Details for: NGFR

Gene ID: 4804

Symbol: NGFR

Ensembl ID: ENSG00000064300

Description: nerve growth factor receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 59.4682
    Cell Significance Index: -9.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.6459
    Cell Significance Index: -9.3000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.8513
    Cell Significance Index: 52.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.7968
    Cell Significance Index: 94.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.3010
    Cell Significance Index: -9.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.1337
    Cell Significance Index: 46.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3630
    Cell Significance Index: 61.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3498
    Cell Significance Index: 36.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1579
    Cell Significance Index: 25.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9400
    Cell Significance Index: 178.8900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8976
    Cell Significance Index: 7.5400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.8614
    Cell Significance Index: 13.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7132
    Cell Significance Index: 70.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5985
    Cell Significance Index: 540.4400
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.5752
    Cell Significance Index: 6.3900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4665
    Cell Significance Index: 7.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4013
    Cell Significance Index: 8.4000
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.3934
    Cell Significance Index: 2.4100
  • Cell Name: myoblast (CL0000056)
    Fold Change: 0.3613
    Cell Significance Index: 3.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3389
    Cell Significance Index: 55.1200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.3244
    Cell Significance Index: 2.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2640
    Cell Significance Index: 28.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2003
    Cell Significance Index: 11.2400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1718
    Cell Significance Index: 2.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1225
    Cell Significance Index: 2.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1205
    Cell Significance Index: 8.3300
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.1003
    Cell Significance Index: 0.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0594
    Cell Significance Index: 37.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0533
    Cell Significance Index: 23.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0496
    Cell Significance Index: 0.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0306
    Cell Significance Index: 3.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0257
    Cell Significance Index: 0.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0208
    Cell Significance Index: 1.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0157
    Cell Significance Index: 0.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0092
    Cell Significance Index: 6.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0083
    Cell Significance Index: 15.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0043
    Cell Significance Index: 0.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0014
    Cell Significance Index: 0.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0010
    Cell Significance Index: 0.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0012
    Cell Significance Index: -0.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0046
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0049
    Cell Significance Index: -3.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0059
    Cell Significance Index: -7.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0061
    Cell Significance Index: -11.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0064
    Cell Significance Index: -3.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0072
    Cell Significance Index: -11.0100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0078
    Cell Significance Index: -0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0097
    Cell Significance Index: -6.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0104
    Cell Significance Index: -7.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0111
    Cell Significance Index: -8.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0149
    Cell Significance Index: -8.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0154
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0165
    Cell Significance Index: -3.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0170
    Cell Significance Index: -7.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0206
    Cell Significance Index: -7.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0214
    Cell Significance Index: -2.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0264
    Cell Significance Index: -4.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0308
    Cell Significance Index: -6.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0315
    Cell Significance Index: -3.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0366
    Cell Significance Index: -1.0500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0384
    Cell Significance Index: -0.2600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0388
    Cell Significance Index: -1.5900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0390
    Cell Significance Index: -0.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0405
    Cell Significance Index: -2.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0414
    Cell Significance Index: -8.3000
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: -0.0420
    Cell Significance Index: -0.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0425
    Cell Significance Index: -4.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0453
    Cell Significance Index: -5.8600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0458
    Cell Significance Index: -5.2300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0473
    Cell Significance Index: -0.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0482
    Cell Significance Index: -7.0000
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0502
    Cell Significance Index: -0.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0517
    Cell Significance Index: -7.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0634
    Cell Significance Index: -1.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0695
    Cell Significance Index: -8.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0739
    Cell Significance Index: -8.7100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0800
    Cell Significance Index: -0.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0819
    Cell Significance Index: -3.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0840
    Cell Significance Index: -6.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0841
    Cell Significance Index: -8.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0852
    Cell Significance Index: -5.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0879
    Cell Significance Index: -2.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0926
    Cell Significance Index: -6.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1192
    Cell Significance Index: -9.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1257
    Cell Significance Index: -4.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1268
    Cell Significance Index: -6.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1286
    Cell Significance Index: -6.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1293
    Cell Significance Index: -8.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1332
    Cell Significance Index: -8.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1351
    Cell Significance Index: -8.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1388
    Cell Significance Index: -6.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1795
    Cell Significance Index: -2.5700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1874
    Cell Significance Index: -1.5500
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.1885
    Cell Significance Index: -1.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1919
    Cell Significance Index: -9.9700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1919
    Cell Significance Index: -2.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2053
    Cell Significance Index: -9.0800
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.2246
    Cell Significance Index: -2.5600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2404
    Cell Significance Index: -3.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2411
    Cell Significance Index: -9.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: NGFR is a transmembrane receptor composed of an extracellular domain, a transmembrane domain, and an intracellular domain. 2. **Expression**: NGFR is widely expressed in various tissues, including the nervous system, immune cells, epithelial tissues, and muscle cells. 3. **Isoforms**: There are two main isoforms of NGFR: p75NTR and LINGO-1. 4. **Ligand binding**: NGFR binds to its ligand, NGF, to activate its signaling pathways. **Pathways and Functions** NGFR signaling pathways are complex and multifaceted, involving various downstream effectors and signaling cascades. Some of the key pathways and functions of NGFR include: 1. **Apoptosis**: NGFR can induce apoptosis in neurons, which is mediated by the activation of the p75NTR isoform. 2. **Neurotrophin binding**: NGFR binds to various neurotrophins, including NGF, brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3), to regulate neuronal growth, differentiation, and survival. 3. **Neurodevelopment**: NGFR plays a critical role in the development and patterning of the nervous system, including the specification of neuronal cell types and the formation of synapses. 4. **Immune responses**: NGFR is also involved in immune responses, including the regulation of T-cell activation and the promotion of tumor cell proliferation. **Clinical Significance** Dysregulation of NGFR signaling has been implicated in various neurological and immunological disorders, including: 1. **Neurodegenerative diseases**: NGFR dysregulation has been linked to Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer**: NGFR overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. 3. **Autoimmune disorders**: NGFR has been implicated in the pathogenesis of autoimmune disorders, including multiple sclerosis and rheumatoid arthritis. In conclusion, NGFR is a multifunctional receptor that plays a critical role in the development, maintenance, and function of the nervous system and immune cells. Its dysregulation has been implicated in various neurological and immunological disorders, highlighting the importance of NGFR in human health and disease.

Genular Protein ID: 299343920

Symbol: TNR16_HUMAN

Name: Tumor necrosis factor receptor superfamily member 16

UniProtKB Accession Codes:

P08138 B2R961 B4E096

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 GO 51 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 11 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3022937

Title: Expression and structure of the human NGF receptor.

PubMed ID: 3022937

DOI: 10.1016/0092-8674(86)90619-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2850481

Title: A constitutive promoter directs expression of the nerve growth factor receptor gene.

PubMed ID: 2850481

DOI: 10.1128/mcb.8.8.3160-3167.1988

PubMed ID: 10514511

Title: TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.

PubMed ID: 10514511

DOI: 10.1074/jbc.274.42.30202

PubMed ID: 9915784

Title: Association of the p75 neurotrophin receptor with TRAF6.

PubMed ID: 9915784

DOI: 10.1074/jbc.274.5.2597

PubMed ID: 10544233

Title: Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation.

PubMed ID: 10544233

DOI: 10.1016/s0014-5793(99)01324-1

PubMed ID: 11244088

Title: The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor.

PubMed ID: 11244088

DOI: 10.1074/jbc.c000869200

PubMed ID: 12963025

Title: RanBPM is a novel binding protein for p75NTR.

PubMed ID: 12963025

DOI: 10.1016/j.bbrc.2003.08.033

PubMed ID: 14966521

Title: LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.

PubMed ID: 14966521

DOI: 10.1038/nn1188

PubMed ID: 8627329

Title: O-linked oligosaccharide on the 75-kDa neurotrophin receptor.

PubMed ID: 8627329

DOI: 10.1046/j.1471-4159.1996.66041707.x

PubMed ID: 19052207

Title: Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth.

PubMed ID: 19052207

DOI: 10.1523/jneurosci.3828-08.2008

PubMed ID: 22155786

Title: Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac.

PubMed ID: 22155786

DOI: 10.1126/scisignal.2002060

PubMed ID: 23785138

Title: p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks.

PubMed ID: 23785138

DOI: 10.1523/jneurosci.2757-12.2013

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24908487

Title: SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia.

PubMed ID: 24908487

DOI: 10.1016/j.neuron.2014.04.022

PubMed ID: 26646181

Title: Structural basis of death domain signaling in the p75 neurotrophin receptor.

PubMed ID: 26646181

DOI: 10.7554/elife.11692

Sequence Information:

  • Length: 427
  • Mass: 45183
  • Checksum: B09FA143FB3D625B
  • Sequence:
    • MGAGATGRAM DGPRLLLLLL LGVSLGGAKE ACPTGLYTHS GECCKACNLG EGVAQPCGAN 
QTVCEPCLDS VTFSDVVSAT EPCKPCTECV GLQSMSAPCV EADDAVCRCA YGYYQDETTG 
RCEACRVCEA GSGLVFSCQD KQNTVCEECP DGTYSDEANH VDPCLPCTVC EDTERQLREC 
TRWADAECEE IPGRWITRST PPEGSDSTAP STQEPEAPPE QDLIASTVAG VVTTVMGSSQ 
PVVTRGTTDN LIPVYCSILA AVVVGLVAYI AFKRWNSCKQ NKQGANSRPV NQTPPPEGEK 
LHSDSGISVD SQSLHDQQPH TQTASGQALK GDGGLYSSLP PAKREEVEKL LNGSAGDTWR 
HLAGELGYQP EHIDSFTHEA CPVRALLASW ATQDSATLDA LLAALRRIQR ADLVESLCSE 
STATSPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.