, including T cell lymphomas and leukemias. 3. **Vaccine responses**: TRBC2 is essential for the recognition of antigens presented by MHC molecules, and dysregulation of TRBC2 can impair vaccine responses. In conclusion, TRBC2 is a critical gene involved in the adaptive immune response, and its dysregulation has been implicated in several immune-related disorders. Further research is needed to fully understand the mechanisms by which TRBC2 regulates T cell function and to develop therapeutic strategies to modulate TRBC2 expression.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.