Details for: GPM6B

Gene ID: 2824

Symbol: GPM6B

Ensembl ID: ENSG00000046653

Description: glycoprotein M6B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 521.8418
    Cell Significance Index: -81.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 320.4893
    Cell Significance Index: -81.2900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 164.8300
    Cell Significance Index: -77.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 66.2798
    Cell Significance Index: -81.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 62.8703
    Cell Significance Index: -60.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 28.4412
    Cell Significance Index: -76.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.8254
    Cell Significance Index: -76.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.5547
    Cell Significance Index: -81.1100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 6.4734
    Cell Significance Index: 90.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 4.1706
    Cell Significance Index: 280.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.7765
    Cell Significance Index: 107.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 3.2554
    Cell Significance Index: 200.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.0248
    Cell Significance Index: 606.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.5033
    Cell Significance Index: 140.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.4411
    Cell Significance Index: 92.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.4398
    Cell Significance Index: 107.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.3883
    Cell Significance Index: 856.6400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.3008
    Cell Significance Index: 55.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.1250
    Cell Significance Index: 272.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.0084
    Cell Significance Index: 126.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9012
    Cell Significance Index: 116.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6725
    Cell Significance Index: 465.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6281
    Cell Significance Index: 40.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6230
    Cell Significance Index: 562.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1699
    Cell Significance Index: 27.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1622
    Cell Significance Index: 30.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1284
    Cell Significance Index: 2.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0708
    Cell Significance Index: 38.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0048
    Cell Significance Index: 0.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0061
    Cell Significance Index: -11.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0070
    Cell Significance Index: -0.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0210
    Cell Significance Index: -2.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0230
    Cell Significance Index: -14.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0234
    Cell Significance Index: -36.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0284
    Cell Significance Index: -38.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0343
    Cell Significance Index: -63.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0433
    Cell Significance Index: -1.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0504
    Cell Significance Index: -37.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0629
    Cell Significance Index: -6.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0647
    Cell Significance Index: -3.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0683
    Cell Significance Index: -30.2000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0819
    Cell Significance Index: -0.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0875
    Cell Significance Index: -2.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0898
    Cell Significance Index: -65.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1074
    Cell Significance Index: -19.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1085
    Cell Significance Index: -67.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1107
    Cell Significance Index: -83.8200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1328
    Cell Significance Index: -0.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1360
    Cell Significance Index: -61.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1361
    Cell Significance Index: -76.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1524
    Cell Significance Index: -3.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1537
    Cell Significance Index: -30.5100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2166
    Cell Significance Index: -1.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2224
    Cell Significance Index: -27.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2325
    Cell Significance Index: -66.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2478
    Cell Significance Index: -11.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2757
    Cell Significance Index: -40.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2975
    Cell Significance Index: -34.6700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3465
    Cell Significance Index: -4.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3596
    Cell Significance Index: -10.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3947
    Cell Significance Index: -83.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.4153
    Cell Significance Index: -70.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4285
    Cell Significance Index: -29.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4320
    Cell Significance Index: -9.3600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.4421
    Cell Significance Index: -4.7400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4615
    Cell Significance Index: -7.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5545
    Cell Significance Index: -33.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5771
    Cell Significance Index: -58.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.6536
    Cell Significance Index: -77.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6970
    Cell Significance Index: -42.7300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.7152
    Cell Significance Index: -9.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7211
    Cell Significance Index: -82.6100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.7242
    Cell Significance Index: -7.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7378
    Cell Significance Index: -54.9900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7736
    Cell Significance Index: -88.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7770
    Cell Significance Index: -80.9100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.8591
    Cell Significance Index: -9.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9317
    Cell Significance Index: -71.5000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0022
    Cell Significance Index: -31.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.0209
    Cell Significance Index: -72.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0291
    Cell Significance Index: -53.4600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.0672
    Cell Significance Index: -12.4500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.0695
    Cell Significance Index: -12.2400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0744
    Cell Significance Index: -21.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.1179
    Cell Significance Index: -58.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1202
    Cell Significance Index: -36.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.2154
    Cell Significance Index: -25.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.2318
    Cell Significance Index: -35.3100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.3341
    Cell Significance Index: -26.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.3482
    Cell Significance Index: -46.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.4039
    Cell Significance Index: -49.1800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.5089
    Cell Significance Index: -32.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.5444
    Cell Significance Index: -72.0100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -1.5728
    Cell Significance Index: -11.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.5775
    Cell Significance Index: -26.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.6236
    Cell Significance Index: -52.0000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.6346
    Cell Significance Index: -25.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.6829
    Cell Significance Index: -35.8400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.6921
    Cell Significance Index: -16.1000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.7102
    Cell Significance Index: -42.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPM6B is a transmembrane glycoprotein that exhibits a unique structure, comprising multiple domains and motifs that enable its interaction with various cellular components. Its ability to regulate protein localization to the cell surface is mediated through its association with membrane rafts and the actin cytoskeleton. Furthermore, GPM6B has been shown to modulate serotonin uptake, suggesting its involvement in neurotransmitter regulation. Its expression is tightly regulated, with changes in GPM6B levels observed in response to developmental and pathological stimuli. **Pathways and Functions:** GPM6B is involved in several critical cellular pathways, including: 1. **Axon development**: GPM6B plays a crucial role in axon growth and guidance, regulating the interaction between axons and their target cells. 2. **Myelination**: As a component of the myelin sheath, GPM6B contributes to the formation and maintenance of the myelin structure, ensuring proper neuronal function and transmission. 3. **Protein transport**: GPM6B regulates the localization of proteins to the cell surface, modulating cell-cell interactions and signaling. 4. **Regulation of actin cytoskeleton organization**: GPM6B's association with the actin cytoskeleton enables its regulation of cellular shape and movement. **Clinical Significance:** Dysregulation of GPM6B has been implicated in various neurological disorders, including: 1. **Autism Spectrum Disorder (ASD)**: Altered GPM6B expression has been linked to ASD, suggesting its involvement in synaptic function and neuronal development. 2. **Schizophrenia**: Abnormal GPM6B expression has been observed in schizophrenia, highlighting its potential role in neurotransmitter regulation and synaptic dysfunction. 3. **Neurodegenerative diseases**: Changes in GPM6B expression have been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, underscoring its importance in maintaining neuronal health and function. In conclusion, GPM6B is a multifunctional protein that plays a critical role in neurological development and maintenance. Its dysregulation has been implicated in various neurological disorders, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 2388509816

Symbol: GPM6B_HUMAN

Name: Neuronal membrane glycoprotein M6-b

UniProtKB Accession Codes:

Q13491 O76077 Q86X43 Q8N956

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 30 Ensembl 4 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8661015

Title: Chromosomal mapping of the human M6 genes.

PubMed ID: 8661015

DOI: 10.1006/geno.1996.0231

PubMed ID: 9674909

Title: Mutation analysis of the M6b gene in patients with Rett syndrome.

PubMed ID: 9674909

DOI: 10.1002/(sici)1096-8628(19980630)78:2<165::aid-ajmg13>3.0.co;2-l

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18581270

Title: Membrane glycoprotein M6B interacts with the human serotonin transporter.

PubMed ID: 18581270

DOI: 10.1007/s12031-008-9092-4

PubMed ID: 21638316

Title: GPM6B regulates osteoblast function and induction of mineralization by controlling cytoskeleton and matrix vesicle release.

PubMed ID: 21638316

DOI: 10.1002/jbmr.435

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 265
  • Mass: 28989
  • Checksum: 560AB12DD2B5AE75
  • Sequence:
    • MKPAMETAAE ENTEQSQERK GCFECCIKCL GGVPYASLVA TILCFSGVAL FCGCGHVALA 
GTVAILEQHF STNASDHALL SEVIQLMQYV IYGIASFFFL YGIILLAEGF YTTSAVKELH 
GEFKTTACGR CISGMFVFLT YVLGVAWLGV FGFSAVPVFM FYNIWSTCEV IKSPQTNGTT 
GVEQICVDIR QYGIIPWNAF PGKICGSALE NICNTNEFYM SYHLFIVACA GAGATVIALL 
IYMMATTYNY AVLKFKSRED CCTKF

Genular Protein ID: 1990514853

Symbol: Q59FD5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FD5

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 2 SMART 1

Sequence Information:

  • Length: 280
  • Mass: 30713
  • Checksum: B9BC5901456216C1
  • Sequence:
    • RSPHPSRQSP AMGCFECCIK CLGGVPYASL VATILCFSGV ALFCGCGHVA LAGTVAILEQ 
HFSTNASDHA LLSEVIQLMQ YVIYGIASFF FLYGIILLAE GFYTTSAVKE LHGEFKTTAC 
GRCISGMFVF LTYVLGVAWL GVFGFSAVPV FMFYNIWSTC EVIKSPQTNG TTGVEQICVD 
IRQYGIIPWN AFPGKICGSA LENICNTNEF YMSYHLFIVA CAGAGATVIA LIHFLMILSS 
NWAYLKDASK MQAYQDIKAK EEQELQDIQS RSKEQLNSYT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.