Details for: LAMC2

Gene ID: 3918

Symbol: LAMC2

Ensembl ID: ENSG00000058085

Description: laminin subunit gamma 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.52
    Marker Score: 6165
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.15
    Marker Score: 10562
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.7
    Marker Score: 5835
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.63
    Marker Score: 1962
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168858
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.45
    Marker Score: 1139
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.42
    Marker Score: 2688
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.41
    Marker Score: 12236
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 862
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.22
    Marker Score: 1792
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.21
    Marker Score: 4676
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.19
    Marker Score: 749
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.18
    Marker Score: 1241
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.12
    Marker Score: 2744
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.08
    Marker Score: 14540
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.08
    Marker Score: 1773.5
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.05
    Marker Score: 692
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 788
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.01
    Marker Score: 34957
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.01
    Marker Score: 687
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1
    Marker Score: 476
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71792
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48017
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.99
    Marker Score: 353
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.99
    Marker Score: 4131
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.93
    Marker Score: 1205
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5190
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.9
    Marker Score: 1718
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.87
    Marker Score: 965
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.87
    Marker Score: 5221
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.86
    Marker Score: 292
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.84
    Marker Score: 491
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1338
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.81
    Marker Score: 2530.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.8
    Marker Score: 5131
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8
    Marker Score: 12488
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 297
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3089
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.72
    Marker Score: 2841
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 458
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 651
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.71
    Marker Score: 1292
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.69
    Marker Score: 311
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.67
    Marker Score: 308
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.67
    Marker Score: 197
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.67
    Marker Score: 193
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.66
    Marker Score: 1163
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.64
    Marker Score: 3084
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.62
    Marker Score: 4633
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 411
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.62
    Marker Score: 250
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.62
    Marker Score: 295
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.6
    Marker Score: 173
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.59
    Marker Score: 587.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.58
    Marker Score: 1181
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.58
    Marker Score: 568
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.57
    Marker Score: 9219
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.57
    Marker Score: 665
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.53
    Marker Score: 207
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.53
    Marker Score: 537
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.53
    Marker Score: 840
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.53
    Marker Score: 813
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.52
    Marker Score: 285
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.51
    Marker Score: 1163
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.5
    Marker Score: 544
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.49
    Marker Score: 489
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.49
    Marker Score: 99
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 472
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.48
    Marker Score: 111
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 201
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.46
    Marker Score: 1783
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.46
    Marker Score: 224.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.44
    Marker Score: 110
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.43
    Marker Score: 113
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.42
    Marker Score: 215
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.42
    Marker Score: 106
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.42
    Marker Score: 194
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.4
    Marker Score: 162
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.4
    Marker Score: 386
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.4
    Marker Score: 1483
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.39
    Marker Score: 169
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.39
    Marker Score: 142
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.38
    Marker Score: 1997
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.37
    Marker Score: 249
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.37
    Marker Score: 95
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.37
    Marker Score: 118
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.37
    Marker Score: 1553
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.37
    Marker Score: 96

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Other Information

**Key characteristics:** - LamC2 is a type I transmembrane protein with a molecular weight of approximately 120 kDa. - It is a glycoprotein that is expressed in high levels in epithelial cells. - LamC2 is a key player in cell adhesion, cell-cell communication, and tissue morphogenesis. **Pathways and functions:** - LamC2 is involved in the anchoring of fibrillin, a protein that is essential for the assembly of collagen fibrils. - It also plays a role in the assembly of other multimeric structures, such as cell adhesion complexes and extracellular matrix proteins. - LamC2 is involved in cell-cell communication and tissue morphogenesis by interacting with other cell adhesion molecules, such as cadherins and integrins. - It is also involved in the regulation of cell population proliferation, migration, and differentiation. **Clinical significance:** - Mutations in the LAMC2 gene have been linked to several human diseases, including prostate cancer, breast cancer, and liver disease. - LamC2 is a potential target for cancer therapy, as it is often overexpressed in cancer cells. - Inhibition of LamC2 has been shown to inhibit cancer cell growth and migration. **Additional information:** - LamC2 is a highly conserved protein, with a similar protein being found in other mammals. - It is expressed in all epithelial cells in the human body. - LamC2 is a key player in maintaining the integrity and function of the ECM.

Genular Protein ID: 35130665

Symbol: LAMC2_HUMAN

Name: Laminin subunit gamma-2

UniProtKB Accession Codes:

Q13753 Q02536 Q02537 Q13752 Q14941 Q14DF7 Q2M1N2 Q5VYE8

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 50 EPD 1 Ensembl 2 GO 11 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1383240

Title: A truncated laminin chain homologous to the B2 chain: structure, spatial expression, and chromosomal assignment.

PubMed ID: 1383240

DOI: 10.1083/jcb.119.3.679

PubMed ID: 8306988

Title: The 100-kDa chain of nicein/kalinin is a laminin B2 chain variant.

PubMed ID: 8306988

DOI: 10.1111/j.1432-1033.1994.tb19932.x

PubMed ID: 8786121

Title: Structure of the human laminin gamma 2 chain gene (LAMC2): alternative splicing with different tissue distribution of two transcripts.

PubMed ID: 8786121

DOI: 10.1006/geno.1996.0076

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8265624

Title: A large cell-adhesive scatter factor secreted by human gastric carcinoma cells.

PubMed ID: 8265624

DOI: 10.1073/pnas.90.24.11767

PubMed ID: 8012393

Title: Mutations in the gamma 2 chain gene (LAMC2) of kalinin/laminin 5 in the junctional forms of epidermolysis bullosa.

PubMed ID: 8012393

DOI: 10.1038/ng0394-293

PubMed ID: 11810295

Title: Laminin 5 mutations in junctional epidermolysis bullosa: molecular basis of Herlitz vs. non-Herlitz phenotypes.

PubMed ID: 11810295

DOI: 10.1007/s00439-001-0630-1

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

Sequence Information:

  • Length: 1193
  • Mass: 130976
  • Checksum: 0BBE1A56516C5C9A
  • Sequence:
    • MPALWLGCCL CFSLLLPAAR ATSRREVCDC NGKSRQCIFD RELHRQTGNG FRCLNCNDNT 
DGIHCEKCKN GFYRHRERDR CLPCNCNSKG SLSARCDNSG RCSCKPGVTG ARCDRCLPGF 
HMLTDAGCTQ DQRLLDSKCD CDPAGIAGPC DAGRCVCKPA VTGERCDRCR SGYYNLDGGN 
PEGCTQCFCY GHSASCRSSA EYSVHKITST FHQDVDGWKA VQRNGSPAKL QWSQRHQDVF 
SSAQRLDPVY FVAPAKFLGN QQVSYGQSLS FDYRVDRGGR HPSAHDVILE GAGLRITAPL 
MPLGKTLPCG LTKTYTFRLN EHPSNNWSPQ LSYFEYRRLL RNLTALRIRA TYGEYSTGYI 
DNVTLISARP VSGAPAPWVE QCICPVGYKG QFCQDCASGY KRDSARLGPF GTCIPCNCQG 
GGACDPDTGD CYSGDENPDI ECADCPIGFY NDPHDPRSCK PCPCHNGFSC SVMPETEEVV 
CNNCPPGVTG ARCELCADGY FGDPFGEHGP VRPCQPCQCN NNVDPSASGN CDRLTGRCLK 
CIHNTAGIYC DQCKAGYFGD PLAPNPADKC RACNCNPMGS EPVGCRSDGT CVCKPGFGGP 
NCEHGAFSCP ACYNQVKIQM DQFMQQLQRM EALISKAQGG DGVVPDTELE GRMQQAEQAL 
QDILRDAQIS EGASRSLGLQ LAKVRSQENS YQSRLDDLKM TVERVRALGS QYQNRVRDTH 
RLITQMQLSL AESEASLGNT NIPASDHYVG PNGFKSLAQE ATRLAESHVE SASNMEQLTR 
ETEDYSKQAL SLVRKALHEG VGSGSGSPDG AVVQGLVEKL EKTKSLAQQL TREATQAEIE 
ADRSYQHSLR LLDSVSRLQG VSDQSFQVEE AKRIKQKADS LSSLVTRHMD EFKRTQKNLG 
NWKEEAQQLL QNGKSGREKS DQLLSRANLA KSRAQEALSM GNATFYEVES ILKNLREFDL 
QVDNRKAEAE EAMKRLSYIS QKVSDASDKT QQAERALGSA AADAQRAKNG AGEALEISSE 
IEQEIGSLNL EANVTADGAL AMEKGLASLK SEMREVEGEL ERKELEFDTN MDAVQMVITE 
AQKVDTRAKN AGVTIQDTLN TLDGLLHLMD QPLSVDEEGL VLLEQKLSRA KTQINSQLRP 
MMSELEERAR QQRGHLHLLE TSIDGILADV KNLENIRDNL PPGCYNTQAL EQQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.