Details for: KRT6B

Gene ID: 3854

Symbol: KRT6B

Ensembl ID: ENSG00000185479

Description: keratin 6B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 3.92
    Marker Score: 5633
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.94
    Marker Score: 22948
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.9
    Marker Score: 2421
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.65
    Marker Score: 942
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.43
    Marker Score: 20969
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.17
    Marker Score: 10679
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1167
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.3
    Marker Score: 863
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 851
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.24
    Marker Score: 299
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 482
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4809
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.98
    Marker Score: 560
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5330
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.88
    Marker Score: 497
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 791
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.77
    Marker Score: 1367
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.74
    Marker Score: 655
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.71
    Marker Score: 1614
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.7
    Marker Score: 368
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.63
    Marker Score: 201
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.61
    Marker Score: 8149
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.58
    Marker Score: 408
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 370
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.58
    Marker Score: 652
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.57
    Marker Score: 264
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.45
    Marker Score: 398
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.42
    Marker Score: 176
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 182
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.37
    Marker Score: 478
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.37
    Marker Score: 413
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.35
    Marker Score: 173
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.33
    Marker Score: 597.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.32
    Marker Score: 341
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3
    Marker Score: 303.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.27
    Marker Score: 78
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.27
    Marker Score: 429
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.24
    Marker Score: 245
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.23
    Marker Score: 1684
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.23
    Marker Score: 312
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.22
    Marker Score: 151
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.22
    Marker Score: 258
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.22
    Marker Score: 852
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.22
    Marker Score: 416.5
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.22
    Marker Score: 55
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.21
    Marker Score: 124
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.21
    Marker Score: 70
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2
    Marker Score: 3100
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.19
    Marker Score: 545
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.19
    Marker Score: 88
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.19
    Marker Score: 6399
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.18
    Marker Score: 305
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.18
    Marker Score: 109
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.16
    Marker Score: 108
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.16
    Marker Score: 155
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.16
    Marker Score: 265
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.16
    Marker Score: 319
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.15
    Marker Score: 31
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.15
    Marker Score: 101
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.14
    Marker Score: 32
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.13
    Marker Score: 146
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.12
    Marker Score: 74
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.12
    Marker Score: 58
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 134
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.12
    Marker Score: 205
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 102
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.11
    Marker Score: 683
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.11
    Marker Score: 32
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.11
    Marker Score: 51
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.11
    Marker Score: 30
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.1
    Marker Score: 54
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.1
    Marker Score: 322
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.1
    Marker Score: 28.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1
    Marker Score: 58
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.1
    Marker Score: 68
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.1
    Marker Score: 30
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 93
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.09
    Marker Score: 25

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Other Information

**Key characteristics:** - The KRT6B gene is located on chromosome 17q21.1. - It is a highly expressed gene in epithelial cells. - It is a member of the keratin family of cytoskeletal proteins. - It is a secreted protein that is found in the extracellular matrix. **Pathways and functions:** - KRT6B is a key component of the cytoskeleton, which is a network of protein filaments that provides structural support for cells. - The cytoskeleton is involved in a variety of cellular processes, including cell adhesion, migration, and signaling. - KRT6B is also involved in the formation of the cornified envelope, which is a protective barrier that surrounds epithelial cells. **Clinical significance:** - Mutations in the KRT6B gene have been linked to a number of human diseases, including psoriasis, eczema, and skin cancer. - These diseases are characterized by abnormal skin inflammation and barrier function. - Targeting KRT6B has been explored as a therapeutic strategy for these diseases.

Genular Protein ID: 3446035613

Symbol: K2C6B_HUMAN

Name: Keratin, type II cytoskeletal 6B

UniProtKB Accession Codes:

P04259 P48669

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 20 EPD 1 Ensembl 1 GO 8 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7543104

Title: Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms.

PubMed ID: 7543104

DOI: 10.1074/jbc.270.31.18581

PubMed ID: 2410904

Title: The sequence of a type II keratin gene expressed in human skin: conservation of structure among all intermediate filament genes.

PubMed ID: 2410904

DOI: 10.1073/pnas.82.14.4683

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 9618173

Title: A mutation in human keratin K6b produces a phenocopy of the K17 disorder pachyonychia congenita type 2.

PubMed ID: 9618173

DOI: 10.1093/hmg/7.7.1143

PubMed ID: 16250206

Title: The genetic basis of pachyonychia congenita.

PubMed ID: 16250206

DOI: 10.1111/j.1087-0024.2005.10204.x

PubMed ID: 21326300

Title: A large mutational study in pachyonychia congenita.

PubMed ID: 21326300

DOI: 10.1038/jid.2011.20

Sequence Information:

  • Length: 564
  • Mass: 60067
  • Checksum: FFA4C351FBF09F09
  • Sequence:
    • MASTSTTIRS HSSSRRGFSA NSARLPGVSR SGFSSISVSR SRGSGGLGGA CGGAGFGSRS 
LYGLGGSKRI SIGGGSCAIS GGYGSRAGGS YGFGGAGSGF GFGGGAGIGF GLGGGAGLAG 
GFGGPGFPVC PPGGIQEVTV NQSLLTPLNL QIDPAIQRVR AEEREQIKTL NNKFASFIDK 
VRFLEQQNKV LDTKWTLLQE QGTKTVRQNL EPLFEQYINN LRRQLDNIVG ERGRLDSELR 
NMQDLVEDLK NKYEDEINKR TAAENEFVTL KKDVDAAYMN KVELQAKADT LTDEINFLRA 
LYDAELSQMQ THISDTSVVL SMDNNRNLDL DSIIAEVKAQ YEEIAQRSRA EAESWYQTKY 
EELQITAGRH GDDLRNTKQE IAEINRMIQR LRSEIDHVKK QCANLQAAIA DAEQRGEMAL 
KDAKNKLEGL EDALQKAKQD LARLLKEYQE LMNVKLALDV EIATYRKLLE GEECRLNGEG 
VGQVNISVVQ STVSSGYGGA SGVGSGLGLG GGSSYSYGSG LGVGGGFSSS SGRATGGGLS 
SVGGGSSTIK YTTTSSSSRK SYKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.