Details for: VGLL1

Gene ID: 51442

Symbol: VGLL1

Ensembl ID: ENSG00000102243

Description: vestigial like family member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 32.5284
    Cell Significance Index: -13.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.5911
    Cell Significance Index: 290.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.0627
    Cell Significance Index: 81.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.2468
    Cell Significance Index: 20.6900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.3278
    Cell Significance Index: 8.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1243
    Cell Significance Index: 15.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6107
    Cell Significance Index: 110.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5752
    Cell Significance Index: 70.7300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.2645
    Cell Significance Index: 3.0800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2390
    Cell Significance Index: 5.7900
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.1386
    Cell Significance Index: 1.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0588
    Cell Significance Index: 7.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0580
    Cell Significance Index: 31.6700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0351
    Cell Significance Index: 0.5000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0242
    Cell Significance Index: 0.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0142
    Cell Significance Index: 1.6600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0028
    Cell Significance Index: 0.1200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0065
    Cell Significance Index: -0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0079
    Cell Significance Index: -14.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0136
    Cell Significance Index: -9.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0148
    Cell Significance Index: -10.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0151
    Cell Significance Index: -9.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0158
    Cell Significance Index: -29.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0185
    Cell Significance Index: -14.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0189
    Cell Significance Index: -29.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0194
    Cell Significance Index: -10.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0213
    Cell Significance Index: -28.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0344
    Cell Significance Index: -0.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0575
    Cell Significance Index: -11.4100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0585
    Cell Significance Index: -0.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0592
    Cell Significance Index: -2.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0631
    Cell Significance Index: -28.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0647
    Cell Significance Index: -9.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0719
    Cell Significance Index: -12.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0736
    Cell Significance Index: -14.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0790
    Cell Significance Index: -9.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0972
    Cell Significance Index: -13.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1288
    Cell Significance Index: -6.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1446
    Cell Significance Index: -7.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1582
    Cell Significance Index: -11.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1653
    Cell Significance Index: -4.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1734
    Cell Significance Index: -10.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1956
    Cell Significance Index: -13.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3081
    Cell Significance Index: -10.7100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3198
    Cell Significance Index: -3.6800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3505
    Cell Significance Index: -8.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3842
    Cell Significance Index: -13.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3913
    Cell Significance Index: -8.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4040
    Cell Significance Index: -14.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4052
    Cell Significance Index: -22.7400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4155
    Cell Significance Index: -8.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4365
    Cell Significance Index: -11.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4372
    Cell Significance Index: -8.0800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4415
    Cell Significance Index: -3.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4584
    Cell Significance Index: -13.1400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4609
    Cell Significance Index: -7.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4658
    Cell Significance Index: -15.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4713
    Cell Significance Index: -13.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4744
    Cell Significance Index: -15.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4782
    Cell Significance Index: -21.1500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4890
    Cell Significance Index: -7.5700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.5099
    Cell Significance Index: -8.6600
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.5490
    Cell Significance Index: -5.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5526
    Cell Significance Index: -12.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5567
    Cell Significance Index: -21.0800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.5637
    Cell Significance Index: -7.7300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6044
    Cell Significance Index: -15.0800
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.6244
    Cell Significance Index: -8.4900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6289
    Cell Significance Index: -13.1300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.6290
    Cell Significance Index: -10.5800
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.6437
    Cell Significance Index: -8.2400
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.6574
    Cell Significance Index: -4.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6620
    Cell Significance Index: -9.4800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.6834
    Cell Significance Index: -17.0700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6838
    Cell Significance Index: -13.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6881
    Cell Significance Index: -18.7300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6976
    Cell Significance Index: -13.7300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6980
    Cell Significance Index: -15.0800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7017
    Cell Significance Index: -12.4000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7063
    Cell Significance Index: -14.9900
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.7194
    Cell Significance Index: -7.1400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.7196
    Cell Significance Index: -14.3500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.7263
    Cell Significance Index: -8.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7323
    Cell Significance Index: -12.2600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.7453
    Cell Significance Index: -10.9000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7474
    Cell Significance Index: -12.5900
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.7523
    Cell Significance Index: -5.4200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7566
    Cell Significance Index: -15.1900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.7570
    Cell Significance Index: -8.2300
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -0.7573
    Cell Significance Index: -7.4400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.7588
    Cell Significance Index: -7.7400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.7614
    Cell Significance Index: -9.8100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.7634
    Cell Significance Index: -8.1100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7692
    Cell Significance Index: -15.2100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.7713
    Cell Significance Index: -19.6500
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.7727
    Cell Significance Index: -7.8600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.7876
    Cell Significance Index: -8.7200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.7924
    Cell Significance Index: -10.9900
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.7972
    Cell Significance Index: -10.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** VGLL1 is expressed in a diverse range of cell types, including embryonic stem cells, bladder urothelial cells, placental villous trophoblasts, and taste receptor cells. This widespread expression suggests that VGLL1 may play a critical role in the development and maintenance of these cell types. 2. **Cellular Localization:** VGLL1 is primarily localized to the nucleus, where it is involved in the regulation of transcription. 3. **Protein Binding:** VGLL1 interacts with various proteins, including RNA polymerase II, which is essential for the regulation of transcription. **Pathways and Functions:** 1. **Transcriptional Regulation:** VGLL1 is involved in the positive regulation of DNA-templated transcription, which is the process by which RNA polymerase II transcribes DNA into RNA. VGLL1 interacts with RNA polymerase II, enhancing its activity and promoting the expression of target genes. 2. **Transcription Coactivator Activity:** VGLL1 exhibits transcription coactivator activity, which means that it can enhance the activity of transcription factors and other coactivators to promote the expression of genes. 3. **Cellular Differentiation:** VGLL1 may play a role in the cellular differentiation of embryonic stem cells and urothelial cells, as it is expressed in these cell types during development. **Clinical Significance:** 1. **Immunological Disorders:** VGLL1 may be involved in the regulation of immune responses, particularly in the context of urothelial cells, which are critical for the maintenance of bladder health. 2. **Cancer:** Aberrant expression of VGLL1 has been observed in various types of cancer, including bladder cancer, suggesting that it may play a role in tumorigenesis. 3. **Developmental Disorders:** VGLL1 may be involved in the development of embryonic stem cells and urothelial cells, which could have implications for the treatment of developmental disorders such as bladder dysfunction. In conclusion, VGLL1 is a gene that has been implicated in various cellular and immunological processes, including transcriptional regulation, cellular differentiation, and immune response. Further research is necessary to elucidate the precise functions of VGLL1 and its role in human disease.

Genular Protein ID: 864096664

Symbol: VGLL1_HUMAN

Name: Transcription cofactor vestigial-like protein 1

UniProtKB Accession Codes:

Q99990 Q5H915

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10518497

Title: TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation.

PubMed ID: 10518497

DOI: 10.1242/dev.126.21.4807

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 258
  • Mass: 28707
  • Checksum: EA688B03E04AAD7F
  • Sequence:
    • MEEMKKTAIR LPKGKQKPIK TEWNSRCVLF TYFQGDISSV VDEHFSRALS NIKSPQELTP 
SSQSEGVMLK NDDSMSPNQW RYSSPWTKPQ PEVPVTNRAA NCNLHVPGPM AVNQFSPSLA 
RRASVRPGEL WHFSSLAGTS SLEPGYSHPF PARHLVPEPQ PDGKREPLLS LLQQDRCLAR 
PQESAARENG NPGQIAGSTG LLFNLPPGSV HYKKLYVSRG SASTSLPNET LSELETPGKY 
SLTPPNHWGH PHRYLQHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.