Details for: GPM6B

Gene ID: 2824

Symbol: GPM6B

Ensembl ID: ENSG00000046653

Description: glycoprotein M6B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 5.06
    Marker Score: 6,307
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 4.75
    Marker Score: 11,383
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 4.47
    Marker Score: 2,938
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.33
    Marker Score: 3,557
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.14
    Marker Score: 66,935
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.04
    Marker Score: 2,591
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.71
    Marker Score: 3,761
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.53
    Marker Score: 9,789
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.4
    Marker Score: 2,262
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.37
    Marker Score: 2,530
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.33
    Marker Score: 88,578
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.29
    Marker Score: 17,571
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.29
    Marker Score: 954
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.22
    Marker Score: 33,120
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.18
    Marker Score: 43,437
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.14
    Marker Score: 8,892
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.14
    Marker Score: 1,343
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.11
    Marker Score: 9,768
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.1
    Marker Score: 1,819
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.09
    Marker Score: 8,080
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.09
    Marker Score: 542
  • Cell Name: glial cell (CL0000125)
    Fold Change: 2.06
    Marker Score: 2,262
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.06
    Marker Score: 75,865
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.05
    Marker Score: 126,264
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.01
    Marker Score: 18,860
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.98
    Marker Score: 1,491
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.94
    Marker Score: 5,542
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.89
    Marker Score: 18,003
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.86
    Marker Score: 2,298
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.86
    Marker Score: 7,739
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.82
    Marker Score: 15,612
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.82
    Marker Score: 9,532
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.72
    Marker Score: 6,995
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.64
    Marker Score: 408
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.62
    Marker Score: 408
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.62
    Marker Score: 2,507
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.6
    Marker Score: 896
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.57
    Marker Score: 818
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.56
    Marker Score: 636
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.54
    Marker Score: 897
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.52
    Marker Score: 2,925
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.52
    Marker Score: 453
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168,013
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.45
    Marker Score: 48,834
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.44
    Marker Score: 409
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.43
    Marker Score: 14,480
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.28
    Marker Score: 444
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.26
    Marker Score: 13,049
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.26
    Marker Score: 369
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.23
    Marker Score: 445
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.21
    Marker Score: 965
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.19
    Marker Score: 664
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.17
    Marker Score: 3,934
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 1.14
    Marker Score: 11,575
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.12
    Marker Score: 552
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.09
    Marker Score: 5,882
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.09
    Marker Score: 1,257
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,712
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.01
    Marker Score: 11,341
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1
    Marker Score: 7,536
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,736
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,961
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.97
    Marker Score: 655
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.94
    Marker Score: 2,163
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.92
    Marker Score: 445
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.91
    Marker Score: 259
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,722
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 361
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.9
    Marker Score: 453
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.89
    Marker Score: 519
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.89
    Marker Score: 1,070
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.89
    Marker Score: 371
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.88
    Marker Score: 1,216
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.88
    Marker Score: 339
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,975
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,255
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.87
    Marker Score: 817
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.86
    Marker Score: 273
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.86
    Marker Score: 565
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.86
    Marker Score: 29,106
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.84
    Marker Score: 2,210
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.83
    Marker Score: 1,030
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.83
    Marker Score: 998
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 620
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.8
    Marker Score: 385
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.79
    Marker Score: 3,886
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.79
    Marker Score: 1,599
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.79
    Marker Score: 852
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.79
    Marker Score: 1,849
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.78
    Marker Score: 497
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3,282
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.77
    Marker Score: 244
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.76
    Marker Score: 1,554
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.76
    Marker Score: 263

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPM6B is a transmembrane glycoprotein that exhibits a unique structure, comprising multiple domains and motifs that enable its interaction with various cellular components. Its ability to regulate protein localization to the cell surface is mediated through its association with membrane rafts and the actin cytoskeleton. Furthermore, GPM6B has been shown to modulate serotonin uptake, suggesting its involvement in neurotransmitter regulation. Its expression is tightly regulated, with changes in GPM6B levels observed in response to developmental and pathological stimuli. **Pathways and Functions:** GPM6B is involved in several critical cellular pathways, including: 1. **Axon development**: GPM6B plays a crucial role in axon growth and guidance, regulating the interaction between axons and their target cells. 2. **Myelination**: As a component of the myelin sheath, GPM6B contributes to the formation and maintenance of the myelin structure, ensuring proper neuronal function and transmission. 3. **Protein transport**: GPM6B regulates the localization of proteins to the cell surface, modulating cell-cell interactions and signaling. 4. **Regulation of actin cytoskeleton organization**: GPM6B's association with the actin cytoskeleton enables its regulation of cellular shape and movement. **Clinical Significance:** Dysregulation of GPM6B has been implicated in various neurological disorders, including: 1. **Autism Spectrum Disorder (ASD)**: Altered GPM6B expression has been linked to ASD, suggesting its involvement in synaptic function and neuronal development. 2. **Schizophrenia**: Abnormal GPM6B expression has been observed in schizophrenia, highlighting its potential role in neurotransmitter regulation and synaptic dysfunction. 3. **Neurodegenerative diseases**: Changes in GPM6B expression have been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, underscoring its importance in maintaining neuronal health and function. In conclusion, GPM6B is a multifunctional protein that plays a critical role in neurological development and maintenance. Its dysregulation has been implicated in various neurological disorders, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 2388509816

Symbol: GPM6B_HUMAN

Name: Neuronal membrane glycoprotein M6-b

UniProtKB Accession Codes:

Q13491 O76077 Q86X43 Q8N956

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 30 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8661015

Title: Chromosomal mapping of the human M6 genes.

PubMed ID: 8661015

DOI: 10.1006/geno.1996.0231

PubMed ID: 9674909

Title: Mutation analysis of the M6b gene in patients with Rett syndrome.

PubMed ID: 9674909

DOI: 10.1002/(sici)1096-8628(19980630)78:2<165::aid-ajmg13>3.0.co;2-l

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18581270

Title: Membrane glycoprotein M6B interacts with the human serotonin transporter.

PubMed ID: 18581270

DOI: 10.1007/s12031-008-9092-4

PubMed ID: 21638316

Title: GPM6B regulates osteoblast function and induction of mineralization by controlling cytoskeleton and matrix vesicle release.

PubMed ID: 21638316

DOI: 10.1002/jbmr.435

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 265
  • Mass: 28989
  • Checksum: 560AB12DD2B5AE75
  • Sequence:
    • MKPAMETAAE ENTEQSQERK GCFECCIKCL GGVPYASLVA TILCFSGVAL FCGCGHVALA 
GTVAILEQHF STNASDHALL SEVIQLMQYV IYGIASFFFL YGIILLAEGF YTTSAVKELH 
GEFKTTACGR CISGMFVFLT YVLGVAWLGV FGFSAVPVFM FYNIWSTCEV IKSPQTNGTT 
GVEQICVDIR QYGIIPWNAF PGKICGSALE NICNTNEFYM SYHLFIVACA GAGATVIALL 
IYMMATTYNY AVLKFKSRED CCTKF

Genular Protein ID: 1990514853

Symbol: Q59FD5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FD5

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 2 SMART 1

Sequence Information:

  • Length: 280
  • Mass: 30713
  • Checksum: B9BC5901456216C1
  • Sequence:
    • RSPHPSRQSP AMGCFECCIK CLGGVPYASL VATILCFSGV ALFCGCGHVA LAGTVAILEQ 
HFSTNASDHA LLSEVIQLMQ YVIYGIASFF FLYGIILLAE GFYTTSAVKE LHGEFKTTAC 
GRCISGMFVF LTYVLGVAWL GVFGFSAVPV FMFYNIWSTC EVIKSPQTNG TTGVEQICVD 
IRQYGIIPWN AFPGKICGSA LENICNTNEF YMSYHLFIVA CAGAGATVIA LIHFLMILSS 
NWAYLKDASK MQAYQDIKAK EEQELQDIQS RSKEQLNSYT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.