Details for: KRT6B

Gene ID: 3854

Symbol: KRT6B

Ensembl ID: ENSG00000185479

Description: keratin 6B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 32.3845
    Cell Significance Index: 278.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7172
    Cell Significance Index: 221.8500
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.4053
    Cell Significance Index: 6.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1059
    Cell Significance Index: 30.9100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.7468
    Cell Significance Index: 12.1000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.4791
    Cell Significance Index: 3.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.3688
    Cell Significance Index: 77.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3540
    Cell Significance Index: 156.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.3502
    Cell Significance Index: 197.4900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.2988
    Cell Significance Index: 0.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2779
    Cell Significance Index: 13.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1392
    Cell Significance Index: 16.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0819
    Cell Significance Index: 3.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0623
    Cell Significance Index: 4.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0530
    Cell Significance Index: 33.0800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0016
    Cell Significance Index: 0.0600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0014
    Cell Significance Index: 0.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0007
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0032
    Cell Significance Index: -2.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0129
    Cell Significance Index: -9.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0251
    Cell Significance Index: -13.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0349
    Cell Significance Index: -15.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0430
    Cell Significance Index: -7.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0605
    Cell Significance Index: -10.9000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0627
    Cell Significance Index: -1.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0654
    Cell Significance Index: -12.9800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0782
    Cell Significance Index: -8.9300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0810
    Cell Significance Index: -1.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0853
    Cell Significance Index: -10.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0891
    Cell Significance Index: -17.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0941
    Cell Significance Index: -10.7800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1026
    Cell Significance Index: -3.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1039
    Cell Significance Index: -14.2700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1083
    Cell Significance Index: -1.1500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1379
    Cell Significance Index: -1.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1602
    Cell Significance Index: -11.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1961
    Cell Significance Index: -5.6200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2116
    Cell Significance Index: -5.2900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3016
    Cell Significance Index: -7.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3060
    Cell Significance Index: -13.8700
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.3145
    Cell Significance Index: -2.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3315
    Cell Significance Index: -17.2200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.4213
    Cell Significance Index: -5.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4334
    Cell Significance Index: -13.8800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4476
    Cell Significance Index: -5.2200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4633
    Cell Significance Index: -7.9200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4660
    Cell Significance Index: -8.2400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4663
    Cell Significance Index: -11.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4828
    Cell Significance Index: -14.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4991
    Cell Significance Index: -6.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5172
    Cell Significance Index: -13.8100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5592
    Cell Significance Index: -13.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5730
    Cell Significance Index: -12.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5808
    Cell Significance Index: -9.7200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6006
    Cell Significance Index: -8.5500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.6109
    Cell Significance Index: -7.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6222
    Cell Significance Index: -20.3700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.6422
    Cell Significance Index: -8.8800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.6433
    Cell Significance Index: -7.8300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6455
    Cell Significance Index: -16.4900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.6588
    Cell Significance Index: -6.9500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.6630
    Cell Significance Index: -7.8900
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.6700
    Cell Significance Index: -8.3200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6787
    Cell Significance Index: -15.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6828
    Cell Significance Index: -12.6200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.6843
    Cell Significance Index: -11.5100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.7007
    Cell Significance Index: -13.7000
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: -0.7410
    Cell Significance Index: -5.2000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.7745
    Cell Significance Index: -11.2500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.7788
    Cell Significance Index: -10.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7858
    Cell Significance Index: -21.3900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.8007
    Cell Significance Index: -16.7000
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.8226
    Cell Significance Index: -8.4900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.8325
    Cell Significance Index: -16.6000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.8399
    Cell Significance Index: -10.5500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.8977
    Cell Significance Index: -10.3300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.9112
    Cell Significance Index: -11.5400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9317
    Cell Significance Index: -20.1300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9543
    Cell Significance Index: -20.2600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.9604
    Cell Significance Index: -16.5000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.9815
    Cell Significance Index: -16.6700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.9821
    Cell Significance Index: -13.0500
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.9921
    Cell Significance Index: -7.3500
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -1.0005
    Cell Significance Index: -8.2700
  • Cell Name: T cell (CL0000084)
    Fold Change: -1.0011
    Cell Significance Index: -11.8200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0027
    Cell Significance Index: -20.1300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -1.0128
    Cell Significance Index: -12.3300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -1.0384
    Cell Significance Index: -14.2600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -1.0407
    Cell Significance Index: -12.3700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -1.0410
    Cell Significance Index: -15.8100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -1.0429
    Cell Significance Index: -16.7700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -1.0524
    Cell Significance Index: -13.5000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -1.0549
    Cell Significance Index: -14.9900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -1.0713
    Cell Significance Index: -13.4900
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -1.0823
    Cell Significance Index: -10.6300
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -1.0869
    Cell Significance Index: -10.3200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -1.0915
    Cell Significance Index: -14.5500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -1.0923
    Cell Significance Index: -15.1500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -1.0931
    Cell Significance Index: -13.8300
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -1.0939
    Cell Significance Index: -12.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KRT6B is a type II keratin, characterized by its rod-like shape and a molecular weight of approximately 55 kDa. It is predominantly expressed in stratified epithelial cells, including keratinocytes, epithelial cells of the esophagus, and colon goblet cells. KRT6B is also found in certain hematopoietic cells and intestinal crypt stem cells, highlighting its role in tissue development and homeostasis. **Pathways and Functions:** KRT6B is involved in various cellular pathways, including: 1. **Keratinization:** KRT6B plays a crucial role in the formation of the cornified envelope, a key structure in stratified epithelial cells that provides mechanical strength and resistance to desiccation. 2. **Intermediate Filament Organization:** KRT6B interacts with other intermediate filament proteins to form a network that maintains cellular structure and resilience. 3. **Cell Adhesion:** KRT6B contributes to cell-cell adhesion by interacting with other keratins and proteins, such as plakins and desmogleins. 4. **Signaling Pathways:** KRT6B is involved in signaling pathways that regulate cell growth, differentiation, and survival. **Clinical Significance:** Dysregulation of KRT6B has been implicated in various diseases, including: 1. **Epidermolysis Bullosa Simplex (EBS):** Mutations in the KRT6B gene have been associated with EBS, a genetic disorder characterized by blistering skin lesions. 2. **Cancer:** Aberrant expression of KRT6B has been observed in certain types of cancer, including esophageal and colon cancer, suggesting its potential role in tumorigenesis. 3. **Inflammatory Diseases:** KRT6B has been implicated in inflammatory diseases, such as psoriasis, where its expression is altered in response to inflammatory stimuli. In conclusion, KRT6B is a vital protein component of stratified epithelial cells, playing a crucial role in maintaining cellular structure and function. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 3446035613

Symbol: K2C6B_HUMAN

Name: Keratin, type II cytoskeletal 6B

UniProtKB Accession Codes:

P04259 P48669

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 20 Ensembl 1 GO 8 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7543104

Title: Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms.

PubMed ID: 7543104

DOI: 10.1074/jbc.270.31.18581

PubMed ID: 2410904

Title: The sequence of a type II keratin gene expressed in human skin: conservation of structure among all intermediate filament genes.

PubMed ID: 2410904

DOI: 10.1073/pnas.82.14.4683

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 9618173

Title: A mutation in human keratin K6b produces a phenocopy of the K17 disorder pachyonychia congenita type 2.

PubMed ID: 9618173

DOI: 10.1093/hmg/7.7.1143

PubMed ID: 16250206

Title: The genetic basis of pachyonychia congenita.

PubMed ID: 16250206

DOI: 10.1111/j.1087-0024.2005.10204.x

PubMed ID: 21326300

Title: A large mutational study in pachyonychia congenita.

PubMed ID: 21326300

DOI: 10.1038/jid.2011.20

Sequence Information:

  • Length: 564
  • Mass: 60067
  • Checksum: FFA4C351FBF09F09
  • Sequence:
    • MASTSTTIRS HSSSRRGFSA NSARLPGVSR SGFSSISVSR SRGSGGLGGA CGGAGFGSRS 
LYGLGGSKRI SIGGGSCAIS GGYGSRAGGS YGFGGAGSGF GFGGGAGIGF GLGGGAGLAG 
GFGGPGFPVC PPGGIQEVTV NQSLLTPLNL QIDPAIQRVR AEEREQIKTL NNKFASFIDK 
VRFLEQQNKV LDTKWTLLQE QGTKTVRQNL EPLFEQYINN LRRQLDNIVG ERGRLDSELR 
NMQDLVEDLK NKYEDEINKR TAAENEFVTL KKDVDAAYMN KVELQAKADT LTDEINFLRA 
LYDAELSQMQ THISDTSVVL SMDNNRNLDL DSIIAEVKAQ YEEIAQRSRA EAESWYQTKY 
EELQITAGRH GDDLRNTKQE IAEINRMIQR LRSEIDHVKK QCANLQAAIA DAEQRGEMAL 
KDAKNKLEGL EDALQKAKQD LARLLKEYQE LMNVKLALDV EIATYRKLLE GEECRLNGEG 
VGQVNISVVQ STVSSGYGGA SGVGSGLGLG GGSSYSYGSG LGVGGGFSSS SGRATGGGLS 
SVGGGSSTIK YTTTSSSSRK SYKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.