Details for: PIP

Gene ID: 5304

Symbol: PIP

Ensembl ID: ENSG00000159763

Description: prolactin induced protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 57.2595
    Cell Significance Index: 318.7100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 50.5445
    Cell Significance Index: 1054.1400
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 22.2467
    Cell Significance Index: 15.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 15.4343
    Cell Significance Index: 719.6200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 13.3723
    Cell Significance Index: 212.1500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 12.9198
    Cell Significance Index: 166.9200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 11.0965
    Cell Significance Index: 68.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.0713
    Cell Significance Index: 303.4300
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 3.0161
    Cell Significance Index: 20.1400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.7038
    Cell Significance Index: 34.8200
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 2.3262
    Cell Significance Index: 16.7400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 2.2589
    Cell Significance Index: 29.2300
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 1.9686
    Cell Significance Index: 19.7000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.5481
    Cell Significance Index: 21.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.5286
    Cell Significance Index: -4.7000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 1.4506
    Cell Significance Index: 15.4100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.3482
    Cell Significance Index: 23.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7576
    Cell Significance Index: 97.8800
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: 0.3719
    Cell Significance Index: 2.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3422
    Cell Significance Index: 16.0900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.1363
    Cell Significance Index: 1.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0139
    Cell Significance Index: 1.4200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0082
    Cell Significance Index: 0.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0039
    Cell Significance Index: 0.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0022
    Cell Significance Index: 1.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0032
    Cell Significance Index: -1.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0045
    Cell Significance Index: -0.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0047
    Cell Significance Index: -0.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0047
    Cell Significance Index: -8.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0102
    Cell Significance Index: -7.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0108
    Cell Significance Index: -8.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0113
    Cell Significance Index: -0.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0116
    Cell Significance Index: -7.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0120
    Cell Significance Index: -8.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0121
    Cell Significance Index: -22.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0142
    Cell Significance Index: -7.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0144
    Cell Significance Index: -22.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0165
    Cell Significance Index: -22.4200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0188
    Cell Significance Index: -0.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0239
    Cell Significance Index: -8.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0270
    Cell Significance Index: -12.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0305
    Cell Significance Index: -6.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0306
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0411
    Cell Significance Index: -8.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0444
    Cell Significance Index: -7.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0448
    Cell Significance Index: -8.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0461
    Cell Significance Index: -13.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0497
    Cell Significance Index: -7.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0544
    Cell Significance Index: -6.6900
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0548
    Cell Significance Index: -0.5500
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0552
    Cell Significance Index: -0.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0601
    Cell Significance Index: -3.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0642
    Cell Significance Index: -8.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0779
    Cell Significance Index: -2.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0821
    Cell Significance Index: -9.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0884
    Cell Significance Index: -9.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1086
    Cell Significance Index: -2.7900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1176
    Cell Significance Index: -1.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1254
    Cell Significance Index: -7.7100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1320
    Cell Significance Index: -2.0000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1342
    Cell Significance Index: -1.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1343
    Cell Significance Index: -9.0300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1344
    Cell Significance Index: -1.3200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1375
    Cell Significance Index: -2.0300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1408
    Cell Significance Index: -0.7400
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1637
    Cell Significance Index: -1.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1700
    Cell Significance Index: -13.0500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1707
    Cell Significance Index: -2.2800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1761
    Cell Significance Index: -3.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1940
    Cell Significance Index: -5.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2103
    Cell Significance Index: -9.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2114
    Cell Significance Index: -7.7600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2196
    Cell Significance Index: -5.6000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2223
    Cell Significance Index: -3.2400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2225
    Cell Significance Index: -4.3500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.2390
    Cell Significance Index: -0.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2427
    Cell Significance Index: -13.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2453
    Cell Significance Index: -9.2900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2649
    Cell Significance Index: -4.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2653
    Cell Significance Index: -5.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2698
    Cell Significance Index: -9.4500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2893
    Cell Significance Index: -4.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2896
    Cell Significance Index: -9.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2967
    Cell Significance Index: -9.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3132
    Cell Significance Index: -8.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3135
    Cell Significance Index: -8.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3205
    Cell Significance Index: -9.1500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3251
    Cell Significance Index: -2.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3563
    Cell Significance Index: -18.5100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3601
    Cell Significance Index: -8.9800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3652
    Cell Significance Index: -5.0500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3769
    Cell Significance Index: -7.6700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3788
    Cell Significance Index: -9.4500
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.4000
    Cell Significance Index: -3.5200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4058
    Cell Significance Index: -9.8300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4124
    Cell Significance Index: -9.8900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4208
    Cell Significance Index: -6.5100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4251
    Cell Significance Index: -9.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4299
    Cell Significance Index: -9.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4332
    Cell Significance Index: -5.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** PIP is predominantly expressed in erythrocytes, acinar cells of the salivary gland, serous-secreting cells, lung secretory cells, and hematopoietic stem cells, indicating its role in various tissues and cell types. 2. **Protein Function:** PIP is a multifunctional protein that interacts with numerous proteins, including actin-binding proteins, enzymes, and receptors, influencing various cellular processes. 3. **Cellular Localization:** PIP is primarily localized to the extracellular space, where it can interact with other molecules and influence cell signaling and gene expression. **Pathways and Functions:** 1. **Immune Regulation:** PIP plays a crucial role in modulating the immune response, particularly in the regulation of T-cell apoptosis and the negative regulation of immune system processes. 2. **Gene Expression:** PIP acts as a transcriptional regulator, influencing the expression of various genes involved in immune response, cell signaling, and protein degradation. 3. **Cell Signaling:** PIP interacts with numerous signaling molecules, including receptors and enzymes, modulating cell signaling pathways involved in immune response, cell growth, and differentiation. 4. **Protein Degradation:** PIP is involved in the regulation of protein degradation, influencing the activity of proteases and the degradation of proteins involved in immune response and cell signaling. **Clinical Significance:** 1. **Immune Disorders:** Alterations in PIP expression have been implicated in various immune disorders, including autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** PIP has been identified as a potential biomarker for cancer, particularly in breast cancer, where its expression is often upregulated. 3. **Neurological Disorders:** PIP has been implicated in neurological disorders, such as Alzheimer's disease, where its expression is altered. 4. **Infectious Diseases:** PIP has been identified as a potential target for the development of novel therapeutics for infectious diseases, such as tuberculosis. In conclusion, Prolactin-Induced Protein (PIP) is a complex gene with far-reaching implications in various cellular processes, including immune regulation, gene expression, cell signaling, and protein degradation. Further research is necessary to fully elucidate the mechanisms underlying PIP's functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2154627552

Symbol: PIP_HUMAN

Name: Prolactin-inducible protein

UniProtKB Accession Codes:

P12273 A0A963 A0A9C3 A0A9F3 A4D2I1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 100 Ensembl 1 EvolutionaryTrace 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3667631

Title: Isolation and sequencing of a cDNA clone for a prolactin-inducible protein (PIP). Regulation of PIP gene expression in the human breast cancer cell line, T-47D.

PubMed ID: 3667631

DOI: 10.1016/s0021-9258(18)48164-1

PubMed ID: 1955075

Title: The prolactin-inducible protein (PIP/GCDFP-15) gene: cloning, structure and regulation.

PubMed ID: 1955075

DOI: 10.1016/0303-7207(91)90153-j

PubMed ID: 9218538

Title: Isolation from a human seminal vesicle library of the cDNA for gp17, a CD4 binding factor.

PubMed ID: 9218538

DOI: 10.1007/s002510050215

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2013294

Title: Primary structure of a new actin-binding protein from human seminal plasma.

PubMed ID: 2013294

DOI: 10.1111/j.1432-1033.1991.tb15873.x

PubMed ID: 25946035

Title: Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.

PubMed ID: 25946035

DOI: 10.1021/acs.jproteome.5b00179

PubMed ID: 16949771

Title: Origin and evolution of gene for prolactin-induced protein.

PubMed ID: 16949771

DOI: 10.1016/j.gene.2006.07.014

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 18930737

Title: Crystal structure of the novel complex formed between zinc alpha2-glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma.

PubMed ID: 18930737

DOI: 10.1016/j.jmb.2008.09.072

Sequence Information:

  • Length: 146
  • Mass: 16572
  • Checksum: 93F3DA201133F03C
  • Sequence:
    • MRLLQLLFRA SPATLLLVLC LQLGANKAQD NTRKIIIKNF DIPKSVRPND EVTAVLAVQT 
ELKECMVVKT YLISSIPLQG AFNYKYTACL CDDNPKTFYW DFYTNRTVQI AAVVDVIREL 
GICPDDAAVI PIKNNRFYTI EILKVE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.