Details for: NOS2

Gene ID: 4843

Symbol: NOS2

Ensembl ID: ENSG00000007171

Description: nitric oxide synthase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.1018
    Cell Significance Index: 109.1800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2872
    Cell Significance Index: 31.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9866
    Cell Significance Index: 59.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9689
    Cell Significance Index: 13.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8740
    Cell Significance Index: 86.4600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.7891
    Cell Significance Index: 11.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7186
    Cell Significance Index: 78.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5904
    Cell Significance Index: 533.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5236
    Cell Significance Index: 15.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4770
    Cell Significance Index: 77.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4199
    Cell Significance Index: 290.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3637
    Cell Significance Index: 25.1600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3577
    Cell Significance Index: 7.4200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.3412
    Cell Significance Index: 3.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2212
    Cell Significance Index: 4.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1874
    Cell Significance Index: 35.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1800
    Cell Significance Index: 8.1600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1679
    Cell Significance Index: 2.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1365
    Cell Significance Index: 27.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0552
    Cell Significance Index: 1.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0452
    Cell Significance Index: 0.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0381
    Cell Significance Index: 1.2200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0379
    Cell Significance Index: 0.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0176
    Cell Significance Index: 6.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0096
    Cell Significance Index: 2.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0060
    Cell Significance Index: 0.2100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0014
    Cell Significance Index: -2.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0021
    Cell Significance Index: -2.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0063
    Cell Significance Index: -3.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0069
    Cell Significance Index: -5.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0072
    Cell Significance Index: -3.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0073
    Cell Significance Index: -5.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0074
    Cell Significance Index: -4.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0080
    Cell Significance Index: -0.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0089
    Cell Significance Index: -5.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0090
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0108
    Cell Significance Index: -2.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0206
    Cell Significance Index: -3.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0206
    Cell Significance Index: -4.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0232
    Cell Significance Index: -1.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0239
    Cell Significance Index: -3.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0250
    Cell Significance Index: -3.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0252
    Cell Significance Index: -4.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0263
    Cell Significance Index: -0.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0322
    Cell Significance Index: -3.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0324
    Cell Significance Index: -2.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0355
    Cell Significance Index: -4.0700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0355
    Cell Significance Index: -1.4500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0370
    Cell Significance Index: -0.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0393
    Cell Significance Index: -1.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0399
    Cell Significance Index: -5.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0430
    Cell Significance Index: -4.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0456
    Cell Significance Index: -2.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0478
    Cell Significance Index: -4.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0493
    Cell Significance Index: -3.1100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0495
    Cell Significance Index: -0.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0496
    Cell Significance Index: -3.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0538
    Cell Significance Index: -2.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0552
    Cell Significance Index: -3.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0654
    Cell Significance Index: -4.0200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0670
    Cell Significance Index: -0.7900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0675
    Cell Significance Index: -0.7400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0690
    Cell Significance Index: -0.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0701
    Cell Significance Index: -5.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0712
    Cell Significance Index: -3.1500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0743
    Cell Significance Index: -1.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0790
    Cell Significance Index: -4.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0803
    Cell Significance Index: -5.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0819
    Cell Significance Index: -0.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0823
    Cell Significance Index: -4.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0829
    Cell Significance Index: -1.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0836
    Cell Significance Index: -2.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0838
    Cell Significance Index: -4.7000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0867
    Cell Significance Index: -1.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0905
    Cell Significance Index: -3.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0906
    Cell Significance Index: -3.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0913
    Cell Significance Index: -2.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0914
    Cell Significance Index: -2.9100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0939
    Cell Significance Index: -2.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0964
    Cell Significance Index: -3.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0968
    Cell Significance Index: -2.1200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1013
    Cell Significance Index: -0.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1048
    Cell Significance Index: -3.4300
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1059
    Cell Significance Index: -1.4500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1061
    Cell Significance Index: -1.0500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1081
    Cell Significance Index: -0.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1083
    Cell Significance Index: -5.0900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1089
    Cell Significance Index: -0.5700
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.1127
    Cell Significance Index: -0.9700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1132
    Cell Significance Index: -1.6500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1145
    Cell Significance Index: -2.8600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1184
    Cell Significance Index: -1.5300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1211
    Cell Significance Index: -1.5300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1217
    Cell Significance Index: -1.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1224
    Cell Significance Index: -3.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1229
    Cell Significance Index: -3.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1247
    Cell Significance Index: -3.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NOS2 is a member of the nitric oxide synthase family, which consists of three main isoforms: neuronal nitric oxide synthase (nNOS), endothelial nitric oxide synthase (eNOS), and inducible nitric oxide synthase (iNOS). NOS2 is distinct from nNOS and eNOS in terms of its expression pattern, substrate specificity, and enzymatic activity. The NOS2 gene is located on chromosome 17q11.2 and consists of 10 exons that encode a 2,212 amino acid protein. NOS2 is a homodimeric enzyme, consisting of two identical subunits, which are stabilized by a disulfide bond. **Pathways and Functions** NOS2 is involved in various cellular processes, including: 1. **Inflammation and Immune Response**: NOS2 is induced in response to inflammatory stimuli, such as bacterial lipopolysaccharides, and produces NO, which acts as a signaling molecule to regulate inflammatory responses. 2. **Nitric Oxide Biosynthesis**: NOS2 is responsible for the production of NO from L-arginine, a key amino acid substrate. 3. **Cellular Signaling**: NO produced by NOS2 acts as a signaling molecule to regulate various cellular processes, including gene expression, protein modification, and cell survival. 4. **Cytokine Production**: NOS2 is involved in the production of pro-inflammatory cytokines, such as IL-6 and IL-8, which are essential for the regulation of immune responses. 5. **Cellular Homeostasis**: NOS2 is involved in the regulation of cellular homeostasis, including the modulation of blood pressure, insulin secretion, and cellular respiration. **Clinical Significance** NOS2 has significant implications in various diseases, including: 1. **Inflammatory Disorders**: NOS2 is involved in the pathogenesis of inflammatory disorders, such as rheumatoid arthritis, asthma, and inflammatory bowel disease. 2. **Neurological Disorders**: NOS2 is implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Cancer**: NOS2 is involved in the regulation of tumor growth and metastasis, and its expression is often altered in cancer cells. 4. **Infectious Diseases**: NOS2 is essential for the regulation of immune responses to bacterial infections, such as tuberculosis. 5. **Cardiovascular Diseases**: NOS2 is involved in the regulation of blood pressure and cardiovascular function, and its expression is often altered in cardiovascular diseases, such as hypertension and atherosclerosis. In conclusion, NOS2 is a crucial enzyme involved in the regulation of inflammation, immune responses, and tissue homeostasis. Its dysregulation is implicated in various diseases, highlighting the importance of NOS2 in human health and disease.

Genular Protein ID: 3119262221

Symbol: NOS2_HUMAN

Name: Hepatocyte NOS

UniProtKB Accession Codes:

P35228 A1L3U5 B7ZLY2 O60757 O94994 Q16263 Q16692 Q4TTS5 Q9UD42

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 58 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 45 DrugCentral 1 EC 1 EMBL 14 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 49 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 5 RefSeq 2 Rhea 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7692964

Title: Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line.

PubMed ID: 7692964

DOI: 10.1021/bi00094a017

PubMed ID: 7682706

Title: Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

PubMed ID: 7682706

DOI: 10.1073/pnas.90.8.3491

PubMed ID: 7504305

Title: Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.

PubMed ID: 7504305

DOI: 10.1073/pnas.90.23.11419

PubMed ID: 7522054

Title: Inducible nitric oxide synthase from human articular chondrocytes: cDNA cloning and analysis of mRNA expression.

PubMed ID: 7522054

DOI: 10.1016/0167-4838(94)90171-6

PubMed ID: 7528017

Title: Human retina expresses both constitutive and inducible isoforms of nitric oxide synthase mRNA.

PubMed ID: 7528017

DOI: 10.1006/bbrc.1994.2633

PubMed ID: 7531687

Title: Cloning and functional expression of human inducible nitric oxide synthase (NOS) cDNA from a glioblastoma cell line A-172.

PubMed ID: 7531687

DOI: 10.1093/oxfordjournals.jbchem.a124563

PubMed ID: 7544004

Title: Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo.

PubMed ID: 7544004

DOI: 10.1073/pnas.92.17.7809

PubMed ID: 9160867

Title: Dedifferentiated human ventricular cardiac myocytes express inducible nitric oxide synthase mRNA but not protein in response to IL-1, TNF, IFNgamma, and LPS.

PubMed ID: 9160867

DOI: 10.1006/jmcc.1996.0349

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7532248

Title: Nitric oxide production by human proximal tubular cells: a novel immunomodulatory mechanism?

PubMed ID: 7532248

DOI: 10.1038/ki.1994.365

PubMed ID: 7528267

Title: Inducible nitric oxide synthase in a human glioblastoma cell line.

PubMed ID: 7528267

DOI: 10.1046/j.1471-4159.1995.64010085.x

PubMed ID: 7558036

Title: Three members of the nitric oxide synthase II gene family (NOS2A, NOS2B, and NOS2C) colocalize to human chromosome 17.

PubMed ID: 7558036

DOI: 10.1006/geno.1995.1086

PubMed ID: 9721329

Title: Inducible nitric oxide synthase in the liver: regulation and function.

PubMed ID: 9721329

PubMed ID: 12080081

Title: Epithelial inducible nitric-oxide synthase is an apical EBP50-binding protein that directs vectorial nitric oxide output.

PubMed ID: 12080081

DOI: 10.1074/jbc.m205764200

PubMed ID: 12433515

Title: A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children.

PubMed ID: 12433515

DOI: 10.1016/s0140-6736(02)11474-7

PubMed ID: 19688109

Title: Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production.

PubMed ID: 19688109

DOI: 10.1155/2009/345838

PubMed ID: 21199876

Title: Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins.

PubMed ID: 21199876

DOI: 10.1074/jbc.m110.190678

PubMed ID: 25417112

Title: Target-selective protein S-nitrosylation by sequence motif recognition.

PubMed ID: 25417112

DOI: 10.1016/j.cell.2014.09.032

PubMed ID: 25180171

Title: Zinc regulates iNOS-derived nitric oxide formation in endothelial cells.

PubMed ID: 25180171

DOI: 10.1016/j.redox.2014.06.011

PubMed ID: 35772285

Title: 2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.

PubMed ID: 35772285

DOI: 10.1016/j.bmc.2022.116878

PubMed ID: 10409685

Title: Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase.

PubMed ID: 10409685

DOI: 10.1074/jbc.274.30.21276

PubMed ID: 10074942

Title: Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation.

PubMed ID: 10074942

DOI: 10.1038/6675

PubMed ID: 19737939

Title: Regulation of interdomain interactions by calmodulin in inducible nitric-oxide synthase.

PubMed ID: 19737939

DOI: 10.1074/jbc.m109.031682

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 24430113

Title: Higher activity of the inducible nitric oxide synthase contributes to very early onset inflammatory bowel disease.

PubMed ID: 24430113

DOI: 10.1038/ctg.2013.17

Sequence Information:

  • Length: 1153
  • Mass: 131117
  • Checksum: 47671E5385CB3A52
  • Sequence:
    • MACPWKFLFK TKFHQYAMNG EKDINNNVEK APCATSSPVT QDDLQYHNLS KQQNESPQPL 
VETGKKSPES LVKLDATPLS SPRHVRIKNW GSGMTFQDTL HHKAKGILTC RSKSCLGSIM 
TPKSLTRGPR DKPTPPDELL PQAIEFVNQY YGSFKEAKIE EHLARVEAVT KEIETTGTYQ 
LTGDELIFAT KQAWRNAPRC IGRIQWSNLQ VFDARSCSTA REMFEHICRH VRYSTNNGNI 
RSAITVFPQR SDGKHDFRVW NAQLIRYAGY QMPDGSIRGD PANVEFTQLC IDLGWKPKYG 
RFDVVPLVLQ ANGRDPELFE IPPDLVLEVA MEHPKYEWFR ELELKWYALP AVANMLLEVG 
GLEFPGCPFN GWYMGTEIGV RDFCDVQRYN ILEEVGRRMG LETHKLASLW KDQAVVEINI 
AVLHSFQKQN VTIMDHHSAA ESFMKYMQNE YRSRGGCPAD WIWLVPPMSG SITPVFHQEM 
LNYVLSPFYY YQVEAWKTHV WQDEKRRPKR REIPLKVLVK AVLFACMLMR KTMASRVRVT 
ILFATETGKS EALAWDLGAL FSCAFNPKVV CMDKYRLSCL EEERLLLVVT STFGNGDCPG 
NGEKLKKSLF MLKELNNKFR YAVFGLGSSM YPRFCAFAHD IDQKLSHLGA SQLTPMGEGD 
ELSGQEDAFR SWAVQTFKAA CETFDVRGKQ HIQIPKLYTS NVTWDPHHYR LVQDSQPLDL 
SKALSSMHAK NVFTMRLKSR QNLQSPTSSR ATILVELSCE DGQGLNYLPG EHLGVCPGNQ 
PALVQGILER VVDGPTPHQT VRLEALDESG SYWVSDKRLP PCSLSQALTY FLDITTPPTQ 
LLLQKLAQVA TEEPERQRLE ALCQPSEYSK WKFTNSPTFL EVLEEFPSLR VSAGFLLSQL 
PILKPRFYSI SSSRDHTPTE IHLTVAVVTY HTRDGQGPLH HGVCSTWLNS LKPQDPVPCF 
VRNASGFHLP EDPSHPCILI GPGTGIAPFR SFWQQRLHDS QHKGVRGGRM TLVFGCRRPD 
EDHIYQEEML EMAQKGVLHA VHTAYSRLPG KPKVYVQDIL RQQLASEVLR VLHKEPGHLY 
VCGDVRMARD VAHTLKQLVA AKLKLNEEQV EDYFFQLKSQ KRYHEDIFGA VFPYEAKKDR 
VAVQPSSLEM SAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.