Details for: LAMC2

Gene ID: 3918

Symbol: LAMC2

Ensembl ID: ENSG00000058085

Description: laminin subunit gamma 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 97.4636
    Cell Significance Index: -15.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.4930
    Cell Significance Index: -15.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.1933
    Cell Significance Index: -11.8600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 21.0872
    Cell Significance Index: -14.1500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.2127
    Cell Significance Index: -11.6600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 5.5452
    Cell Significance Index: 83.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.8008
    Cell Significance Index: 103.4600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.5930
    Cell Significance Index: 30.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.3451
    Cell Significance Index: 45.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.8027
    Cell Significance Index: 80.7500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.5770
    Cell Significance Index: -5.6400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.5282
    Cell Significance Index: 17.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.4540
    Cell Significance Index: 127.4800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.3438
    Cell Significance Index: 14.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7508
    Cell Significance Index: 79.3600
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 1.6370
    Cell Significance Index: 11.7800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.6164
    Cell Significance Index: 23.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4930
    Cell Significance Index: 284.1200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.4682
    Cell Significance Index: 33.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3086
    Cell Significance Index: 28.3500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.0510
    Cell Significance Index: 11.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7518
    Cell Significance Index: 97.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7194
    Cell Significance Index: 649.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.6533
    Cell Significance Index: 22.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6425
    Cell Significance Index: 350.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5065
    Cell Significance Index: 55.1000
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.4506
    Cell Significance Index: 1.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4191
    Cell Significance Index: 68.1600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.4018
    Cell Significance Index: 5.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4015
    Cell Significance Index: 10.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3954
    Cell Significance Index: 8.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3660
    Cell Significance Index: 161.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3396
    Cell Significance Index: 9.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3334
    Cell Significance Index: 32.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.3233
    Cell Significance Index: 37.0500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.3042
    Cell Significance Index: 3.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2931
    Cell Significance Index: 20.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2221
    Cell Significance Index: 16.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2104
    Cell Significance Index: 2.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1947
    Cell Significance Index: 35.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1875
    Cell Significance Index: 23.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1124
    Cell Significance Index: 5.2900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0692
    Cell Significance Index: 7.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0591
    Cell Significance Index: 40.9100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0419
    Cell Significance Index: 0.8700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0399
    Cell Significance Index: 0.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0365
    Cell Significance Index: 6.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0256
    Cell Significance Index: 0.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0189
    Cell Significance Index: 1.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0060
    Cell Significance Index: 0.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0006
    Cell Significance Index: 0.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0032
    Cell Significance Index: -1.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0040
    Cell Significance Index: -7.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0062
    Cell Significance Index: -0.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0077
    Cell Significance Index: -14.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0086
    Cell Significance Index: -13.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0103
    Cell Significance Index: -5.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0115
    Cell Significance Index: -15.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0128
    Cell Significance Index: -9.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0170
    Cell Significance Index: -12.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0183
    Cell Significance Index: -11.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0278
    Cell Significance Index: -9.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0284
    Cell Significance Index: -5.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0293
    Cell Significance Index: -5.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0296
    Cell Significance Index: -5.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0310
    Cell Significance Index: -14.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0328
    Cell Significance Index: -9.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0329
    Cell Significance Index: -0.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0523
    Cell Significance Index: -6.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0616
    Cell Significance Index: -8.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0671
    Cell Significance Index: -0.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0677
    Cell Significance Index: -8.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0719
    Cell Significance Index: -9.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0829
    Cell Significance Index: -1.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0859
    Cell Significance Index: -2.7500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0906
    Cell Significance Index: -0.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1046
    Cell Significance Index: -10.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1092
    Cell Significance Index: -3.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1163
    Cell Significance Index: -7.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1313
    Cell Significance Index: -15.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1455
    Cell Significance Index: -15.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1599
    Cell Significance Index: -8.3300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1643
    Cell Significance Index: -6.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1759
    Cell Significance Index: -13.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1941
    Cell Significance Index: -14.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1998
    Cell Significance Index: -13.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2325
    Cell Significance Index: -14.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2362
    Cell Significance Index: -8.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2405
    Cell Significance Index: -10.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2914
    Cell Significance Index: -16.3500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2970
    Cell Significance Index: -2.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2981
    Cell Significance Index: -11.2900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.3140
    Cell Significance Index: -3.4000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3190
    Cell Significance Index: -2.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3272
    Cell Significance Index: -17.1800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3342
    Cell Significance Index: -8.5900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.3578
    Cell Significance Index: -2.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3674
    Cell Significance Index: -12.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3714
    Cell Significance Index: -12.9100
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.4044
    Cell Significance Index: -4.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LAMC2 is a subunit of laminin, a high-molecular-weight glycoprotein that forms a network of fibers in the ECM. The LAMC2 gene encodes for a 858-amino acid protein that is rich in hydrophobic and hydrophilic regions, allowing it to interact with various molecules, including integrins, growth factors, and other laminin subunits. LAMC2 is characterized by its ability to form heterotrimers with laminin subunits α1 and α2, which are essential for the assembly of laminin fibers and the formation of the ECM. **Pathways and Functions** LAMC2 is involved in various cellular processes, including: 1. **Anchoring fibril formation**: LAMC2 plays a critical role in the formation of anchoring fibrils, which are essential for maintaining the integrity of the ECM and preventing its degradation. 2. **Cell-cell communication**: LAMC2 interacts with other laminin subunits and ECM components to facilitate cell-cell communication, which is crucial for tissue development and maintenance. 3. **Cell adhesion**: LAMC2 binds to integrins and other ECM components, promoting cell adhesion and migration. 4. **Cell migration**: LAMC2 promotes cell migration by interacting with growth factors and other ECM components. 5. **Signaling by receptor tyrosine kinases**: LAMC2 can activate signaling pathways by interacting with receptor tyrosine kinases, such as Met, which is involved in cell migration and proliferation. **Clinical Significance** Dysregulation of LAMC2 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of LAMC2 has been observed in various cancers, including prostate, breast, and lung cancer, suggesting its potential role as a tumor suppressor. 2. **Muscular dystrophy**: Mutations in the LAMC2 gene have been associated with muscular dystrophy, highlighting its importance in muscle development and function. 3. **Neurological disorders**: Abnormal expression of LAMC2 has been linked to neurological disorders, such as amyotrophic lateral sclerosis (ALS) and multiple sclerosis. 4. **Cardiovascular disease**: LAMC2 may play a role in cardiovascular disease, as it is involved in the formation of the ECM and the regulation of cell migration and proliferation. In conclusion, LAMC2 is a critical protein component of the ECM that plays a vital role in various cellular processes, including cell adhesion, migration, proliferation, and differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its role in human health and disease.

Genular Protein ID: 35130665

Symbol: LAMC2_HUMAN

Name: Laminin subunit gamma-2

UniProtKB Accession Codes:

Q13753 Q02536 Q02537 Q13752 Q14941 Q14DF7 Q2M1N2 Q5VYE8

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 50 Ensembl 2 GO 11 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1383240

Title: A truncated laminin chain homologous to the B2 chain: structure, spatial expression, and chromosomal assignment.

PubMed ID: 1383240

DOI: 10.1083/jcb.119.3.679

PubMed ID: 8306988

Title: The 100-kDa chain of nicein/kalinin is a laminin B2 chain variant.

PubMed ID: 8306988

DOI: 10.1111/j.1432-1033.1994.tb19932.x

PubMed ID: 8786121

Title: Structure of the human laminin gamma 2 chain gene (LAMC2): alternative splicing with different tissue distribution of two transcripts.

PubMed ID: 8786121

DOI: 10.1006/geno.1996.0076

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8265624

Title: A large cell-adhesive scatter factor secreted by human gastric carcinoma cells.

PubMed ID: 8265624

DOI: 10.1073/pnas.90.24.11767

PubMed ID: 8012393

Title: Mutations in the gamma 2 chain gene (LAMC2) of kalinin/laminin 5 in the junctional forms of epidermolysis bullosa.

PubMed ID: 8012393

DOI: 10.1038/ng0394-293

PubMed ID: 11810295

Title: Laminin 5 mutations in junctional epidermolysis bullosa: molecular basis of Herlitz vs. non-Herlitz phenotypes.

PubMed ID: 11810295

DOI: 10.1007/s00439-001-0630-1

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

Sequence Information:

  • Length: 1193
  • Mass: 130976
  • Checksum: 0BBE1A56516C5C9A
  • Sequence:
    • MPALWLGCCL CFSLLLPAAR ATSRREVCDC NGKSRQCIFD RELHRQTGNG FRCLNCNDNT 
DGIHCEKCKN GFYRHRERDR CLPCNCNSKG SLSARCDNSG RCSCKPGVTG ARCDRCLPGF 
HMLTDAGCTQ DQRLLDSKCD CDPAGIAGPC DAGRCVCKPA VTGERCDRCR SGYYNLDGGN 
PEGCTQCFCY GHSASCRSSA EYSVHKITST FHQDVDGWKA VQRNGSPAKL QWSQRHQDVF 
SSAQRLDPVY FVAPAKFLGN QQVSYGQSLS FDYRVDRGGR HPSAHDVILE GAGLRITAPL 
MPLGKTLPCG LTKTYTFRLN EHPSNNWSPQ LSYFEYRRLL RNLTALRIRA TYGEYSTGYI 
DNVTLISARP VSGAPAPWVE QCICPVGYKG QFCQDCASGY KRDSARLGPF GTCIPCNCQG 
GGACDPDTGD CYSGDENPDI ECADCPIGFY NDPHDPRSCK PCPCHNGFSC SVMPETEEVV 
CNNCPPGVTG ARCELCADGY FGDPFGEHGP VRPCQPCQCN NNVDPSASGN CDRLTGRCLK 
CIHNTAGIYC DQCKAGYFGD PLAPNPADKC RACNCNPMGS EPVGCRSDGT CVCKPGFGGP 
NCEHGAFSCP ACYNQVKIQM DQFMQQLQRM EALISKAQGG DGVVPDTELE GRMQQAEQAL 
QDILRDAQIS EGASRSLGLQ LAKVRSQENS YQSRLDDLKM TVERVRALGS QYQNRVRDTH 
RLITQMQLSL AESEASLGNT NIPASDHYVG PNGFKSLAQE ATRLAESHVE SASNMEQLTR 
ETEDYSKQAL SLVRKALHEG VGSGSGSPDG AVVQGLVEKL EKTKSLAQQL TREATQAEIE 
ADRSYQHSLR LLDSVSRLQG VSDQSFQVEE AKRIKQKADS LSSLVTRHMD EFKRTQKNLG 
NWKEEAQQLL QNGKSGREKS DQLLSRANLA KSRAQEALSM GNATFYEVES ILKNLREFDL 
QVDNRKAEAE EAMKRLSYIS QKVSDASDKT QQAERALGSA AADAQRAKNG AGEALEISSE 
IEQEIGSLNL EANVTADGAL AMEKGLASLK SEMREVEGEL ERKELEFDTN MDAVQMVITE 
AQKVDTRAKN AGVTIQDTLN TLDGLLHLMD QPLSVDEEGL VLLEQKLSRA KTQINSQLRP 
MMSELEERAR QQRGHLHLLE TSIDGILADV KNLENIRDNL PPGCYNTQAL EQQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.