Details for: TRBC2

Gene ID: 28638

Symbol: TRBC2

Ensembl ID: ENSG00000211772

Description: T cell receptor beta constant 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 82.7775
    Cell Significance Index: -34.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.0704
    Cell Significance Index: -34.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 56.8920
    Cell Significance Index: -26.8600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 19.1087
    Cell Significance Index: 51.1900
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 8.5182
    Cell Significance Index: 69.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.3558
    Cell Significance Index: -16.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.3763
    Cell Significance Index: 109.4000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.3420
    Cell Significance Index: 33.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5008
    Cell Significance Index: 68.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1066
    Cell Significance Index: 210.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8935
    Cell Significance Index: 88.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7522
    Cell Significance Index: 679.1700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.7252
    Cell Significance Index: 11.2200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.6895
    Cell Significance Index: 3.7600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.4687
    Cell Significance Index: 4.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3904
    Cell Significance Index: 63.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2706
    Cell Significance Index: 31.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2015
    Cell Significance Index: 5.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1900
    Cell Significance Index: 20.6700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0767
    Cell Significance Index: 1.0900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0489
    Cell Significance Index: 0.5200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0070
    Cell Significance Index: 0.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0125
    Cell Significance Index: -0.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0132
    Cell Significance Index: -24.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0151
    Cell Significance Index: -6.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0169
    Cell Significance Index: -0.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0239
    Cell Significance Index: -1.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0254
    Cell Significance Index: -19.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0333
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0384
    Cell Significance Index: -28.4400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0406
    Cell Significance Index: -1.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0475
    Cell Significance Index: -26.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0477
    Cell Significance Index: -35.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0504
    Cell Significance Index: -1.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0544
    Cell Significance Index: -34.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0694
    Cell Significance Index: -31.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0739
    Cell Significance Index: -26.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0896
    Cell Significance Index: -2.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0914
    Cell Significance Index: -1.9800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1143
    Cell Significance Index: -4.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1190
    Cell Significance Index: -23.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1285
    Cell Significance Index: -25.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1375
    Cell Significance Index: -18.8800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1470
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1572
    Cell Significance Index: -26.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1578
    Cell Significance Index: -20.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1596
    Cell Significance Index: -28.7700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1852
    Cell Significance Index: -1.6200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1972
    Cell Significance Index: -1.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2034
    Cell Significance Index: -12.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2165
    Cell Significance Index: -15.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2208
    Cell Significance Index: -27.1500
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.2215
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2361
    Cell Significance Index: -27.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2367
    Cell Significance Index: -30.5800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2374
    Cell Significance Index: -3.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2376
    Cell Significance Index: -34.5400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2380
    Cell Significance Index: -2.8100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2384
    Cell Significance Index: -2.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2403
    Cell Significance Index: -4.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2405
    Cell Significance Index: -25.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2490
    Cell Significance Index: -25.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2505
    Cell Significance Index: -11.7800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2661
    Cell Significance Index: -4.5200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2728
    Cell Significance Index: -3.9900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2747
    Cell Significance Index: -4.1400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2761
    Cell Significance Index: -2.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3171
    Cell Significance Index: -24.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3228
    Cell Significance Index: -19.3800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.3433
    Cell Significance Index: -2.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3442
    Cell Significance Index: -25.6600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.3888
    Cell Significance Index: -3.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.4099
    Cell Significance Index: -3.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4174
    Cell Significance Index: -26.3100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.4378
    Cell Significance Index: -4.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4450
    Cell Significance Index: -24.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4535
    Cell Significance Index: -23.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4651
    Cell Significance Index: -24.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4740
    Cell Significance Index: -30.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4827
    Cell Significance Index: -10.2800
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.5493
    Cell Significance Index: -4.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5579
    Cell Significance Index: -26.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5661
    Cell Significance Index: -25.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6309
    Cell Significance Index: -12.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6647
    Cell Significance Index: -25.1700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.6856
    Cell Significance Index: -5.8400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7134
    Cell Significance Index: -26.1900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.7216
    Cell Significance Index: -7.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7326
    Cell Significance Index: -25.6700
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.7739
    Cell Significance Index: -7.5800
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.7997
    Cell Significance Index: -5.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8318
    Cell Significance Index: -17.4100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8340
    Cell Significance Index: -27.3100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.8357
    Cell Significance Index: -10.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8440
    Cell Significance Index: -26.8800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.8471
    Cell Significance Index: -6.5900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.8690
    Cell Significance Index: -14.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8726
    Cell Significance Index: -23.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8912
    Cell Significance Index: -18.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8972
    Cell Significance Index: -24.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TRBC2 is a member of the TCR beta constant family, which is characterized by its ability to form a stable complex with the TCR alpha chain. This complex is essential for the recognition of antigens presented by major histocompatibility complex (MHC) molecules. TRBC2 is highly conserved across species, suggesting its critical role in T cell function. The gene is also highly expressed in T cell subsets, including naive and memory T cells, which are essential for immune responses. **Pathways and Functions** TRBC2 is involved in several key pathways, including: 1. **Adaptive immune response**: TRBC2 is essential for the recognition of antigens and the activation of T cells, which is a critical step in the adaptive immune response. 2. **Alpha-beta T cell activation**: TRBC2 plays a key role in the activation of alpha-beta T cells, which is a critical step in the immune response. 3. **T cell receptor signaling pathway**: TRBC2 is involved in the signaling pathway that occurs upon TCR engagement, which is essential for T cell activation and proliferation. 4. **Plasma membrane**: TRBC2 is embedded in the plasma membrane, where it interacts with other proteins and lipids to form a stable complex. **Functions** The primary function of TRBC2 is to form a stable complex with the TCR alpha chain, which is essential for T cell recognition and activation. TRBC2 also plays a role in the regulation of T cell function, including: 1. **T cell proliferation**: TRBC2 is involved in the regulation of T cell proliferation, which is critical for the expansion of activated T cells. 2. **T cell differentiation**: TRBC2 is involved in the regulation of T cell differentiation, which is critical for the development of effector T cells. 3. **T cell survival**: TRBC2 is involved in the regulation of T cell survival, which is critical for the maintenance of T cell populations. **Clinical Significance** Dysregulation of TRBC2 has been implicated in several immune-related disorders, including: 1. **Autoimmune diseases**: Dysregulation of TRBC2 has been implicated in autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Cancer**: Dysregulation of TRBC2 has been implicated in cancer, including T cell lymphomas and leukemias. 3. **Vaccine responses**: TRBC2 is essential for the recognition of antigens presented by MHC molecules, and dysregulation of TRBC2 can impair vaccine responses. In conclusion, TRBC2 is a critical gene involved in the adaptive immune response, and its dysregulation has been implicated in several immune-related disorders. Further research is needed to fully understand the mechanisms by which TRBC2 regulates T cell function and to develop therapeutic strategies to modulate TRBC2 expression.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.