Details for: SERPINB4

Gene ID: 6318

Symbol: SERPINB4

Ensembl ID: ENSG00000206073

Description: serpin family B member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 35.4701
    Cell Significance Index: -14.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.9729
    Cell Significance Index: -15.2500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 13.8605
    Cell Significance Index: 147.2400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.0595
    Cell Significance Index: 26.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.4939
    Cell Significance Index: 117.2100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.5920
    Cell Significance Index: 24.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4709
    Cell Significance Index: 24.4600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.4125
    Cell Significance Index: 4.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0748
    Cell Significance Index: 2.0900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0371
    Cell Significance Index: 1.6100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0072
    Cell Significance Index: 0.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0038
    Cell Significance Index: -0.1500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0087
    Cell Significance Index: -0.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0105
    Cell Significance Index: -1.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0172
    Cell Significance Index: -7.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0327
    Cell Significance Index: -24.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0450
    Cell Significance Index: -33.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0618
    Cell Significance Index: -11.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1219
    Cell Significance Index: -24.4500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1472
    Cell Significance Index: -2.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1895
    Cell Significance Index: -26.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1938
    Cell Significance Index: -33.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2191
    Cell Significance Index: -28.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2421
    Cell Significance Index: -8.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2602
    Cell Significance Index: -30.3200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2636
    Cell Significance Index: -1.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2653
    Cell Significance Index: -13.8200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2745
    Cell Significance Index: -3.1200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2755
    Cell Significance Index: -6.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2901
    Cell Significance Index: -33.2400
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.3285
    Cell Significance Index: -2.5100
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.3436
    Cell Significance Index: -2.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3635
    Cell Significance Index: -24.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3751
    Cell Significance Index: -13.7700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3869
    Cell Significance Index: -8.3600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.3872
    Cell Significance Index: -5.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4269
    Cell Significance Index: -8.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4420
    Cell Significance Index: -32.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5074
    Cell Significance Index: -31.1900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.5460
    Cell Significance Index: -6.5100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.5729
    Cell Significance Index: -8.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5838
    Cell Significance Index: -27.2200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.6162
    Cell Significance Index: -8.4500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.6239
    Cell Significance Index: -7.9900
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.6532
    Cell Significance Index: -5.6200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6984
    Cell Significance Index: -20.5700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.7058
    Cell Significance Index: -8.5200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.7231
    Cell Significance Index: -8.6100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.7934
    Cell Significance Index: -7.8500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.7970
    Cell Significance Index: -8.5700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8568
    Cell Significance Index: -24.4500
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.8732
    Cell Significance Index: -8.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.8789
    Cell Significance Index: -30.8900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.8845
    Cell Significance Index: -9.3300
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.8922
    Cell Significance Index: -8.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.9162
    Cell Significance Index: -24.4700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.9301
    Cell Significance Index: -17.1900
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.9424
    Cell Significance Index: -9.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0462
    Cell Significance Index: -33.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.0687
    Cell Significance Index: -30.7900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.0723
    Cell Significance Index: -23.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0879
    Cell Significance Index: -18.2100
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -1.1348
    Cell Significance Index: -8.6400
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -1.1349
    Cell Significance Index: -9.0200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -1.1519
    Cell Significance Index: -13.2600
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -1.1606
    Cell Significance Index: -11.4500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.1791
    Cell Significance Index: -23.3200
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -1.1811
    Cell Significance Index: -8.4900
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -1.2041
    Cell Significance Index: -8.3500
  • Cell Name: club cell (CL0000158)
    Fold Change: -1.2157
    Cell Significance Index: -13.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.2245
    Cell Significance Index: -35.1000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -1.2314
    Cell Significance Index: -12.5600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.2816
    Cell Significance Index: -31.2700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -1.2873
    Cell Significance Index: -8.5400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.3066
    Cell Significance Index: -33.2900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -1.3378
    Cell Significance Index: -8.5400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.3414
    Cell Significance Index: -32.1700
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -1.3795
    Cell Significance Index: -15.2100
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -1.4186
    Cell Significance Index: -8.8500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.4208
    Cell Significance Index: -27.7800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -1.4496
    Cell Significance Index: -24.6200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -1.4717
    Cell Significance Index: -9.0200
  • Cell Name: T cell (CL0000084)
    Fold Change: -1.5398
    Cell Significance Index: -18.1800
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -1.5484
    Cell Significance Index: -17.2200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -1.5499
    Cell Significance Index: -19.9600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.5529
    Cell Significance Index: -14.3000
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -1.5616
    Cell Significance Index: -15.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.5772
    Cell Significance Index: -42.9300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -1.6026
    Cell Significance Index: -18.5900
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -1.6433
    Cell Significance Index: -15.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.6581
    Cell Significance Index: -24.4800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -1.6593
    Cell Significance Index: -18.2200
  • Cell Name: basophil (CL0000767)
    Fold Change: -1.6920
    Cell Significance Index: -15.5700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -1.6960
    Cell Significance Index: -20.6300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -1.6969
    Cell Significance Index: -20.1700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -1.7253
    Cell Significance Index: -21.6700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -1.7716
    Cell Significance Index: -22.4200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -1.7814
    Cell Significance Index: -16.9200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -1.8019
    Cell Significance Index: -22.5100
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -1.8168
    Cell Significance Index: -17.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** * SERPINB4 belongs to the serpin family of protease inhibitors, which are characterized by their ability to bind to and inhibit proteases. * The gene is encoded by a single copy in humans and is expressed in multiple cell types, suggesting its involvement in various physiological processes. * SERPINB4 has been shown to inhibit endopeptidase activity, peptidase activity, and proteolysis, which are essential for cell signaling, inflammation, and immune responses. * The gene also plays a role in protecting cells from natural killer cell-mediated cytotoxicity, which is a mechanism of immune evasion used by tumor cells. **Pathways and Functions:** * SERPINB4 is involved in the negative regulation of endopeptidase activity, which is essential for cell signaling and inflammation. * The gene inhibits peptidase activity, which is involved in protein degradation and cell signaling. * SERPINB4 also regulates proteolysis, which is a critical process in cell signaling, inflammation, and immune responses. * The gene protects cells from natural killer cell-mediated cytotoxicity, which is a mechanism of immune evasion used by tumor cells. * SERPINB4 is also involved in the regulation of protease binding, which is essential for its inhibitory function. **Clinical Significance:** * SERPINB4 has been implicated in various diseases, including cancer, inflammatory disorders, and autoimmune diseases. * The gene's ability to inhibit endopeptidase activity and peptidase activity makes it a potential therapeutic target for treating diseases characterized by dysregulated proteolytic processes. * SERPINB4's role in protecting cells from natural killer cell-mediated cytotoxicity also makes it a potential target for cancer therapy. * Further studies are needed to fully understand the clinical significance of SERPINB4 and its potential as a therapeutic target. In conclusion, SERPINB4 is a serpin gene that plays a crucial role in the negative regulation of proteases and protection from immune cell-mediated cytotoxicity. Its involvement in various physiological processes and its potential as a therapeutic target make it an important area of research for understanding the molecular mechanisms underlying disease and developing new treatments.

Genular Protein ID: 339348085

Symbol: SPB4_HUMAN

Name: Serpin B4

UniProtKB Accession Codes:

P48594 A8K847

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 2 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7589435

Title: Identification of a novel human serpin gene; cloning sequencing and expression of leupin.

PubMed ID: 7589435

DOI: 10.1016/0014-5793(95)01015-7

PubMed ID: 7724531

Title: A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene.

PubMed ID: 7724531

DOI: 10.1073/pnas.92.8.3147

PubMed ID: 11267667

Title: Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter.

PubMed ID: 11267667

DOI: 10.1016/s0167-4781(01)00174-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10956412

Title: Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells.

PubMed ID: 10956412

DOI: 10.1002/1097-0215(20000720)89:4<368::aid-ijc9>3.0.co;2-6

Sequence Information:

  • Length: 390
  • Mass: 44854
  • Checksum: 04E213CD892587D5
  • Sequence:
    • MNSLSEANTK FMFDLFQQFR KSKENNIFYS PISITSALGM VLLGAKDNTA QQISKVLHFD 
QVTENTTEKA ATYHVDRSGN VHHQFQKLLT EFNKSTDAYE LKIANKLFGE KTYQFLQEYL 
DAIKKFYQTS VESTDFANAP EESRKKINSW VESQTNEKIK NLFPDGTIGN DTTLVLVNAI 
YFKGQWENKF KKENTKEEKF WPNKNTYKSV QMMRQYNSFN FALLEDVQAK VLEIPYKGKD 
LSMIVLLPNE IDGLQKLEEK LTAEKLMEWT SLQNMRETCV DLHLPRFKME ESYDLKDTLR 
TMGMVNIFNG DADLSGMTWS HGLSVSKVLH KAFVEVTEEG VEAAAATAVV VVELSSPSTN 
EEFCCNHPFL FFIRQNKTNS ILFYGRFSSP

Genular Protein ID: 2721796940

Symbol: Q9BYF7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BYF7

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 2 Gene3D 2 IntAct 1 InterPro 6 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 369
  • Mass: 42287
  • Checksum: CED7A2426378DE3E
  • Sequence:
    • MNSLSEANTK FMFDLFQQFR KSKENNIFYS PISITSALGM VLLGAKDNTA QQISKVLHFD 
QVTENTTEKA ATYHVDRSGN VHHQFQKLLT EFNKSTDAYE LKIANKLFGE KTYQFLQEYL 
DAIKKFYQTS VESTDFANAP EESRKKINSW VESQTNEKIK NLFPDGTIGN DTTLVLVNAI 
YFKGQWENKF KKENTKEEKF WPNKDVQAKV LEIPYKGKDL SMIVLLPNEI DGLQKLEEKL 
TAEKLMEWTS LQNMRETCVD LHLPRFKMEE SYDLKDTLRT MGMVNIFNGD ADLSGMTWSH 
GLSVSKVLHK AFVEVTEEGV EAAAATAVVV VELSSPSTNE EFCCNHPFLF FIRQNKTNSI 
LFYGRFSSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.