Details for: GPM6B

Gene ID: 2824

Symbol: GPM6B

Ensembl ID: ENSG00000046653

Description: glycoprotein M6B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 5.06
    Marker Score: 6307
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 4.75
    Marker Score: 11383
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 4.47
    Marker Score: 2938
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.33
    Marker Score: 3557
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.14
    Marker Score: 66935
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.04
    Marker Score: 2591
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.71
    Marker Score: 3761
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.53
    Marker Score: 9788.5
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.4
    Marker Score: 2262
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.37
    Marker Score: 2530
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.33
    Marker Score: 88578
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.29
    Marker Score: 17571
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.29
    Marker Score: 954
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.22
    Marker Score: 33120
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.18
    Marker Score: 43437
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.14
    Marker Score: 8892
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.14
    Marker Score: 1343
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.11
    Marker Score: 9768
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.1
    Marker Score: 1819
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.09
    Marker Score: 8080
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.09
    Marker Score: 542
  • Cell Name: glial cell (CL0000125)
    Fold Change: 2.06
    Marker Score: 2262
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.06
    Marker Score: 75865
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.05
    Marker Score: 126264
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.01
    Marker Score: 18860
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.98
    Marker Score: 1491
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.94
    Marker Score: 5542
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.89
    Marker Score: 18003
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.86
    Marker Score: 2298
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.86
    Marker Score: 7739
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.82
    Marker Score: 15612
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.82
    Marker Score: 9532
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.72
    Marker Score: 6995
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.64
    Marker Score: 408
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.62
    Marker Score: 408
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.62
    Marker Score: 2507
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.6
    Marker Score: 896
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.57
    Marker Score: 818
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.56
    Marker Score: 636
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.54
    Marker Score: 897
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.52
    Marker Score: 2925
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.52
    Marker Score: 453
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168013
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.45
    Marker Score: 48834
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.44
    Marker Score: 409
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.43
    Marker Score: 14480
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.28
    Marker Score: 444
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.26
    Marker Score: 13049
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.26
    Marker Score: 369
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.23
    Marker Score: 445
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.21
    Marker Score: 965
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.19
    Marker Score: 664
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.17
    Marker Score: 3934
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 1.14
    Marker Score: 11574.5
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.12
    Marker Score: 552
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.09
    Marker Score: 5882
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.09
    Marker Score: 1257
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251712
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.01
    Marker Score: 11341
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1
    Marker Score: 7536
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71736
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47961
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.97
    Marker Score: 655
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.94
    Marker Score: 2163
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.92
    Marker Score: 445
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.91
    Marker Score: 259
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2722
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 361
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.9
    Marker Score: 453
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.89
    Marker Score: 519
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.89
    Marker Score: 1070
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.89
    Marker Score: 371
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.88
    Marker Score: 1216
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.88
    Marker Score: 339
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4975
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5255
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.87
    Marker Score: 817
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.86
    Marker Score: 272.5
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.86
    Marker Score: 565
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.86
    Marker Score: 29106
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.84
    Marker Score: 2210
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.83
    Marker Score: 1030
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.83
    Marker Score: 998
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 620
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.8
    Marker Score: 385
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.79
    Marker Score: 3886
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.79
    Marker Score: 1598.5
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.79
    Marker Score: 851.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.79
    Marker Score: 1849
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.78
    Marker Score: 497
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3282
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.77
    Marker Score: 244
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.76
    Marker Score: 1554
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.76
    Marker Score: 263

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Other Information

**Key characteristics:** - GPM6B is a glycoprotein with a molecular weight of approximately 120 kDa. - It is a transmembrane protein that is predominantly expressed in neurons and oligodendrocytes. - It is a key component of the myelin sheath, which is essential for the electrical and structural integrity of nerve cells. **Pathways and functions:** - GPM6B is involved in several important pathways, including axon development, central nervous system (CNS) myelination, extracellular matrix assembly, and negative regulation of protein localization to cell surface. - It is crucial for the formation of the myelin sheath, a process known as oligodendrocyte differentiation. - It also plays a role in the regulation of neuronal migration, survival, and differentiation. **Clinical significance:** - Mutations in GPM6B have been linked to several neurological disorders, including multiple sclerosis (MS), a chronic autoimmune disease that affects the CNS. - In MS, GPM6B is expressed in oligodendrocytes and is essential for the formation and maintenance of the myelin sheath. - Dysregulation of GPM6B signaling has been shown to contribute to the pathogenesis of MS. **Additional points:** - GPM6B is a highly conserved protein, with similar sequences found in mammals and fish. - It is a member of the immunoglobulin superfamily, which are involved in cell adhesion, signaling, and immune responses. - GPM6B is a promising target for therapeutic interventions in MS and other neurological disorders that are characterized by myelin damage.

Genular Protein ID: 2388509816

Symbol: GPM6B_HUMAN

Name: Neuronal membrane glycoprotein M6-b

UniProtKB Accession Codes:

Q13491 O76077 Q86X43 Q8N956

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 30 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8661015

Title: Chromosomal mapping of the human M6 genes.

PubMed ID: 8661015

DOI: 10.1006/geno.1996.0231

PubMed ID: 9674909

Title: Mutation analysis of the M6b gene in patients with Rett syndrome.

PubMed ID: 9674909

DOI: 10.1002/(sici)1096-8628(19980630)78:2<165::aid-ajmg13>3.0.co;2-l

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18581270

Title: Membrane glycoprotein M6B interacts with the human serotonin transporter.

PubMed ID: 18581270

DOI: 10.1007/s12031-008-9092-4

PubMed ID: 21638316

Title: GPM6B regulates osteoblast function and induction of mineralization by controlling cytoskeleton and matrix vesicle release.

PubMed ID: 21638316

DOI: 10.1002/jbmr.435

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 265
  • Mass: 28989
  • Checksum: 560AB12DD2B5AE75
  • Sequence:
    • MKPAMETAAE ENTEQSQERK GCFECCIKCL GGVPYASLVA TILCFSGVAL FCGCGHVALA 
GTVAILEQHF STNASDHALL SEVIQLMQYV IYGIASFFFL YGIILLAEGF YTTSAVKELH 
GEFKTTACGR CISGMFVFLT YVLGVAWLGV FGFSAVPVFM FYNIWSTCEV IKSPQTNGTT 
GVEQICVDIR QYGIIPWNAF PGKICGSALE NICNTNEFYM SYHLFIVACA GAGATVIALL 
IYMMATTYNY AVLKFKSRED CCTKF

Genular Protein ID: 1990514853

Symbol: Q59FD5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FD5

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 2 SMART 1

Sequence Information:

  • Length: 280
  • Mass: 30713
  • Checksum: B9BC5901456216C1
  • Sequence:
    • RSPHPSRQSP AMGCFECCIK CLGGVPYASL VATILCFSGV ALFCGCGHVA LAGTVAILEQ 
HFSTNASDHA LLSEVIQLMQ YVIYGIASFF FLYGIILLAE GFYTTSAVKE LHGEFKTTAC 
GRCISGMFVF LTYVLGVAWL GVFGFSAVPV FMFYNIWSTC EVIKSPQTNG TTGVEQICVD 
IRQYGIIPWN AFPGKICGSA LENICNTNEF YMSYHLFIVA CAGAGATVIA LIHFLMILSS 
NWAYLKDASK MQAYQDIKAK EEQELQDIQS RSKEQLNSYT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.