Details for: SPARCL1

Gene ID: 8404

Symbol: SPARCL1

Ensembl ID: ENSG00000152583

Description: SPARC like 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 6.77
    Marker Score: 3829
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 6.66
    Marker Score: 3611
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.62
    Marker Score: 7322
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 5.17
    Marker Score: 3402
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 4.53
    Marker Score: 2980
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 4.51
    Marker Score: 6557
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.33
    Marker Score: 4627
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.33
    Marker Score: 3688
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.28
    Marker Score: 10872.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.14
    Marker Score: 2178
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.89
    Marker Score: 4849
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.82
    Marker Score: 3284
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.81
    Marker Score: 7151
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.72
    Marker Score: 7425
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.65
    Marker Score: 3477
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.64
    Marker Score: 9524
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.63
    Marker Score: 5254
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.49
    Marker Score: 7652
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.43
    Marker Score: 1430
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.27
    Marker Score: 3761
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.18
    Marker Score: 67970.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.16
    Marker Score: 5344
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.05
    Marker Score: 34300
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.94
    Marker Score: 1114
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.92
    Marker Score: 12576
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.89
    Marker Score: 2058
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.86
    Marker Score: 1707
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.85
    Marker Score: 1664
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.8
    Marker Score: 3454
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.75
    Marker Score: 1809
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.72
    Marker Score: 17661.5
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.69
    Marker Score: 1044
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.66
    Marker Score: 1904
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.64
    Marker Score: 89944
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.62
    Marker Score: 52044
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.57
    Marker Score: 2230
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.56
    Marker Score: 10614.5
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 2.56
    Marker Score: 1060
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.55
    Marker Score: 634
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.54
    Marker Score: 2450
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.53
    Marker Score: 634
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.45
    Marker Score: 5759.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.4
    Marker Score: 88717
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 2.38
    Marker Score: 6727.5
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.36
    Marker Score: 612
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.35
    Marker Score: 666
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.29
    Marker Score: 2054
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.29
    Marker Score: 30201
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.26
    Marker Score: 2279
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.23
    Marker Score: 19580.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.22
    Marker Score: 650
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.19
    Marker Score: 558
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.18
    Marker Score: 2347
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 2.16
    Marker Score: 459
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.14
    Marker Score: 2937
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.08
    Marker Score: 484.5
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 2.04
    Marker Score: 1844
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2
    Marker Score: 693
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.98
    Marker Score: 121637.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.91
    Marker Score: 18101.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.88
    Marker Score: 433
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.83
    Marker Score: 15742
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.83
    Marker Score: 904.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.83
    Marker Score: 2263
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.78
    Marker Score: 993
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.78
    Marker Score: 988
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.76
    Marker Score: 424
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.76
    Marker Score: 16541
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.73
    Marker Score: 1089
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.7
    Marker Score: 694.5
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.69
    Marker Score: 1502.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.69
    Marker Score: 2605
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 1.69
    Marker Score: 502
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.6
    Marker Score: 2477
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.54
    Marker Score: 406
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.51
    Marker Score: 1010
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.5
    Marker Score: 630
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5
    Marker Score: 3672
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.43
    Marker Score: 354
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.41
    Marker Score: 1332
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.41
    Marker Score: 804
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.38
    Marker Score: 2612
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.29
    Marker Score: 466
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.27
    Marker Score: 2103
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.25
    Marker Score: 607
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.23
    Marker Score: 269
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.21
    Marker Score: 332
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.17
    Marker Score: 925
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.16
    Marker Score: 132846
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.16
    Marker Score: 584
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.14
    Marker Score: 1232
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.14
    Marker Score: 476
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.14
    Marker Score: 722
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.12
    Marker Score: 2746
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.1
    Marker Score: 1293
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.1
    Marker Score: 345
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.09
    Marker Score: 499
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.08
    Marker Score: 2076
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.07
    Marker Score: 337
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.07
    Marker Score: 40461

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** 1. **Multi-functional protein**: SPARCL1 contains multiple functional domains, including calcium ion binding, collagen binding, and protein binding capabilities, which enable it to interact with various cellular components. 2. **Significant expression in diverse cell types**: SPARCL1 is expressed in a wide range of cell types, including endocardial cells, uterine smooth muscle cells, and hematopoietic stem cells, indicating its potential involvement in various physiological processes. 3. **Regulation of protein metabolism**: SPARCL1 is involved in the regulation of protein metabolism, including post-translational protein modification and protein binding, which may impact cellular signaling and function. **Pathways and Functions:** 1. **Anatomical structure development**: SPARCL1 is involved in the development of anatomical structures, including the extracellular matrix, which is essential for tissue organization and function. 2. **Calcium ion binding**: The ability of SPARCL1 to bind calcium ions suggests its involvement in calcium-dependent cellular processes, such as muscle contraction and cell signaling. 3. **Collagen binding**: SPARCL1's collagen-binding capacity indicates its role in maintaining the integrity of the extracellular matrix and regulating collagen-mediated cellular processes. 4. **Signal transduction**: SPARCL1's involvement in signal transduction pathways, including those regulating insulin-like growth factor (IGF) transport and uptake, highlights its potential role in modulating cellular responses to external stimuli. 5. **Protein binding**: The protein-binding capabilities of SPARCL1 enable it to interact with various cellular components, including proteins involved in metabolism, protein modification, and signal transduction. **Clinical Significance:** 1. **Implications for cardiovascular disease**: The expression of SPARCL1 in endocardial cells and its involvement in calcium ion binding and collagen binding suggest its potential role in cardiovascular disease, including atherosclerosis and cardiac remodeling. 2. **Role in cancer progression**: SPARCL1's involvement in signal transduction pathways, including those regulating IGF transport and uptake, may contribute to cancer progression and metastasis. 3. **Potential therapeutic targets**: The identification of SPARCL1 as a regulator of cellular processes, including protein metabolism and signal transduction, may lead to the development of novel therapeutic strategies for various diseases. 4. **Implications for immunological disorders**: The expression of SPARCL1 in hematopoietic stem cells and its involvement in signal transduction pathways suggest its potential role in immunological disorders, including autoimmune diseases and immunodeficiency disorders. In conclusion, SPARCL1 is a multifunctional protein that plays a crucial role in regulating various cellular processes, including protein metabolism, signal transduction, and extracellular matrix function. Its significant expression in diverse cell types and involvement in multiple pathways highlight its potential implications for various diseases, including cardiovascular disease, cancer, and immunological disorders. Further research is needed to elucidate the specific functions of SPARCL1 and its role in disease pathogenesis.

Genular Protein ID: 2530952382

Symbol: SPRL1_HUMAN

Name: SPARC-like protein 1

UniProtKB Accession Codes:

Q14515 B4E2Z0 E7ESU2 Q14800

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PROSITE 5 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 4 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7600298

Title: Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC.

PubMed ID: 7600298

DOI: 10.1016/1074-7613(95)90083-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

Sequence Information:

  • Length: 664
  • Mass: 75208
  • Checksum: 0750B0080FDB96B6
  • Sequence:
    • MKTGLFFLCL LGTAAAIPTN ARLLSDHSKP TAETVAPDNT AIPSLRAEAE ENEKETAVST 
EDDSHHKAEK SSVLKSKEES HEQSAEQGKS SSQELGLKDQ EDSDGHLSVN LEYAPTEGTL 
DIKEDMSEPQ EKKLSENTDF LAPGVSSFTD SNQQESITKR EENQEQPRNY SHHQLNRSSK 
HSQGLRDQGN QEQDPNISNG EEEEEKEPGE VGTHNDNQER KTELPREHAN SKQEEDNTQS 
DDILEESDQP TQVSKMQEDE FDQGNQEQED NSNAEMEEEN ASNVNKHIQE TEWQSQEGKT 
GLEAISNHKE TEEKTVSEAL LMEPTDDGNT TPRNHGVDDD GDDDGDDGGT DGPRHSASDD 
YFIPSQAFLE AERAQSIAYH LKIEEQREKV HENENIGTTE PGEHQEAKKA ENSSNEEETS 
SEGNMRVHAV DSCMSFQCKR GHICKADQQG KPHCVCQDPV TCPPTKPLDQ VCGTDNQTYA 
SSCHLFATKC RLEGTKKGHQ LQLDYFGACK SIPTCTDFEV IQFPLRMRDW LKNILMQLYE 
ANSEHAGYLN EKQRNKVKKI YLDEKRLLAG DHPIDLLLRD FKKNYHMYVY PVHWQFSELD 
QHPMDRVLTH SELAPLRASL VPMEHCITRF FEECDPNKDK HITLKEWGHC FGIKEEDIDE 
NLLF

Genular Protein ID: 4095364940

Symbol: Q8N4S1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N4S1

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 GO 4 Gene3D 2 GenomeRNAi 1 IntAct 1 InterPro 10 MINT 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PROSITE 7 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 2 SMART 2 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 664
  • Mass: 75230
  • Checksum: F6552825D1A3999E
  • Sequence:
    • MKTGLFFLCL LGTAAAIPTN ARLLSDHSKP TAETVAPDNT AIPSLRAEDE ENEKETAVST 
EDDSHHKAEK SSVLKSKEES HEQSAEQGKS SSQELGLKDQ EDSDGDLSVN LEYAPTEGTL 
DIKEDMSEPQ EKKLSENTDF LAPGVSSFTD SNQQESITKR EENQEQPRNY SHHQLNRSSK 
HSQGLRDQGN QEQDPNISNG EEEEEKEPGE VGTHNDNQER KTELPREHAN SKQEEDNTQS 
DDILEESDQP TQVSKMQEDE FDQGNQEQED NSNAEMEEEN ASNVNKHIQE TEWQSQEGKT 
GLEAISNHKE TEEKTVSEAL LMEPTDDGNT TPRNHGVDDD GDDDGDDGGT DGPRHSASDD 
YFIPSQAFLE AERAQSIAYH LKIEEQREKV HENENIGTTE PGEHQEAKKA ENSSNEEETS 
SEGNMRVHAV DSCMSFQCKR GHICKADQQG KPHCVCQDPV TCPPTKPLDQ VCGTDNQTYA 
SSCHLFATKC RLEGTKKGHQ LQLDYFGACK SIPTCTDFEV IQFPLRMRDW LKNILMQLYE 
ANSEHAGYLN EKQRNKVKKI YLDEKRLLAG DHPIDLLLRD FKKNYHMYVY PVHWQFSELD 
QHPMDRVLTH SELAPLRASL VPMEHCITRF FEECDPNKDK HITLKEWGHC FGIKEEDIDE 
NLLF

Genular Protein ID: 1058857388

Symbol: B7ZB68_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZB68

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 GenomeRNAi 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 Pfam 3 RefSeq 1 SAM 1 SMART 2 SUPFAM 3

Sequence Information:

  • Length: 539
  • Mass: 61780
  • Checksum: D85BDFEEF95B340F
  • Sequence:
    • MSEPQEKKLS ENTDFLAPGV SSFTDSNQQE SITKREENQE QPRNYSHHQL NRSSKHSQGL 
RDQGNQEQDP NISNGEEEEE KEPGEVGTHN DNQERKTELP REHANSKQEE DNTQSDDILE 
ESDQPTQVSK MQEDEFDQGN QEQEDNSNAE MEEENASNVN KHIQETEWQS QEGKTGLEAI 
SNHKETEEKT VSEALLMEPT DDGNTTPRNH GVDDDGDDDG DDGGTDGPRH SASDDYFIPS 
QAFLEAERAQ SIAYRLKIEE QREKVHENEN IGTTEPGEHQ EAKKAENSSN EEETSSEGNM 
RVHAVDSCMS FQCKRGHICK ADQQGKPHCV CQDPVTCPPT KPLDQVCGTD NQTYASSCHL 
FATKCRLEGT KKGHQLQLDY FGACKSIPTC TDFEVIQFPL RMRDWLKNIL MQLYEANSEH 
AGYLNEKQRN KVKKIYLDEK RLLAGDHPND LLLRDFKKNY HMYVYPVHWQ FSELDQHPMD 
RVLTHSELAP LRASLVPMEH CITRFFEECD PNKDKHITLK EWGHCFGIKE EDIDENLLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.