Details for: TRBC2

Gene ID: 28638

Symbol: TRBC2

Ensembl ID: ENSG00000211772

Description: T cell receptor beta constant 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.68
    Marker Score: 8,027
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.62
    Marker Score: 35,835
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.5
    Marker Score: 9,809
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.4
    Marker Score: 6,071
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.39
    Marker Score: 2,460
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.22
    Marker Score: 2,737
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.19
    Marker Score: 1,640
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.16
    Marker Score: 2,779
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.09
    Marker Score: 1,545
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.08
    Marker Score: 2,590
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.01
    Marker Score: 979
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.95
    Marker Score: 2,758
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.94
    Marker Score: 2,843
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.85
    Marker Score: 993
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.78
    Marker Score: 3,937
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.77
    Marker Score: 7,664
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.77
    Marker Score: 8,097
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.76
    Marker Score: 850
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.66
    Marker Score: 826
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.59
    Marker Score: 6,325
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 2.58
    Marker Score: 684
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.54
    Marker Score: 134,547
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.52
    Marker Score: 10,819
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.43
    Marker Score: 1,043
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.42
    Marker Score: 1,044
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.4
    Marker Score: 3,530
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.35
    Marker Score: 1,698
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.34
    Marker Score: 7,388
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.32
    Marker Score: 9,499
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.25
    Marker Score: 2,424
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.24
    Marker Score: 4,390
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.18
    Marker Score: 3,698
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.16
    Marker Score: 2,258
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.1
    Marker Score: 24,449
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.1
    Marker Score: 3,664
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.04
    Marker Score: 1,548
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2
    Marker Score: 1,780
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.99
    Marker Score: 1,651
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.98
    Marker Score: 1,766
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.93
    Marker Score: 1,900
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.9
    Marker Score: 1,092
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.88
    Marker Score: 572
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.87
    Marker Score: 1,410
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.8
    Marker Score: 1,693
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.8
    Marker Score: 1,003
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.74
    Marker Score: 3,651
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.73
    Marker Score: 1,270
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.71
    Marker Score: 393
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.69
    Marker Score: 383
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.65
    Marker Score: 969
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.64
    Marker Score: 987
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.62
    Marker Score: 575
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.61
    Marker Score: 1,220
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.61
    Marker Score: 408
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.57
    Marker Score: 1,143
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.56
    Marker Score: 764
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.52
    Marker Score: 1,021
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.48
    Marker Score: 1,480
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.48
    Marker Score: 1,164
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,672
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.46
    Marker Score: 899
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.42
    Marker Score: 3,192
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.41
    Marker Score: 309
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.34
    Marker Score: 974
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.32
    Marker Score: 1,462
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.27
    Marker Score: 655
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.23
    Marker Score: 835
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.21
    Marker Score: 777
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.19
    Marker Score: 700
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.19
    Marker Score: 392
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 1.17
    Marker Score: 318
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.17
    Marker Score: 264
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.13
    Marker Score: 392
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.13
    Marker Score: 929
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.11
    Marker Score: 7,409
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.11
    Marker Score: 505
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 1.05
    Marker Score: 813
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.99
    Marker Score: 1,072
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.95
    Marker Score: 228
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.95
    Marker Score: 697
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,408
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.94
    Marker Score: 396
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.94
    Marker Score: 1,016
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,289
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 365
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,723
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.88
    Marker Score: 1,431
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,276
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.87
    Marker Score: 278
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.86
    Marker Score: 433
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.83
    Marker Score: 291
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.81
    Marker Score: 712
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.78
    Marker Score: 306
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.78
    Marker Score: 472
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 592

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TRBC2 is a member of the TCR beta constant family, which is characterized by its ability to form a stable complex with the TCR alpha chain. This complex is essential for the recognition of antigens presented by major histocompatibility complex (MHC) molecules. TRBC2 is highly conserved across species, suggesting its critical role in T cell function. The gene is also highly expressed in T cell subsets, including naive and memory T cells, which are essential for immune responses. **Pathways and Functions** TRBC2 is involved in several key pathways, including: 1. **Adaptive immune response**: TRBC2 is essential for the recognition of antigens and the activation of T cells, which is a critical step in the adaptive immune response. 2. **Alpha-beta T cell activation**: TRBC2 plays a key role in the activation of alpha-beta T cells, which is a critical step in the immune response. 3. **T cell receptor signaling pathway**: TRBC2 is involved in the signaling pathway that occurs upon TCR engagement, which is essential for T cell activation and proliferation. 4. **Plasma membrane**: TRBC2 is embedded in the plasma membrane, where it interacts with other proteins and lipids to form a stable complex. **Functions** The primary function of TRBC2 is to form a stable complex with the TCR alpha chain, which is essential for T cell recognition and activation. TRBC2 also plays a role in the regulation of T cell function, including: 1. **T cell proliferation**: TRBC2 is involved in the regulation of T cell proliferation, which is critical for the expansion of activated T cells. 2. **T cell differentiation**: TRBC2 is involved in the regulation of T cell differentiation, which is critical for the development of effector T cells. 3. **T cell survival**: TRBC2 is involved in the regulation of T cell survival, which is critical for the maintenance of T cell populations. **Clinical Significance** Dysregulation of TRBC2 has been implicated in several immune-related disorders, including: 1. **Autoimmune diseases**: Dysregulation of TRBC2 has been implicated in autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Cancer**: Dysregulation of TRBC2 has been implicated in cancer, including T cell lymphomas and leukemias. 3. **Vaccine responses**: TRBC2 is essential for the recognition of antigens presented by MHC molecules, and dysregulation of TRBC2 can impair vaccine responses. In conclusion, TRBC2 is a critical gene involved in the adaptive immune response, and its dysregulation has been implicated in several immune-related disorders. Further research is needed to fully understand the mechanisms by which TRBC2 regulates T cell function and to develop therapeutic strategies to modulate TRBC2 expression.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.