PTPRC | ENSG00000081237 | NCBI 5788

Details for: PTPRC

Gene ID: 5788

Symbol: PTPRC

Ensembl ID: ENSG00000081237

Description: protein tyrosine phosphatase receptor type C

Associated with

Adaptive immune system
(R-HSA-1280218)
Axon guidance
(R-HSA-422475)
Developmental biology
(R-HSA-1266738)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Nervous system development
(R-HSA-9675108)
Neutrophil degranulation
(R-HSA-6798695)
Other semaphorin interactions
(R-HSA-416700)
Phosphorylation of cd3 and tcr zeta chains
(R-HSA-202427)
Semaphorin interactions
(R-HSA-373755)
Tcr signaling
(R-HSA-202403)
Alpha-beta t cell proliferation
(GO:0046633)
Ankyrin binding
(GO:0030506)
B cell differentiation
(GO:0030183)
B cell proliferation
(GO:0042100)
B cell receptor signaling pathway
(GO:0050853)
Bleb
(GO:0032059)
Bone marrow development
(GO:0048539)
Cell cycle phase transition
(GO:0044770)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cytoplasmic side of plasma membrane
(GO:0009898)
Defense response to virus
(GO:0051607)
Dephosphorylation
(GO:0016311)
Dn2 thymocyte differentiation
(GO:1904155)
External side of plasma membrane
(GO:0009897)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Focal adhesion
(GO:0005925)
Gamma-delta t cell differentiation
(GO:0042492)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Heparan sulfate proteoglycan binding
(GO:0043395)
Heparin binding
(GO:0008201)
Heterotypic cell-cell adhesion
(GO:0034113)
Leukocyte cell-cell adhesion
(GO:0007159)
Mapk cascade
(GO:0000165)
Membrane
(GO:0016020)
Natural killer cell differentiation
(GO:0001779)
Negative regulation of cell adhesion involved in substrate-bound cell migration
(GO:0006933)
Negative regulation of cytokine-mediated signaling pathway
(GO:0001960)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of interleukin-2 production
(GO:0032703)
Negative regulation of interleukin-4-mediated signaling pathway
(GO:1902215)
Negative regulation of microglial cell activation
(GO:1903979)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of receptor signaling pathway via jak-stat
(GO:0046426)
Negative regulation of t cell mediated cytotoxicity
(GO:0001915)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative thymic t cell selection
(GO:0045060)
Plasma membrane
(GO:0005886)
Positive regulation of alpha-beta t cell proliferation
(GO:0046641)
Positive regulation of antigen receptor-mediated signaling pathway
(GO:0050857)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of calcium-mediated signaling
(GO:0050850)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of extrinsic apoptotic signaling pathway
(GO:2001238)
Positive regulation of fc receptor mediated stimulatory signaling pathway
(GO:0060369)
Positive regulation of gamma-delta t cell differentiation
(GO:0045588)
Positive regulation of hematopoietic stem cell migration
(GO:2000473)
Positive regulation of humoral immune response mediated by circulating immunoglobulin
(GO:0002925)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of isotype switching to igg isotypes
(GO:0048304)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of protein kinase activity
(GO:0045860)
Positive regulation of stem cell proliferation
(GO:2000648)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive thymic t cell selection
(GO:0045059)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein kinase binding
(GO:0019901)
Protein tyrosine phosphatase activity
(GO:0004725)
Regulation of cell cycle
(GO:0051726)
Regulation of gene expression
(GO:0010468)
Regulation of interleukin-8 production
(GO:0032677)
Regulation of phagocytosis
(GO:0050764)
Regulation of protein tyrosine kinase activity
(GO:0061097)
Regulation of t cell receptor signaling pathway
(GO:0050856)
Release of sequestered calcium ion into cytosol
(GO:0051209)
Response to aldosterone
(GO:1904044)
Response to gamma radiation
(GO:0010332)
Secretory granule membrane
(GO:0030667)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Spectrin binding
(GO:0030507)
Stem cell development
(GO:0048864)
T cell activation
(GO:0042110)
T cell differentiation
(GO:0030217)
T cell receptor signaling pathway
(GO:0050852)
Transmembrane receptor protein tyrosine phosphatase activity
(GO:0005001)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 265.9677
Cell Significance Index: -41.3700
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 144.0098
Cell Significance Index: -58.5100
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 115.3416
Cell Significance Index: -59.3300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 112.6385
Cell Significance Index: -28.5700
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 101.2237
Cell Significance Index: -47.7900
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 62.8546
Cell Significance Index: -60.0100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 33.6103
Cell Significance Index: -41.4400
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 31.1809
Cell Significance Index: 83.5300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 17.5478
Cell Significance Index: -38.4100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 16.1064
Cell Significance Index: -49.4700
Cell Name: centroblast (CL0009112)
Fold Change: 12.3871
Cell Significance Index: 28.9000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.9603
Cell Significance Index: -43.2500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 8.8862
Cell Significance Index: 164.2400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 7.8914
Cell Significance Index: -21.1400
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 5.8725
Cell Significance Index: 172.4700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 5.3919
Cell Significance Index: 134.7800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 4.6810
Cell Significance Index: 552.0300
Cell Name: helper T cell (CL0000912)
Fold Change: 3.6722
Cell Significance Index: 52.1800
Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.6263
Cell Significance Index: 233.9500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 2.0711
Cell Significance Index: 55.4000
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 1.4240
Cell Significance Index: 4.3400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.3458
Cell Significance Index: 256.1200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.3349
Cell Significance Index: 28.9200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8738
Cell Significance Index: 788.9600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8352
Cell Significance Index: 82.6200
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.6631
Cell Significance Index: 5.8000
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.3472
Cell Significance Index: 1.4500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3361
Cell Significance Index: 54.6700
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.2182
Cell Significance Index: 1.1900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.2045
Cell Significance Index: 43.0700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1002
Cell Significance Index: 69.2900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0684
Cell Significance Index: 7.4500
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.0602
Cell Significance Index: 0.8800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0071
Cell Significance Index: 1.4000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0024
Cell Significance Index: -1.4800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0102
Cell Significance Index: -7.5600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0211
Cell Significance Index: -39.8200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0231
Cell Significance Index: -0.8100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0297
Cell Significance Index: -45.6600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0309
Cell Significance Index: -56.9500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0386
Cell Significance Index: -21.7700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0392
Cell Significance Index: -1.1300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0422
Cell Significance Index: -57.4000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0486
Cell Significance Index: -36.8000
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0760
Cell Significance Index: -1.3100
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0799
Cell Significance Index: -43.6100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0828
Cell Significance Index: -60.7300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0881
Cell Significance Index: -55.9500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.1032
Cell Significance Index: -45.6200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.1060
Cell Significance Index: -38.0300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1151
Cell Significance Index: -11.7600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1193
Cell Significance Index: -54.1500
Cell Name: leukocyte (CL0000738)
Fold Change: -0.1260
Cell Significance Index: -2.1400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1430
Cell Significance Index: -6.4800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1680
Cell Significance Index: -48.3500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1780
Cell Significance Index: -35.7000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.1923
Cell Significance Index: -13.3000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1978
Cell Significance Index: -33.7800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.2249
Cell Significance Index: -40.5400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.3015
Cell Significance Index: -41.4100
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.3086
Cell Significance Index: -13.4200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.3479
Cell Significance Index: -42.7800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3513
Cell Significance Index: -51.0700
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.3850
Cell Significance Index: -3.8600
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3850
Cell Significance Index: -43.9500
Cell Name: lactocyte (CL0002325)
Fold Change: -0.3964
Cell Significance Index: -51.2100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4087
Cell Significance Index: -47.6300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4126
Cell Significance Index: -42.9600
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: -0.4152
Cell Significance Index: -3.2300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.4315
Cell Significance Index: -20.2800
Cell Name: odontoblast (CL0000060)
Fold Change: -0.4654
Cell Significance Index: -59.6600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4657
Cell Significance Index: -53.3500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4742
Cell Significance Index: -29.0700
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4883
Cell Significance Index: -12.4800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.5048
Cell Significance Index: -38.7400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5183
Cell Significance Index: -16.6000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.5805
Cell Significance Index: -34.8500
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: -0.6369
Cell Significance Index: -5.4300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.6582
Cell Significance Index: -46.5500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.6895
Cell Significance Index: -51.3900
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.7417
Cell Significance Index: -7.6900
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.7579
Cell Significance Index: -38.3000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.8026
Cell Significance Index: -16.6500
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.8135
Cell Significance Index: -6.5900
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: -0.8162
Cell Significance Index: -3.6500
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: -0.8347
Cell Significance Index: -6.2100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.8413
Cell Significance Index: -47.2100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.9032
Cell Significance Index: -46.9200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.9154
Cell Significance Index: -48.0600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.9612
Cell Significance Index: -60.5800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.9889
Cell Significance Index: -43.7400
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -1.0166
Cell Significance Index: -9.5100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.0827
Cell Significance Index: -56.4000
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -1.0948
Cell Significance Index: -21.4100
Cell Name: lymphocyte (CL0000542)
Fold Change: -1.1136
Cell Significance Index: -15.1500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -1.1222
Cell Significance Index: -52.3200
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.1523
Cell Significance Index: -43.6400
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -1.1908
Cell Significance Index: -11.2900
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -1.2018
Cell Significance Index: -9.8000
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: -1.2383
Cell Significance Index: -10.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** PTPRC is a type C receptor tyrosine phosphatase, characterized by its distinct structure and function. It is a transmembrane protein with a single transmembrane domain, a cytoplasmic domain, and a catalytic domain that contains a conserved phosphatase motif. PTPRC is a negative regulator of immune responses, as it can dephosphorylate and inactivate immune receptors, such as T cell receptors (TCRs) and B cell receptors (BCRs), thereby preventing excessive activation and immune suppression. PTPRC is also involved in the regulation of cell adhesion, migration, and proliferation, and its expression is tightly regulated by various signaling pathways. **Pathways and Functions** PTPRC is involved in multiple signaling pathways, including: 1. **Immune receptor signaling**: PTPRC regulates the signaling of immune receptors, such as TCRs and BCRs, by dephosphorylating and inactivating them. 2. **Cell adhesion and migration**: PTPRC regulates cell adhesion and migration by modulating the activity of cell surface receptors, such as integrins and selectins. 3. **Cell proliferation and survival**: PTPRC regulates cell proliferation and survival by modulating the activity of cell surface receptors, such as CD40 and CD28. 4. **Developmental biology**: PTPRC is involved in the regulation of embryonic development, including the development of the nervous system and the immune system. **Clinical Significance** Dysregulation of PTPRC has been implicated in various immune-related disorders, including: 1. **Immunodeficiency diseases**: Defects in PTPRC have been associated with immunodeficiency diseases, such as X-linked agammaglobulinemia (XLA). 2. **Autoimmune diseases**: Dysregulation of PTPRC has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer**: PTPRC has been identified as a potential oncogene, as its dysregulation has been associated with cancer development and progression. 4. **Infectious diseases**: PTPRC has been implicated in the regulation of immune responses to infectious diseases, such as tuberculosis and HIV. In conclusion, PTPRC is a critical regulator of immune responses, cell signaling, and development. Its dysregulation has been implicated in various immune-related disorders, and further studies are needed to fully understand its role in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Leukocyte common antigen
M9MML4_HUMAN

Genular Protein ID: 2219652631

Symbol: PTPRC_HUMAN

Name: Leukocyte common antigen

UniProtKB Accession Codes:

P08575 A0A0A0MT22 A8K7W6 Q16614 Q9H0Y6 X6R433

Database IDs:

Citations:

PubMed ID: 2824653

Title: Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens.

PubMed ID: 2824653

DOI: 10.1084/jem.166.5.1548

PubMed ID: 2956090

Title: Structural variants of human T200 glycoprotein (leukocyte-common antigen).

PubMed ID: 2956090

DOI: 10.1002/j.1460-2075.1987.tb02361.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 2531281

Title: Integrity of the exon 6 sequence is essential for tissue-specific alternative splicing of human leukocyte common antigen pre-mRNA.

PubMed ID: 2531281

DOI: 10.1128/mcb.9.10.4550-4555.1989

PubMed ID: 2971730

Title: Complete exon-intron organization of the human leukocyte common antigen (CD45) gene.

PubMed ID: 2971730

PubMed ID: 2845400

Title: The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase.

PubMed ID: 2845400

DOI: 10.1073/pnas.85.19.7182

PubMed ID: 1695146

Title: Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR.

PubMed ID: 1695146

DOI: 10.1002/j.1460-2075.1990.tb07415.x

PubMed ID: 10700239

Title: Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease.

PubMed ID: 10700239

DOI: 10.1038/73208

PubMed ID: 11975983

Title: A study on CD45 isoform expression during T-cell development and selection events in the human thymus.

PubMed ID: 11975983

DOI: 10.1016/s0198-8859(02)00379-8

PubMed ID: 11909961

Title: SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription.

PubMed ID: 11909961

DOI: 10.1128/mcb.22.8.2673-2686.2002

PubMed ID: 12676959

Title: A role for interleukin-12 in the regulation of T cell plasma membrane compartmentation.

PubMed ID: 12676959

DOI: 10.1074/jbc.m212978200

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22174689

Title: The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells.

PubMed ID: 22174689

DOI: 10.1371/journal.ppat.1002432

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 35767951

Title: Tetraspanin CD53 controls T cell immunity through regulation of CD45RO stability, mobility, and function.

PubMed ID: 35767951

DOI: 10.1016/j.celrep.2022.111006

PubMed ID: 15684325

Title: Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45.

PubMed ID: 15684325

DOI: 10.1084/jem.20041890

PubMed ID: 11101853

Title: A point mutation in PTPRC is associated with the development of multiple sclerosis.

PubMed ID: 11101853

DOI: 10.1038/82659

PubMed ID: 11145714

Title: A deletion in the gene encoding the CD45 antigen in a patient with SCID.

PubMed ID: 11145714

DOI: 10.4049/jimmunol.166.2.1308

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 22689986

Title: CD45-deficient severe combined immunodeficiency caused by uniparental disomy.

PubMed ID: 22689986

DOI: 10.1073/pnas.1202249109

Sequence Information:

Length: 1306
Mass: 147486
Checksum: 6E942E2BF6B17AC5
Sequence:

MTMYLWLKLL AFGFAFLDTE VFVTGQSPTP SPTGLTTAKM PSVPLSSDPL PTHTTAFSPA 
STFERENDFS ETTTSLSPDN TSTQVSPDSL DNASAFNTTG VSSVQTPHLP THADSQTPSA 
GTDTQTFSGS AANAKLNPTP GSNAISDVPG ERSTASTFPT DPVSPLTTTL SLAHHSSAAL 
PARTSNTTIT ANTSDAYLNA SETTTLSPSG SAVISTTTIA TTPSKPTCDE KYANITVDYL 
YNKETKLFTA KLNVNENVEC GNNTCTNNEV HNLTECKNAS VSISHNSCTA PDKTLILDVP 
PGVEKFQLHD CTQVEKADTT ICLKWKNIET FTCDTQNITY RFQCGNMIFD NKEIKLENLE 
PEHEYKCDSE ILYNNHKFTN ASKIIKTDFG SPGEPQIIFC RSEAAHQGVI TWNPPQRSFH 
NFTLCYIKET EKDCLNLDKN LIKYDLQNLK PYTKYVLSLH AYIIAKVQRN GSAAMCHFTT 
KSAPPSQVWN MTVSMTSDNS MHVKCRPPRD RNGPHERYHL EVEAGNTLVR NESHKNCDFR 
VKDLQYSTDY TFKAYFHNGD YPGEPFILHH STSYNSKALI AFLAFLIIVT SIALLVVLYK 
IYDLHKKRSC NLDEQQELVE RDDEKQLMNV EPIHADILLE TYKRKIADEG RLFLAEFQSI 
PRVFSKFPIK EARKPFNQNK NRYVDILPYD YNRVELSEIN GDAGSNYINA SYIDGFKEPR 
KYIAAQGPRD ETVDDFWRMI WEQKATVIVM VTRCEEGNRN KCAEYWPSME EGTRAFGDVV 
VKINQHKRCP DYIIQKLNIV NKKEKATGRE VTHIQFTSWP DHGVPEDPHL LLKLRRRVNA 
FSNFFSGPIV VHCSAGVGRT GTYIGIDAML EGLEAENKVD VYGYVVKLRR QRCLMVQVEA 
QYILIHQALV EYNQFGETEV NLSELHPYLH NMKKRDPPSE PSPLEAEFQR LPSYRSWRTQ 
HIGNQEENKS KNRNSNVIPY DYNRVPLKHE LEMSKESEHD SDESSDDDSD SEEPSKYINA 
SFIMSYWKPE VMIAAQGPLK ETIGDFWQMI FQRKVKVIVM LTELKHGDQE ICAQYWGEGK 
QTYGDIEVDL KDTDKSSTYT LRVFELRHSK RKDSRTVYQY QYTNWSVEQL PAEPKELISM 
IQVVKQKLPQ KNSSEGNKHH KSTPLLIHCR DGSQQTGIFC ALLNLLESAE TEEVVDIFQV 
VKALRKARPG MVSTFEQYQF LYDVIASTYP AQNGQVKKNN HQEDKIEFDN EVDKVKQDAN 
CVNPLGAPEK LPEAKEQAEG SEPTSGTEGP EHSVNGPASP ALNQGS

Genular Protein ID: 716960968

Symbol: M9MML4_HUMAN

Name: N/A

UniProtKB Accession Codes:

M9MML4

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

Length: 87
Mass: 9713
Checksum: FFA18A8827F025BC
Sequence:

MTMYLWLKLL AFGFAFLDTE VFVTGQSPTP SPTGHLQAEE QGSQSKSPNL KSREADSSAF 
SWWPKAREPL TNHWSKSKSP KAEELGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PTPRC

Associated with

Cells (max top 100)

Other Information

Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens. PubMed ID: 2824653

Structural variants of human T200 glycoprotein (leukocyte-common antigen). PubMed ID: 2956090

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Integrity of the exon 6 sequence is essential for tissue-specific alternative splicing of human leukocyte common antigen pre-mRNA. PubMed ID: 2531281

Complete exon-intron organization of the human leukocyte common antigen (CD45) gene. PubMed ID: 2971730

The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase. PubMed ID: 2845400

Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR. PubMed ID: 1695146

Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease. PubMed ID: 10700239

A study on CD45 isoform expression during T-cell development and selection events in the human thymus. PubMed ID: 11975983

SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription. PubMed ID: 11909961

A role for interleukin-12 in the regulation of T cell plasma membrane compartmentation. PubMed ID: 12676959

Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. PubMed ID: 19367720

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells. PubMed ID: 22174689

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Tetraspanin CD53 controls T cell immunity through regulation of CD45RO stability, mobility, and function. PubMed ID: 35767951

Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45. PubMed ID: 15684325

A point mutation in PTPRC is associated with the development of multiple sclerosis. PubMed ID: 11101853

A deletion in the gene encoding the CD45 antigen in a patient with SCID. PubMed ID: 11145714

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

CD45-deficient severe combined immunodeficiency caused by uniparental disomy. PubMed ID: 22689986

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Database document:

PubMed ID: 2824653

PubMed ID: 2956090

PubMed ID: 14702039

PubMed ID: 16710414

PubMed ID: 2531281

PubMed ID: 2971730

PubMed ID: 2845400

PubMed ID: 1695146

PubMed ID: 10700239

PubMed ID: 11975983

PubMed ID: 11909961

PubMed ID: 12676959

PubMed ID: 19367720

PubMed ID: 19159218

PubMed ID: 19349973

PubMed ID: 19690332

PubMed ID: 21269460

PubMed ID: 22174689

PubMed ID: 23186163

PubMed ID: 25944712

PubMed ID: 35767951

PubMed ID: 15684325

PubMed ID: 11101853

PubMed ID: 11145714

PubMed ID: 16959974

PubMed ID: 22689986

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 16710414